Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Allergy
Nicholas J. Campion, Sergio Villazala-Merino, Ryan S. Thwaites, Victoria Stanek, Helen Killick, Eleftheria Pertsinidou, Mohammed Zghaebi, Josef Toth, Renate Froschl, Thomas Perkmann, Katharina Gangl, Sven Schneider, Robin Ristl, Ian C. Scott, Emma Suzanne Cohen, Magnus Molin, Margit Focke-Tejkl, Guenther Regelsberger, Trevor T. Hansel, Rudolf Valenta, Verena Niederberger-Leppin, Julia Eckl-Dorna
Summary: This study aimed to characterize the immunologic and clinical nasal responses to birch pollen allergen challenge, with a special focus on the late allergic response.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marika Lanza, Giovanna Casili, Alessia Filippone, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: The xyloglucan-based nasal spray showed significant efficacy in reducing histological damage, improving nasal rubbing and histamine-induced hyper-responsiveness in allergic rhinitis mice. It also reduced IgE levels and pro-inflammatory cytokines, with improved effectiveness when used in combination with an antihistamine. Additionally, it maintained tight junction protein expression and reduced HDAC1 expression, similar to corticosteroid-treated mice, indicating a potential novel therapeutic strategy for nasal respiratory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Otorhinolaryngology
Donata Gellrich, Florian Pfab, Miriam Ortiz, Sylvia Binting, Benno Brinkhaus, Moritz Groeger
Summary: This study found that acupuncture can reduce nasal inflammation in the treatment of seasonal allergic rhinitis (SAR), but its immunological effect on Th1-Th2 imbalance is still unclear.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Immunology
Li Li, Yuanding Zhang, Hong Liu, Tianqi Wang, Junxin Li, Xin Wang
Summary: This Mendelian Randomization (MR) study aims to evaluate the causal relationships between 41 inflammatory cytokines and the incidence of Allergic Rhinitis (AR), Chronic Rhinosinusitis (CRS), and Nasal Polyps (NP). The results showed that elevated levels of MIP-1 alpha and TNF-alpha were associated with an increased risk of AR, while elevated levels of IL-2 were associated with an increased susceptibility to NP. Furthermore, increased levels of circulating PDGF-BB were linked to a reduced risk of NP. However, there was no positive association found between levels of inflammatory cytokines and the incidence of CRS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Siti Muhamad Nur Husna, Hern-Tze Tina Tan, Norasnieda Md Shukri, Noor Suryani Mohd Ashari, Kah Keng Wong
Summary: Allergic rhinitis is a common disorder affecting up to 40% of the global population, characterized by impaired nasal epithelial barrier and crucial involvement of TJ molecules in its pathogenesis. Various regulatory factors have been identified, offering hope for the development of novel therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Siti Muhamad Nur Husna, Norasnieda Md Shukri, Hern-Tze Tina Tan, Noor Suryani Mohd Ashari, Kah Keng Wong
Summary: This study investigated the association between SPT wheal sizes of common house dust mite allergens and demographic, clinical, and environmental characteristics, as well as nasal and non-nasal symptom severity scores in AR patients. The results showed that SPT wheal sizes were not associated with clinical, demographic, and environmental characteristics, but significant correlations were observed between SPT wheal sizes of D. farinae sensitization and severity scores of nasal and non-nasal symptoms. Increased SPT wheal sizes for D. farinae sensitization may predict more severe nasal and, to a lesser extent, non-nasal manifestations in AR patients.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hahn Jin Jung, Young-Kyung Ko, Woo Sub Shim, Hyun Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Moo Kyun Park, Doo Hee Han
Summary: This study investigated the effect of DEP exposure on allergic rhinitis using a mouse model sensitized to house dust mite. The results showed that mice co-exposed to HDM and DEP exhibited increased allergic symptom scores compared to mice exposed to HDM alone. This suggests that DEP may exacerbate allergic rhinitis by increasing levels of interleukin-17A in the nasal mucosa.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Hongfei Lou, Yanran Huang, Xiaohan Chu, Yang Wang, Chengshuo Wang, Luo Zhang
Summary: This study aimed to evaluate the change in M2 macrophages during pollen exposure in patients with seasonal allergic rhinitis (SAR). The percentage of CD163+ M2 macrophages in CD14+ monocytes increased during the pollen season and at the end of treatment in the SLIT group. The percentage of CD206-CD86+ M2 cells in M2 macrophages significantly increased at the end of treatment in the SLIT group compared to baseline, the peak pollen period, and the placebo group.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ana Dugic, Cristina Verdejo Gil, Claudia Mellenthin, Miroslav Vujasinovic, J-Matthias Lohr, Steffen Muehldorfer
Summary: This systematic review examines the clinical utility of various serum biomarkers in diagnosing AIP, distinguishing it from pancreatic cancer, and predicting disease course, steroid therapy response, and relapse. Several autoantibodies and biomarkers, in addition to IgG4, show potential for AIP diagnosis and differentiation from pancreatic cancer.
