Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Agnieszka Skorska-Stania, Agnieszka Kyziol, Francesco Tisato
Summary: In this study, new complexes based on ruthenium(II) and iridium(III) with phosphine ligands and phenyl rings with/without methoxy motifs were synthesized and characterized. The complexes showed high catalytic efficiency in the oxidation of NADH to NAD(+) and exhibited potential applications in biological and medical fields. Furthermore, they demonstrated redox activity and significant cytotoxicity against various cancer cell lines.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Peiling Dai, Jiangshan Li, Man Tang, Dong Yan, Zihan Xu, Yonghua Li, Zejing Chen, Shujuan Liu, Qiang Zhao, Kenneth Yin Zhang
Summary: Phosphorescent iridium(III) complexes modified with different groups were used as imaging reagents for living cells. One complex stained the entire cell, while others localized in the cytoplasm. The nuclear uptake of the complex was mediated by clathrin and microtubules and was related to the cell division cycle.
DALTON TRANSACTIONS
(2022)
Article
Nutrition & Dietetics
Wang Yuan, Bisheng Zheng, Tong Li, Rui Hai Liu
Summary: Pistachios contain phytochemicals that are beneficial to health, including phenolics, vitamin E, and carotenoids. Both raw and roasted pistachios have high levels of phenolics and flavonoids, and exhibit strong total antioxidant and cellular antioxidant activity. Roasted pistachios have higher levels of vitamin E, while raw pistachios have more carotenoids. Roasted pistachio extracts show superior antiproliferative activity against certain cancer cells.
Article
Chemistry, Multidisciplinary
Enrique Ortega-Forte, Anna Rovira, Marta Lopez-Corrales, Alba Hernandez-Garcia, Francisco Jose Ballester, Eduardo Izquierdo-Garcia, Mireia Jorda-Redondo, Manel Bosch, Santi Nonell, Maria Dolores Santana, Jose Ruiz, Vicente Marchan, Gilles Gasser
Summary: Photodynamic therapy (PDT) is a promising cancer treatment method, but it is limited by its oxygen dependency and poor tissue penetration of some photosensitizers (PSs) activatable with short wavelengths. In this study, a novel hypoxia-active PS with operability in the near-infrared (NIR) region was developed, which showed high photoactivity toward cancer cells even under hypoxic environments. This strategy could potentially pave the way for the development of novel NIR- and hypoxia-active Ru(ii)-based theragnostic PSs.
Review
Chemistry, Inorganic & Nuclear
Binoy Kar, Utpal Das, Nilmadhab Roy, Priyankar Paira
Summary: Organelle specificity is crucial for the development of efficient and selective drugs with reduced side effects. Photodynamic therapy (PDT) has emerged as a selective treatment for cancer that minimizes damage to normal cells. This article showcases the potential of metal complexes, particularly ruthenium (II), iridium (III), and rhenium (I) complexes, in targeting specific organelles for PDT.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Andrea E. Gallio, Leonardo Brustolin, Nicolo Pettenuzzo, Dolores Fregona
Summary: Binuclear dithiocarbamate complexes of Ru(III) have shown promise as potential metal-based anticancer agents. This study proposes the use of heteroleptic ligands as tunable features to develop improved ruthenium-based antiproliferative agents. The cytotoxic activity of a selection of binuclear heteroleptic Ru(III) compounds towards MDA-MB-231 and PC3 cells was evaluated.
Review
Chemistry, Inorganic & Nuclear
Sudhindra Pete, Nilmadhab Roy, Binoy Kar, Priyankar Paira
Summary: This review article discusses the research on the cellular uptake, localization, mechanism of action, and cytotoxicity profiles of ruthenium, iridium, and rhenium-based complexes as potential target-specific chemotherapeutic agents.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Food Science & Technology
Ningxuan Gao, Xu Si, Wenzhong Han, Ersheng Gong, Chi Shu, Jinlong Tian, Yuehua Wang, Jiyue Zhang, Binxu Li, Bin Li
Summary: This study analyzed the polyphenol composition of 7 chokeberry varieties produced in China and evaluated their antioxidant and antiproliferative activities. The results showed that proanthocyanidins were the main polyphenols in chokeberry. 'Viking' and purple chokeberry had the strongest antioxidant activity, while 'Fukangyuan 1#' had the strongest antiproliferative activity. The contribution of free polyphenols and proanthocyanidins in total polyphenols played a key role in the antiproliferative activity.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Materials Science, Multidisciplinary
Moorthy Muruganandham, Fatimah Oleyan Al-Otibi, Raedah Ibrahim Alharbi, Kanagasabapathy Sivasubramanian, Anon Chaulagain, Palanivel Velmurugan, Nagaraj Basavegowda
Summary: The present study involved the green synthesis of silver nanoparticles (AgNPs) using Tabebuia rosea seeds as a reducing agent. The synthesized AgNPs exhibited potential antibacterial, antioxidant, and cytotoxicity effects. The findings suggest that utilizing T. rosea seeds to produce AgNPs holds promise for their potential application as nano drugs.
