期刊
JOURNAL OF CELL SCIENCE
卷 133, 期 6, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.240614
关键词
Dynein-2; Cilia; Intraflagellar transport; Microtubule motors
类别
资金
- UK Research and Innovation-Biotechnology and Biological Sciences Research Council [UKRI-BBSRC] [BB/S005390/1]
- UKRI-BBSRC [BB/S013024/1, BB/S007202/1, BB/P008348/1]
- Wellcome Trust [104196/Z/14/Z]
- Royal Society [104196/Z/14/Z]
- BBSRC [BB/P008348/1, BB/S007202/1, BB/N000420/1, BB/S013024/1, BB/S005390/1] Funding Source: UKRI
- Wellcome Trust [104196/Z/14/Z] Funding Source: Wellcome Trust
Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial for ciliary function, as evidenced by deleterious mutations in patients with skeletal abnormalities. Long-standing questions include how the dynein-2 complex is assembled, regulated, and switched between active and inactive states. A combination of model organisms, in vitro cell biology, live-cell imaging, structural biology and biochemistry has advanced our understanding of the dynein-2 motor. In this Cell Science at a Glance article and the accompanying poster, we discuss the current understanding of dynein-2 and its roles in ciliary assembly and function.
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