Article
Gastroenterology & Hepatology
Natsuki Ishida, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto
Summary: Serum albumin level plays a crucial role in the therapeutic effect of tacrolimus for ulcerative colitis, with a week 2/week 0 albumin ratio of ≤ 1 predicting treatment failure.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Hafliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Babler, Kirstin Atrott, Silvia Lang, Michael Scharl
Summary: This study investigated the interaction between the food additive TiO2 and the IBD risk gene Ptpn2 in the development of intestinal inflammation. Results showed that TiO2 exacerbated intestinal inflammation in Ptpn2 deficient mice by impacting the differentiation of intestinal macrophages. Furthermore, TiO2 was found to induce the secretion of IL-1 beta and suppress the expression of IL-10 in macrophages through different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Sun-Ho Lee, Margaret Walshe, Eun Hye Oh, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Tomer Greener, Adam Weizman, Mark S. Silverberg, Byong Duk Ye
Summary: The study suggests that changes in serum albumin levels within the first 2 weeks of anti-TNF treatment can predict primary nonresponse, endoscopic outcomes, time to colectomy, and anti-TNF failure in patients with UC. Early access to this biomarker may help identify patients at risk of treatment failure and guide early optimization of anti-TNF therapy.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Gaurav Syal, Lori Robbins, Amir Kashani, Nirupama Bonthala, Edward Feldman, Phillip Fleshner, Eric Vasiliauskas, Dermot McGovern, Christina Ha, Stephan Targan, Gil Y. Melmed
Summary: Serum albumin and band neutrophil percentage are independent predictors of failure of infliximab rescue therapy in patients with acute severe ulcerative colitis. The combination of serum albumin <= 2.5 g/dl and band neutrophil count >= 13% has a 100% positive predictive value for 90-day colectomy.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Wei Ouyang, Min Wu, Anshan Wu, Heng Xiao
Summary: The study confirmed that circ_0001187 facilitates the progression of UC through the miR-1236-3p/MYD88 axis, which might serve as a potential treatment and diagnosis biomarker for UC.
Article
Medicine, General & Internal
Zhou Zhou, Yinghui Zhang, Yan Pan, Xue Yang, Liangping Li, Caiping Gao, Chong He
Summary: The study showed that in patients with UC, increased levels of NAR are positively associated with disease activity and inflammatory load. Pre-treatment NAR levels can predict patient response to IFX therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Ailing Liu, Hong Lv, Bei Tan, Huijun Shu, Hong Yang, Ji Li, Jiaming Qian
Summary: This study found that the highly sensitive C-reactive protein/albumin ratio (CAR) is more accurate in determining disease activity in inflammatory bowel disease (IBD), compared to other laboratory indexes. CAR is a useful biomarker for identifying disease activity in patients with CD and UC, with higher CAR levels indicating increased IBD activity.
Article
Gastroenterology & Hepatology
Sarah C. Sasson, Stephanie M. Slevin, Vincent T. F. Cheung, Isar Nassiri, Anna Olsson-Brown, Eve Fryer, Ricardo C. Ferreira, Dominik Trzupek, Tarun Gupta, Lulia Al-Hillawi, Mari-lenna Issaias, Alistair Easton, Leticia Campo, Michael E. B. FitzPatrick, Joss Adams, Meenali Chitnis, Andrew Protheroe, Mark Tuthill, Nicholas Coupe, Alison Simmons, Miranda Payne, Mark R. Middleton, Simon P. L. Travis, Benjamin P. Fairfax, Paul Klenerman, Oliver Brain
Summary: Our study demonstrates that CD8(+) tissue resident memory T (T-RM) cells are the main activated T cell subset in ICI colitis. The pattern of gastrointestinal immunopathology in ICI colitis is distinct from ulcerative colitis at both the immune and epithelial-signaling levels. Activation of CD8+ T-RM cells correlates with clinical and endoscopic severity of ICI colitis.
