Article
Biochemistry & Molecular Biology
He Liu, Zixia Hu, Ningning Han, Yi Yang, Guode Zhao, Mengdie Su, Yue Zhang, Weiwei Li, Ying Peng, Jiang Zheng
Summary: The study aimed to investigate the metabolic activation of MTX and its possible correlation with cytotoxicity. An oxidative metabolite (M1) and a GSH conjugate (M2) were observed in S9 fraction incubations and rat primary hepatocyte culture after MTX exposure. M1 and M2 were also detected in the bile of MTX-treated rats. CYP2A6 was found to be the dominant enzyme responsible for the oxidation of MTX. Inhibition of CYP2A6 and sulfotransferase significantly decreased the formation of M2. Pretreatment of primary hepatocytes with inhibitors reduced the susceptibility to MTX-induced cytotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biotechnology & Applied Microbiology
Zhenxing Zhang, Min Meng, Qiong Wu, Jeong-Han Kim, Yongzhe Zhu
Summary: In this study, the metabolic pathways of Quinalphos were investigated using Cunninghamella elegans. It was found that Quinalphos degraded by 92% in 7 days and produced ten metabolites. The involvement of cytochrome P450 monooxygenases in Quinalphos metabolism was indirectly demonstrated, and the inhibition effect of methimazole was less efficient. The comprehensive metabolic pathways of Quinalphos were deduced from the detailed analysis of metabolite profiles.
BIOTECHNOLOGY LETTERS
(2023)
Article
Environmental Sciences
Xiaoxia Yang, Xuemei Zhang, Xiao Shu, Jiuping Gong, Junying Yang, Biquan Li, Junjie Lin, Yong Chai, Jianfei Liu
Summary: This study found that polyethylene (PE) microplastics (MPs) smaller than 5 mm exert toxic effects on earthworms, with concentrations exceeding 2.5 g/kg causing significant changes in metabolic enzyme activities and metabolites. The toxicity of PE MPs to earthworms is likely associated with neurotoxicity, oxidative damage, decreased detoxification capacity, energy metabolism imbalance, and impaired amino acid and purine metabolism due to bioaccumulation. The findings of this study contribute to a better understanding of the molecular toxicity mechanisms of PE MPs and the ecological risks they pose.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Shu-Ting Zhang, Tao Li, Shi-Kai Deng, Jim C. Spain, Ning-Yi Zhou
Summary: This study reveals a novel bacterial metabolic pathway for the degradation of 4-nitroanisole, initiated by a three-component cytochrome P450 system (pnaABC). This system exhibits broad substrate specificity and can catalyze the degradation of nitroanisole derivatives.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Line Skute Braten, Tore Haslemo, Marin M. Jukic, Maxim Ivanov, Magnus Ingelman-Sundberg, Espen Molden, Marianne Kristiansen Kringen
Summary: Escitalopram, a commonly used antidepressant drug, shows substantial interindividual variation in clinical response, which can be attributed to the polymorphic nature of the CYP2C19 gene. A novel CYP2C-haplotype associated with ultrarapid metabolism of escitalopram was identified in this study.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Engineering, Environmental
Nikita Yadav, Hyun-Jo Ahn, Niraj R. Rane, Mayur B. Kurade, Xiaofang Li, Young-Kwon Park, Moonis Ali Khan, Woo Jin Chung, Soon Woong Chang, Byong-Hun Jeon
Summary: This study assessed the potential of three aquatic macrophytes (Iris pseudacorus, Ipomoea aquatica, and Typha angustifolia) to remove BPS from secondary wastewater effluent. The results showed that these plants could remove BPS at a concentration of 0.005 mg/L with removal rates of 100%, 97%, and 97.5% for I. pseudacorus, I. aquatica, and T. angustifolia, respectively. Twelve biotransformed products of BPS were identified, and a lab-scale vertical phytoreactor was constructed to completely remove BPS along with nutrients and inorganic contaminants from the wastewater.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Xia Zhao, Xiaojing Li, Shengchen Wang, Zijiang Yang, Honggui Liu, Shiwen Xu
Summary: Studies have shown that cadmium exposure activates XRs and increases CYP450s expression, leading to the production of ROS and decreased antioxidant capacity, ultimately triggering mitochondria pathway apoptosis through the oxidative stress-MAPK pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marta Nowak, Katarzyna Zawadzka, Janusz Szemraj, Aleksandra Goralczyk-Binkowska, Katarzyna Lisowska
Summary: This study investigated the biodegradation mechanism of chloroxylenol by fungal strains and analyzed the ecotoxicity of emerging by-products. The results showed a high elimination rate of PCMX by the tested microorganisms, and the identification of new fungal by-products. Furthermore, the study revealed a detoxifying nature of the biodegradation process of PCMX.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Marcelo R. A. De Figueiredo, Hamlin Barnes, Claudia M. Boot, Ana Beatriz T. B. De Figueiredo, Scott J. Nissen, Franck E. Dayan, Todd A. Gaines
Summary: Amaranthus tuberculatus, a waterhemp plant species resistant to 2,4-dichlorophenoxyacetic acid (2,4-D), has been found to possess rapid metabolic detoxification ability. Through a novel detoxification mechanism, resistant plants hydroxylate 2,4-D into a less toxic metabolite, while susceptible plants conjugate 2,4-D to aspartate. This evolution of detoxification reactions in resistant plants allows for more efficient detoxification of 2,4-D.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Ling Huang, Weiwei Wang, Giulio Zanaroli, Ping Xu, Hongzhi Tang
Summary: This study identified a cytochrome P450-encoding gene responsible for HBCD catabolism in Pseudomonas aeruginosa HS9, showing that debromination and hydrogenation reactions are carried out by the enzyme CYP168A1. Detection of metabolites and O-18 isotope experiments confirmed the degradation mechanism of HBCDs.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Gustavo Perez Ortiz, John D. Sidda, Emmanuel L. C. de los Santos, Catherine B. Hubert, Sarah M. Barry
Summary: The antimycobacterial peptides rufomycins exhibit antibiotic activity due to oxidative tailoring of the cyclic peptide. Cytochrome P450s RufS and RufM play roles in regioselective epoxidation and alkyl oxidation, creating a complex product profile dependent on redox partner availability. Additionally, in vitro one pot conversion of rufomycin B to rufomycin C has been successfully demonstrated.
