Article
Infectious Diseases
Zhiying Su, Wenjia Hu, Qianyun Liu, Yongxi Zhang, Tielong Chen, Yingying Zhou, Zhen Zhang, Yu Chen, Rongrong Yang, Yong Xiong, Xinghuan Wang
Summary: The humoral and cellular immunity in convalescent COVID-19 patients play a role in disease pathogenesis and vaccine immunity. Studies have shown higher levels of memory/naive CD4(+) T lymphocytes and anti-SARS-CoV-2 antibodies in severe convalescent patients compared to non-severe cases. Specific cellular and humoral immunity against SARS-CoV-2 is detectable regardless of disease severity during the acute phase, providing insights into the immune status post-SARS-CoV-2 infection.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Review
Hematology
Aaron A. R. Tobian, Claudia S. Cohn, Beth H. Shaz
Summary: COVID-19 convalescent plasma (CCP) is a treatment option for COVID-19 that works through the mediation of antibodies and is primarily effective for elderly outpatients in the early stages of the disease. However, it is not effective for hospitalized patients with moderate to severe disease. Collection of CCP should be as close as possible to the time and location of the patient.
Editorial Material
Pharmacology & Pharmacy
Mirco Muller-Olling, Ute Vahlensieck, Anneliese Hilger
Summary: The outbreak of COVID-19 has accelerated clinical trial research on the efficacy and safety evaluation of convalescent plasma globally. Clinical researchers and regulatory agencies face challenges in trial planning and approval due to limited evidence from previous viral disease outbreaks and different study approaches. The analysis of CT designs aims to identify opportunities for data aggregation and facilitate the generation of decision-relevant evidence.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Virology
Guenalp Uzun, Rebecca Mueller, Karina Althaus, Matthias Becker, Patrick Marsall, Daniel Junker, Stefanie Nowak-Harnau, Nicole Schneiderhan-Marra, Harald Klueter, Hubert Schrezenmeier, Peter Bugert, Tamam Bakchoul
Summary: This study investigated the relationship between clinical donor characteristics and neutralizing anti-SARS-CoV-2 antibodies in COVID-19 convalescent plasma (CCP) donors. Time since symptom onset, BMI, and fever were found to be associated with neutralizing capacity. These clinical parameters can be easily incorporated into the preselection of CCP donors.
Letter
Medicine, General & Internal
David Fisher, Stephen Malnick
Summary: The researchers administered convalescent plasma to high-risk outpatients within 1 week after the onset of symptoms of Covid-19, which differs from previous studies with shorter time frames.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Infectious Diseases
Xuejie Fang, Kongmiao Lu, Shuqi Sun, Hao Zhang, Xinjuan Yu, Wei Han
Summary: A case of C. gilardii infection was reported in a previously healthy 78-year-old male with COVID-19, who had recently used corticosteroids. The bacterium was identified from the patient's bronchoalveolar lavage fluid and this is the first time C. gilardii has been isolated from such a sample.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Shiyao Pei, Xi Yuan, Zhimin Zhang, Run Yao, Yubin Xie, Minxue Shen, Bijuan Li, Xiang Chen, Mingzhu Yin
Summary: The recent global outbreak of COVID-19 poses a significant threat to global health and economy. Convalescent plasma has shown effectiveness against the novel coronavirus in preliminary studies and can be used for treating COVID-19 infections.
Review
Microbiology
Daniele Focosi, Massimo Franchini, Liise-Anne Pirofski, Thierry Burnouf, Nigel Paneth, Michael J. Joyner, Arturo Casadevall
Summary: Convalescent plasma (CP) is a frontline treatment in epidemics due to its immediate availability. The COVID-19 pandemic provided an opportunity to study the mechanisms, safety, and efficacy of CP using evidence-based medicine. However, studies have reported highly variable efficacy results for COVID-19 CP (CCP), leading to uncertainty.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Article
Medicine, General & Internal
D. J. Sullivan, K. A. Gebo, S. Shoham, E. M. Bloch, B. Lau, A. G. Shenoy, G. S. Mosnaim, T. J. Gniadek, Y. Fukuta, B. Patel, S. L. Heath, A. C. Levine, B. R. Meisenberg, E. S. Spivak, S. Anjan, M. A. Huaman, J. E. Blair, J. S. Currier, J. H. Paxton, J. M. Gerber, J. R. Petrini, P. B. Broderick, W. Rausch, M-E Cordisco, J. Hammel, B. Greenblatt, V. C. Cluzet, D. Cruser, K. Oei, M. Abinante, L. L. Hammitt, C. G. Sutcliffe, D. N. Forthal, M. S. Zand, E. R. Cachay, J. S. Raval, S. G. Kassaye, E. C. Foster, M. Roth, C. E. Marshall, A. Yarava, K. Lane, N. A. McBee, A. L. Gawad, N. Karlen, A. Singh, D. E. Ford, D. A. Jabs, L. J. Appel, D. M. Shade, S. Ehrhardt, S. N. Baksh, O. Laeyendecker, A. Pekosz, S. L. Klein, A. Casadevall, A. A. R. Tobian, D. F. Hanley
Summary: This study evaluated the efficacy and safety of COVID-19 convalescent plasma in symptomatic adults and found that receiving convalescent plasma transfusion reduced the risk of hospitalization due to COVID-19-related reasons.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Xiaorong Huang, Chumin Liang, Manman Li, Huimin Chen, Zhaowan Li, Qianqian Ruan, Ximing Hu, Lilian Zeng, Huifang Lin, Wei Zhao, Jianpeng Xiao, Limei Sun, Jiufeng Sun
Summary: Mass immunization programs have been successful in controlling SARS-CoV-2, but new VOCs pose challenges as they can evade vaccine-induced immunity and increase the risk of reinfection.
Article
Biology
Giovanni Belcari, Alberto Conti, Alessandro Mazzoni, Maria Lanza, Paola Mazzetti, Daniele Focosi
Summary: This case report demonstrates the successful treatment of COVID-19 pneumonia in an immunocompromised patient with chronic lymphocytic leukemia and venetoclax treatment using high-titer and large-volume convalescent plasma. This adds to the growing evidence of convalescent plasma efficacy in immunocompromised patients.
Article
Immunology
Oliver F. Wirz, Katharina Roltgen, Bryan A. Stevens, Suchitra Pandey, Malaya K. Sahoo, Lorna Tolentino, Michelle Verghese, Khoa Nguyen, Molly Hunter, Theo Thomas Snow, Abhay Raj Singh, Catherine A. Blish, Jennifer R. Cochran, James L. Zehnder, Kari C. Nadeau, Benjamin A. Pinsky, Tho D. Pham, Scott D. Boyd
Summary: The study found that early transfusion of high-titer CCP is beneficial for COVID-19 patients, and high-titer CCP should be collected within 60 days post-recovery from donors who experienced fever. Transfused antibody titers were significantly lower than endogenously produced antibodies, underscoring the importance of providing CCP prior to endogenous seroconversion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
William T. Lee, Roxanne C. Girardin, Alan P. Dupuis, Karen E. Kulas, Anne F. Payne, Susan J. Wong, Suzanne Arinsburg, Freddy T. Nguyen, Damodara Rao Mendu, Adolfo Firpo-Betancourt, Jeffrey Jhang, Ania Wajnberg, Florian Krammer, Carlos Cordon-Cardo, Sherlita Amler, Marisa Montecalvo, Brad Hutton, Jill Taylor, Kathleen A. McDonough
Summary: Passive transfer of antibodies from COVID-19 convalescent patients is used as an experimental treatment for SARS-CoV-2 infections. As time post symptom onset increases, neutralizing activity in sera significantly rises to reach a peak, emphasizing the value of serum characterization for neutralization activity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Pasquale Ambrosino, Antonio Molino, Ilenia Calcaterra, Roberto Formisano, Silvia Stufano, Giorgio Alfredo Spedicato, Andrea Motta, Antimo Papa, Matteo Nicola Dario Di Minno, Mauro Maniscalco
Summary: This study found that endothelial function improved in convalescent COVID-19 patients after pulmonary rehabilitation, with a direct correlation between pulmonary function and endothelial health. Endothelial function testing may be useful for follow-up care in these patients.