Review
Pharmacology & Pharmacy
Alix Demaris, Ella S. K. Widigson, Johan F. K. F. Ilvemark, Casper Steenholdt, Jakob B. Seidelin, Wilhelm Huisinga, Robin Michelet, Linda B. S. Aulin, Charlotte Kloft
Summary: This review aims to analyze the population PK models of infliximab (IFX) in patients with ulcerative colitis (UC) and acute severe UC (ASUC), and assess the impact of disease activity on IFX PK. The results showed that there are still many gaps in the current research, such as a limited number of models specifically developed for UC patients, a lack of studies on severe UC patients, and a lack of evaluation of predictive performance for the models. Therefore, more comprehensive research and adequate reporting and evaluation of the models are needed for clinical application.
Article
Gastroenterology & Hepatology
P. Riviere, A. Le Chevillier, A. Rullier, M. Marty, E. Schurr, B. Lapuyade, B. Celerier, B. Fernandez, T. Bessissow, X. Treton, M. Uzzan, F. Poullenot, A. Berger, F. Zerbib, D. Laharie
Summary: This study aimed to investigate the connection between CRP elevation and deep ulcers in UC. The results showed that patients with CRP > 100 mg/L had a higher likelihood of having deep ulcers, which may influence the choice of treatment for acute severe UC.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Immunology
Fengqin Zhu, Zongjing Hu, Wei Yu, Fengxian Dai, Dehuai Jing, Guangxi Zhou
Summary: This case report describes a patient with ulcerative colitis (UC) who developed cytomegalovirus (CMV) infection and bullous Sweet's syndrome (a cutaneous extra-intestinal manifestation of UC) after treatment. The patient subsequently developed acute myeloid leukemia (AML) and died.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Shinya Furukawa, Sen Yagi, Kana Shiraishi, Teruki Miyake, Kazuhiro Tange, Yu Hashimoto, Shogo Kitahata, Tomoe Kawamura, Tomoyuki Ninomiya, Kenichirou Mori, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Aki Hasebe, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Yoichi Hiasa
Summary: CAR may be significantly positively associated with moderate to severe endoscopic activity but not clinical remission or MH in Japanese patients with UC. In patients with long UC duration, CAR might be a useful serum marker for disease activity.
BMC GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Karolinny Cristiny de Oliveira Vieira, Ana Beatriz Batista da Silva, Suelen Aparecida Felicio, Fabio Santos Lira, Caique de Figueiredo, Eugenia Bezirtzoglou, Valeria Cataneli Pereira, Wilson Romero Nakagaki, Gisele Alborghetti Nai, Lizziane Kretli Winkelstroter
Summary: This study evaluated the effects of probiotic orange juice containing Pediococcus acidilactici CE51 in a mouse model of colitis. The probiotic treatment reduced inflammation and modulated the gut microbiota composition.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Liraz Shmuel-Galia, Fiachra Humphries, Xuqiu Lei, Simona Ceglia, Ruth Wilson, Zhaozhao Jiang, Natalia Ketelut-Carneiro, Sage E. Foley, Susanne Pechhold, JeanMarie Houghton, Khaja Muneeruddin, Scott A. Shaffer, Beth A. McCormick, Andrea Reboldi, Doyle Ward, Ann Marshak-Rothstein, Katherine A. Fitzgerald
Summary: Alterations in the cGAS-STING DNA-sensing pathway can affect intestinal homeostasis and lead to inflammation. Increased STING expression is a feature of intestinal inflammation in both mice with colitis and humans with inflammatory bowel disease. STING accumulation in intestinal myeloid cells can be triggered by dysbiosis and bacterial products, leading to a positive feedback loop that drives intestinal inflammation.
Review
Gastroenterology & Hepatology
Nicholas E. Burr, David J. Gracie, Christopher J. Black, Alexander C. Ford
Summary: In a network meta-analysis, upadacitinib 45 mg once daily ranked first for clinical remission in all patients, patients naive to anti-TNF-alpha drugs and patients previously exposed. Infliximab 10 mg/kg ranked first for endoscopic improvement. Most drugs were safe and well tolerated.
