Article
Chemistry, Multidisciplinary
Odey Bsharat, Michael G. J. Doyle, Maxime Munch, Braeden A. Mair, Christopher J. C. Cooze, Volker Derdau, Armin Bauer, Duanyang Kong, Benjamin H. Rotstein, Rylan J. Lundgren
Summary: The isotopic labelling of small molecules is crucial for drug development and biochemical processes. However, the labelling of carbon-labelled alpha-amino acids is difficult and time-consuming, resulting in high cost and scarcity of C-labelled products. This study demonstrates that aldehydes can catalyse the isotopic carboxylate exchange of alpha-amino acids with *CO2, providing a new method for late-stage C-11 radiolabelling.
Article
Chemistry, Organic
Kellie L. Weeks, Jack D. Williams, Gregory R. Boyce
Summary: The stereocontrolled three-step synthesis of either enantiomer of alpha-thujone from commercially available 3-methyl-1-butyne is described. The enantioselectivity originates from a Brown crotylation which is then conferred to the all-carbon quaternary center via chiratity transfer in a gold-catalyzed cycloisomerization. The route is highly atom economical and requires no protecting groups or redox manipulations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Paramvir Ahlawat, Alexander Hinderhofer, Essa A. Alharbi, Haizhou Lu, Amita Ummadisingu, Haiyang Niu, Michele Invernizzi, Shaik Mohammed Zakeeruddin, M. Ibrahim Dar, Frank Schreiber, Anders Hagfeldt, Michael Graetzel, Ursula Rothlisberger, Michele Parrinello
Summary: This study investigated the solid-solid phase transition during two-step sequential deposition, revealing microscopic details through metadynamics, x-ray diffraction, and Raman spectroscopy. Polymorphs were identified for methylammonium lead iodide and formamidinium lead iodide, with a possible crystallization pathway for the highly efficient metastable alpha phase of formamidinium lead iodide discovered through simulations. Experiments guided by these simulations successfully achieved low-temperature crystallization of phase-pure alpha-formamidinium lead iodide.
Article
Biochemical Research Methods
Minoo Afshar, Gerrit van Hall
Summary: This study developed a high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous analysis of ketone bodies, alpha-keto acids, lactate, pyruvate, and their tracer enrichments in human plasma. The method showed good sensitivity and accuracy, and can be used to quantify the synthesis and degradation rates of these metabolites.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Electrochemistry
Jiakui Wu, Penglin Zhang, Xiujuan Chen, Youliang Wang, Quanwen Zhang, Shurong Yu, Mingliang Wu
Summary: Using single-crystalline erythrocyte-like α-Fe2O3 nanoparticles as the anode material for lithium-ion batteries can improve the electrochemical performance and stability of the anode.
Article
Cardiac & Cardiovascular Systems
Ana Nogal, Taryn Alkis, Yura Lee, Domagoj Kifer, Jie Hu, Rachel A. Murphy, Zhe Huang, Rui Wang-Sattler, Gabi Kastenmueler, Birgit Linkohr, Clara Barrios, Marta Crespo, Christian Gieger, Annette Peters, Jackie Price, Kathryn M. Rexrode, Bing Yu, Cristina Menni
Summary: In this study, metabolomic profiling was used to identify 10 novel metabolites associated with myocardial infarction (MI). Metabolite profiles might help identify high-risk individuals before the onset of disease, and further research is needed to understand the mechanisms and pathways involved.
