期刊
CHEMBIOCHEM
卷 18, 期 1, 页码 111-118出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201600381
关键词
antibacterial; antibiotics; antiproliferation; cross kingdom; peptoid; quantification
资金
- Queen's University Belfast
- Biochemical Society's Eric Reid Fund for Methodology
- Health and Social Care Research and Development Office, Northern Ireland
- Engineering and Physical Sciences Research Council
- Swiss National Science Foundation
- Engineering and Physical Sciences Research Council [1342926] Funding Source: researchfish
Biofilms containing Candida albicans are responsible for a wide variety of clinical infections. The protective effects of the biofilm matrix, the low metabolic activity of microorganisms within a biofilm and their high mutation rate, significantly enhance the resistance of biofilms to conventional antimicrobial treatments. Peptoids are peptide-mimics that share many features of host defence antimicrobial peptides but have increased resistance to proteases and therefore have better stability in vivo. The activity of a library of peptoids was tested against monospecies and polymicrobial bacterial/fungal biofilms. Selected peptoids showed significant bactericidal and fungicidal activity against the polymicrobial biofilms. This coupled with low cytotoxicity suggests that peptoids could offer a new option for the treatment of clinically relevant polymicrobial infections.
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