Article
Engineering, Biomedical
Ruo-Yi Xue, Chang Liu, Jia-Qi Wang, Yan Deng, Rang Feng, Guo-Cheng Li, Jing-Yi Liu, Hao Cheng, Shan- Shan Zhang, Hao Duan, Zhe Jin, Quan-Ming Zou, Hai-Bo Li
Summary: Helicobacter pylori (H. pylori) colonizes the stomach epithelium of half the world's population, causing various digestive diseases and stomach cancer. Synthetic lipopeptide vaccines Hp4 and Hp10 can activate bone marrow derived dendritic cells (BMDCs), inducing secretion of cytokines and improving T-cell activation and differentiation. Hp10 provides protection against H. pylori infection by inducing specific sIgA response at mucosal sites. Interestingly, combination of Hp4 and Hp10 enhances protective response against H. pylori infection, with improved T-cell and mucosal antibody responses.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Carlo Pifferi, Leire Aguinagalde, Ane Ruiz-de-Angulo, Nagore Sacristan, Priscila Tonon Baschirotto, Ana Poveda, Jesus Jimenez-Barbero, Juan Anguita, Alberto Fernandez-Tejada
Summary: The overexpression of aberrantly glycosylated tumor-associated mucin-1 (TA-MUC1) in human cancers makes it a major target for the development of anticancer vaccines derived from synthetic MUC1-(glyco)peptide antigens. However, glycopeptide-based subunit vaccines are weakly immunogenic, requiring adjuvants and/or additional immunopotentiating approaches to generate optimal immune responses.
Article
Chemistry, Multidisciplinary
Xiang Luo, Qinghai Lian, Wenwei Li, Liqing Chen, Renyu Zhang, Deying Yang, Lingqiang Gao, Xiaoxiao Qi, Zhongqiu Liu, Guochao Liao
Summary: The strategy of using Mincle agonist with STn antigen conjugates shows promising results in inducing robust immune responses and inhibiting tumor growth, demonstrating the potential for developing new vaccine carriers with self-adjuvanting properties for cancer treatment.
Review
Materials Science, Biomaterials
Daryl Ariawan, Janet van Eersel, Adam D. Martin, Yazi D. Ke, Lars M. Ittner
Summary: This paper summarizes different self-adjuvant structures, including self-assembly peptides, lipids, glycolipids, and polymers, which enhance the immune response to peptide or small molecule antigens.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Lingqiang Gao, Qinghai Lian, Leilei Ma, Shiwei Su, Menglan Yang, Yuan Fang, Zhongqiu Liu, Xiang Luo, Guochao Liao
Summary: An efficient strategy for constructing RC-529 and its derivatives has been established, with four conjugates of RC-529 derivatives with Tn antigen inducing strong T cell dependent immune responses in mice and showing specific cytotoxicity towards Tn-overexpressing cancer cells. This suggests RC-529 as a potential platform for the development of new vaccine carriers with self-adjuvanting properties for cancer treatment, supported by preliminary structure-activity relationship analysis.
CHINESE CHEMICAL LETTERS
(2021)
Article
Nanoscience & Nanotechnology
Yanqiu Song, Qi Su, Huijuan Song, Xiaoguang Shi, Mingming Li, Na Song, Shaofeng Lou, Weiwei Wang, Zhilin Yu
Summary: This study investigated the impact of two groups of self-adjuvanting peptide vaccines with different morphologies on immune responses, revealing that nanofibril vaccines exhibited enhanced performance in inducing DCs maturation, accumulation at lymph nodes, and antitumor immune responses compared to nanoparticle vaccines. The findings suggest that there is a strong relationship between the morphology of peptide vaccines and their immune response, emphasizing the critical role of morphological control in designing efficient peptide vaccines.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Thomas C. van den Ende, Jeroen M. M. Heuts, Geoffroy P. P. Gential, Marten Visser, Michel J. van de Graaff, Nataschja Ho, Wim Jiskoot, A. Rob P. M. Valentijn, Nico J. Meeuwenoord, Herman S. Overkleeft, Jeroen D. C. Codee, Sjoerd H. van der Burg, Els M. E. Verdegaal, Gijsbert A. van der Marel, Ferry Ossendorp, Dmitri Filippov
Summary: Synthetic vaccines based on antigenic peptides expressed by tumors show promise for cancer immunotherapy, especially when adjuvanted with immunostimulatory additives. A novel conjugatable TLR2 ligand, mini-UPam, has been developed to improve solubility and physicochemical properties of synthetic peptides. The immunogenicity of mini-UPam-SP conjugates was demonstrated using T-cells from a cancer patient.
