Review
Biochemistry & Molecular Biology
Tiziana Bacchetti, Gianna Ferretti, Federico Carbone, Stefano Ministrini, Fabrizio Montecucco, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Low circulating HDL levels are linked to ASCVD and other chronic diseases, with oxidative stress impacting HDL activity. The enzymes MPO and PON1 play opposing roles in modifying HDL structure and function, with a high MPO/PON1 ratio potentially serving as a marker for cardiovascular disease.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Rossana Galassi, Lorenzo Luciani, Valentina Gambini, Silvia Vincenzetti, Giulio Lupidi, Augusto Amici, Cristina Marchini, Junbiao Wang, Stefania Pucciarelli
Summary: Phosphane gold(I) compounds were evaluated for screening on breast cancer cell panels, with compounds showing specific environments and components displaying activity. These compounds exhibited strong cytotoxicity, varying enzymatic activities, and binding properties in different cell lines.
FRONTIERS IN CHEMISTRY
(2021)
Article
Oncology
H. Prely, C. Herledan, A. G. Caffin, A. Baudouin, V Larbre, M. Maire, V Schwiertz, N. Vantard, F. Ranchon, C. Rioufol
Summary: This study found that potentially clinically relevant drug interactions were frequently identified in outpatients taking oral anticancer drugs, highlighting the need for multiple databases and structured screening to detect more interactions and optimize medication safety.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Saska Djekic, Jelena Vekic, Aleksandra Zeljkovic, Jelena Kotur-Stevuljevic, Srdjan Kafedzic, Marija Zdravkovic, Ivan Ilic, Sasa Hinic, Milivoje Cerovic, Milica Stefanovic, Marija Mihajlovic, Aleksandar Neskovic, Natasa Bogavac-Stanojevic
Summary: The aim of this study was to assess the impacts of oxidative stress, inflammation, and the presence of sdLDL on the antioxidative function of HDL subclasses and the distribution of PON1 activity within HDL in patients with STEMI. The results showed significant differences in the proportions of HDL subclasses and the distribution of PON1 in STEMI patients compared to the control group. There were positive associations between sdLDL and PON1 activity within HDL subclasses. The increased oxidative stress and sdLDL in STEMI patients are closely related to the compromised antioxidative function of small HDL3 particles and the altered PON1 distribution within HDL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Kadriye Erdogan, Nazli Tunca Sanlier, Emine Utlu Ozen, Sueleyman Erol, Inci Kahyaoglu, Salim Neselioglu, Ozcan Erel, Serra Akar, Yaprak Engin Ustun
Summary: This study evaluates the role of oxidative stress in unexplained infertility (UEI) by assessing dysfunctional high-density lipoprotein (HDL) through the myeloperoxidase (MPO) and paraoxonase (PON) ratio. The results show that patients with UEI have higher total dosages of gonadotropin, lower number of Grade 1 embryos and quality of blastocysts, and higher serum MPO/PON ratio. Serum MPO/PON ratio can significantly predict the duration of infertility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Boyan Liu, Min Zhao, Junli Xue, Qianqian Gu, Xiaoyi Zhang, Shucun Qin
Summary: The study demonstrated that inhalation of 4% H-2 reduced the accumulation of OxPLs in rats and altered the components of HDL, enhancing its antioxidative capacity. Additionally, H-2 significantly regulated the activity and expression of HDL-associated enzymes. These findings suggest that H-2 may be used as a therapeutic approach for diseases related to lipid peroxidation caused by oxidative stress.
