Article
Clinical Neurology
Piotr Alster, Anna Dunalska, Bartosz Migda, Natalia Madetko, Leszek Krolicki
Summary: In this study, higher glycemic variability in PSP and CBS patients was associated with more severe hypoperfusion in certain brain regions, potentially impacting the rate of cognitive deterioration.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Ryota Satoh, Stephen D. Weigand, Nha Trang Thu Pham, Farwa Ali, Arvin Arani, Matthew L. Senjem, Clifford R. Jack Jr, Jennifer L. Whitwell, Keith A. Josephs
Summary: This study identified different patterns of magnetic susceptibility in the subcortical regions among different PSP variants and CBS, contributing to our understanding of iron profiles and pathophysiology of PSP. These findings may also serve as a potential biomarker in differentiating PSP variants, PD, and CBS.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Negin Holland, Maura Malpetti, Timothy Rittman, Elijah E. Mak, Luca Passamonti, Sanne S. Kaalund, Frank H. Hezemans, P. Simon Jones, George Savulich, Young T. Hong, Tim D. Fryer, Franklin Aigbirhio, John T. O'Brien, James B. Rowe
Summary: The relationship between in vivo synaptic density and molecular pathology in primary tauopathies, especially in progressive supranuclear palsy and corticobasal degeneration, is investigated in this study. It is found that there is a biphasic correlation between synaptic density and molecular pathology, with regions rich in synapses more vulnerable to pathological aggregates accumulation, followed by synaptic loss as a response to the molecular pathology. These findings contribute to a better understanding of the pathophysiology of primary tauopathies and may inform the design of future clinical trials.
Article
Medicine, General & Internal
Natalia Madetko-Alster, Piotr Alster, Bartosz Migda, Michal Nieciecki, Dariusz Koziorowski, Leszek Krolicki
Summary: The differential diagnosis of MSA-P and PSP-P is challenging in clinical practice. This study investigated the usefulness of SPECT HMPAO in differentiating between these two diseases. The results indicated that the most significant difference in perfusion was observed in the anterior quadrangular lobule of the cerebellum, which could potentially aid in the diagnosis.
Article
Medicine, General & Internal
Piotr Alster, Natalia Madetko-Alster, Bartosz Migda, Michal Nieciecki, Dariusz Koziorowski, Leszek Krolicki
Summary: Progressive Supranuclear Palsy-Parkinsonism Predominant (PSP-P) is clinically difficult to diagnose and often misdiagnosed as Parkinson's Disease or Multiple System Atrophy-Parkinsonian type (MSA-P). This study used Single Photon Emission Computed Tomography to evaluate the differences between PSP-P and MSA-P patients and found that the right middle frontal gyrus was the most affected region in PSP-P.
Article
Clinical Neurology
Nils Schroeter, Thilo van Eimeren, Joseph Classen, Johannes Levin, Christoph Redecker, Martin Wolz, Lars Toenges
Summary: The clinical presentation of Parkinson's disease and atypical Parkinsonian syndromes is heterogeneous. Additional diagnostic procedures and clinical evaluation are necessary to achieve a high diagnostic standard.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Geriatrics & Gerontology
Ming-Liang Wang, Zheng Sun, Wen-Bin Li, Qiao-Qiao Zou, Peng-Yang Li, Xue Wu, Yue-Hua Li
Summary: This study found that BS-EPVS could be a potential indicator of disease severity in PSP-RS and CBS, while PWMH could reflect the severity of bvFTD, nfvPPA, and svPPA.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Piotr Alster, Natalia Madetko, Bartosz Migda, Michal Nieciecki, Michal Kutylowski, Leszek Krolicki, Andrzej Friedman
Summary: Progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS) are clinical manifestations of tauopathic Parkinsonian syndromes. This study found significant asymmetry of perfusion of the amygdala in corticobasal syndrome, with more pronounced abnormalities observed in the left amygdala among patients with more severe Parkinsonian syndromes in CBS on the right. The comparison of the perfusion of tauopathic Parkinsonian syndromes should be extended by asymmetry analysis.
