Article
Chemistry, Applied
Francisco J. Ballester, Enrique Ortega-Forte, Delia Bautista, M. Dolores Santana, Giampaolo Barone, Jose Ruiz
Summary: In this study, a series of compounds with different substituents were synthesized and characterized using NMR and X-ray diffraction. It was found that compounds with stronger electron-donating groups exhibited larger Stokes shift and higher quantum yield. Additionally, some of the compounds showed higher activity in cancer cell lines while displaying low cytotoxicity in healthy cells. One of the compounds also showed the ability to stain the cytoplasm.
Article
Chemistry, Multidisciplinary
Aline D. Araujo, Huy N. Hoang, Junxian Lim, Jeffrey Y. W. Mak, David P. Fairlie
Summary: Summary: Aromatic groups play a crucial role in protein-membrane association and cell uptake. The electrostatic and hydrophobic properties of aromatic ring substituents influence the affinity towards phospholipid membranes. The combination of fluorine and sulfur substituents induces microdipoles, enhancing the cell uptake of peptides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Niklas H. Fischer, Erik Fumi, Maria Teresa Oliveira, Peter W. Thulstrup, Frederik Diness
Summary: A catalyst-free stapling method for cysteine-containing peptides has been developed, which enables fine-tuning of the macrocycle by using different types of linkers. The method was applied to a set of potential agonists and generated a library of macrocyclic potent ligands with different relationships between the thioethers. The results demonstrate the facile fine-tuning of macrocyclic peptides towards biological targets.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Vinay G. Joshi, Kantaraja Chindera, Manish Bais, Basavaraj Sajjanar, Ashok K. Tiwari, Satish Kumar
Summary: PNA is a chimeric molecule with advantages over natural antisense nucleic acid molecules, but faces challenges in cellular delivery due to its charge-neutral nature. The proposed novel RATH-2 peptide-based non-covalent PNA delivery mechanism showed promising results in cellular delivery and therapeutic application in antiviral intervention.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yan Gao, Ke Men, Congbin Pan, Jingmei Li, Jieping Wu, Xiaohua Chen, Sibei Lei, Xiang Gao, Xingmei Duan
Summary: Gene therapy using mRNA has shown promise in cancer treatment, with the development of an advanced mRNA delivery system DMP-039. By combining a cell-penetrating peptide with a cationic nano-sized DMP backbone, the DMP-039 nanoparticles efficiently delivered mRNA and inhibited colon cancer growth. The results suggest that DMP-039 is a promising candidate for mRNA-based suicide gene therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Luana S. Gomes, Erica O. Costa, Thuany G. Duarte, Mateus H. Kohler, Bruna M. Rodrigues, Vitor F. Ferreira, Fernando de C. da Silva, Bernardo A. Iglesias, Vanessa Nascimento
Summary: This study presents a comprehensive analysis of a novel series of chalcogen-naphthoquinone-1,2,3-triazole hybrids, including their synthesis, structural elucidation, photophysical behavior, and electrochemical properties. These hybrids were synthesized with remarkable efficiency and exhibit exceptional photophysical and electrochemical properties, promising potential applications in biological assays.
Article
Biochemistry & Molecular Biology
Dimitra Hadjipavlou-Litina, Iwona E. Glowacka, Jose Marco-Contelles, Dorota G. Piotrowska
Summary: In this study, the synthesis and antioxidant capacity of twelve novel 1,2,3-triazole-containing nitrones were reported. Among them, nitrones 9f exhibited the strongest antioxidant and LOX inhibitory activity.
Article
Chemistry, Inorganic & Nuclear
Ying-Xian Li, Liu-Ping Yang, Meng Yang, Ji-Jun Jiang, Gao-Feng Liu, Hsiu-Yi Chao
Summary: Three bipyridine platinum (II) complexes Pt-2-Pt-4 bearing indolyl ligand(s) were synthesized through intramolecular hydroamidation of alkynyl moieties of Pt-1. The structures of Pt-1-Pt-4 were determined by single crystal X-ray diffraction. The photophysical properties of these structurally related complexes Pt-1-Pt-4 have been studied.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Jinxiong Cai, Changpeng Xie, Jin Xiong, Jinya Zhang, Ping Yin, Siping Pang
Summary: Driven by the increasing application of thermal stable explosives in industries like deep mining and aerospace, the search for heat-resistant energetic materials with high-energy level has gained significant attention. In this study, two advanced heat-resistant explosives were synthesized using straightforward methods, and they showed excellent thermal decomposition temperature and energy properties, making them promising candidates for advanced heat-resistant explosives.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Organic
Qianqian Zhang, Hanyu Nie, Kun Zhang, He Huang, Chuanjun Song
Summary: A facile transition-metal-free method for the synthesis of benzofurans and related compounds was developed. This method showed good substrate tolerability and moderate to good yields. The practicality of this method was demonstrated through the total synthesis of a natural product coumestrol.
Article
Virology
Mikael Cristofer Sitinjak, Jui-Kai Chen, Chi-Young Wang
Summary: Novel cell-penetrating peptides (CPPs) in the capsid protein of BFDV were identified and characterized in this study. Both CPP1 and CPP2 of BFDV showed superior cell-penetrating activities compared to a typical CPP-TAT. These CPPs successfully delivered plasmids and proteins into target cells and triggered apoptosis, demonstrating their potential as delivery vehicles.
Article
Chemistry, Multidisciplinary
Jin Xiong, Jinxiong Cai, Qi Lai, Ping Yin, Siping Pang
Summary: An asymmetric N-bridged strategy was used to link two different energetic building blocks, resulting in compounds with good properties. This study expands the research horizon of regiochemistry of energetic compounds.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Xin Deng, Ruiyao Mai, Chenyu Zhang, Dianbao Yu, Yichang Ren, Gang Li, Binbin Cheng, Ling Li, Zhiqiang Yu, Jianjun Chen
Summary: A novel PDC was synthesized to intelligently deliver paclitaxel, showing higher cellular uptake and cytotoxicity in experiments, with less toxicity to normal cells and the ability to overcome paclitaxel resistance. The results demonstrated that this new PDC had better in vivo anti-tumor efficacy than paclitaxel.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Jayvic C. Jimenez, Zehao Zhou, Arnold L. Rheingold, Shane M. Parker, Genevieve Sauve
Summary: Tetraphenylazadipyrromethenes (ADPs) are promising near-infrared (NIR) dyes with potential applications in transparent solar cells and NIR photodetectors. By optimizing the coordination and substitutions, the properties of ADP complexes can be enhanced, making them suitable for organic electronic applications with low optical gap and high quantum yield.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Fatima C. Teixeira, Carla Lucas, M. Joao M. Curto, Vania Andre, M. Teresa Duarte, Antonio P. S. Teixeira
Summary: Novel pyrazolo[3,4-b]quinoline alpha-ketophosphonic and hydroxymethylenebisphosphonic acid compounds were synthesized using different methodologies, resulting in unexpected addition-cyclization cascade reaction to form a tetracyclic ring system. Spectroscopic data, including NMR, infrared, and high-resolution mass spectroscopy, were used to fully characterize and elucidate the structures of all compounds.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Dirk Lindenblatt, Mareike Horn, Claudia Goetz, Karsten Niefind, Ines Neundorf, Markus Pietsch
Article
Multidisciplinary Sciences
Isabel Gessner, Xiaojie Yu, Christian Juengst, Annika Klimpel, Lingyu Wang, Thomas Fischer, Ines Neundorf, Astrid C. Schauss, Margarete Odenthal, Sanjay Mathur
