Article
Biotechnology & Applied Microbiology
Neelam Mishra, Kavita Rana, Siva Deepthi Seelam, Rakesh Kumar, Vijyendra Pandey, Bharathi P. Salimath, Dayanand Agsar
Summary: Pseudomonas aeruginosa DNM50 was identified as a biosurfactant-producing bacterium with 12 different congeners of rhamnolipid identified through structural characterization. The rhamnolipid showed radical scavenging activity with an IC50 value of 101.8 μg/ml and exhibited cytotoxic activity against MDA-MB-231 breast cancer cell line with a low IC50 of 0.05 μg/ml at 72 h of treatment. This suggests that DNM50RL may have potential in breast cancer treatment by targeting inhibition of p38MAPK.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biophysics
Rahman Hallaj, Zhaleh Ghafary, Osama kamal Mohammed, Raheleh Shakeri
Summary: The study developed an electrochemical biosensor for detecting the endogenous protein of breast cancer cells using RNA-cleaving DNAzymes. Thionine-modified gold nanoparticles and modified magnetic nanoparticles were used to prepare a probe, which was then pulled to the electrode surface with the help of a magnetic field. The presence of gold nanoparticle-thionine hybrid as an electroactive label ensured strong detection signals. The biosensor showed a linear range of (1.0E-06 to 1.0E+01) pg/ml for the protein marker and a detection limit of (1.0129E-07 pg/ml) using differential pulse voltammetry and electrochemical impedance spectroscopy (EIS).
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Environmental Sciences
Chun-Wen Cheng, Gwo-Tarng Sheu, Jing-Shiuan Chou, Pei-Han Wang, Yu-Chun Cheng, Chane-Yu Lai
Summary: The study demonstrated that soluble PM2.5 from building demolition sites can promote the survival and metastasis of triple-negative breast cancer cells, with increased cell viability, migration capacity, and activation of malignant signaling pathways in cancer cells exposed to the particulates.
Article
Biochemistry & Molecular Biology
Kamylla Fernanda Souza de Souza, Danilo Tofoli, Indiara Correia Pereira, Kelly Juliana Filippin, Ana Tereza Gomes Guerrero, Edgar Julian Paredes-Gamero, Maria de Fatima Cepa Matos, Walmir Silva Garcez, Fernanda Rodrigues Garcez, Renata Trentin Perdomo
Summary: The study isolated three compounds from the leaves of Aniba heringeri, with compound 3 showing strong cytotoxicity against breast cancer cells and a high selective index. This compound exhibited promising apoptosis induction effects on triple-negative breast cancer cells, demonstrating potential as a prototype for targeting TNBC cells that are usually resistant to conventional therapies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Xingjian Zhang, Trevor Chan, Michael Mak
Summary: This study investigated the phenotypes of highly aggressive cancer cells in confined microenvironments, revealing two distinct migratory phenotypes in fast migrating single cells and an increase in protrusions at the leading edge of cells under geometric confinement. The findings elucidate the impact of geometric constraints on cell behavior and morphodynamics associated with different cell phenotypes.
SCIENTIFIC REPORTS
(2021)
Article
Crystallography
Madiha Batool, Shazia Khurshid, Walid M. Daoush, Sabir Ali Siddique, Tariq Nadeem
Summary: The study developed a green synthesis method for ZnO-NPs, utilizing Aloe barbadensis leaf extract as a stabilizing agent. The antitumor cytotoxic activity, surface-functionalization, drug loading capacity, and morphological properties of ZnO-NPs were characterized. Results showed that DOX had superior drug loading efficiency and capacity compared to GEM, indicating potential for enhanced therapeutic techniques against TNBC.