Review
Pharmacology & Pharmacy
Laura Molenaar-Kuijsten, Dorieke E. M. Van Balen, Jos H. Beijnen, Neeltje Steeghs, Alwin D. R. Huitema
Summary: Many oral anticancer drugs are metabolized by CYP3A. Recommendations for dealing with DDIs of these drugs when only data from strong CYP3A inhibitors or inducers is available have been provided. If data from moderate or weak inhibitors/inducers is not available, a change in exposure of 50% compared with strong inhibitors/inducers can be assumed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Irene Schilcher, Julia T. Stadler, Margarete Lechleitner, Andelko Hrzenjak, Andrea Berghold, Gudrun Pregartner, Marie Lhomme, Michael Holzer, Melanie Korbelius, Florian Reichmann, Anna Springer, Christian Wadsack, Tobias Madl, Dagmar Kratky, Anatol Kontush, Gunther Marsche, Sasa Frank
Summary: The study demonstrates a significant regulatory role of endothelial lipase in the structure, composition, and function of high-density lipoprotein (HDL), particularly in influencing HDL paraoxonase 1 (PON1) content and arylesterase (AE) activity. In mouse experiments, overexpression of EL significantly decreased HDL serum levels but unexpectedly increased HDL PON1 content and AE activity. In humans, there is a positive correlation between EL serum levels and HDL PON1 content.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Mark Trinder, Yanan Wang, Christian M. Madsen, Tatjana Ponomarev, Lubos Bohunek, Brendan A. Daisely, HyeJin Julia Kong, Lisanne L. Blauw, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Mark M. Wurfel, James A. Russell, Keith R. Walley, Patrick C. N. Rensen, John H. Boyd, Liam R. Brunham
Summary: Clinical genetics and humanized mouse models suggest that inhibiting CETP may preserve high-density lipoprotein levels and improve outcomes for individuals with sepsis.
Article
Immunology
Himani Thakkar, Vinnyfred Vincent, Ambuj Roy, Archna Singh
Summary: The study reveals that impaired HDL functionality and altered HDL subfraction distribution may be responsible for the reduced anti-athero protective activity in individuals with coronary artery disease (CAD). The combination of AOA and HDL subfraction distribution can accurately differentiate between the two groups of CAD patients.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Paul N. N. Durrington, Bilal Bashir, Handrean Soran
Summary: PON1 is an esterase mainly found on HDL, with hydrolytic activity towards organophosphates and other substrates. It plays a critical role in protecting LDL and outer cell membranes against oxidative damage, and its activity is inversely related to the occurrence of atherosclerotic cardiovascular disease. More specific medications targeting PON1 need to be developed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Suman Basak, Harshvardhan Ajay Khare, Martin Roursgaard, Paul J. Kempen, Jong Hyun Lee, Salime Bazban-Shotorbani, Martin Kraemer, Sergey Chernyy, Thomas L. Andresen, Kristoffer Almdal, Nazila Kamaly
Summary: This study focuses on the initiating mechanism of atherosclerosis and presents the development of therapeutic nanogels using biocompatible PEG cross-linking method. The nanogels release anti-inflammatory and anti-oxidizing enzyme PON-1 to reduce the production of ox-LDL, effectively inhibiting macrophage foam cell and reactive oxygen species formation.
Review
Biochemistry & Molecular Biology
Gabriela Barszczewska-Pietraszek, Malgorzata Drzewiecka, Piotr Czarny, Tomasz Skorski, Tomasz Sliwinski
Summary: DNA polymerase theta (Pol theta)-mediated end joining (TMEJ) is a crucial mechanism for repairing DNA double-strand breaks (DSBs), and its inhibition has potential therapeutic value in cancer treatment. Pol theta has synthetic lethal interactions with other DNA repair mechanisms and is being studied as a target in cancer research. Different methods, including RNA interference and small molecule inhibitors, have been used to inhibit Pol theta. This review provides an overview of Pol theta and its role in DNA repair, discusses the current state of Pol theta inhibitors, and highlights the promise of Pol theta as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shuyang Liu, Hajime Hirao
Summary: This study investigated the coordination bonding in the inhibition of P450 enzymes using density functional theory and generalized Kohn-Sham energy decomposition analysis. The results revealed the significant role of electron correlation effect in P450 inhibition, especially for specific types of inhibitors.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Ling Mei, Minzhi Yu, Yayuan Liu, Eric Weh, Mercy Pawar, Li Li, Cagri G. Besirli, Anna A. Schwendeman
Summary: The incorporation of rapamycin into synthetic high-density lipoprotein nanoparticles can increase the drug's aqueous concentration and holds potential as a treatment for age-related macular degeneration.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ali Mehri, Karim Mahnam, Hajar Sirous, Mahmoud Aghaei, Leila Rafiei, Mahboubeh Rostami
Summary: One potential approach for tumor therapy is inhibiting the binding between MDM2 and p53 to reactivate p53 in tumor cells. In this study, Monastrol derivatives were designed as MDM2 inhibitors and evaluated for their cytotoxicity on cancer cells. Compound 5d showed the best inhibitory results in silico and in vitro experiments. These findings suggest that Monastrol derivatives have the potential to be candidates for MDM2 inhibition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2024)