CHEMICAL COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Hanqing Chen, Shuang Zhou, Meilin Zhu, Bing Wang, Wei Chen, Lingna Zheng, Meng Wang, Weiyue Feng
Summary: The study reveals that PEI-GNPs have significant effects on hepatic drug-metabolic enzymes and de novo lipogenesis in mice, leading to liver inflammation and partial hepatotoxicity. Therefore, it is crucial to consider the interaction between nanomaterials and the liver and modify the surface chemistry of GNPs before biomedical application.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Ruiming Zhang, Pengfei Li, Xiangli Shi, Ruiying Zhang, Junjie Wang, Yanwei Li, Qingzhu Zhang, Wenxing Wang
Summary: Understanding the metabolic mechanism and derivatives of PBDEs is crucial for risk assessment. This study elucidated the metabolic mechanism of BDE-47 catalyzed by P450 enzymes and found that electrophilic addition is the main pathway. The resulting 6-OH-BDE-47 is a more kinetically preferable product and can lead to the formation of toxic PBDD/Fs.
Article
Multidisciplinary Sciences
Sumiko Ohnami, Akane Naruoka, Mitsuhiro Isaka, Maki Mizuguchi, Sou Nakatani, Fukumi Kamada, Yuji Shimoda, Ai Sakai, Keiichi Ohshima, Keiichi Hatakeyama, Kouji Maruyama, Yasuhisa Ohde, Hirotsugu Kenmotsu, Toshiaki Takahashi, Yasuto Akiyama, Takeshi Nagashima, Kenichi Urakami, Shumpei Ohnami, Ken Yamaguchi
Summary: The differences in genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma are still not clear. Researchers developed a gene sequencing panel to detect germline variants in these two types of cancer. The study found that certain gene variants were associated with an increased risk of squamous cell carcinoma, while whole-gene deletion was associated with adenocarcinoma.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Dezhi Kong, Yuan Tian, Kunfeng Duan, Wenyan Guo, Qingning Zhang, Panpan Zhang, Zuxiao Yang, Xia Qin, Leiming Ren, Wei Zhang
Summary: In this study, we identified 34 metabolites of doxazosin (DOX) in rats and analyzed their relationship based on kinetic parameters and multivariate statistical methods. The study revealed the stereoselective metabolic characteristics and mechanisms of DOX, and found significant differences in the metabolic profiles between the enantiomers. The results also demonstrated the importance of different in vivo and in vitro environments in influencing the metabolic characteristics of DOX. This study provides valuable insights into the pharmacokinetics and pharmacodynamics of DOX.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Mycology
Pengfei Xiao, Ryuichiro Kondo
Article
Forestry
Pengfei Xiao, Ryuichiro Kondo
JOURNAL OF WOOD SCIENCE
(2020)
Article
Environmental Sciences
Jianqiao Wang, Ru Yin, Xue Zhang, Nana Wang, Pengfei Xiao, Hirofumi Hirai, Tangfu Xiao
Summary: The study demonstrated for the first time that the white-rot fungus Phanerochaete sordida YK-624 could effectively degrade Bisphenol F (BPF), with the involvement of functional genes detected by RNA-Seq. Results indicated that P. sordida YK-624 could secrete high levels of ligninolytic enzymes for BPF degradation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Pengfei Xiao, Dedong Wu, Jianqiao Wang
Summary: This study conducted a bibliometric analysis on the research progress of white rot fungi (WRFs) biotechnology in environmental pollution control, revealing China and the USA as the most active countries in this field and identifying important research directions and hotspots. The analysis also showed that most authors tend to cooperate within small groups.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Engineering, Environmental
Jing Zhao, Pengfei Xiao, Shuang Han, Musajan Zulhumar, Dedong Wu
Summary: Magnetic CuFe2O4 nanoparticles were synthesized successfully and utilized as peroxymonosulfate (PMS) activators for degrading LEV. The designed CuFe2O4/PMS system showed high activity and excellent stability, maintaining above 80% degradation efficiency of LEV even after four recycles. The presence of superoxide radicals, single oxygen, hydroxy radicals, and sulfate radicals was confirmed, with superoxide radicals and single oxygen as the dominant radical oxygen species.