Article
Clinical Neurology
Mario Torso, Gerard R. Ridgway, Mark Jenkinson, Steven Chance
Summary: The study investigated the cortical architecture of FTLD syndromes using cortical diffusion tensor imaging (DTI) analysis, finding that PerpPD was the best feature for distinguishing between healthy controls and FTLD syndromes as well as among different FTLD syndromes.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Geriatrics & Gerontology
Cheng-Hsuan Li, Ta-Fu Chen, Ming-Jang Chiu, Ruoh-Fang Yen, Ming-Chieh Shih, Chin-Hsien Lin
Summary: Tau-specific PET imaging with F-18-T807 tracer showed only modest changes in patients with non-AD tauopathies, with significant increases in cortical uptake observed in AD. Cortical tau tracer uptake correlated with plasma tau levels and regional cortical thinning, suggesting the need for further research using a more specific tracer for classifying tauopathy parkinsonism syndromes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Editorial Material
Medicine, General & Internal
Shun-Chieh Chen, Daniel Hueng-Yuan Shen, Hung-Yen Chan, Ming-Hui Yang, Hung-Pin Chan
Summary: This article reports the symptoms of a 78-year-old female patient with rapidly progressive cognitive impairment, and reveals decreased cerebral blood flow and signal enhancement in the brain through SPECT/CT and MRI examinations, which are associated with sCJD.
Article
Clinical Neurology
Piotr Alster, Natalia Madetko, Andrzej Friedman
Summary: This study aimed to examine the features of neuroinflammation in progressive supranuclear palsy - Richardson syndrome and corticobasal syndrome, and found that the neutrophil-to-lymphocyte ratio (NLR) could be a promising non-specific parameter in evaluating neurodegenerative diseases. The study compared NLR in these conditions for the first time, confirming significant differences between PSP-RS and control groups.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2021)
Article
Clinical Neurology
Ulufer Celebi, Mehmet Fevzi Oztekin, Nuriye Ozlem Kucuk
Summary: This study aimed to explain the connection between aphasia and subcortical lesions using SPECT. The results showed that aphasia is more common in cases with cortical hypoperfusion in the dominant hemisphere.
NEUROLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Rosalie M. Grijalva, Nha Trang Thu Pham, Qiao Huang, Peter R. Martin, Farwa Ali, Heather M. Clark, Joseph R. Duffy, Rene L. Utianski, Hugo Botha, Mary M. Machulda, Stephen D. Weigand, J. Eric Ahlskog, Dennis W. Dickson, Keith A. Josephs, Jennifer L. Whitwell
Summary: Background magnetic resonance brainstem measurements are useful as structural biomarkers in the Richardson's syndrome variant of progressive supranuclear palsy (PSP), with potential for predicting underlying pathology. Different PSP clinical variants show varying brainstem measurements, with the most abnormal results seen in the PSP-Richardson's syndrome and frontal variants. Magnetic resonance brainstem measures have utility as diagnostic biomarkers across PSP clinical variants.
MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Piotr Alster, Natalia Madetko-Alster, Anna Migda, Bartosz Migda, Michal Kutylowski, Leszek Krolicki, Andrzej Friedman
Summary: The review discusses the significance of sleep abnormalities in PSP and CBS patients, as well as their potential application in the differential diagnosis of synucleinopathic parkinsonian syndromes.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2023)
Review
Neurosciences
Maria Ejma, Natalia Madetko, Anna Brzecka, Piotr Alster, Slawomir Budrewicz, Magdalena Koszewicz, Marta Misiuk-Hojlo, Irina K. Tomilova, Siva G. Somasundaram, Cecil E. Kirkland
Summary: This article reviews the current literature on stem-cell-based therapy after stroke and the possibilities of inducing neuroregeneration. The attempts to stimulate neuroregeneration after stroke include supporting endogenous neurogenesis, providing exogenous stem cells through different routes, and using extracellular vesicles as a method of particle transport. Although further research is needed, post-stroke brain recovery supported by exogenous stem cells appears to be a promising therapy that could revolutionize modern neurology.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Clinical Neurology
Natalia Madetko, Bartosz Migda, Piotr Alster, Pawel Turski, Dariusz Koziorowski, Andrzej Friedman
Summary: This study assessed the usefulness of NLR and PLR in evaluating the inflammatory process in alpha-synucleinopathies. The results showed that patients with PD and MSA-P had higher NLR and PLR values, suggesting the presence of different neuroinflammatory patterns in these diseases.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2022)
Review
Geriatrics & Gerontology
Patrycja Krzosek, Natalia Madetko, Anna Migda, Bartosz Migda, Dominika Jagus, Piotr Alster
Summary: Currently, there is growing interest in rare PSP variants and PSP-like syndromes. Diagnosing these subtypes is a major challenge for clinicians as it is primarily based on clinical symptoms. The individual phenotypes often resemble other diseases, making it difficult to make a definitive diagnosis prior to death.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Piotr Alster, Michal Nieciecki, Bartosz Migda, Michal Kutylowski, Natalia Madetko, Karolina Duszynska-Was, Ingeborga Charzynska, Dariusz Koziorowski, Leszek Krolicki, Andrzej Friedman
Summary: This study examined patients with MSA-P and PSP-P, two types of atypical parkinsonism that are difficult to differentiate in the early years of development. The researchers found that extended examination using MRI and perfusion SPECT, focusing on the evaluation of the mesencephalon/pons ratio, mesencephalic volume decrease, MRPI, and frontal perfusion, may be more feasible than cognitive evaluation in the 3-6-year duration of symptoms.
Review
Immunology
Natalia Madetko, Weronika Marzec, Agata Kowalska, Dominika Przewodowska, Piotr Alster, Dariusz Koziorowski
Summary: This article summarizes the current knowledge on anti-IgLON5 disease, including its etiology, symptomatology, clinical progression, differential diagnosis, and treatment. The disease presents a challenge due to its nonspecific symptoms, diverse clinical course, and complex nature.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Natalia Madetko, Piotr Alster, Michal Kutylowski, Bartosz Migda, Michal Nieciecki, Dariusz Koziorowski, Leszek Krolicki
Summary: Differential diagnosis of progressive supranuclear palsy, especially the parkinsonism-predominant type (PSP-P), remains challenging. MRI focused on the evaluation of the mesencephalon is crucial, with parameters such as mesencephalon/pons ratio and MRPI showing significant differences between PSP-P and MSA-P.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Piotr Alster, Natalia Madetko, Bartosz Migda, Michal Nieciecki, Michal Kutylowski, Leszek Krolicki, Andrzej Friedman
Summary: Progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS) are clinical manifestations of tauopathic Parkinsonian syndromes. This study found significant asymmetry of perfusion of the amygdala in corticobasal syndrome, with more pronounced abnormalities observed in the left amygdala among patients with more severe Parkinsonian syndromes in CBS on the right. The comparison of the perfusion of tauopathic Parkinsonian syndromes should be extended by asymmetry analysis.
Article
Medicine, General & Internal
Piotr Alster, Natalia Madetko-Alster, Bartosz Migda, Michal Nieciecki, Dariusz Koziorowski, Leszek Krolicki
Summary: Progressive Supranuclear Palsy-Parkinsonism Predominant (PSP-P) is clinically difficult to diagnose and often misdiagnosed as Parkinson's Disease or Multiple System Atrophy-Parkinsonian type (MSA-P). This study used Single Photon Emission Computed Tomography to evaluate the differences between PSP-P and MSA-P patients and found that the right middle frontal gyrus was the most affected region in PSP-P.
