Article
Chemistry, Physical
Ti Fang, Chaoqun Li, Ao Liang, Hui Zhang, Fan Zhang, Xian-En Zhang, Yi-Yu Yang, Feng Li
Summary: Here, we report a cell membrane integrity probe based on protein nanocage Dps, which can selectively stain cells with damaged membranes, and demonstrate the potential of Dps as a bioimaging platform.
Article
Engineering, Biomedical
Haotian Shen, Lulu Jin, Qiangqiang Zheng, Ziqiang Ye, Linxiang Cheng, Yuxu Wu, Honghao Wu, Tae Gyong Jon, Wenduo Liu, Zongyou Pan, Zhengwei Mao, Yue Wang
Summary: This study demonstrated that STING activation played a crucial role in the pathogenesis of rheumatoid arthritis (RA). Researchers developed PEI-PDA@C-176 NPs nanoparticles as a treatment for RA, targeting the accumulation of dsDNA in RA. These nanoparticles showed good biocompatibility, could effectively inhibit the STING pathway and inflammation in macrophages. Intra-articular administration of PEI-PDA@C-176 NPs effectively reduced joint damage in mouse models of dsDNA-induced arthritis and collagen-induced arthritis by inhibiting the STING pathway.
BIOACTIVE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Jianhai Chen, Silue Zeng, Qiang Xue, Yuchuan Hong, Liangjian Liu, Liang Song, Chihua Fang, Hai Zhang, Benguo Wang, Adam C. Sedgwick, Peng Zhang, Jonathan L. Sessler, Chengbo Liu, Jingqin Chen
Summary: This study presents a new strategy for the diagnosis, treatment, and monitoring of rheumatoid arthritis (RA) by using macrophage biomimetic nanoparticles and small interfering RNA (siRNA) to regulate the RA microenvironment. The siRNA is able to silence proinflammatory cytokine expression, while the nanoparticles scavenge reactive oxygen species (ROS). Near-infrared photoacoustic (PA) imaging allows real-time monitoring and evaluation of the treatment. Overall, this approach shows potential for improving the management of RA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Iona J. MacDonald, Chien-Chung Huang, Shan-Chi Liu, Yen-You Lin, Chih-Hsin Tang
Summary: The CCN family of matricellular proteins play essential roles in processes like angiogenesis, wound healing, and inflammation, particularly in the inflammatory pathologies of rheumatoid arthritis and osteoarthritis. Several proteins within the CCN family are thought to be potential therapeutic targets for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Pharmacology & Pharmacy
Pei-Rong Gan, Rong-Hui Wang, Ran Deng, Hong Wu, Yan-Hong Bu, Fang-Yuan Chen, Xin-Tong Dong, Jiang-Tao Ke
Summary: This study demonstrated that GE could restore the imbalance of macrophage polarization in CIA mice by inhibiting SphK1 membrane targeting, thereby promoting a balanced polarization of macrophages.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Abhishek Bhattacherjee, Gour C. Daskhan, Arjun Bains, Adrianne E. S. Watson, Ghazaleh Eskandari-Sedighi, Chris D. St Laurent, Anastassia Voronova, Matthew S. Macauley
Summary: The glycan-binding properties of CD33 can be utilized to modulate microglia function by enhancing phagocytosis in a CD33-dependent manner, which involves the loss of CD33 from the cell surface and internalization of liposomes. This multivalent engagement of CD33 with glycan ligands shows promise in the treatment of neurodegenerative diseases by targeting microglia.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Qi Jiang, Xin Wang, Enyu Huang, Qiao Wang, Chengping Wen, Guocan Yang, Liwei Lu, Dawei Cui
Summary: Inflammasome is a cellular complex involved in the innate inflammatory response, and its excessive or abnormal activation has been implicated in various diseases. In rheumatoid arthritis, inflammasome activation plays a key role in immune dysregulation and joint inflammation. This review summarizes recent research on inflammasome activation and its effector mechanisms in the pathogenesis of rheumatoid arthritis, as well as potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Simona Gabriela Bungau, Tapan Behl, Anuja Singh, Aayush Sehgal, Sukhbir Singh, Sridevi Chigurupati, Shantini Vijayabalan, Suprava Das, Vasanth Raj Palanimuthu
Summary: Rheumatoid arthritis (RA) is a progressive inflammatory disorder that can be caused by genetic, environmental, and gut microbiota imbalance factors. Probiotics, such as Lactobacillus, may help alleviate RA symptoms and could be a potential therapeutic option for treatment.
