Article
Plant Sciences
Kaichun Wang, Wei Liu, Qinfen Xu, Chao Gu, Daode Hu
Summary: This study found that Tenacissoside G (TG) exhibited dose-dependent growth inhibitory activity and cell cycle arrest induction in colorectal cancer cells, enhancing the anticancer effects of 5-fluorouracil (5-FU). The synergistic effects may be attributed to increased activation of caspase cascade, enhancement of DNA damage, and induction of p53 phosphorylation at Serine 46.
Article
Biotechnology & Applied Microbiology
Aseel Kamil Mohammad Al-Mosawi, Ahmad Reza Bahrami, Sirous Nekooei, Amir Sh. Saljooghi, Maryam M. Matin
Summary: In this study, magnetic mesoporous silica nanoparticles (MSNs) loaded with 5-fluorouracil (5-FU) and surface-decorated with polyethylene glycol (PEG) and epithelial cell adhesion molecule (EpCAM) aptamer (Apt) were developed for controlled release of 5-FU and targeted treatment of colorectal cancer (CRC). Au NPs were conjugated to the exterior surface of MSNs as a gatekeeper for intelligent drug release. The results demonstrated the potential of this theranostic platform in targeted drug delivery and treatment of CRC.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Hao Yang, Sha Xie, Beibei Liang, Qiqi Tang, Huanchen Liu, Dongliang Wang, Gang Huang
Summary: In this study, high expression of IDH1 in human colorectal cancer tissues was found to indicate high-grade tumors. Exosomal IDH1 derived from 5FU-resistant cells enhanced resistance to 5FU in sensitive cells by decreasing the level of IDH1-mediated NADPH, potentially acting as a driver of chemoresistance in colorectal cancer.
Article
Chemistry, Applied
Mostafa Yusefi, Michiele Soon Lee-Kiun, Kamyar Shameli, Sin-Yeang Teow, Roshafima Rasit Ali, Kit-Kim Siew, Hui-Yin Chan, Magdelyn Mei-Theng Wong, Wei-Ling Lim, Kamil Kuca
Summary: The study developed a multifunctional magnetic cellulose nanocomposite MC/5-FU, demonstrating potential as a low-cost drug carrier for colorectal cancer treatments.
CARBOHYDRATE POLYMERS
(2021)
Article
Oncology
Shuohui Dong, Songhan Li, Xiaoyan Wang, Shuo Liang, Wenjie Zhang, Linchuan Li, Qian Xu, Bowen Shi, Zhiqiang Cheng, Xiang Zhang, Mingwei Zhong, Guangyong Zhang, Sanyuan Hu
Summary: This study found that the high expression of CD147 is associated with decreased chemosensitivity and unfavorable prognosis in colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). CD147 regulates glycolipid metabolism by upregulating HIF-1 alpha-mediated glycolysis and attenuating PPAR alpha-mediated fatty acid oxidation, resulting in 5-FU resistance in CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mengmeng Wang, Xuqin Guo, Man Yang, Yawen Zhang, Fanyi Meng, Yinshuang Chen, Mengxi Chen, Tian Qiu, Jiawei Li, Zhi Li, Qi Zhang, Fang Xu, Haiyang Zhang, Weipeng Wang
Summary: Atosiban potentiates the antitumor effect of 5-Fu by enhancing its inhibitory effect on MSS-type CRC cells and eliminating 5-Fu-induced GATA3 expression.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pathology
Yu-Ling Qu, Xiao-Li Liu, Shan-Yu Zhao, Xue-Feng Zhai
Summary: This study found that SPOCK1 is upregulated in 5-FU-resistant CRC cells and that knockdown of SPOCK1 increases their sensitivity to 5-FU. Conversely, overexpression of SPOCK1 enhances CRC cell resistance to 5-FU and reduces cell apoptosis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, Research & Experimental
Simona Salerno, Anders Stahlberg, Andre Holdfeldt, Elinor Bexe Lindskog, Goran Landberg
Summary: Colorectal cancer is a common diagnosis worldwide, with many patients not responding to standard chemotherapy. This study used patient-derived scaffolds to investigate how individual patient-specific microenvironments influence the chemotherapy response in colorectal cancer. The findings suggest that tumor microenvironment can influence drug resistance and potential disease relapse, providing insights for optimized precision medicine in colorectal cancer treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sareh Kamran, Ajantha Sinniah, Zamri Chik, Mohammed Abdullah Alshawsh
Summary: The combination of 5-FU and diosmetin has a synergistic effect against colorectal cancer cells, reducing the toxicity of 5-FU while enhancing its anticancer efficacy. This combination induces apoptosis and interrupts cell mitosis to achieve its anticancer effects.
