Article
Endocrinology & Metabolism
Jun Choul Lee, Byong-Sop Song, Young Mi Kang, Yu-Ri Kim, Yea Eun Kang, Ju Hee Lee, Minho Shong, Hyon-Seung Yi
Summary: The study found a correlation between TSH concentration and muscle mass, muscle function related parameters in DTC patients undergoing TSH suppression therapy. Particularly, low TSH concentration was associated with decreased grip strength, especially in male patients under 70 years old.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Angela De Stefano, Raffaele Ambrosio, Tommaso Porcelli, Gianfranco Orlandino, Domenico Salvatore, Cristina Luongo
Summary: Skeletal muscle atrophy is characterized by altered protein turnover, with protein degradation exceeding synthesis, leading to muscle mass loss and weakness. Thyroid hormone plays a key role, regulating TH levels in muscle through deiodinases. Modulation of deiodinases may offer a therapeutic approach for treating muscle atrophy.
Article
Cell Biology
Dong Lin, Ruijie Qin, Lixin Guo
Summary: DR is a common complication of diabetes, with high TSH levels being associated with an increased prevalence; TSH may regulate glucose-induced PCs loss through mitochondrial apoptosis involving TSHR.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Anna Malgorzata Kucharska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Beata Pyrzak
Summary: This paper presents literature data describing changes in thyroid function related to rhGH therapy and provides a current explanation of the mechanisms involved in this phenomenon, emphasizing the importance of changes in central and peripheral regulation during treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Caiyan Mo, Han Chen, Ying Guo, Zheng Li, Yao Wang, Liyong Zhong
Summary: The effect and potential mechanism of high growth hormone (GH)/insulin-like growth factor (IGF)-1 on thyroid function were explored by analyzing the changes in thyroid function in patients with growth hormone-secreting pituitary adenoma (GHPA).
ENDOCRINE PRACTICE
(2023)
Article
Endocrinology & Metabolism
Junpei Sanada, Fuminori Tatsumi, Shinji Kamei, Yoshiro Fushimi, Masashi Shimoda, Kenji Kohara, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune, Hideaki Kaneto
Summary: Pituitary adenoma producing both growth hormone (GH) and thyroid-stimulating hormone (TSH) is rare but possible. This case study presented a 27-year-old woman with symptoms of acromegaly and simultaneous production of both GH and TSH by the pituitary adenoma. Treatment included pituitary tumor resection, cyber knife therapy, somatostatin analog, GH receptor antagonist, and anti-thyroid drug thiamazole.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emilie Blanchet, Laurence Pessemesse, Christine Feillet-Coudray, Charles Coudray, Chantal Cabello, Christelle Bertrand-Gaday, Francois Casas
Summary: Deletion of p43 leads to a reduction in pancreatic islet density and loss of glucose-stimulated insulin secretion in mice. Our study showed that p43 is involved in beta cell development and maturation through regulation of the transcription factor MafA. Additionally, p43 deletion resulted in oxidative stress in pancreatic islets and affected insulin secretion in response to glucose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Hyunggyu Kim, Kyunghee Ji
Summary: This study investigated the effects of TMBPF on the endocrine system using zebrafish embryos and larvae. The results showed that TMBPF exposure led to reduced body weight, increased triiodothyronine levels, decreased growth hormone levels, and altered gene transcription associated with thyroid hormones and growth hormones.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Endocrinology & Metabolism
Weibin Wang, Xingyun Su, Yongfeng Ding, Weina Fan, Weibin Zhou, Junwei Su, Zhendong Chen, Hong Zhao, Kaijin Xu, Qin Ni, Xiaowei Xu, Yunqing Qiu, Lisong Teng
Summary: Thyroid function abnormalities are common in COVID-19 patients, especially in severe cases. This might be partially explained by nonthyroidal illness syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Robert H. Mak, Sujana Gunta, Eduardo A. Oliveira, Wai W. Cheung
