Review
Oncology
Aomei Shen, Wanmin Qiang, Liyuan Zhang, Jingru Bian, Fei Zhu, Zijuan Zhang, Qian Lu
Summary: The study identified innate personal trait-related risk factors for breast cancer-related lymphedema (BCRL), with some factors showing significant associations with BCRL incidence. The methodological quality and evidence quality of the study were generally low. Further well-designed studies and robust meta-analyses are needed to explore potential associations between behavioral, interpersonal, and environmental factors with BCRL.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sacha A. Roberts, Tessa C. Gillespie, Amy M. Shui, Cheryl L. Brunelle, Kayla M. Daniell, Joseph J. Locascio, George E. Naoum, Alphonse G. Taghian
Summary: This study aimed to determine the relationship between postoperative weight change and breast cancer-related lymphedema. The findings suggest that weight loss alone may not decrease the risk of developing BCRL.
Article
Oncology
Shkala Karzai, Elisa Port, Cleo Siderides, Christopher Valente, Soojin Ahn, Erin Moshier, Meng Ru, Kereeti Pisapati, Ronald Couri, Laurie Margolies, Hank Schmidt, Sarah Cate
Summary: This study aimed to assess the association between the frequency of mammography in young women and the extent of surgery and chemotherapy required for breast cancer treatment. The results showed that compared to those screened within 1-24 months, the group who were never screened and the group screened over 25 months prior to diagnosis were more likely to receive chemotherapy and undergo surgery. This suggests that initiating screening mammography at age 40 can help reduce the risk of aggressive treatments for newly diagnosed breast cancers in this age group.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Xiaozhen Liu, Kewang Sun, Hongjian Yang, Lingli Xia, Kefeng Lu, Xuli Meng, Yongfeng Li
Summary: This study aimed to identify intraoperative and preoperative risk factors of severe lymphedema and develop a nomogram for estimating the risk of severe lymphedema within 3 years of surgery. It was found that age, positive lymph nodes, interpectoral (Rotter's) lymph nodes (IPNs) dissection, and educational level were independent risk factors for severe lymphedema. A nomogram was developed by integrating these factors and showed moderate performance in predicting the risk of severe lymphedema within 3 years of surgery.
Article
Pharmacology & Pharmacy
Stav Brown, Joseph H. Dayan, Michelle Coriddi, Leslie McGrath, Raghu P. Kataru, Babak J. Mehrara
Summary: This retrospective study analyzed the efficacy of using doxycycline to treat breast cancer-related lymphedema. The results showed no significant improvements in limb volume or L-Dex scores, but patients reported significant improvements in quality of life measures. This suggests that doxycycline may have a role in improving quality of life for patients with breast cancer-related lymphedema, although further larger studies are needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Louise A. Koelmeyer, Katrina Gaitatzis, Mary S. Dietrich, Chirag S. Shah, John Boyages, Sarah A. McLaughlin, Bret Taback, Deonni P. Stolldorf, Elisabeth Elder, T. Michael Hughes, James R. French, Nicholas Ngui, Jeremy M. Hsu, Andrew Moore, Sheila H. Ridner
Summary: The study aimed to evaluate risk factors for breast cancer-related lymphedema (BCRL) and found that factors associated with this condition included axillary lymph node dissection, taxane-based chemotherapy, regional nodal irradiation, body mass index >30, and rurality. The findings of this study are important for the treatment and intervention of breast cancer patients.
Article
Oncology
Tessa De Vrieze, Nick Gebruers, Ines Nevelsteen, Wiebren A. A. Tjalma, Sarah Thomis, An De Groef, Lore Dams, Vincent Haenen, Nele Devoogdt
Summary: This study aimed to estimate the direct healthcare costs related to BCRL and its treatment in a European setting. The results showed that the total direct healthcare costs per patient were 2248.93 euros on average during the entire period of 3 weeks of intensive treatments and 12 months of maintenance decongestive therapy.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Giacomo Montagna, Jennifer Zhang, Varadan Sevilimedu, Jillian Charyn, Kelly Abbate, Ethan A. Gomez, Babak Mehrara, Monica Morrow, Andrea Barrio
Summary: The study evaluated the rates of BCRL and associated risk factors in women treated with ALND, highlighting that Black race, Hispanic ethnicity, older age, NAC receipt, and longer follow-up were independently associated with an increased risk of BCRL. Further research is needed to explore the biological mechanisms behind racial and ethnic disparities in BCRL development.
Article
Oncology
Kazumi Jinbo, Takaaki Fujita, Ryuichi Kasahara, Ryohei Jinbo, Sayaka Kisara, Jun Onobe, Izo Kimijima, Mitsuhiko Yasuda, Yuichi Yamamoto
Summary: This study aimed to investigate the combined risk factors for the development of breast cancer-related lymphedema (BCRL) in patients who underwent breast cancer resection. A decision tree analysis was performed to determine the combination of risk factors, including age, body mass index (BMI), surgical side, mastectomy, extent of axillary lymph node dissection (ALND), and adjuvant therapy (chemotherapy, hormone therapy, and radiation therapy). Postoperative chemotherapy was found to be the optimal variable for classifying patients with BCRL.
Review
Oncology
Maureen P. McEvoy, Ameer Gomberawalla, Mark Smith, Francesco M. Boccardo, Dennis Holmes, Risal Djohan, Paul Thiruchelvam, Suzanne Klimberg, Jill Dietz, Sheldon Feldman
Summary: Breast cancer-related lymphedema affects millions of patients worldwide. Prevention and treatment require a multidisciplinary team, emphasizing early detection and awareness of risk factors to reduce the progression of lymphedema. Treatment can be costly, time-consuming, and not always effective, therefore prevention is the ultimate goal.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Mingfang Li, Wanbing Huang, Xiaomin Zhang, Jing Chen, Xia Luo, Yue Zhang, Chenxia Xiong, Jun Yan
Summary: This study aimed to investigate illness perceptions of breast cancer-related lymphedema and adherence to risk management behaviours in postoperative breast cancer survivors in China. The results indicated the importance of illness perceptions for adherence to risk management behaviours.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Editorial Material
Oncology
Cheryl L. Brunelle, Alphonse G. Ag
Summary: Nighttime compression is effective for patients with breast cancer-related lymphedema, improving arm volume and lymphedema-specific quality of life. It is recommended to be included in the self-maintenance program for these patients.
Review
Oncology
Aomei Shen, Qian Lu, Xin Fu, Xiaoxia Wei, Liyuan Zhang, Jingru Bian, Wanmin Qiang, Dong Pang
Summary: This study reviewed and updated the incidence and risk factors for breast cancer-related lymphedema based on cohort studies. The study found that factors such as ethnicity, body mass index, weight increase, hypertension, cancer stage, tumor size, and surgery mode were associated with lymphedema, while age, number of positive lymph nodes, and exercise were not correlated with lymphedema.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Oncology
Gunel Guliyeva, Maria T. Huayllani, Daniel Boczar, Francisco R. Avila, Xiaona Lu, Antonio Jorge Forte
Summary: This review evaluated the impact of age on the development of BCRL. The majority of studies did not identify age as a risk factor for lymphedema development, although the level of evidence was low.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Gizem Cansiz, Ayse Arikan Donmez, Sevgisun Kapucu, Pinar Borman
Summary: This study found that the self-management lymphedema education program had significant effects on lymphedema, lymphedema-related symptoms, patient compliance, activities of daily living, and patient activation in patients with breast cancer-related lymphedema.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
