Article
Biology
Shuan Liu, Zhenlin Dong, Wenjie Tang, Jian Zhou, Liu Guo, Chengyan Gong, Guang Liu, Dan Wan, Yulong Yin
Summary: Iron is an important micronutrient that plays a vital role in host defenses and bacterial pathogenicity. Adequate dietary iron intake improves mucus layer function and decelerates the invasion of pathogenic bacteria.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Fisheries
Elisa Ciavoni, Roel M. Maas, Marc Koppelaars, Oystein Saele, Johan W. Schrama, Antony J. Prabhu Philip
Summary: Aquaculture feed formulation is transitioning from fish meal and fish oil to plant-based ingredients, impacting the levels and forms of minerals in the diet. This study examined the effects of dietary electrolyte balance (dEB) and feeding time on chyme characteristics and water fluxes along the gastrointestinal tract (GIT) of rainbow trout. The results showed that dEB and time after feeding influenced chyme characteristics, water fluxes, pH, and sodium fluxes in the stomach and proximal intestine. Additionally, the digestibility of dry matter and crude protein, as well as mineral digestibility, varied in different gut segments, with the middle and distal intestine being most affected.
Article
Agriculture, Dairy & Animal Science
Qingqing Deng, Yirui Shao, Qiye Wang, Jianzhong Li, Yali Li, Xueqin Ding, Pengfei Huang, Jia Yin, Huansheng Yang, Yulong Yin
Summary: The study found that the 250 mEq/kg dietary electrolyte balance (dEB) diet with citric acid (CA) improved piglet intestinal morphology and digestive enzyme activities, enhancing intestinal digestion and absorption function. Similar improvements were also observed in piglets fed the 100 mEq/kg dEB diet without CA.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Review
Food Science & Technology
Yong Chen, Jing Wang, Liang Zou, Hui Cao, Xiaoling Ni, Jianbo Xiao
Summary: This review discusses the beneficial effects of dietary proanthocyanidins (PAC) on gastrointestinal functions. The findings suggest that PAC can directly act on the gastrointestinal tract through its antioxidant, antibacterial, anti-inflammatory, and anti-proliferative properties. PAC can also interact with carbohydrates, proteins, and lipids, reducing their digestion and absorption. Additionally, PAC has a prebiotic-like effect on the intestinal microbiota, which may contribute to the potential health benefits.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Yue Sun, Qi Wang, Xian Wu, Fang Li, Mingyue Song, Minqi Wang, Xiaokun Cai, Zhengze Li, Zili Gao, Jinkai Zheng, Ce Qi, Jin Sun, Hang Xiao
Summary: The study revealed that pterostilbene underwent demethylation, hydroxylation, and conjugation in the mouse gastrointestinal tract, with microbiota playing an important role in deconjugation and demethylation. The metabolites of pterostilbene may have significant implications for its bioactivity in mice.
Review
Endocrinology & Metabolism
Kanishka N. N. Nilaweera, Paul D. D. Cotter
Summary: Calorie restriction and bariatric surgery can reduce both visceral and subcutaneous adipose tissues, whereas the effects of monounsaturated fatty acids and polyunsaturated fatty acids are inconsistent. Dietary proteins, especially whey proteins, can reduce one or both depots based on their interaction with other macronutrients. This specificity is related to changes in gut microbiota and their metabolites, and the effect may vary with the host's sex. This knowledge can contribute to the development of nutritional strategies to improve metabolic health in humans and other species.
