期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 91, 页码 13353-13356出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc07855a
关键词
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资金
- National Institutes of Health [R15 GM101604-01]
- National Science Foundation [CHE-1401700]
- National Science Foundation of China [NSFC-21472018]
- Sao Paulo Research Foundation (FAPESP) [2015/08541-6]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1401700] Funding Source: National Science Foundation
We developed an efficient fluorination protocol that converts easily accessible aziridines into beta-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU-HF has shown both higher reactivity and regioselectivity and good functional group tolerance; thus, a wide scope of beta-fluoroamines can now be accessed conveniently. The stereochemical behavior of the ring opening depends on the substitution pattern of the aziridine substrate.
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