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Andreas Maassen, Jan M. Gebauer, Elena Theres Abraham, Isabelle Grimm, Joerg-Martin Neudoerfl, Ronald Kuehne, Ines Neundorf, Ulrich Baumann, Hans-Guenther Schmalz
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Inorganic & Nuclear
Simon Garbe, Maren Krause, Annika Klimpel, Ines Neundorf, Petra Lippmann, Ingo Ott, Dana Brunink, Cristian A. Strassert, Nikos L. Doltsinis, Axel Klein
Review
Biochemistry & Molecular Biology
Isabel Gessner, Ines Neundorf
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
A. Negrete-Hurtado, M. Overhoff, S. Bera, E. De Bruyckere, K. Schaetzmueller, M. J. Kye, C. Qin, M. Lammers, V. Kondylis, I. Neundorf, N. L. Kononenko
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Benjamin Albrecht, Elena Voronina, Carola Schipke, Oliver Peters, Maria Kristina Parr, M. Dolores Diaz-Hernandez, Nils E. Schloerer
Review
Biochemistry & Molecular Biology
Felix Gayraud, Merlin Klussmann, Ines Neundorf
Summary: This review focuses on recent developments in conjugation techniques for synthesizing cell-penetrating peptide (CPP)-drug conjugates targeting cancer cells, including small organic molecules and metal complexes as cytostatic payloads. The use of bifunctional linkers is gaining attention due to its advantages in linker chemistry, with three main categories of linkers highlighted. Pros and cons of each technique are thoroughly discussed to aid in choosing the optimal conjugation technique for synthesizing a specific CPP-drug conjugate.
Review
Biochemistry & Molecular Biology
Marco G. Drexelius, Ines Neundorf
Summary: This review summarizes recent developments in functionalizing implant surfaces with antibiotic agents, focusing on AMP-based medical devices. Three different approaches to peptide coatings, using binding sequences, linker layers, or loading in matrixes, are discussed in the context of current research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tamara Lutzenburg, Nele Burdina, Matthias S. Scholz, Ines Neundorf
Summary: Cell-penetrating peptides (CPPs) are used to increase the intracellular accumulation of cargoes by forming stable secondary structures at the outer surface of the plasma membrane. Incorporation of hydrophobic moieties like carboranes (CBs) can alter the lipophilicity of peptides and enhance secondary structure formation, leading to potential applications in nucleic acid delivery.
Article
Biochemistry & Molecular Biology
Sabine Schuster, Eva Juhasz, Gabor Halmos, Ines Neundorf, Cesare Gennari, Gabor Mezo
Summary: The cleavable GnRH-III bioconjugates showed a growth inhibitory effect on GnRH receptor-expressing A2780 ovarian cancer cells. Furthermore, the antiproliferative activity of the non-cleavable GnRH-III-drug conjugates using cathepsin B-cleavable linker systems was significantly reduced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joshua Grabeck, Tamara Luetzenburg, Pia Frommelt, Ines Neundorf
Summary: This study presents the design and synthesis of peptide-drug conjugates (PDCs) with different variants of the cell-penetrating peptide sC18. By generating sequence mutants of sC18 and testing their biological activity, a promising analog sC18(Delta E) with higher uptake efficacy was identified. However, cellular uptake and cargo entrapment still remain critical challenges in CPP-containing peptide-drug development.
Article
Chemistry, Medicinal
Sewar Alkhashrom, Jintawee Kicuntod, Katharina Stillger, Tamara Luetzenburg, Christian Anzenhofer, Ines Neundorf, Manfred Marschall, Jutta Eichler
Summary: The study identifies a peptide that can interfere with human cytomegalovirus infection and inhibit the interaction of viral proteins pUL50 and pUL53, indicating its potential as a target for new antiviral drugs.
Article
Chemistry, Multidisciplinary
Lucia Feni, Linda Juetten, Sara Parente, Umberto Piarulli, Ines Neundorf, Dolores Diaz
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Isabel Gessner, Annika Klimpel, Merlin Klussmann, Ines Neundorf, Sanjay Mathur
NANOSCALE ADVANCES
(2020)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
