期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 75, 页码 11199-11202出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc05112j
关键词
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资金
- Platform for Drug Discovery, Informatics, and Structural Life Science from MEXT, Japan
- Platform for Drug Discovery, Informatics, and Structural Life Science from AMED, Japan
- CREST from JST, Japan
- JSPS KAKENHI [15H03118, 16H01133, 26350971]
- Cooperative Research Program of Network Joint Research Center for Materials and Devices
- CREST from AMED, Japan
- Grants-in-Aid for Scientific Research [15H03118, 26350971, 16H01133] Funding Source: KAKEN
Thiazolobenzyne, which is a benzyne species fused with a thiazole ring, was efficiently generated via an iodine-magnesium exchange reaction of an ortho-iodoaryl triflate-type precursor using a trimethylsilylmethyl Grignard reagent as an activator. A wide range of arynophiles reacted efficiently with the thiazolobenzynes generated by this method to afford various multisubstituted benzothiazoles.
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