Review
Biochemistry & Molecular Biology
Zilin Deng, Yingying Zhao, Zhiyuan Ma, Minglin Zhang, Hu Wang, Zhiqiang Yi, Biguang Tuo, Taolang Li, Xuemei Liu
Summary: The incidence of gastrointestinal mucosal diseases is increasing, highlighting the need to identify new therapeutic targets. Ion channels/transporters play a crucial role in maintaining GI mucosal integrity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Immunology
Johanna Rohrhofer, Benjamin Zwirzitz, Evelyne Selberherr, Eva Untersmayr
Summary: The large surfaces of gastrointestinal organs are adapted to their tasks of nutritional uptake and defense, with immune cells within the mucosa regulating a balance to prevent inflammation. An increase in GI disorders in Western societies is linked to dietary changes and gut microbiome imbalance, leading to chronic inflammation. Understanding the mechanisms of immuno-nutrition and the impact of dietary compounds on gut immune homeostasis is essential for disease prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Roberta Imperatore, Baldassare Fronte, Daniel Scicchitano, Graziella Orso, Maria Marchese, Serena Mero, Rosario Licitra, Elena Coccia, Marco Candela, Marina Paolucci
Summary: The large-scale fish farming industry requires a significant amount of animal-based feed, leading to the depletion of aquatic species. The development of alternative plant-based feed is hindered by its inflammatory effects on fish. This study used zebrafish as a model to investigate the potential of tannins to alleviate intestinal inflammation caused by a plant-based diet.
Article
Nutrition & Dietetics
Kefyalew Gebeyew, Kai Chen, Teketay Wassie, Md. Abul Kalam Azad, Jianhua He, Weimin Jiang, Wu Song, Zhixiong He, Zhiliang Tan
Summary: Increasing the ratio of amylose in the diet has significant effects on the microbiota and metabolites of the cecum in goats, promoting the abundance of beneficial bacteria. A diet with 50% high amylose was found to have better immunomodulatory effects and maintain a healthier cecal microbiota composition.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Muhammad Abaidullah, Shaokai La, Mengqi Liu, Boshuai Liu, Yalei Cui, Zhichang Wang, Hao Sun, Sen Ma, Yinghua Shi
Summary: This study demonstrates the protective effects of polysaccharides from Smilax glabra on intestinal mucosal injury and the regulation of gut flora and innate immune functions. It provides a novel potential treatment for inflammatory bowel disease and sheds light on the symbiotic associations between host immune mechanisms and the gut microbiome.
Article
Microbiology
Minjuan Li, Dantong Shao, Jiachen Zhou, Jianhua Gu, Junjie Qin, Xinqing Li, Changqing Hao, Wenqiang Wei
Summary: Upper gastrointestinal (UGI) tract cancer is one of the most common cancers worldwide, but the UGI microbiota has received limited attention. This study revealed that each gastrointestinal site has its own microbial characteristics that overlap those of adjacent sites. The microbial compositions between the UGI sites and feces showed significant differences. Helicobacter pylori played a more significant role in the microbial composition of the noncardia stomach than in that of the cardia. Gastric pH and Helicobacter pylori had similar additive effects on the microbial diversity of gastric juice.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Bharath S. Avirineni, Arashdeep Singh, Rizaldy C. Zapata, Caleb D. Phillips, Prasanth K. Chelikani
Summary: This study showed that diets enriched with protein and prebiotic fiber, such as egg or whey protein with inulin, can improve energy balance, reduce adiposity, and modulate gut microbiota and metabolites. The satiety effects of diets were partly mediated by the presence of prebiotic fiber, specifically inulin.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Gastroenterology & Hepatology
Samantha K. Gill, Megan Rossi, Balazs Bajka, Kevin Whelan
Summary: Dietary fiber has been shown to benefit gastrointestinal health through consumption of unrefined whole foods. Studies have demonstrated that dietary fiber can regulate gut and microbial effects, with important implications for gastrointestinal disorders.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
YoHan Choi, Abdolreza Hosseindoust, Sang Hun Ha, Joeun Kim, YeJin Min, YongDae Jeong, JunYoung Mun, SooJin Sa, JinSoo Kim