Article
Biochemistry & Molecular Biology
Emanuele Andreano, Emanuele Nicastri, Ida Paciello, Piero Pileri, Noemi Manganaro, Giulia Piccini, Alessandro Manenti, Elisa Pantano, Anna Kabanova, Marco Troisi, Fabiola Vacca, Dario Cardamone, Concetta De Santi, Jonathan L. Torres, Gabriel Ozorowski, Linda Benincasa, Hyesun Jang, Cecilia Di Genova, Lorenzo Depau, Jlenia Brunetti, Chiara Agrati, Maria Rosaria Capobianchi, Concetta Castilletti, Arianna Emiliozzi, Massimiliano Fabbiani, Francesca Montagnani, Luisa Bracci, Giuseppe Sautto, Ted M. Ross, Emanuele Montomoli, Nigel Temperton, Andrew B. Ward, Claudia Sala, Giuseppe Ippolito, Rino Rappuoli
Summary: Human monoclonal antibodies have been identified as safe, preventive, and therapeutic tools against COVID-19. Through single-cell sorting from COVID-19 survivors, a large number of spike protein-specific memory B cells have been identified, leading to the discovery of highly effective neutralizing antibodies. The most potent monoclonal antibody, engineered to reduce risk and prolong half-life, has been shown to neutralize both the original virus and emerging variants.
Article
Computer Science, Artificial Intelligence
Penghai Zhao, Weilan Wang, Guowei Zhang, Yuqi Lu
Summary: This study focuses on the binarization problem in degraded historical Tibetan document images and proposes an improved approach. By rescaling the input and output of the attention U-Net and accelerating the construction of the training set, the issue of pseudo-touching is successfully addressed, leading to better performance across several metrics.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Green & Sustainable Science & Technology
Aijing Wu, Yongbo Zhang, Xuehua Zhao, Jiamin Li, Guowei Zhang, Hong Shi, Lina Guo, Shuyuan Xu
Summary: This paper investigates the phytoremediation technology and mechanism for Acid Mine Drainage (AMD) through hydroponic experiments, using six wetland plants as research objects. The results show the most effective plants for removing sulfate and manganese from AMD, and their growth conditions are considered for selecting the dominant plants for AMD treatment. The study provides a theoretical reference for phytoremediation technology for AMD.
Article
Biotechnology & Applied Microbiology
Hailin Ke, Songling Wu, Yueyi Zhang, Guowei Zhang
Summary: miR-139-3p suppresses gastric cancer by inhibiting the proliferative, migratory, and invasive abilities of GC cells through targeting KIF18B.
Article
Management
Guowei Zhang, Ning Jia, Ning Zhu, Yossiri Adulyasak, Shoufeng Ma
Summary: Assessing a humanitarian transportation network early after a disaster is crucial for reducing casualties. Drones are considered for the assessment operations due to their potential. However, a novel challenge arises in the drone arc routing problem where drones can travel off the road network. To address this challenge, a graph transformation technique and a robust team orienteering problem with uncertain assessment time are proposed. The problem is solved efficiently using path-based reformulation and Lagrangian decomposition, and an exact branch-and-price framework is applied.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2023)
Article
Chemistry, Physical
Cong Wang, Zhaojie Wang, Hong Xu, Guowei Zhang
Summary: Al-7Si-0.6Mg/Fe bimetal prepared by compound casting was heat-treated to study the age hardening behavior of the aluminum matrix near the interface. The presence of an oxide layer near the interface reduces the age-hardening ability and bonding strength of the aluminum matrix. The growth of the intermetallic layer is accompanied by a decrease in Si and Mg2Si particles within the diffusion reach.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Guowei Zhang, Fengxian Guo, Maomao Zeng, Zhaojun Wang, Fang Qin, Jie Chen, Zongping Zheng, Zhiyong He
Summary: In this study, Colla corii asini (CCA) was fractionated into three fractions with different molecular weights. Components with a molecular weight of >10 kDa were found to have stronger immunomodulatory and antioxidant abilities.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Physical
Cong Wang, Zhaojie Wang, Hong Xu, Guowei Zhang
Summary: The effect of Si content on the quench sensitivity of Al-Si-Mg alloys was investigated. It was found that the quench sensitivity increases with increasing Si content. The microstructure, cooling rate, and strain energy also have an impact on the quench sensitivity.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Dongya Yang, Jiajun Li, Gengrui Zhao, Honggang Wang, Zhenyu Li, Shengsheng Chen, Gui Gao, Guowei Zhang, Hong Xu
Summary: This study investigated the effects of molybdenum disilicide and ferrophosphorus particles on the tribological properties of copper-tin bismuth bimetallic bearing materials. The addition of these particles was found to improve the mechanical and wear resistance properties of the alloys.
