期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 130, 期 3, 页码 1073-1083出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI133679
关键词
-
资金
- American Cancer Society [RSG-10-160-01-LIB]
- Melanoma Research Alliance
- NIH [AI097852, AI094478, CA184379]
The functional state of the preexisting T cells in the tumor microenvironment is a key determinant for effective antitumor immunity and immunotherapy. Increasing evidence suggests that immunosenescence is an important state of T cell dysfunction that is distinct from exhaustion, a key strategy used by malignant tumors to evade immune surveillance and sustain the suppressive tumor microenvironment. Here, we discuss the phenotypic and functional characteristics of senescent T cells and their role in human cancers. We also explore the possible mechanisms and signaling pathways responsible for induction of T cell senescence by malignant tumors, and then discuss potential strategies to prevent and/or reverse senescence in tumor-specific T cells. A better understanding of these critical issues should provide novel strategies to enhance cancer immunotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据