Summary: This study evaluated the effects of bacteriophage cocktail and ZnO on piglets exposed to a non-sanitary environment. The supplementation of bacteriophage cocktail effectively controlled the population of Proteobacteria phylum and mitigated the adverse influences of weaning stress in piglets.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Qingqing Deng, Yirui Shao, Qiye Wang, Jianzhong Li, Yali Li, Xueqin Ding, Pengfei Huang, Jia Yin, Huansheng Yang, Yulong Yin
Summary: The study found that the 250 mEq/kg dietary electrolyte balance (dEB) diet with citric acid (CA) improved piglet intestinal morphology and digestive enzyme activities, enhancing intestinal digestion and absorption function. Similar improvements were also observed in piglets fed the 100 mEq/kg dEB diet without CA.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Lei Wang, Lijun Zou, Jianzhong Li, Huansheng Yang, Yulong Yin
Summary: The study found that folate supplementation could increase organ weight and stomach pH in weaned piglets, benefiting gut health by altering the intestinal microbiota through the interaction with SCFAs.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Veterinary Sciences
Peng-Fei Huang, Qi Mou, Ying Yang, Jia-Ming Li, Ming-Lang Xu, Jing Huang, Jian-Zhong Li, Huan-Sheng Yang, Xiao-Xiao Liang, Yu-Long Yin
Summary: The addition of Pennisetum purpureum in late gestation diets can increase serum equol concentration, improve antioxidant capacity and immune function of sows. Furthermore, adding 5% P. purpureum in the diet may alter the composition of sow intestinal microbiota, particularly increasing the relative abundance of Coriobacteriaceae.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Veterinary Sciences
Jun Xia, Linlin Chen, Pengfei Huang, Qi Mou, Ying Yang, Jiaming Li, Minglang Xu, Jianzhong Li, Huansheng Yang, Yulong Yin
Summary: Supplementation of Amaranthus hypochondriacus (AH) in the diets of gestating sows decreased digestibility of crude protein and dry matter, resulting in lesser backfat depth. However, in lactating sows, AH supplementation had little effect on digestibility and milk composition, increased feed intake, and decreased backfat loss. Suckling piglets in the AH group showed significantly greater growth performance compared to those in the control diet group.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Jing Zhou, Yan Qin, Xia Xiong, Zhaobin Wang, Min Wang, Yancan Wang, Qiye Y. Wang, Huansheng S. Yang, Yulong Yin
Summary: This study revealed significant effects of iron and vitamin A on intestinal development and cell differentiation in piglets. Iron increased intestinal length and villus height, while vitamin A enhanced intestinal weight and relative weight.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Guolin Pi, Junmin Wang, Wenxin Song, Yali Li, Huansheng Yang
Summary: This study investigated the effects of isomalto-oligosaccharide (IMO), Chinese herbal medicine extract (CHE), or their combination on weaned piglets. The results showed that adding IMO, CHE, or their combination did not affect the diarrhoea rate and intestinal morphology. However, combining IMO with CHE tended to increase the average daily gain. Biochemical analysis revealed that dietary CHE decreased aspartate aminotransferase levels, while inclusion of IMO decreased high-density lipoprotein. Moreover, co-administration of IMO with CHE upregulated the expression of the anti-inflammatory cytokine TGF-beta in the jejunal mucosa of piglets. The abundance of Bifidobacterium in the ileal and caecal digesta was also increased by dietary supplementation with CHE and the combination of IMO and CHE, respectively. Additionally, supplementation with IMO, CHE, or their combination reduced the number of potential entero-pathogen Escherichia coli and Clostridium species in the intestines of piglets.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Yan Qin, Jing Zhou, Xia Xiong, Jing Huang, Jianzhong Li, Qiye Wang, Huansheng Yang, Yulong Yin
Summary: This study found that riboflavin levels can regulate the morphology of piglet duodenum by affecting the renewal and differentiation of intestinal epithelial cells. Different doses of riboflavin have effects on piglet growth performance, intestinal morphology, and antioxidant capacity.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Food Science & Technology
Yanjun Huang, Caimei He, Zheng Hu, Xuetong Chu, Sichun Zhou, Xin Hu, Jun Deng, Di Xiao, Ting Tao, Huansheng Yang, Alex F. Chen, Yulong Yin, Xiaoping Yang
Summary: This study demonstrates that α-tocopherol can increase tight junction protein expression and enhance intestinal integrity, both in vitro and in vivo.