MATERIALS SCIENCE AND TECHNOLOGY
(2023)
Article
Computer Science, Information Systems
Guo-Wei Zhang, Wei Chen, Guan-Jie Fan-Yuan, Li Zhang, Fang-Xiang Wang, Shuang Wang, Zhen-Qiang Yin, De-Yong He, Wen Liu, Jun-Ming An, Guang-Can Guo, Zheng-Fu Han
Summary: A polarization-insensitive time-bin decoder chip for self-stabilizing QKD system is developed and verified, which shows its feasibility in experimental tests.
SCIENCE CHINA-INFORMATION SCIENCES
(2022)
Article
Chemistry, Physical
Huan Yu, Guowei Zhang, Weize Lv, Hong Xu, Changjun Xu
Summary: An Al-7Si-Cu-Mg-Mn/steel bimetal was prepared by compound casting, and the effect of a coupled traveling and rotating magnetic field on the interface microstructure and shear strength was investigated. The magnetic field resulted in changes in the interface layer thickness, element concentration gradient, and dissolution rate of intermetallic compounds, leading to an increase in shear strength.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Physical
Guowei Zhang, Zhaojie Wang, Changjun Xu, Hong Xu, Cong Wang
Summary: The age-hardening behavior of the Al-7Si-0.5Mg alloy was studied with different sizes and distributions of Si phase. The specimen with fine and homogeneous Si exhibited accelerated age-hardening kinetics and higher hardness compared to the specimen with coarse and clustered Si, attributed to the higher dislocation density caused by thermal contraction mismatch. The overlapping of the plastically-affected zone of adjacent Si in the specimen with large and clustered Si resulted in reduced volume fraction of the plastically-affected zone, lower dislocation density, and slower age-hardening kinetics. The relationship between Si radius and critical inter-particle spacing for minimizing interaction and maximizing dislocation density and age-hardening kinetics was established.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Engineering, Multidisciplinary
Xiao Wang, Guowei Zhang, Yongqiang Li, Na Qu
Summary: This paper investigates the maintenance policy for a 2M1B assembly line system. By using an SMDP model and the HAMRL method, the learning process is accelerated and the maintenance strategy for the system is obtained. Empirical results show that the HAMRL algorithm has advantages in larger space and practical problems.
JOURNAL OF INDUSTRIAL AND MANAGEMENT OPTIMIZATION
(2023)
Article
Ophthalmology
Lihua Kang, Jiawei Luo, Pengfei Li, Guowei Zhang, Miao Wei, Min Ji, Huaijin Guan
Summary: This study discovered that miR-125a-3p regulates apoptosis in LECs by suppressing TMBIM4, offering a new therapeutic target for cataract.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Meeting Abstract
Psychiatry
Qi Mu, Guowei Zhang
PSYCHIATRIA DANUBINA
(2022)
Article
Ophthalmology
Han Li, Feng Zhou, Xingjian Cao, Ping Zhao, Xiaobo Huang, Wei Xie, Guowei Zhang, Xiang Chen
Summary: This study reveals that CtBP2 promotes cell proliferation, angiogenesis, and cellular adhesion of human retinal endothelial cells under high glucose conditions. Furthermore, CtBP2 functions through the Akt signaling pathway. These findings suggest that CtBP2 may be a potential target for the prevention and treatment of diabetic retinopathy.
INTERNATIONAL OPHTHALMOLOGY
(2022)