WATER SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Chemical
Qirui Wang, Pengfei Xiao
Summary: In this study, a self-synthesized hetero-geneous CuFe2O4-MoS2@BC composite was prepared as an activator for peroxymonosulfate (PMS) to degrade tetracycline (TC). The obtained composite showed excellent surface properties, catalytic stability, and anti-interference ability. It achieved high degradation efficiency even under various environmental conditions. The CuFe2O4-MoS2@BC composite has great potential for the treatment of tetracycline antibiotic wastewater using activated PMS.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Environmental
Huiwen Ding, Guosheng Zhang, Jianqiao Wang, Pengfei Xiao
Summary: Chloroquine phosphate (CQP) is widely used for treating COVID-19, but its release into water can have potential health impacts. Finding a reusable and efficient catalyst to treat CQP wastewater is urgent. In this study, LaCo0.5Cu0.5O3-CeO2 was prepared and used to degrade CQP by activating peroxymonosulfate (PMS). LaCo0.5Cu0.5O3-CeO2 showed better stability, larger specific surface area, and more uniform pore structure. It effectively degraded CQP within a short time and under wide pH and water quality ranges. The addition of CeO2 promoted multipath electron transfer and the degradation of CQP into low toxicity products. LaCo0.5Cu0.5O3-CeO2 has great potential for practical application in treating pharmaceutical wastewater.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Engineering, Environmental
Guosheng Zhang, Huiwen Ding, Jianqiao Wang, Pengfei Xiao
Summary: This study describes the preparation and investigation of an affordable Ni-doped CoMoO4 catalyst for peroxymonosulfate (PMS) mediated degradation of organic pollutants. The synthesized Ni0.5Co0.5MoO4 catalyst showed excellent surface properties and stability, achieving over 95% degradation of chloroquine phosphate (CQP) within 20 min under optimal conditions. The catalytic system exhibited high efficiency and tolerance towards interfering substances, and Ni doping promoted catalyst durability. Mechanistic studies revealed the generation of 1O2 as the predominant reactive species, and proposed pathways for CQP degradation. The Ni0.5Co0.5MoO4/PMS system has potential applications in the treatment of organic pollutants and high-concentration organic wastewater.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Environmental Sciences
Zulhumar Musajan, Pengfei Xiao
Summary: Mesoporous carbon-anchored cobalt ferrite nanocomposites (nano-CoFe2O4@MC) were prepared via hydrothermal method as heterogeneous catalysts to activate peroxymonosulfate (PMS) for the treatment of antibiotic wastewater. The nanocomposites exhibited excellent surface properties, structural stability, and magnetic properties. The activation process of PMS by nano-CoFe2O4@MC involved both radical and nonradical pathways, and the redox cycle of Co3+/Co2+ and Fe2+/Fe3+ was found to enhance multipath electron transfer for reactive oxygen species generation. The catalytic efficiency of nano-CoFe2O4@MC remained high after five cycles of use.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Mingyi Liu, Hanchun Chen, Pengfei Xiao, Haodong Ji
Summary: Copper-manganese composite metal oxides were used for the first time to activate sulfite and degrade chlortetracycline hydrochloride. The study identified the optimal degradation conditions and confirmed the important role of reactive oxygen species in the degradation process. The copper-manganese composite metal oxides showed excellent catalytic performance and stability, with potential applications in water treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Chemistry, Multidisciplinary
Lingxing Zhang, Rui Zhang, Wenna Wang, Shuang Han, Pengfei Xiao
Summary: The study successfully prepared nano-nickel ferrite (NiFe2O4) using hydrothermal synthesis and applied it for the oxidative removal of chlortetracycline hydrochloride (CTH) in the presence of ultraviolet radiation (UV) and peroxymonosulfate (PMS). The UV + nano-NiFe2O4/PMS system showed higher removal efficiency of CTH compared to other systems, achieving 96.98% removal efficiency under optimal conditions. Inorganic anions and free radical identification tests were used to study the degradation mechanisms, confirming the potential applicability of nano-NiFe2O4 as a green and efficient catalyst for antibiotic wastewater treatment.
Article
Chemistry, Multidisciplinary
Qirui Wang, Yixuan Shi, Shiyi Lv, Ying Liang, Pengfei Xiao
Summary: The recycling of agricultural and food waste is an effective way to reduce resource waste and ameliorate the shortage of natural resources. The study successfully prepared a heterogeneous catalyst (Fe3O4@T-BC) using waste tea residue and demonstrated its efficiency in degrading tetracycline hydrochloride. Under suitable conditions, the Fe3O4@T-BC catalyst could achieve a high degradation rate of TCH.
Article
Chemistry, Multidisciplinary
Lu An, Pengfei Xiao
Proceedings Paper
Engineering, Environmental
Pengfei Xiao
ADVANCES IN ENVIRONMENTAL TECHNOLOGIES, PTS 1-6
(2013)