FOOD SCIENCE & NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Fengjie Ji, Huansheng Yang, Qiye Wang, Jianzhong Li, Hanlin Zhou, Shengmin Liu
Summary: This study aimed to investigate the efficacy of porcine intestinal antimicrobial peptide (PIAP) as an alternative to in-feed antibiotics for growth performance, intestinal morphology, digestive enzymes, immunity, and microbiota community of post-weaning piglets. The results showed that dietary supplementation with a relatively low dose of PIAP demonstrated beneficial effects on intestinal morphology, digestive enzymes, immunity, and permeability by shaping the gut microbiota composition in weaned piglets. This study provides valuable reference for using PIAP as an in-feed antibiotic alternative in swine production.
Article
Agriculture, Dairy & Animal Science
Xianglin Zeng, Yuan Yang, Junmin Wang, Zhaobin Wang, Jun Li, Yulong Yin, Huansheng Yang
Summary: This study evaluated the effects of supplementation with saturated fatty acids of different chain lengths on weaned piglets. The results showed that supplementation with butyrate, lauric acid, or stearic acid promoted intestinal cell renewal and proliferation, and improved intestinal morphology in the piglets.
Article
Agriculture, Dairy & Animal Science
Min Wang, Lixia Wang, Xian Tan, Lei Wang, Xia Xiong, Yancan Wang, Qiye Wang, Huansheng Yang, Yulong Yin
Summary: Intestinal epithelial homeostasis undergoes significant changes during early weaning in piglets, affecting intestinal morphology, cell turnover, and gene expression. The mTOR signaling pathway plays a crucial role in these developmental changes.
Article
Agriculture, Dairy & Animal Science
Zhaobin Wang, Jie Hu, Xinyuan Yang, Lanmei Yin, Min Wang, Yuebang Yin, Jianzhong Li, Huansheng Yang, Yulong Yin
Summary: Supplementing D-GIcNAc in the diet of weaned piglets has no significant effect on growth performance and diarrhea. However, it promotes the growth and development of the intestinal tract, improves digestion and absorption capacity, and affects the activity of intestinal stem cells.
Article
Biochemistry & Molecular Biology
Zhenfeng Yi, Xian Tan, Qiye Wang, Pengfei Huang, Yali Li, Xueqin Ding, Jianzhong Li, Jing Huang, Huansheng Yang, Yulong Yin
Summary: The dietary supplementation of niacin in weaned piglets had varying effects on intestinal morphology and function in the first and second weeks post-weaning, potentially modulating intestinal health by influencing intestinal cell proliferation.
Article
Agriculture, Dairy & Animal Science
Lei Wang, Xian Tan, Huiru Wang, Qiye Wang, Pengfei Huang, Yali Li, Jianzhong Li, Jing Huang, Huansheng Yang, Yulong Yin
Summary: The present study evaluated the effect of dietary folic acid on growth performance, intestinal morphology, and intestinal epithelial cells renewal in post-weaning piglets. The results showed that folic acid supplementation improved villus height, VH-to-crypt depth ratio, villus surface area, lactase and sucrase activities in the jejunal mucosa, along with several other significant linear changes in gene expression and cell shedding rate. Overall, folic acid supplementation can enhance growth performance and intestinal morphology in weaned piglets by maintaining epithelial cell renewal balance.
Article
Agriculture, Dairy & Animal Science
Xianglin Zeng, Yuan Yang, Junmin Wang, Zhaobin Wang, Jun Li, Yulong Yin, Huansheng Yang
Summary: Supplementation of saturated fatty acids with different chain lengths has significant effects on the growth performance, intestinal morphology, and cell proliferation of weaned piglets, with BT, LA, or SA dietary supplementation promoting jejunal cell renewal and increasing proliferation of ileal crypt cells by promoting p-mTOR expression.