Article
Nutrition & Dietetics
Monika Kalinowska, Ewelina Golebiewska, Grzegorz Swiderski, Sylwia Meczynska-Wielgosz, Hanna Lewandowska, Anna Pietryczuk, Adam Cudowski, Aleksander Astel, Renata Swislocka, Mariola Samsonowicz, Anna Barbara Zlowodzka, Waldemar Priebe, Wlodzimierz Lewandowski
Summary: The study investigated seven derivatives of plant-derived hydroxybenzoic acid for their structural and biological properties, including antioxidant, lipophilicity, antimicrobial activity, and cytotoxicity. It discussed the relationship between the molecular structure and biological activity of hydroxybenzoic acids, providing valuable information for their potential application in dietary supplements, functional foods, or drugs.
Article
Cell Biology
Florian Keller, Roman Bruch, Franziska Clauder, Mathias Hafner, Ruediger Rudolf
Summary: The study found that extracellular matrix components play a significant role in regulating BSP expression, suggesting mechanisms for the formation of bone-associated metastasis in breast cancer that may involve local control of BSP levels through extracellular matrix degradation and release of growth factors.
Article
Biochemistry & Molecular Biology
Ana-Isabel Naranjo, Maria-Julia Gonzalez-Gomez, Victoriano Baladron, Jorge Laborda, Maria-Luisa Nueda
Summary: DLK2 expression levels can affect the tumor properties and growth dynamics of MDA-MB-231 breast cancer cells by regulating NOTCH signaling and other cell signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Khadijeh Hamidian, Mina Sarani, Mahmood Barani, Faeze Khakbaz
Summary: In this study, dual doped Zinc oxide nanoparticles consisting of silver and magnesium were prepared using Salvadora persica extract. The nanoparticles exhibited a wurtzite ZnO phase nanostructure and hexagonal morphology. The toxicity effects of the nanoparticles on breast cancer cells and normal cells were investigated, and it was found that the doped nanoparticles had lower toxicity compared to the undoped nanoparticles.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Food Science & Technology
Ling Xie, Jun Yi, Yongjia Song, Mengyao Zhao, Liqiang Fan, Liming Zhao
Summary: GOLM1 has been identified as a prime target for cancer therapy, and EGCG is the first natural product found to downregulate GOLM1 expression, inhibiting MDA-MB-231 cell migration through the HGF/HGFR/AKT/GSK-3/ beta-catenin/c-Myc signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ling Chen, Li-Quan Ren, Zhong Liu, Xin Liu, Han Tu, Xu-Ying Huang
Summary: This study investigated the anti-cancer mechanism of Schisandrin A in breast cancer through bio-informatics analysis and in vitro experiments. The results showed that SchA could promote cell migration and inhibit apoptosis by regulating specific targets, making it a potential adjuvant treatment for breast cancer.
Article
Chemistry, Physical
R. Rawat, A. Tiwari, N. Arun, S. V. S. Nageswara Rao, A. P. Pathak, Yagnesh Shadangi, N. K. Mukhopadhyay, S. Venugopal Rao, A. Tripathi
Summary: Nanosecond laser pulses were used to synthesize Cu/CuO/Fe3O4 and Al2O3 nanocomposites by ablating Al-Cu-Fe quasicrystal (QC) in two different solvents, which showed that the solvent choice can impact the structural and morphological transformations of the nanoparticles.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Nanoscience & Nanotechnology
Yu -Han Su, Han-Chen Lin, Hsing-Yen Li, Chih-Hsuan Lien, Yao-Hsiang Shih, Chian -Hui Lai
Summary: The aim of this study was to develop a carbohydrate silica nanocomposite, M-mDOX@SiO2, which can specifically target cancer cells and release the drug doxorubicin (DOX) specifically in an acidic tumor microenvironment (TME). The synthesized M-mDOX@SiO2 demonstrated high antitumor efficacy, making it a promising drug delivery carrier.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Haibin Lu, Lei Wan, Xiaoling Li, Mu Zhang, Adnan Shakoor, Wenqiang Li, Xueyang Zhang
Summary: The study successfully synthesized KF-CeO2 NPs nanoparticles using extract from Kochiae Fructus and found that they exhibited significant antibacterial and anticancer activities against multi-drug resistant bacteria and cancer cells, while also demonstrating good cell compatibility.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Physics, Applied
Muntadher I. I. Rahmah, Hasan Sh. Majdi, Waleed Khaild Al-Azzawi, Moayad Jabbar Rasn, Hadi Hassan Jasim, Majid S. S. Jabir, Roonak Abdul Salam A. Alkareem, Taha M. M. Rashid
Summary: A zinc oxide-silver doped with graphite and nitrogen (ZnO/Ag doped with C/N) heterostructure was prepared and used for the photodegradation of methylene blue (MB) dye under sunlight irradiation. The characterization results showed the presence of ZnO, Ag, and C nanoparticles, and confirmed the high-absorption ability in the visible area. The photocatalysis results demonstrated the efficient degradation of MB dye by the prepared ZnO/Ag doped with C/N heterostructure under sunlight irradiation.