Article
Biochemistry & Molecular Biology
Jian Bi, Kang Sun, Hao Wu, Xiuli Chen, Haiying Tang, Jingwei Mao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Oncology
Jing-Wei Mao, Hai-Ying Tang, Xiao-Yan Tan, Ying-De Wang
MOLECULAR MEDICINE REPORTS
(2012)
Article
Gastroenterology & Hepatology
Jing-Wei Mao, Xiao-Mei He, Hai-Ying Tang, Ying-De Wang
WORLD JOURNAL OF GASTROENTEROLOGY
(2012)
Article
Gastroenterology & Hepatology
Jing-Wei Mao, Hai-Ying Tang, Ying-De Wang
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2012)
Article
Gastroenterology & Hepatology
Jing-Wei Mao, Yu-Shuang Huang, Hai-Ying Tang, Jian Bi, Yan-Fei Liu, Ying-De Wang
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2014)
Article
Biochemistry & Molecular Biology
Haiying Tang, Jingwei Mao, Xujun Ye, Fengrui Zhang, William G. Kerr, Tao Zheng, Zhou Zhu
Article
Biochemistry & Molecular Biology
Wei Gao, Yufen Wang, Jian Bi, Xiuli Chen, Na Li, Yingde Wang, Haiying Tang, Jingwei Mao
Summary: The abnormal crosstalk between gut immune system and liver in nonalcoholic steatohepatitis (NASH) may be related to the changes in the numbers and activity of CD4+ T cells and DC subsets. This imbalance in gut immunity in NASH could be due to impaired gut chemokine receptor 9 (CCR9)/chemokine ligand 25 (CCL25) signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Hematology
Xiuli Chen, Lian Lou, Haiying Tang, Xiaoyan Tan, Jian Bi, Hao Wu, Na Li, Yingde Wang, Jingwei Mao
Summary: Active UC is closely associated with gut microbiota dysbiosis. GMA therapy has a significant regulatory effect on the gut microbiota in patients with UC, increasing microbial diversity and promoting the growth of beneficial bacteria while reducing harmful bacteria.
JOURNAL OF CLINICAL APHERESIS
(2021)
Review
Gastroenterology & Hepatology
Hao Wu, Yalan Lei, Jingwei Mao
Summary: NAFLD interacts with gut immunity, with intestinal immune imbalance promoting liver inflammation. Disorders of immune cells in both liver and intestines are influenced by NAFLD. Biological agents targeting intestinal immunity show promise in preclinical studies for immune modulation and injury alleviation in NAFLD.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Toxicology
Jian Bi, Jia Liu, Xiuli Chen, Na Shi, Hao Wu, Haiying Tang, Jingwei Mao
Summary: The role of liver macrophages and their derived miR-155-5p in hepatic lymphangiogenesis in liver fibrosis and cirrhosis was investigated. The study found that miR-155-5p participates in hepatic lymphangiogenesis by regulating the polarization of macrophages. This finding is important for a better understanding of the pathogenesis of liver diseases.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Toxicology
Chen Liu, Shaoqiang Sun, Jingwei Mao
Summary: This study examined the cytotoxicity of upconversion nanoparticles (UCNP) on SGC-7901 cells and explored the underlying mechanisms. The findings showed that UCNP inhibited cell viability and induced cell apoptosis through promoting mitochondrial dysfunction and ROS-mediated endoplasmic reticulum (ER) stress.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Review
Medical Laboratory Technology
Na Shi, Kang Sun, Haiying Tang, Jingwei Mao
Summary: This article summarizes the recent research progress on long noncoding RNAs (lncRNAs) involved in nonalcoholic fatty liver disease (NAFLD), revealing the crucial regulatory roles of lncRNAs in the pathogenesis of NAFLD. Studies have shown that lncRNAs participate in the pathological and physiological processes of NAFLD through mechanisms such as regulating gene expression and activities. Therefore, a better understanding of the mechanisms controlled by lncRNAs in NAFLD is of great significance for the identification of novel therapeutic targets and the improvement of noninvasive diagnostic methods.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)