Article
Chemistry, Multidisciplinary
Rachel C. Ollier, Yuanhui Xiang, Adriana M. Yacovelli, Matthew J. Webber
Summary: Mechanoresponsiveness, including strain-stiffening and self-healing features, is vital for preventing and repairing deformation-induced damage in natural biological tissues. However, synthetic polymeric hydrogels often fail to replicate these properties. In this study, strain-stiffening behavior is achieved in fully synthetic ideal network hydrogels via dynamic-covalent boronate ester crosslinks. The mechanism underlying this unusual stiffening response is attributed to a combination of entropic and enthalpic elasticity. This work provides insights into crosslink-driven strain-stiffening in dynamic-covalent phenylboronic acid-diol hydrogels and offers a promising platform for future applications.
Article
Multidisciplinary Sciences
Cameron C. Hanna, Anneliese S. Ashhurst, Diana Quan, Joshua W. C. Maxwell, Warwick J. Britton, Richard J. Payne
Summary: Researchers have developed a method for generating synthetic self-adjuvanted protein vaccines for tuberculosis and demonstrated their efficacy in providing significant protection in the lungs of mice. This flexible synthetic platform allows for incorporation of adjuvants to multiantigenic vaccines, offering a general approach for rapidly assessing vaccination strategies against a range of diseases, including novel pandemic pathogens such as SARS-CoV-2.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Multidisciplinary
Peter H. Seeberger
Summary: Researchers are using synthetic glycan-based medicinal chemistry to understand mammalian antiglycan immune response and define glycan epitopes for novel synthetic glycoconjugate vaccines against bacteria such as Streptococcus pneumoniae, Clostridium difficile, and Klebsiella pneumoniae. These efforts provide fundamental insights into how the human immune system recognizes carbohydrates and drive the discovery of carbohydrate vaccines.
Review
Biochemistry & Molecular Biology
Magdalena E. Zaslona, A. Michael Downey, Peter H. Seeberger, Oren Moscovitz
Summary: Vaccine-induced protection has been crucial in preventing infectious diseases, especially highlighted during the recent COVID-19 pandemic. Carbohydrates in the capsular sugar coat of bacteria serve as important vaccine targets. The introduction of synthetic fragments has provided well-defined and homogenous structures, advancing the development of vaccines.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Fan Lee, Ki Hyun Bae, Shengyong Ng, Atsushi Yamashita, Motoichi Kurisawa
Summary: The study found that hyaluronic acid-EGCG conjugates have the potential as an anti-arthritic agent, targeting fibroblast-like synoviocytes, and exhibiting superior anti-proliferative and anti-inflammatory activities.
Article
Chemistry, Physical
Cristian Rosso, Sara Cuadros, Giorgia Barison, Paolo Costa, Marina Kurbasic, Marcella Bonchio, Maurizio Prato, Luca Dell'Amico, Giacomo Filippini
Summary: We present an efficient photocatalytic method for the direct iodosulfonylation of terminal olefins using alpha-iodo phenylsulfones. The process utilizes a phenol derivative as the precatalytic system and visible-light irradiation. Mechanistic investigations demonstrate the crucial role of the in situ generated phenolate anion in the catalytic process, achieving high yields of up to 95%.