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
(2023)
Article
Physics, Multidisciplinary
Mayyadah H. Mohsin, Khawla S. Khashan, Ghassan M. Sulaiman
Summary: In this paper, hexagonal BN, Gd2O3 nanoparticles, and BN@Gd2O3 hybrid nanocomposites were synthesized by novel laser ablation in liquid. Various analytical techniques were used to investigate their structural and optical properties. The results showed the formation of h-BN NPs, sheet-like and spherical nanoparticles, hexagonal-type nanoflake of Gd2O3, and needle-like shapes. The optical energy gap of h-BN, Gd2O3, and h-BN@Gd2O3 was found to be in the range of (4.5-5.5) eV.
Article
Chemistry, Physical
Susan Hasan, Khawla S. S. Khashan, Aseel A. A. Hadi
Summary: In this study, Pd@Ag(core/shell) nanoparticles were synthesized using Q-switched Nd:YAG laser at a wavelength of 1064 nm in distilled water. The synthesized nanoparticles were characterized by various techniques, including UV-visible spectrophotometry, FT-IR, XRD, TEM, and EDS. The results showed that the Pd@Ag core-shell nanoparticles exhibited excellent antibacterial activity, especially against Gram-positive pathogens. The use of PLAL-prepared Pd@Ag core-shell nanoparticles as antimicrobial agents shows promising potential.
Article
Chemistry, Physical
Zainab A. A. Abbas, Khawla S. S. Khashan, Zainab T. T. Hussain
Summary: Pulsed laser ablation in liquid technique was used to prepare pure and doped CdO NPs with varied Ag concentrations. The prepared nanoparticles were characterized using FTIR, XRD, UV-vis spectroscopy, FESEM with EDS, and atomic force microscopy. The morphology of pure CdO NPs changed from agglomerated bundles to nanorods and interconnecting web architectures as Ag concentration increased. The gas-sensing response of the composite nanoparticles' sensor to NO2 was 46, which was 1.8 times larger than the response of the pure CdO NP sensor (24.9), indicating that oxidizing gas (NO2) was less sensitive to Ag-doped CdO nanocomposite sensors than reducing gas (H2S).
Article
Chemistry, Multidisciplinary
Jaafar Suhail Wadi, Dunya AL-Duhaidahawi, Sarmad Salam Abdullah, Majid Jabir, Mazin A. A. Najim, Sabrean Farhan Jawad, Sawsan S. Hamzah, Faizan Abdul Qais
Summary: Toll-like receptor 9 (TLR9) plays a crucial role in the development of autoimmune diseases. Previous research suggests that prostaglandins have a significant impact on TLRs, and this study found that Bimatoprost has direct interactions with TLR9. This discovery opens up new possibilities for the treatment of autoimmune diseases.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Cell Biology
Haydar M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Ali K. Albuhadily
Summary: Prolactin appears to have a neuroprotective effect against Parkinson's disease neuropathology by inhibiting inflammation and protecting against neuroinflammation. Further research is needed to fully understand the potential role and mechanisms.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Hayder M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha, Daniel J. Klionsky
Summary: This study explores the protective and harmful effects of autophagy in the pathogenesis of multiple sclerosis (MS). Autophagy can prevent the progression of MS by reducing oxidative stress and inflammatory disorders, but over-activated autophagy can worsen the neuropathology of MS. Additionally, autophagy can modulate cell proliferation and affect demyelination and remyelination. Overall, autophagy plays a significant role in the pathogenesis of MS.
