Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

(2019) Jamie A Macpherson et al.   eLife

Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2

(2019) Dhiraj Srivastava et al.   BIOCHEMISTRY

Targeting HIBCH to reprogram valine metabolism for the treatment of colorectal cancer

(2019) Yunlong Shan et al.   Cell Death & Disease

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

(2018) Meng Yuan et al.   BIOCHEMICAL JOURNAL

Aspartate is an endogenous metabolic limitation for tumour growth

(2018) Lucas B. Sullivan et al.   NATURE CELL BIOLOGY

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

Polder maps: improving OMIT maps by excluding bulk solvent

(2017) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5′-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form

(2016) Ming Yan et al.   BIOCHEMISTRY

Bacillus anthracisProlyl 4-Hydroxylase Modifies Collagen-like Substrates in Asymmetric Patterns

(2016) Nicholas J. Schnicker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The importance of serine metabolism in cancer

(2016) Katherine R. Mattaini et al.   JOURNAL OF CELL BIOLOGY

Synergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis

(2016) Jingxu Yang et al.   Journal of Chemical Information and Modeling

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Structural insight into mechanisms for dynamic regulation of PKM2

(2015) Ping Wang et al.   Protein & Cell

In Silico Screening, Genotyping, Molecular Dynamics Simulation and Activity Studies of SNPs in Pyruvate Kinase M2

(2015) Ponnusamy Kalaiarasan et al.   PLoS One

Biochemical, Kinetic, and Spectroscopic Characterization of Ruegeria pomeroyi DddW—A Mononuclear Iron-Dependent DMSP Lyase

(2015) Adam E. Brummett et al.   PLoS One

Investigational cancer drugs targeting cell metabolism in clinical development

(2014) Douglas W Sborov et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells

(2014) Kirstie E. Keller et al.   MOLECULAR CELL

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

(2013) H. P. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual roles of PKM2 in cancer metabolism

(2012) S. Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase

(2012) Avihai Yacovan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

(2012) Charles Kung et al.   CHEMISTRY & BIOLOGY

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

(2009) Gilles A. Spoden et al.   EXPERIMENTAL CELL RESEARCH

Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation

(2008) Gilles A. Spoden et al.   INTERNATIONAL JOURNAL OF CANCER