Article
Agriculture, Dairy & Animal Science
Aya M. Al-Rahim, Rawaa AlChalabi, Ali Z. Al-Saffar, Ghassan M. Sulaiman, Salim Albukhaty, Tareg Belali, Elsadig M. Ahmed, Khalil A. A. Khalil
Summary: The study aimed to reduce the expression of inflammatory cytokines by synthesizing FA-MTX-BSA NPs and tested the potential of MTX, MTX-BSA NPs, and FA-MTX-BSA NPs in reducing interleukin and tumor necrosis factor levels.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Xiaoshan Zhao, Yankui Yi, Cuiping Jiang, Xintao Huang, Xiaomin Wen, Huajun Liao, Yongyan Zhu, Yanyan Liu, Nan Li, Dongmei Pan
Summary: This study demonstrates the therapeutic effect of GCFZD on mice with CIA, and the mechanism is related to an improvement in the Th17/Treg cell imbalance by targeting Foxp3 via miR-34a.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yu Han, Xin Pang, Guofu Pi
Summary: Rheumatoid arthritis is a significant healthcare problem with no curative treatment yet developed. Nanomedicines offer potential solutions, but synthetic nanoparticles may be toxic. Biomimetic nanodrug delivery systems have the potential to improve biocompatibility and reduce immunogenicity.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Huanghe Yu, Jialong Fan, Nuzhat Shehla, Yixing Qiu, Ye Lin, Zhou Wang, Liang Cao, Bin Li, Muhammad Daniyal, Yan Qin, Caiyun Peng, Xiong Cai, Bin Liu, Wei Wang
Summary: The development of multifunctional nanoparticles utilizing nanotechnology for targeted treatment of rheumatoid arthritis has shown promising results in vivo, effectively inhibiting the progression of arthritis.
Review
Oncology
Ronnie H. Fang, Weiwei Gao, Liangfang Zhang
Summary: Cell membrane-coated nanoparticles (CNPs) are emerging nanocarriers that have the potential to improve cancer therapy by overcoming limitations of traditional nanoparticles. CNPs, consisting of a synthetic nanoparticulate core surrounded by a layer of naturally derived cell membranes, offer improved biocompatibility, immune evasion, and tumor targeting. They have been used for drug delivery, phototherapy, and immunotherapy.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Nupur Vasdev, Bhakti Pawar, Tanisha Gupta, Mahi Mhatre, Rakesh Kumar Tekade
Summary: Arthritis is characterized by inflammation and tenderness of the joints, which can be caused by metabolic, infectious, or constitutional factors. Current treatments for arthritis focus on controlling symptoms rather than curing the disease completely. Biomimetic nanomedicine offers a promising approach for arthritis treatment by minimizing toxicity and overcoming limitations of current therapies. This review discusses various biomimetic systems, including cell-membrane-coated biomimetic systems, extracellular-vesicle-based systems, and platelets-based systems, as potential therapeutics for arthritis. Biomimetic systems guide nanomedicines to the targeted site and can be functionalized to enhance their efficacy. However, there are challenges that need to be addressed for clinical translation of biomimetic systems.