Summary: Cachexia associated with chronic kidney disease (CKD) is linked to growth hormone (GH) resistance. This study found that GH treatment improved metabolism, food intake, weight growth, and muscular function in CKD mice. GH also decreased lipolysis, reversed adipose tissue browning, and normalized molecular markers of muscle wasting. Additionally, GH restored aberrant expression of muscle genes associated with thermogenesis, fibrosis, and regeneration. These findings suggest that GH may be an effective treatment for CKD-related cachexia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yoshifumi Horie
Summary: The study aimed to investigate the effects of environmentally relevant concentrations of triclosan on zebrafish development. It was found that triclosan at environmentally detected residual concentrations can cause lethal effects and disrupt thyroid hormone activity in zebrafish.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Eun Kyung Lee, Hwa Young Ahn, Eu Jeong Ku, Won Sang Yoo, Young Ki Lee, Kee-Hyun Nam, Young Jun Chai, Shinje Moon, Yuh-Seog Jung
Summary: Patients with differentiated thyroid cancer (DTC) are at an increased risk of atrial fibrillation, coronary artery disease, cerebrovascular accidents, and all-cause mortality, with abnormal echocardiographic and hemodynamic parameters indicating cardiac dysfunction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Eun Kyung Lee, Hwa Young Ahn, Eu Jeong Ku, Won Sang Yoo, Young Ki Lee, Kee-Hyun Nam, Young Jun Chai, Shinje Moon, Yuh-Seog Jung
Summary: Patients with DTC are at an increased risk of atrial fibrillation, cardiovascular disease, increased heart rate, and left ventricular mass development.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Caterina Miro, Annarita Nappi, Serena Sagliocchi, Emery Di Cicco, Melania Murolo, Sepehr Torabinejad, Lucia Acampora, Arianna Pastore, Paolo Luciano, Evelina La Civita, Daniela Terracciano, Mariano Stornaiuolo, Monica Dentice, Annunziata Gaetana Cicatiello
Summary: Thyroid hormones play a role in regulating muscle formation and energy utilization by modulating carbohydrates, lipids, and proteins. They can change the lipid composition and fatty acid ratio in skeletal muscle, with increased proportion of unsaturated fatty acids improving insulin sensitivity and endurance exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Blanca Soler Palacios, Ricardo Villares, Pilar Lucas, Jose Miguel Rodriguez-Frade, Ana Cayuela, Jonathan G. Piccirillo, Manuel Lombardia, David Delgado Gestoso, Miguel Fernandez-Garcia, Cristina Risco, Coral Barbas, Fernando Corrales, Carlos Oscar S. Sorzano, Nuria Martinez-Martin, Jose Javier Conesa, Francisco J. Iborra, Mario Mellado
Summary: This study found that growth hormone can alter the metabolism of inflammatory macrophages, increase mitochondrial volume and alter mitochondrial dynamics. It reduces glycolysis and lactate production, and increases the density of the inner mitochondrial membrane. The results suggest that targeting macrophage metabolism could be a new approach for intervening in inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Isabella Loughland, Alexander Little, Frank Seebacher
Summary: The study reveals that DNMT3a plays a key role in regulating developmental thermal plasticity, and the phenotypic effects of different DNMT3a isoforms are additive. However, DNMT3a interacts with other mechanisms, such as histone (de)acetylation, induced during short-term acclimation to buffer phenotypes from environmental change. These interactions make phenotypic compensation for climate change more efficient.
Article
Biodiversity Conservation
Nicholas C. Wu, Frank Seebacher
Summary: The study found that exposure to BPF and BPS can reduce swimming performance in adult zebrafish, while BPA, BPS, and BPF can all affect the activities of citrate synthase and lactate dehydrogenase. This suggests that bisphenols at ecologically relevant concentrations may disrupt the thermal responses of fish.
CONSERVATION PHYSIOLOGY
(2021)
Article
Ecology
Frank Seebacher, Ensiyeh Kazerouni-Ghanizadeh
Summary: The health of running freshwater systems relies significantly on flow rates and temperature variations, which can affect the oxidative status, muscle function, and locomotion of aquatic animals. This study demonstrates that fish living in flowing water have greater swimming capacity, especially when acclimated to warm temperatures. Dispersal behavior is influenced by acclimation to flow and temperature, indicating the importance of considering physiological traits in predicting the impact of environmental change on movement.