MATERIALS RESEARCH EXPRESS
(2023)
Article
Chemistry, Inorganic & Nuclear
Maryam Taghizadeh Shool, Hadi Amiri Rudbari, Tania Gil-Anton, Jose V. Cuevas-Vicario, Begona Garcia, Natalia Busto, Nakisa Moini, Olivier Blacque
Summary: Ru(II) polypyridyl complexes are widely used in biological fields due to their physico-chemical and photophysical properties. The authors synthesized and characterized a series of new chiral Ru(II) polypyridyl complexes and analyzed their structures. The study revealed that dihalogenated ligands enhance the cytotoxicity of Ru(II) complexes and bromine provides the highest cytotoxicity. All complexes induced cell cycle arrest and apoptosis, while only the complexes with bromine increased intracellular ROS levels and mitochondrial dysfunction.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Applied
Reem G. Deghadi, Gehad G. Mohamed, Nessma F. Mahmoud
Summary: In this study, bioactive complexes were synthesized and characterized. The complexes showed good anticancer and antibacterial activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Catuzo Canonico Silva, Mariane de Almeida Machado, Karina Sakumoto, Rodrigo Sadao Inumaro, Jose Eduardo Goncalves, Filipa Mandim, Josiana Vaz, Juliana Silveira do Valle, Maria Graciela Iecher Faria, Suelen Pereira Ruiz, Ranulfo Piau Junior, Daniela Dib Goncalves, Zilda Cristiani Gazim
Summary: This study investigated the antioxidant, antiproliferative, and anti-inflammatory activities of the essential oils and crude extracts from Gallesia integrifolia. The results showed that these extracts have potential against tumor cells and a relative safety profile. Therefore, oils and extracts derived from G. integrifolia have potential for use in various industrial sectors.
Article
Chemistry, Inorganic & Nuclear
Daria Wojtala, Urszula K. Komarnicka, Agnieszka Kyziol, Sandra Koziel, Magdalena Szmitka, Mateusz Slowikowski, Julia Kulczynska, Grazyna Stochell
Summary: This study investigated the potential anticancer activity of two ruthenium complexes and two iridium complexes on a selected cell line. The results showed that iridium complexes had higher cellular uptake and cytotoxicity compared to the ruthenium complexes. Mechanistic considerations revealed that the iridium complexes triggered multiple cytotoxic pathways, while the ruthenium complexes mainly relied on the generation of reactive oxygen species (ROS) for cytotoxicity.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Malik, Dariusz C. Bienko, Urszula K. Komarnicka, Agnieszka Kyziol, Magdalena Drys, Anna Switlicka, Edyta Dyguda-Kazimierowicz, Wiktoria Jedwabny
Summary: The synthesis and characterization of a gold(III) complex containing 2-pyridineethanol, as well as its anti-cancer properties in various cell lines, have been investigated in this study. The complex showed significant cytotoxicity against A549 and MCF-7 cells, comparable to the reference drug cisplatin. Docking simulations suggested that the complex exerts anticancer effects through different mechanisms of action compared to cisplatin.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Jie Gao, Lihua Guo, Yuting Wu, Yihan Cheng, Xueyan Hu, Jinfeng Liu, Zhe Liu
Summary: The 16-electron piano-stool rhodium, iridium, and ruthenium complexes were successfully synthesized and characterized through rearranged coordination reactions, demonstrating stability and fluorescence in solution. These complexes showed promising activity against cancer cells, with cytotoxicity comparable to or even better than cisplatin, and exhibited structure-activity relationships that influenced their potency. Furthermore, the mechanism of action studies revealed that the cytotoxicity of the complex Rh5 was associated with perturbations in the cell cycle and induction of apoptosis, as well as disruption of lysosomal integrity.
Article
Chemistry, Inorganic & Nuclear
Junhyeok Seo, Seungjin Song, Wonjung Lee, Youngseob Lee, Kyung-Bin Cho, Junseong Lee
Summary: The reorganization of catalysts induced by electron transfer plays a crucial role in catalytic reactivity. In this study, the electron-induced reorganization patterns of Co complexes with neutral N-donor ligands were investigated. The different ligand characteristics led to different reorganization patterns, such as the release of solvent or bond dissociation. Furthermore, the metal-ligand cooperative redox steps shifted the reactivity of Co(I) towards CO2 reduction, and the amine pendant stabilized the CO2 reduction intermediate through hydrogen bonding.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Gajendra Gupta, Junseong Lee, Chang Yeon Lee
Summary: Mononuclear and dinuclear palladium-centered boron dipyrromethene (BODIPY) complexes, HBDPPdI and BDPPd2I2, were synthesized by inserting a palladium source directly into iodine-substituted BODIPY chromophores. The molecular structures of both complexes were characterized using various analytical techniques, revealing direct coordination of Pd(0) to the ligand through a Pd-C bond facilitated by the insertion reaction. The photophysical properties of these complexes were also described in detail.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Mansu Kim, Seung-hoon Kim, Jonghwan Park, Seongsoo Lee, Injoon Jang, Sohui Kim, Chang Yeon Lee, Oh Joong Kwon, Hyung Chul Ham, Joseph T. T. Hupp, Namgee Jung, Sung Jong Yoo, Dongmok Whang
Summary: Downsizing a catalyst nanoparticle to a single atom has been successful in increasing its catalytic activity and reducing the amount of catalyst needed for electrochemical reactions. However, the stability of single-atom site catalysts remains a challenge. This study proposes using stable metal oxide nanoparticles as supports to enhance the electrochemical activity and stability of single-atom catalysts for the hydrogen evolution reaction.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Crystallography
Gajendra Gupta, Chang Yeon Lee
Summary: Metal macrocyclic complexes formed through self-assembly show interesting structures and functionalities, but their exact molecular structures remain challenging to determine. Single-crystal X-ray diffraction provides detailed information about crystalline structures, but requires suitable single crystals. This study provides an overview of methods for developing single crystals of metal macrocyclic complexes, especially in low quantities, and investigates the reproducibility of previous methods.