Article
Immunology
Yuze Yuan, Chao Wang, Guoqiang Wang, Xiaoping Guo, Shengyu Jiang, Xu Zuo, Xinlei Wang, Alan Chen-Yu Hsu, Mingran Qi, Fang Wang
Summary: Allergic rhinitis is a common chronic disease influenced by genetic and environmental factors. Analyzing the microbiome and serum composition, we found potential biomarkers and disrupted metabolic pathways that may be used for the diagnosis of allergic rhinitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Otorhinolaryngology
Gennaro Liccardi, Matteo Martini, Maria Beatrice Bilo, Manlio Milanese, Paola Rogliani
Summary: The scientific quantification of symptoms in pollen-related allergic rhinitis requires considering the aerobiological data of the geographical area.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Immunology
Anna Gard, Fredrik Vedung, Fredrik Piehl, Mohsen Khademi, Maria Portonova Wernersson, Ia Rorsman, Yelverton Tegner, Helene Pessah-Rasmussen, Karsten Ruscher, Niklas Marklund
Summary: A sports-related concussion (SRC) often leads to shearing and stretching of axons in the white matter, causing secondary inflammatory processes and persistent post-concussive symptoms (PPCS). In this study, athletes with PPCS showed signs of ongoing neuroinflammation, as indicated by altered profiles of cerebrospinal fluid (CSF) biomarkers. The findings suggest the importance of studying treatments targeting the post-injury inflammatory response in sports-related concussion.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Otorhinolaryngology
Erdem Mengi, Cuneyt Orhan Kara, Ugur Alpturk, Bulent Topuz
Summary: This study found that the use of face masks reduced both nasal and ocular allergic rhinitis symptoms in individuals with pollen allergy during the covid-19 pandemic. The most significant improvements were seen in sneezing and nasal discharge symptoms. These results support the hypothesis that face masks could alleviate the severity of allergic rhinitis symptoms.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Haotao Zeng, Jiangqi Liu, Lihua Mo, Minyao Li, Aifa Tang, Xianhai Zeng, Miao Zhao, Pingchang Yang
Summary: In this study, nasal secretions of allergic rhinitis patients were analyzed, and 15 differentially expressed proteins (DEPs) were identified. These DEPs were significantly correlated with the total nasal symptom scores of patients with allergic rhinitis.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Alexander Heldner, Matthew D. Heath, Benjamin Schnautz, Sebastian Kotz, Adam Chaker, Matthias F. Kramer, Constanze A. Jakwerth, Ulrich M. Zissler, Carsten B. Schmidt-Weber, Simon Blank
Summary: This study investigated the immunomodulatory effects of the synbiotics Pollagen(R) and Kallergen(R) on grass pollen allergy. The results showed that the synbiotics can downregulate the Th2 immune response in allergic patients and promote the shift towards Th1 and Th17 immune responses.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Allergy
Dominika Polak, Ute Vollmann, Joao Grilo, Ivan V. Bogdanov, Lorenz Aglas, Tatiana V. Ovchinnikova, Fatima Ferreira, Barbara Bohle
Summary: In areas dominated by birch trees, allergies to pollen from trees of the order Fagales are mainly caused by the major birch pollen allergen Bet v 1. However, the sensitizing activity of Bet v 1-homologs in Fagales pollen might be underestimated. This study found that the cellular cross-reactivity of major Fagales pollen allergens with Bet v 1 was not significant, especially for Aln g 1, which is most similar to Bet v 1.