Article
Clinical Neurology
Natalia Madetko-Alster, Piotr Alster, Tereza Bartosova, Jiri Klempir, Bartosz Migda, Dominika Przewodowska, Anna Migda, Andrzej Friedman
Summary: In this study, the differences in vascular risk factors between patients with Corticobasal syndrome (CBS) and progressive supranuclear palsy Richardson-Steele phenotype (PSP-RS) were analyzed. The results showed a significantly higher level of total cholesterol in the CBS group, indicating a possible role of vascular pathology in the development of CBS. Further research is needed to explore this issue.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2023)
Article
Medicine, General & Internal
Natalia Madetko-Alster, Piotr Alster, Bartosz Migda, Michal Nieciecki, Dariusz Koziorowski, Leszek Krolicki
Summary: The differential diagnosis of MSA-P and PSP-P is challenging in clinical practice. This study investigated the usefulness of SPECT HMPAO in differentiating between these two diseases. The results indicated that the most significant difference in perfusion was observed in the anterior quadrangular lobule of the cerebellum, which could potentially aid in the diagnosis.
Review
Clinical Neurology
Piotr Alster, Natalia Madetko-Alster, Anna Migda, Bartosz Migda, Michal Kutylowski, Leszek Krolicki, Andrzej Friedman
Summary: The review discusses the significance of sleep abnormalities in PSP and CBS patients, as well as their potential application in the differential diagnosis of synucleinopathic parkinsonian syndromes.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2023)
Review
Immunology
Marta Lenska-Mieciek, Natalia Madetko-Alster, Piotr Alster, Leszek Krolicki, Urszula Fiszer, Dariusz Koziorowski
Summary: Misfolding and aggregation of proteins are major pathological features of several neurodegenerative diseases. These diseases include neurodegenerative diseases with atypical Parkinsonism and the accumulation of insoluble fibrillary alpha-synuclein or hyperphosphorylated tau protein fragments. In the absence of available therapies to slow or halt disease progression, targeting the inflammatory process shows promise. Inflammatory biomarkers may also aid in the differential diagnosis of Parkinsonian syndromes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natalia Madetko-Alster, Dagmara Otto-Slusarczyk, Alicja Wiercinska-Drapalo, Dariusz Koziorowski, Stanislaw Szlufik, Joanna Samborska-Cwik, Marta Struga, Andrzej Friedman, Piotr Alster
Summary: This study aimed to evaluate possible differences in neuroinflammatory patterns between the two most common progressive supranuclear palsy (PSP) phenotypes. The results indicate that levels of tau are significantly higher in PSP-P and PSP-RS patients, and the lowest concentrations of interleukins are observed in PSP-RS patients. This suggests that distinct neuroinflammatory patterns or increased inflammatory activity may play a role in the phenotypes and clinical course of PSP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Piotr Alster, Natalia Madetko-Alster, Dagmara Otto-Slusarczyk, Anna Migda, Bartosz Migda, Marta Struga, Andrzej Friedman
Summary: The pathogenesis of parkinsonisms is not well understood and endocrine abnormalities may play a role in the progression of neurodegenerative diseases, which has been under-evaluated. The neuropeptide orexin, produced by orexigenic neurons in the hypothalamus, is associated with wakefulness, excitement, and appetite, and further investigation into its role may provide insights into the cause or consequence of neurodegeneration.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2023)
Article
Medicine, General & Internal
Michal Kutylowski, Piotr Alster, Natalia Madetko-Alster, Anna Marta Migda, Leszek Krolicki, Bartosz Migda
Summary: This study examined a group of patients with atypical parkinsonism using a 1.5 T MRI system and aimed to find simple and repeatable measurements that may be useful to distinguish between these diseases. The results suggest that the maximal width of the frontal horns of the lateral ventricles and Evans' Index may be useful as basic and simple measurements in the diagnostic imaging of patients with atypical parkinsonism.
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)