CRYSTAL RESEARCH AND TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yen Jea Lee, Yujeong Kim, Haesol Kim, Jieun Choi, Ga Hee Noh, Kug-Seung Lee, Junseong Lee, Chang Hyuck Choi, Sun Hee Kim, Jiwon Seo
Summary: Replacing the imidazole moiety in the ATCUN structure with thiazole and oxazole enhances the activity of Cu(II)-ATCUN complexes and promotes the rate of ROS-mediated DNA cleavage. This study presents a new strategy for the design of peptide ligands with potential applications in the development of ROS-mediated metallodrugs.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Nikhil Baban Ghate, Sungmin Kim, Roasa Mehmood, Yonghwan Shin, Kyunghwan Kim, Woojin An
Summary: VprBP is an overexpressed kinase in cancer cells that plays a major role in epigenetic gene silencing and tumorigenesis. It has been found to phosphorylate p53 at serine 367 (S367p), leading to attenuation of p53's transcriptional and growth suppressive activities.
Article
Multidisciplinary Sciences
Nikhil B. Ghate, Sungmin Kim, Yonghwan Shin, Jinman Kim, Michael Doche, Scott Valena, Alan Situ, Sangnam Kim, Suhn K. Rhie, Heinz-Josef Lenz, Tobias S. Ulmer, Shannon M. Mumenthaler, Woojin An
Summary: DCAF1/VprBP phosphorylates and stabilizes EZH2 to induce oncogenic gene silencing and colon cancer growth. They have shown that DCAF1 is overexpressed in colon cancer and phosphorylates histone H2AT120 to drive epigenetic gene inactivation and oncogenic transformation. They further demonstrate that DCAF1 phosphorylates EZH2 at T367 to augment its nuclear stabilization and enzymatic activity in colon cancer cells.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
John G. Fisher, Su-Hyeon Sim, Trung Thanh Doan, Eugenie Uwiragiye, Jungwi Mok, Junseong Lee
Summary: In this study, (K0.5Na0.5)NbO3-based single crystals were successfully grown using both seed-free solid-state crystal growth and seeded solid-state crystal growth methods. It was found that using Ba(Cu0.13Nb0.66)O-3 could significantly reduce the porosity in the single crystals. However, the problem of repeatable single crystal growth remains.
Article
Chemistry, Inorganic & Nuclear
Gajendra Gupta, Filipe Gusmao, Anup Paul, Biljana Sljukic, Diogo M. F. Santos, Junseong Lee, M. Fatima C. Guedes da Silva, Armando J. L. Pombeiro, Chang Yeon Lee
Summary: This study describes the excellent electrocatalytic activity towards the oxygen evolution reaction (OER) in alkaline media using a new cobalt-based mixed-ligand metal-organic framework. The composites of the framework with different carbon materials showed enhanced OER performance, surpassing the benchmark electrocatalyst IrO2.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Hyeonbin Park, Heenang Choi, Sunyoung Shin, Bo Keun Park, Kibum Kang, Ji Yeon Ryu, Taeyong Eom, Taek-Mo Chung
Summary: Novel Sn precursors Sn(tbip)(2), Sn(tbtp)(2), and Sn(tbta)(2) were synthesized and used to successfully prepare Sn3N4 thin films. The precursors exhibited exceptional volatility and unique molecular structures as observed through thermogravimetric analysis and X-ray crystallography. Sn(tbtp)(2) showed the lowest residual weight and demonstrated ideal characteristics for atomic layer deposition.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yoseph Kim, Jaehoon Kim, Ji Hye Lee, Hyeongkwon Moon, Ga Hee Noh, Hyonseok Hwang, Junseong Lee, Jun Hui Park, Youngjo Kim, Myung Hwan Park
Summary: In this study, we investigated 4-carbazole (CBZ)-appended salen-based indium complexes, CBZIn1 and CBZIn2. Our findings revealed that CBZIn2 exhibited significantly higher photoluminescence quantum efficiency in toluene compared to CBZIn1. The high efficiency of CBZIn2 can be attributed to the intramolecular charge-transfer transition between the moderately twisted CBZ and the 1,2-dicyanoethylene-bridged salen, which exhibits a strong electron-accepting ability. These results were supported by theoretical calculations.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