Article
Chemistry, Multidisciplinary
Huimin Zhu, Jingwen Yu, Jinfa Ye, Yiming Wu, Jintao Pan, Yingying Li, Chuan Chen, Li Zheng, Gang Liu, Chengchao Chu
Summary: Corneal neovascularization (CNV) is a major cause of vision impairment and blindness worldwide. Current treatment options, such as topical eyedrops and coagulation-based procedures, have limitations in terms of efficacy and side effects. Nanoparticle-based drug delivery systems show promise in improving treatment outcomes for CNV.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Environmental
Fenglin Miao, Huirong Lin, Tianhong Yao, Ruyi Zhang, Xinfei Sun, Hongwei Cheng, Lingwei Gu, Xiaogang Xia, Ting Wu, Wengang Li, Gang Liu
Summary: A vesicle derived from gene-engineering cell membrane was developed to control intraoperative hemorrhage in patients with chemotherapy-induced thrombocytopenia. The vesicle exhibited a double clotting-triggering strategy that resulted in quick and stable clot formation, surpassing the effectiveness of commonly used thrombin and gelatin coagulants. This innovative approach has the potential to improve surgical outcomes for patients with myelosuppression.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Chemical
Jiaxuan Xie, Xuan Liu, Gang Liu
Summary: The emergence and re-emergence of antibiotic-resistant bacteria, especially superbugs, are leading to complicated infections that are increasingly difficult to treat. Therefore, novel alternative antimicrobial therapies are urgently needed to reduce the morbidity and mortality caused by antibiotic resistance.
Article
Engineering, Environmental
Dong Li, Jie Pan, Shuyu Xu, Bingwei Cheng, Shuaiying Wu, Qixuan Dai, Mei-Rong Ke, Bi-Yuan Zheng, Chengchao Chu, Chao Liu, Yang Zhang, Xiao Xu, Jian-Dong Huang, Gang Liu
Summary: In this study, a novel nanoreactor FeS2@PcD, programmatically regulated by the bivariate factors of H+ and H2O2 in the tumor microenvironment (TME), was designed for specific fluorescence and MR dual-modality imaging-guided sono/chemodynamic therapies, representing a promising precision medicine approach.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Jianzhong Zhang, Xue Liu, Yutian Xia, Shuyu Xu, Xuan Liu, Haiqing Xiao, Xiaoyong Wang, Chao Liu, Gang Liu
Summary: A novel genetically engineered vesicular antibody-melittin (VAM) drug delivery platform was developed for targeted cancer combination therapy. The VAM could release nanomelittin at tumor sites in a controlled manner, reducing off-target toxicity and allowing co-delivery of small-molecule drugs or nanoparticles. This strategy achieved enhanced therapeutic effects through the synergistic action of nanomelittin and anticancer agents.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Jianzhong Zhang, Yutian Xia, Xuan Liu, Gang Liu
Summary: Vaccination is the most cost-effective means in the fight against infectious diseases. Safe and efficient vaccines are the key elements to stop the pandemic from attacking the world now. This review summarizes state-of-the-art vaccine strategies for controlling the transmission of SARS-CoV-2 and its variants, as well as discusses challenges and future directions for rational vaccine design.
BIOENGINEERING-BASEL
(2023)
Article
Pharmacology & Pharmacy
Peng Lv, Hu Chen, Hongwei Cheng, Xuan Liu, Chao Liu, Yun Zeng, Lai Jiang, Xiaoyong Wang, Jingsong Mao, Gang Liu
Summary: The use of OA@Alg beads in TAVE can enhance and prolong the antitumor efficacy of OA in hepatocellular carcinoma treatment. These beads can sustain the release of OA, prevent shedding from the tumor site, and preserve OA's ability to induce an antitumor immune response, resulting in higher intratumoral infiltration by CD4(+)/CD8(+) T cells.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Dazhuang Xu, Jianlin Ge, Yibo An, Shuang Bai, Ziying Wang, Shuaiying Wu, Qixuan Dai, Zhixiang Lu, Gang Liu
Summary: Given the complexity and heterogeneity of tumors, efficient combination therapy is an ideal strategy for treating primary and distant tumors. A novel phototherapeutic agent called T-TBBTD, with a donor-acceptor-donor (D-A-D) structure and enhanced NIR-II emission, has been developed. Its precise molecular structure and versatility make it promising for anti-tumor molecular therapy. Additionally, the fluorescence imaging in the NIR-II window offers advantages for enhanced imaging resolution and penetration depth. Overall, this method provides a new strategy for tumor therapy.
