Insulin-stimulated lipogenesis gets an epigenetic makeover

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

(2020) Jose A. Viscarra et al.   Nature Communications

Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes

(2020) Yan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis

(2018) Yan Liu et al.   Nature Communications

NAFLD and diabetes mellitus

(2016) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

Histone Lysine Demethylase Inhibitors

(2016) Ashwini Jambhekar et al.   Cold Spring Harbor Perspectives in Medicine

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

(2014) Rebecca A. Haeusler et al.   Nature Communications

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism