Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach

Design, Synthesis, and Biological Evaluation of Novel 2-(Pyridin-3-yloxy)acetamide Derivatives as Potential Anti-HIV-1 Agents

(2015) Boshi Huang et al.   Chemical Biology & Drug Design

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif

(2015) Wenxin Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

(2015) Peng Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors

(2014) Xiao Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Anti-HIV Activity of 4-(Naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl Derivatives

(2014) Diwakar Rai et al.   Chemical Biology & Drug Design

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011 – 2014)

(2014) Xiao Li et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Recent Advances in the Discovery and Development of Novel HIV-1 NNRTI Platforms (Part II): 2009-2013 Update#

(2013) Yu’ning Song et al.   CURRENT MEDICINAL CHEMISTRY

Heterocycle-thioacetic Acid Motif: A Privileged Molecular Scaffold with Potent, Broad-Ranging Pharmacological Activities

(2013) Yu’ning Song et al.   CURRENT PHARMACEUTICAL DESIGN

Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

(2013) Zhenyu Li et al.   Medicinal Chemistry

Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach

(2013) Yu’ning Song et al.   MedChemComm

Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors

(2012) Eugene L. Asahchop et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rilpivirine, a novel non-nucleoside reverse transcriptase inhibitor for the management of HIV-1 infection

(2012) Jason J Schafer et al.   ANTIVIRAL THERAPY

Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach

(2012) Peng Zhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aglycone-focused randomization of 2-difluoromethylphenyl-type sialoside suicide substrates for neuraminidases

(2012) Hirokazu Kai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Arylazolyl(azinyl)thioacetanilides. Part 10: Design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors

(2012) Xiao Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs

(2012) Peng Zhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In search of a treatment for HIV – current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)

(2012) Chevonne Reynolds et al.   CHEMICAL SOCIETY REVIEWS

Structure-Activity Relationship Studies on Clinically Relevant HIV-1 NNRTIs

(2012) R.K. Rawal et al.   CURRENT MEDICINAL CHEMISTRY

Etravirine

(2012) Jamie D. Croxtall   DRUGS

Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

(2012) Xuwang Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New therapeutic landscape of NNRTIs for treatment of HIV: a look at recent data

(2012) Dushyantha Jayaweera et al.   EXPERT OPINION ON PHARMACOTHERAPY

Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms

(2012) Dongyue Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sulfanyltriazole/tetrazoles: A Promising Class of HIV-1 NNRTIs

(2012) Peng Zhan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase

(2011) Stephan Braun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005 – 2010)

(2011) Peng Zhan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design

(2011) Peng Zhan et al.   MEDICINAL RESEARCH REVIEWS

S-Farnesyl-Thiopropionic Acid Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase

(2011) Joel A. Bergman et al.   ACS Medicinal Chemistry Letters

Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naive Subjects

(2010) G. Moyle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Recent Advances in the Discovery and Development of Novel HIV-1 NNRTI Platforms: 2006-2008 Update

(2009) Peng Zhan et al.   CURRENT MEDICINAL CHEMISTRY

Design Strategies of Novel NNRTIs to Overcome Drug Resistance

(2009) Peng Zhan et al.   CURRENT MEDICINAL CHEMISTRY

Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

(2008) Alexandre Gagnon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Biological Evaluation of Potent c-Met Inhibitors

(2008) Noel D. D’Angelo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

(2008) Nicolas Sluis-Cremer et al.   VIRUS RESEARCH