CARDIOVASCULAR RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
So Jeong Lee, Min Ji Park, Seyeon Kim, Yong Sun Park
Summary: A method for the preparation of highly enantioenriched six-membered 1,4-N,N- and N,O-heterocycles through [4 + 2] heteroannulation of alpha-bromoacetates with 1,4-binucleophiles has been developed. Convenient access to a wide range of C-aryl/aliphatic substituted 1,4-N,N- and N,O-heterocycles with up to 99:1 enantiomeric ratio is achieved through two consecutive substitutions of highly diastereoenriched L-serinate-derived alpha-bromoacetates.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Severin Merget, Lorenzo Catti, Shani Zev, Dan T. Major, Nils Trapp, Konrad Tiefenbacher
Summary: A large hexameric cage based on intermolecular amide-amide dimerization is reported, with a diameter of 2.3 nm and a cavity volume of 2800 Å(3), larger than any previously known capsule/cage structure relying solely on hydrogen bonds. The self-assembly process in chlorinated organic solvents is strongly concentration-dependent, with the monomeric form prevailing at low concentrations. Additionally, the formation of host-guest complexes with fullerenes (C-60 and C-70) was observed.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Applied
Fanny Coffigniez, Michael Rychlik, Christian Mestres, Lisa Striegel, Philippe Bohuon, Aurelien Briffaz
Summary: The study found that in the germination process of cowpea seeds, the enzymatic interconversion of folate forms into 5-methyltetrahydrofolate was intense. After 48 hours, there was a high enzymatic production of 5-methyltetrahydrofolate, 5-formyltetrahydrofolate, and tetrahydrofolate, suggesting that a long germination process may be more beneficial than soaking in increasing the production of bioavailable folates within the seed for human consumption.
Article
Chemistry, Applied
Li Zou, Wee Kee Tan, Yuanyuan Du, Hui Wen Lee, Xu Liang, Jiajia Lei, Lisa Striegel, Nadine Weber, Michael Rychlik, Choon Nam Ong
Summary: Significant metabolic profile shifts were observed in different developmental stages of choy sum, with most nutritional metabolites concentrated either in the microgreens or seedlings. Essential amino acids decreased while plant sugars increased from microgreens to seedlings, and carotenoids and essential minerals exhibited different distribution patterns among the developmental stages.
Article
Mycology
Sophie Scheibenzuber, Fabian Dick, Stefan Asam, Michael Rychlik
Summary: A multi-mycotoxin LC-MS/MS method was developed to quantify 13 free and modified Alternaria toxins in different beer types, showing no contamination with Alternaria toxins apart from tenuazonic acid (TeA) in concentrations between 0.69 μg/L and 16.5 μg/L in 50 beer samples. The exposure towards TeA through beer consumption was considered relatively low, as the threshold of toxicological concern (TTC) value might not be reached when consuming reasonable amounts of beer.
MYCOTOXIN RESEARCH
(2021)
Article
Chemistry, Applied
Larissa E. Pferdmenges, Annett Schroeter, Regina Lohmayer, Lisa Striegel, Michael Rychlik, Alexandra Mueller, Ann-Katrin Meinhardt, Bernhard Trierweiler, Bernd M. Hartmann, Lara Frommherz
Summary: This study revealed significant differences in nutrient composition among different German beer styles, providing an improved basis for understanding the nutritional value of beer. The new data showed higher daily nutrient recommendation percentages for niacin, vitamin B6, and folate, but lower values for alcohol and elements like copper and iodine for the average beer consumer. These findings demonstrate the importance of updated data for future studies on nutritional value calculation in beer consumption.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Organic
Fabian Huck, Lorenzo Catti, Gian Lino Reber, Konrad Tiefenbacher
Summary: Chiral pyrrolidine derivatives are crucial for natural product synthesis, and carbonyl olefin metathesis is a powerful tool for constructing these building blocks. The supramolecular resorcinarene catalyst enables access to chiral 2,5-dihydropyrroles under Bronsted acid catalysis, even tolerating Lewis-basic protecting groups. The product yield and selectivity in this catalytic system depend on the size of the substrates due to reaction occurring inside a closed cavity.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Food Science & Technology
Felix Hoheneder, Eva Maria Biehl, Katharina Hofer, Johannes Petermeier, Jennifer Groth, Markus Herz, Michael Rychlik, Michael Hess, Ralph Hueckelhoven
Summary: The epidemiology of Fusarium Head Blight (FHB) in spring barley was assessed in this study. Soil and spray inoculation were used to increase disease pressure and provoke genotypic differentiation. The evaluation of stable quantitative FHB resistance in barley genotypes was achieved through the quantification of fungal DNA contents and multiple Fusarium toxins. The study also identified the impact of weather conditions on fungal colonization in mature barley grain.