Article
Chemistry, Multidisciplinary
Litty Johnson, Lorenz Aglas, Benjamin Punz, Hieu-Hoa Dang, Constantin Christ, Lisa Pointner, Mario Wenger, Norbert Hofstaetter, Sabine Hofer, Mark Geppert, Ancuela Andosch, Fatima Ferreira, Jutta Horejs-Hoeck, Albert Duschl, Martin Himly
Summary: The incorporation of nanomaterials into consumer products has raised safety concerns due to their ability to cross epithelial barriers and interact with allergens, potentially affecting immune responses. This study investigates the impact of silica nanoparticle-allergen interactions on allergic sensitization by studying molecular mechanisms affecting allergic responses. The results suggest that the interaction of birch pollen allergen with silica nanoparticles skews the immune response towards a Th1-dominated profile, indicating a potential decrease in allergic sensitization.
Article
Medicine, General & Internal
Viviana Fajardo Martinez, Dajie Zhang, Sophia Paiola, Thalia Mok, Mary C. Cambou, Tara Kerin, Rashmi Rao, Patricia Brasil, Fatima Ferreira, Trevon Fuller, Debika Bhattacharya, Suan-Sin Foo, Weiqiang Chen, Jae Jung, Christa Einspieler, Peter B. Marschik, Karin Nielsen-Saines
Summary: This longitudinal cohort study evaluated neuromotor development in infants exposed to antenatal COVID-19. It found that compared to pre-pandemic controls, infants exposed to COVID-19 were more likely to have suboptimal neuromotor development.
Article
Multidisciplinary Sciences
Ingrida Sauliene, Arunas Valiulis, Ilona Keriene, Laura Sukiene, Dovile Dovydaityte, Nina Prokopciuk, Vaidotas Valskys, Roberta Valskiene, Athanasios Damialis
Summary: The number of children suffering from respiratory allergies and asthma has been increasing globally, making it crucial to understand the presence of inhalant biological particles in school facilities, where children spend a significant amount of their time. While there have been numerous studies on outdoor bioaerosol exposure, there are still uncertainties regarding the diversity and deposition of airborne pollen and fungi indoors, especially in schools. This study aimed to examine the indoor environment of public schools and assess the biodiversity and abundance of bioaerosols, such as fungi and pollen, in order to determine potential health risks for children.
Review
Allergy
Isabella Annesi-Maesano, Lorenzo Cecchi, Benedetta Biagioni, Kian Fan Chung, Bernard Clot, Martine Collaud Coen, Gennaro D. Amato, Athanasios Damialis, Javier Dominguez-Ortega, Carmen Galan, Stefanie Gilles, Stephen Holgate, Mohamed Jeebhay, Stelios Kazadzis, Nikolaos G. Papadopoulos, Santiago Quirce, Joaquin Sastre, Fiona Tummon, Claudia Traidl-Hoffmann, Jolanta Walusiak-Skorupa, Pablo Alonso-Coello, Carlos Canelo-Aybar, Yahveth Cantero-Fortiz, David Rigau, Josefina Salazar, Francisca Verdugo-Paiva, Marek Jutel, Cezmi A. Akdis, Ioana Agache
Summary: This study aimed to investigate the impact of pollen exposure on asthma exacerbations and found that outdoor pollen exposure may have an effect on asthma exacerbation, particularly in children under 18 years of age. Further research is needed to evaluate the effects of pollen on asthma exacerbation, considering factors such as pollen sensitization, hay fever, air pollution, green spaces, and pre-existing medications, in order to improve preventive measures.