Article
Medicine, Research & Experimental
Rinad A. Algehani, Raefa Abou Khouzam, Gehan A. Hegazy, Aliaa A. Alamoudi, Ali M. El-Halawany, Riham S. El Dine, Ghada A. Ajabnoor, Fahad A. Al-Abbasi, Mohammed A. Baghdadi, Ibrahim Elsayed, Masao Hattori, Ahmed M. Al-Abd
Summary: A synergistic effect in terms of anticancer properties was observed when colossolactone-G was combined with 5-FU and GCB, influencing both apoptosis and autophagic cell death mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Neda Khosravi, Vahid Khaze Shahgoli, Mohammad Amini, Sahar Safaei, Ahad Mokhtarzadeh, Behzad Mansoori, Afshin Derakhshani, Amir Baghbanzadeh, Behzad Baradaran
Summary: The study demonstrated that Nanog knockdown in combination with 5-FU treatment effectively suppressed the pathophysiological processes induced by Nanog in CRC cells, including reducing migration and enhancing drug sensitivity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Fangzhou Li, Fen Qiu, Xu Fan, Qingqing Yu, Shuaitong Liu, Yang Guo, Yunhe Zhu, Xueyan Xi, Boyu Du
Summary: The development of chemoresistance in colorectal cancer cells is mainly attributed to the existence of cancer stem cells. This study found that the expression of ELF3 gene is associated with the increase of CD44, and inhibiting ELF3 can decrease CD44 expression. ELF3 is significantly higher in CD44+ colorectal cancer cells.
Article
Nanoscience & Nanotechnology
Yi-Qing Chen, Wen-Ting Zhu, Cai-Yan Lin, Zhong-Wen Yuan, Zhen-Hua Li, Peng-Ke Yan
Summary: This study successfully constructed a liposome delivery system for rapamycin to enhance its efficacy in treating colorectal cancer. The rapamycin liposomes showed superior antitumor effects compared to free rapamycin both in vitro and in vivo, and were able to synergistically enhance the efficacy of 5-FU in colorectal cancer via the Akt/mTOR and P53 pathways.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Oncology
Helena de Castro e Gloria, Laura Jesuino Nogueira, Patricia Bencke Grudzinski, Paola Victoria da Costa Ghignatti, Temenouga Nikolova Guecheva, Natalia Motta Leguisamo, Jenifer Saffi
Summary: Our study demonstrated that Olaparib enhances the cytotoxicity of 5-FU in MMR-deficient CRC cells, while it reduces clonogenic survival and induces DNA damage in MMR-proficient CRC cells. Combined therapy with Olaparib could be a strategy to overcome 5-FU chemotherapeutic resistance in MMR-deficient CRC.
Article
Oncology
Ya Niu, Xinyi Fan, Yaping Wang, Jiaxin Lin, Luchun Hua, Xiaobo Li, Ruizhe Qian, Chao Lu
Summary: This study revealed a new mechanism where the core circadian gene BMAL1 enhances the effectiveness of 5-FU by increasing the expression and enzymatic activities of key genes in the pyrimidine metabolic pathway in CRC cells. These findings suggest a novel strategy for CRC chemotherapy by targeting chrono-modulated genes of the 5-FU metabolic pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Materials Science, Ceramics
Burcu Karakuzu-lkizler, Pinar Terzioglu, Bilge Sema Oduncu-Tekerek, Sevil Yucel
JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
(2020)
Article
Materials Science, Ceramics
Yeliz Basaran Elalmis, Burcu Karakuzu Ikizler, Serpil Kilic Depren, Sevil Yucel, Ismail Aydin
Summary: The study found that incorporating non-silanized Al2O3-doped BG can improve the flexural strength, modulus, and microhardness of EDCs, but may decrease bioactivity. On the other hand, adding silanized BG and Al2O3-doped BG can enhance the flexural strength and modulus of EDCs, while reducing water sorption, solubility, and bioactivity.
INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE
(2021)
Article
Materials Science, Ceramics
Ali Can Ozarslan, Yeliz Basaran Elalmis, Sevil Yucel
Summary: This study compared the rheological features, bioactivity behavior, and effect on cell viability of composite putties containing biosilica and commercial silica based bioactive glasses. The results showed differences between the two types of materials in rheological and bioactivity properties, but both did not have adverse effects on cell viability.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Materials Science, Composites
Yeliz Basaran Elalmis, Sevil Yucel, Ismail Aydin
Summary: The study aimed to synthesize biogenic silica and investigate the impact of pH on silica gel formation on the properties of silica powders and light-cured dental composites. Results showed that the pH of silica gel formation significantly affected the properties of EDCs, suggesting that biogenic silica powders could be a low-cost alternative for dental fillers.
POLYMER COMPOSITES
(2021)
Article
Biochemistry & Molecular Biology
Ceren Kececiler-Emir, Yeliz Basaran-Elalmis, Yesim Muge Sahin, Erdi Bulus, Sevil Yucel
Summary: This study investigated the fabrication, characterization, bioactivity, and in vitro biological properties of polyvinyl alcohol-based nanofibrous membranes containing bioactive glass loaded with chlorhexidine gluconate for dental barrier membranes. The nanofibrous membranes had an average fiber diameter of 210 nm, pore size of 24.73 μm, and porosity of 12.42%. They exhibited fibroblastic proliferation and antibacterial properties, making them suitable for dental applications.
Correction
Materials Science, Ceramics
Yeliz Basaran Elalmis, Burcu Karakuzu Ikizler, Serpil Kilic Depren, Sevil Yucel, Ismail Aydin
INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE
(2022)
Article
Food Science & Technology
Sadik Gones, Sevil Yucel
MITTEILUNGEN KLOSTERNEUBURG
(2020)
Article
Engineering, Biomedical
Burcu Karakuzu-Ikizler, Pinar Terzioglu, Yeliz Basaran-Elalmis, Bilge Sema Tekerek, Sevil Yucel
BIOACTIVE MATERIALS
(2020)
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)