Article
Chemistry, Multidisciplinary
Mariusz Skwarczynski, Guangzu Zhao, Victoria Ozberk, Ashwini Kumar Giddam, Zeinab G. Khalil, Manisha Pandey, Waleed M. Hussein, Reshma J. Nevagi, Michael R. Batzloff, Robert J. Capon, Michael F. Good, Istvan Toth
Summary: Peptide-based vaccines are composed of minimal microbial components that are required to stimulate immune responses. Peptides themselves are poor immunogens and usually need to be co-administered with an adjuvant to produce desired immune responses. Recent research has shown that poly(hydrophobic amino acids) can self-assemble into nanoparticles and induce strong humoral immune responses when conjugated with a peptide antigen.
AUSTRALIAN JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Biomedical
Niall J. Treacy, Shane Clerkin, Jessica L. Davis, Ciaran Kennedy, Aline F. Miller, Alberto Saiani, Jacek K. Wychowaniec, Dermot F. Brougham, John Crean
Summary: Human induced pluripotent stem cell (hiPSC)-derived kidney organoids were matured within synthetic self-assembling peptide hydrogels (SAPHs) of variable stiffness. The organoids exhibited complex structures comparable to those differentiated within animal-derived matrix, Matrigel. Differentiation within a higher stiffness SAPH generated podocytes with more mature gene expression profiles. Maturing the organoids within a 3D microenvironment significantly reduced off-target cell types.
BIOACTIVE MATERIALS
(2023)
Review
Chemistry, Medicinal
Songbo Xie, Angela Ogden, Ritu Aneja, Jun Zhou
MEDICINAL RESEARCH REVIEWS
(2016)
Review
Chemistry, Medicinal
Padmashree C. G. Rida, Dillon LiVecche, Angela Ogden, Jun Zhou, Ritu Aneja
MEDICINAL RESEARCH REVIEWS
(2015)
Article
Cell Biology
Yunfan Yang, Jun Zhou
JOURNAL OF CELL SCIENCE
(2016)
Review
Cell Biology
Rui Lyu, Jun Zhou
JOURNAL OF CELLULAR PHYSIOLOGY
(2017)
Article
Chemistry, Medicinal
Hua Sun, Partick Y. K. Yue, Shao-Rong Wang, Lihong Huo, Ying Zhao, Songbo Xie, Jens V. Kringelum, Ole Lund, Olivier Taboureau, Jun Zhou, Ricky N. S. Wong, Wei-Shuo Fang
MEDICINAL CHEMISTRY
(2016)
Review
Pharmacology & Pharmacy
Linlin Zhang, Angela Ogden, Ritu Aneja, Jun Zhou
PHARMACOLOGY & THERAPEUTICS
(2016)
Review
Pharmacology & Pharmacy
Fan Yu, Jie Ran, Jun Zhou
TRENDS IN PHARMACOLOGICAL SCIENCES
(2016)
Article
Oncology
Youguang Luo, Siqi Gao, Ziwei Hao, Yang Yang, Songbo Xie, Dengwen Li, Min Liu, Jun Zhou
Article
Oncology
Jie Ran, Fan Yu, Juan Qin, Yijun Zhang, Yunfan Yang, Dengwen Li, Jun Zhou, Min Liu
Article
Oncology
Juan Qin, Dengwen Li, Yunqiang Zhou, Songbo Xie, Xin Du, Ziwei Hao, Ruming Liu, Xinqi Liu, Min Liu, Jun Zhou
Article
Multidisciplinary Sciences
Songbo Xie, Juan Qin, Shiyu Liu, Yijun Zhang, Jun Wang, Xingjuan Shi, Dengwen Li, Jun Zhou, Min Liu
SCIENTIFIC REPORTS
(2016)
Article
Medicine, Research & Experimental
Yijun Zhang, Youguang Luo, Rui Lyu, Jie Chen, Ruming Liu, Dengwen Li, Min Liu, Jun Zhou
Article
Medicine, Research & Experimental
Linlin Zhang, Sheng Tong, Jun Zhou, Gang Bao
Article
Cell Biology
Youguang Luo, Jie Ran, Songbo Xie, Yunfan Yang, Jie Chen, Shanshan Li, Wenqing Shui, Dengwen Li, Min Liu, Jun Zhou
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