Article
Biochemistry & Molecular Biology
Thorria R. Marzoog, Majid S. Jabir, Sumayah Ibraheem, Sabrean F. Jawad, Sawsan S. Hamzah, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Riaz A. Khan
Summary: Bacterial-extracellular-vesicles (BEVs) derived from Escherichia coli, strain-A5922, were used to treat colon cancer cells, HT-29. The BEVs induced oxidative stress and mitophagy in HT-29 cells, causing adenocarcinomic cytotoxicity and inhibiting cell growth. The cytotoxicity and mitophagy were mediated through the Akt/mTOR pathway, triggered by BEVs-induced cellular oxidative stress, ultimately leading to cell death.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Ameer A. Imarah, Majid S. Jabir, Ali H. Abood, Ghassan M. Sulaiman, Salim Albukhaty, Hamdoon A. Mohammed, Riaz A. Khan, Hayder M. Al-Kuraishy, Ali Al-Gareeb, Waleed K. Al-Azzawi, Mazin A. Najm, Sabrean F. Jawad
Summary: In this study, the cytotoxic effects of graphene oxide nanoparticles (GONPs) were evaluated using MTT assays, observation of apoptotic markers, and oxidative stress. Significant cytotoxic and apoptotic effects were observed. Analyses of CYP2E1 and malondialdehyde concentrations confirmed the toxicity of GONPs, while the levels of glutathione showed a reduction compared to the control. The alterations in cytochrome CYP2E1, glutathione, malondialdehyde, and caspase-3 suggest an interlinked relationship.
Article
Chemistry, Physical
Alya A. Mohammed, Kareem H. Jawad, Sinem Cevik, Ghassan M. Sulaiman, Salim Albukhaty, P. Sasikumar
Summary: In this study, silver nanoparticles were synthesized using Elettaria cardamomum seed extract. The synthesized nanoparticles showed antioxidant and antibacterial activities. Furthermore, they exhibited cytotoxicity against breast cancer cells in vitro.
Article
Chemistry, Physical
Asraa Burhan, Khawla S. Khashan, Ghassan M. Sulaiman
Summary: The nanosecond Nd:YAG pulsed laser ablation in liquid (PLAL) technique was used to successfully synthesize hybrid Fe3O4-Au nanoparticles (NPs). The synthesized nanoparticles were investigated using different techniques, and the properties of the nanoparticles and their application in bacterial pathogen were studied.
Article
Chemistry, Multidisciplinary
D. Nadhiya, A. Kala, P. Sasikumar, Mustafa K. A. Mohammed, P. Thirunavukkarasu, M. Prabhaharan, C. Karnan, Salim Albukhaty, Majid S. Jabir, Asad Syed, Abdallah M. Elgorban, Nouf S. S. Zaghloul
Summary: CuxZn(1-x)Fe2O4 nanoparticles were synthesized using a simple non-aqueous sol-gel method, and their structural formation and magnetic properties were investigated. The results showed that the samples had single-phase cubic structures, and the lattice parameters and energy gap changed with the increase in Cu2+ concentration. Additionally, an increase in Cu2+ content improved the antibacterial activities of Cu2+-doped zinc ferrite.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Yasameen K. Al-Majedy, Hiba H. Ibraheem, Ali Abdullah Issa, Majid S. Jabir, Buthenia A. Hasoon, Hanady S. Al-Shmgani, Ghassan M. Sulaiman
Summary: Coumarins and their derivatives, such as coumarinyl chalcone, have significant pharmacological effects, including antioxidant, antibacterial, and anticancer activity. This study synthesized different compounds and evaluated their biomedical properties, finding that compound (C) exhibited the highest antioxidant and antibacterial activity and inhibited the growth of breast cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2024)