FRESHWATER BIOLOGY
(2021)
Article
Biology
Isabella Loughland, Gigi Y. Lau, Jordan Jolly, Frank Seebacher
Summary: The potential negative effects of thermal variation on physiological functions depend on the time scale of phenotypic adjustment and the rate of temperature change. In this study, different rates of temperature increase were tested on zebrafish, and it was found that both fast and slow rates of warming led to increased oxidative stress. However, mitochondrial substrate oxidation rates, leak respiration rates, and coupling did not show significant differences. The increase in ROS production at the slowest rate of warming suggests that seemingly benign environments can still be stressful for organisms.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Biology
Nicholas C. Wu, Alexander M. Rubin, Frank Seebacher
Summary: The energetic cost of growth is affected by temperature and environmental endocrine disruption. Plastic pollution and climate warming can impact animal growth efficiency and population dynamics.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biology
Nicholas C. Wu, Frank Seebacher
Summary: Physiological traits influence individual movement and differences in physiological characteristics between range edges and cores may be associated with dispersal success. However, the results may be biased due to undersampling.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biology
Frank Seebacher, Julian Beaman
Summary: Phenotypic plasticity of physiological functions allows organisms to respond quickly to environmental changes and increase their resilience. The Last Universal Common Ancestor (LUCA) likely had metabolic plasticity that allowed it to adjust energy production to meet demand. Metabolic plasticity originated with the advent of Darwinian evolution and played a crucial role in genetic material replication and cell division. Since LUCA, metabolic networks have become more complex, with complexity being specific to environmental contexts and phylogenetic lineages.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Review
Biology
Miki Jahn, Frank Seebacher
Summary: This article explores the costs of movement (COT) in animals and its impact on ecological systems. Environmental conditions, morphology, and underlying physiological mechanisms contribute to differences in COT between individuals and species. Increasing temperatures notably increase COT, while thermal acclimation and exercise have varied effects on COT across taxa. Anthropogenic pollutants can also increase COT. COT can influence energy allocation and individual fitness, ultimately affecting the dynamics of animal communities. Future research should consider multiple stressors on COT, including a broader range of pollutants, and quantifying potential allocation trade-offs induced by COT.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Zoology
A. G. Little, T. S. Prystay, E. A. Hardison, T. Dressler, K. Kraskura, S. J. Cooke, D. A. Patterson, S. G. Hinch, E. J. Eliason
Summary: Female-biased mortality has been observed in Pacific salmon during their adult upriver migration. This study examined whether females are more susceptible to cardiac oxygen limitations after exercise stress. The results showed no significant differences in oxygen levels between males and females, suggesting that females do not suffer from oxygen limitations after a single exercise event upon arrival to their spawning grounds. However, further research is needed to investigate potential oxygen limitations in different conditions and earlier on the migratory route.
CANADIAN JOURNAL OF ZOOLOGY
(2023)
Article
Cell Biology
Frank Seebacher
Summary: Human activities have created unique environmental drivers that may have unexpected effects on the endocrine responses of non-human animals, such as impacting reproduction and growth through hormones like gonadotropins and thyroid hormones. Interactions between temperature, light, endocrine disrupting compounds, light-at-night, and noise can lead to different physiological responses across generations of animals.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Jean-Guy J. Godin, Amelie Le Roy, Alicia L. Burns, Frank Seebacher, Ashley J. W. Ward
Summary: Consistent individual differences in behavior exist within populations. In this study, adult male guppies were tested to investigate the correlation between behavioral and metabolic traits. The findings did not support the prediction of the pace-of-life-syndrome (POLS) hypothesis, as there was no significant correlation between metabolic traits and behavioral traits. Male color ornamentation also did not predict behavioral or metabolic phenotypes. Therefore, individual differences in metabolism may not underlie the evolution and maintenance of behavioral variation in this study population.
Article
Marine & Freshwater Biology
Tiana Pelaia, Alexander M. Rubin, Frank Seebacher
Summary: Human activity has introduced novel chemicals into aquatic ecosystems, such as BPA which disrupts hormone-mediated processes. BPA is being replaced by BPS, but studies show that BPS can also disrupt hormone signalling, particularly of thyroid hormone. This study found that BPS exposure decreased swimming performance in zebrafish and had ecological consequences, likely mediated by thyroid hormone disruption.
AQUATIC TOXICOLOGY
(2023)
Article
Biology
Frank Seebacher, Stephanie M. Bamford, Amelie Le Roy
Summary: Each parent can impact offspring phenotype through zygote provisioning or sex-specific DNA methylation. Transgenerational plasticity may depend on the environmental conditions experienced by each parent. In a factorial experiment using guppies, we found that the thermal background of mothers and fathers influenced mass, length, and thermal performance of sons and daughters. Offspring sex played a significant role in most traits. The study showed that parental thermal variation can modify offspring phenotype, highlighting the importance of considering the thermal background of each parent.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Behavioral Sciences
Geoffrey P. F. Mazue, Maxim W. D. Adams, Frank Seebacher, Ashley J. W. Ward
Summary: To adjust their foraging strategy, individuals may use a combination of private and social information. The reliability of private information about environmental characteristics, such as prey distribution, can influence individuals' movement patterns. This study investigated how movement characteristics changed as individuals acquired reliable private information about prey distribution during foraging.
Article
Biodiversity Conservation
Frank Seebacher, Edward Narayan, Jodie L. Rummer, Sean Tomlinson, Steven J. Cooke
Summary: This article emphasizes the important role of physiology in addressing climate warming, including environmental monitoring and measuring individual sensitivities to temperature change. Physiology can be incorporated by institutions and organizations to bring a mechanistic approach to conservation and the management of biological resources.
CONSERVATION PHYSIOLOGY
(2023)