Article
Food Science & Technology
Maria Z. Tsimidou, Stella A. Ordoudi, Fani Th Mantzouridou, Nikolaos Nenadis, Tamara Stelzl, Michael Rychlik, Nastasia Belc, Claudia Zoani
Summary: The pan-European distributed research infrastructure for promoting metrology in food and nutrition, known as METROFOOD-RI, aims to provide high-quality metrology services across the food chain. It includes physical and electronic facilities and is currently preparing to apply for ERIC legal status. METROFOOD-RI partners have identified key thematic areas and strategic priorities to contribute to global societal challenges and emergencies.
Article
Mycology
Sophie Scheibenzuber, Fabian Dick, Marina Brettraeger, Martina Gastl, Stefan Asam, Michael Rychlik
Summary: A liquid chromatography tandem mass spectrometry (LC-MS/MS) multi-mycotoxin method was developed for the analysis of multiple Alternaria toxins in barley and malt. The method employed stable isotope dilution analysis and matrix-matched calibration for quantitation. The study revealed the potential formation of mycotoxins during the malting process.
MYCOTOXIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lance Buckett, Sabrina Schoenberger, Veronika Spindler, Nadine Sus, Christian Schoergenhofer, Jan Frank, Oliver Frank, Michael Rychlik
Summary: This study presents a synthetic approach to obtain reference standards for the identification of human xanthohumol metabolites. The metabolites were analyzed using qTOF LC-MS/MS, and some were matched to a human blood sample. Isomers of the reference standards were also identified. The methods used in this study unequivocally identified the metabolites of xanthohumol in the blood circulatory system.
Article
Biochemical Research Methods
Lisa Monika Klein, Angelika Miriam Gabler, Michael Rychlik, Christoph Gottschalk, Florian Kaltner
Summary: This study developed a sensitive analytical approach for simultaneous detection and quantification of unsaturated pyrrolizidine alkaloids, their corresponding N-oxides, and tropane alkaloids in milk of dairy cows. The method showed low limits of detection and quantification, good recovery rates and repeatability. Traces of pyrrolizidine alkaloids were detected in three milk samples obtained from milk vending stations and local marketers in Bavaria, Germany.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Sabir Khan, Ademar Wong, Michael Rychlik, Maria del Pilar Taboada Sotomayor
Summary: This study developed a novel voltammetric sensor for the quantitation of folate in foodstuffs. The sensor, made from magnetic molecularly imprinted polymers (MMIPs), showed high sensitivity and selectivity. The sensor successfully detected folate in different food samples with high recovery percentages. The results demonstrated the efficiency and reliability of the biomimetic sensor for folate determination in real food samples.
Article
Food Science & Technology
Marina Brettraeger, Sophie Scheibenzuber, Stefan Asam, Michael Rychlik, Martina Gastl, Thomas Becker
Summary: Brewing experiments were conducted to assess the impact of black-colored grain on Alternaria mycotoxin concentrations throughout the brewing process. The concentrations of 13 different Alternaria mycotoxins were analyzed in each step using liquid chromatography-tandem mass spectrometry, and the toxin concentrations were balanced over the entire process. The results showed that TeA was the only toxin to migrate into the final beer, while other toxins were mainly found in the spent grains. This study suggests that optical sorting of malt batches can be a useful tool for preventing elevated mycotoxin concentrations in the malting and brewing industry.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Leopold Weidner, Daniel Hemmler, Michael Rychlik, Philippe Schmitt-Kopplin
Summary: We developed DBDIpy, a Python library for processing and analyzing untargeted, time-sensitive plasma ionization MS datasets. It is capable of identifying in-source fragments and rivaling ionization pathways of the same analytes in time-sensitive datasets. DBDIpy also includes basic functions for processing untargeted metabolomics data and interfaces to existing tools for MS data analysis in Python.
Article
Biotechnology & Applied Microbiology
Yvonne Methner, Nadine Weber, Oliver Kunz, Martin Zarnkow, Michael Rychlik, Mathias Hutzler, Fritz Jacob
Summary: Nonalcoholic beers are gaining popularity due to increasing consumer awareness of healthier lifestyles. These beers, produced using non-Saccharomyces yeasts, offer a diverse range of flavors. This study found that nonalcoholic beers contain significant amounts of B vitamins, making them a potential dietary supplement.
FEMS YEAST RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