Review
Chemistry, Multidisciplinary
Gan Lin, Jiajing Zhou, Hongwei Cheng, Gang Liu
Summary: The development of smart nanosystems has attracted significant attention in improving the efficacy of traditional nanomedicines. However, the diversity and scattered knowledge of these nanosystems pose challenges for their rational design. This review provides a summary of biological barriers and the strategies employed by smart nanosystems to overcome them, offering guidelines for the development of new-generation nanomedicines.
Review
Virology
Shuo Li, Xue Liu, Gang Liu, Chao Liu
Summary: Over 600 million people worldwide have been infected with SARS-CoV-2, resulting in the COVID-19 pandemic. New waves of COVID-19 caused by emerging SARS-CoV-2 variants pose new health risks. Nanotechnology offers effective solutions, such as ACE2-based nanodecoys, nanobodies, nanovaccines, and drug nanocarriers. Lessons and strategies from battling SARS-CoV-2 variants may inspire nanotechnology-based strategies for future global infectious diseases and their variants.
Review
Engineering, Biomedical
Dong Li, Shundong Cai, Peiyu Wang, Hongwei Cheng, Bingwei Cheng, Yang Zhang, Gang Liu
Summary: Due to their long absorption wavelengths, high molar absorptivity, and tunable photosensitivity, phthalocyanines have been widely used in photodynamic therapy. However, they still suffer from poor targeting, always-on photosensitizing properties, and unsatisfactory therapeutic efficiency, hindering their broad applications in biomedicine. Therefore, new design strategies such as modification of targeting molecules, formation of nanoparticles, and activation of photosensitizers have been developed to overcome these limitations. Recent studies have also demonstrated the diverse applications of novel phthalocyanines in fluorescence imaging, photoacoustic imaging, photothermal imaging, sonodynamic therapy, and photothermal therapy. This review focuses on the design strategies, biomedical applications, and clinical development of phthalocyanines, offering insights and references for their future translation into clinical practice.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Biao-Qi Chen, Yi Zhao, Yang Zhang, Yu-Jing Pan, Hong-Ying Xia, Ranjith Kumar Kankala, Shi-Bin Wang, Gang Liu, Ai-Zheng Chen
Summary: This article reviews the challenges in nano-immunotherapy related to immune elimination and immunosuppressive microenvironment in cancer treatment. To address these issues, immune-regulating camouflaged nanocomposites have emerged as prevailing strategies. The article discusses the composition, performances, and mechanisms of various immune-regulating nanoplatforms and their applications in cancer immunotherapy and other immunotherapeutic modalities.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoxiao Shi, Dazhuang Xu, Hongwei Cheng, Chengchao Chu, Gang Liu
Summary: Interventional fluorescence imaging is a promising strategy for disease diagnosis in clinic, facilitating targeted treatment. However, there are crucial issues such as fast probe clearance, light instability, and residual lesions. The development of SHIFT technology addresses these clinical problems and enables stable and long-lasting imaging, as well as precise visualization of microsatellite lesions.
ACCOUNTS OF MATERIALS RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Bingwei Cheng, Dong Li, Changhong Li, Ziqi Zhuang, Peiyu Wang, Gang Liu
Summary: Chemodynamic therapy (CDT) is an innovative cancer treatment approach that utilizes nanocatalytic medicines to release metal ions within tumor cells, inducing apoptosis specifically within the tumor microenvironment. However, the limited endogenous hydrogen peroxide (H2O2), overexpressed reducing substances, and weak acidity of solid tumors hinder the effectiveness of CDT in vivo. Various nanozymes and remodeling strategies have been developed to enhance CDT, such as increasing H2O2 levels, depleting reductive substances, and lowering the pH value of the tumor microenvironment. This review provides an overview of the design and development of nanocatalysts and strategies for enhancing catalytic drug targeting, as well as discusses the future prospects and challenges of CDT.
BIOENGINEERING-BASEL
(2023)
Article
Pharmacology & Pharmacy
Pengfei Zhang, Lei Zhao, Heng Liu, Hu Chen, Yaming Wu, Xiaoyong Wang, Gang Liu, Yun Zeng
Summary: A new class of targeted membrane-camouflaged nanosystem has been successfully constructed, which achieves targeted gene delivery to specific cell populations and shows remarkable therapeutic efficacy in inflammatory models.
ADVANCED THERAPEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)