Letter
Allergy
Lisa Pointner, Vanda Adamkova, Athanasios Bethanis, Swetlana Gerkhardt, Leopold Moelter, Claudia Traidl-Hoffmann, Stefanie Gilles, Lorenz Aglas
Article
Environmental Sciences
Stefanie Gilles, Meike Meinzer, Maria Landgraf, Franziska Kolek, Susanne von Bargen, Kaja Pack, Athanasios Charalampopoulos, Surendra Ranpal, Daria Luschkova, Claudia Traidl-Hoffmann, Susanne Jochner-Oette, Athanasios Damialis, Carmen Buettner
Summary: Viruses are a common biocontaminant in healthy plants and can be caused by environmental stress such as urbanization, air pollution, and climate change. This study found that worsened air quality and fewer green areas may increase the frequency of viral infections in birch trees. The presence of two viruses, Cherry leaf roll virus (CLRV) and a newly discovered birch idaeovirus (BIV), was determined in pollen samples from birch trees in Germany. The occurrence of BIV was found to be influenced by the urban index and NO2 levels, particularly in urban birch trees near high-traffic roads.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biophysics
Surendra Ranpal, Susanne von Bargen, Stefanie Gilles, Daria Luschkova, Maria Landgraf, Claudia Traidl-Hoffmann, Carmen Buettner, Athanasios Damialis, Susanne Jochner-Oette
Summary: High-altitude environments are susceptible to climate change, making it important to study plant traits in these regions to understand future impacts. The research on pollen production at different altitudes in mountains is currently limited. In this study, birch pollen production was investigated along an altitudinal gradient in the European Alps. It was found that mean pollen production varied between 0.4 and 8.3 million grains per catkin. No significant relationships were observed between reproductive metrics and altitude. However, the minimum temperature of the previous summer was significantly correlated to pollen, flower, and catkin production.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Article
Allergy
Stephanie Dramburg, Christiane Hilger, Alexandra F. Santos, Leticia de las Vecillas, Rob C. Aalberse, Nathalie Acevedo, Lorenz Aglas, Friedrich Altmann, Karla L. Arruda, Riccardo Asero, Barbara Ballmer-Weber, Domingo Barber, Kirsten Beyer, Tilo Biedermann, Maria Beatrice Bilo, Simon Blank, Philipp P. Bosshard, Heimo Breiteneder, Helen A. Brough, Merima Bublin, Dianne Campbell, Luis Caraballo, Jean Christoph Caubet, Giorgio Celi, Martin D. Chapman, Maksymilian Chruszcz, Adnan Custovic, Rebecca Czolk, Janet Davies, Nikolaos Douladiris, Bernadette Eberlein, Motohiro Ebisawa, Anna Ehlers, Philippe Eigenmann, Gabriele Gadermaier, Mattia Giovannini, Francisca Gomez, Rebecca Grohman, Carole Guillet, Christine Hafner, Robert G. Hamilton, Michael Hauser, Thomas Hawranek, Hans Juergen Hoffmann, Thomas Holzhauser, Tomona Iizuka, Alain Jacquet, Thilo Jakob, Bente Janssen-Weets, Uta Jappe, Marek Jutel, Tanja Kalic, Sandip Kamath, Sabine Kespohl, Joerg Kleine-Tebbe, Edward Knol, Andre Knulst, Jon R. Konradsen, Peter Korosec, Annette Kuehn, Gideon Lack, Thuy-My Le, Andreas Lopata, Olga Luengo, Mika Maekelae, Alessandro Maria Marra, Clare Mills, Martine Morisset, Antonella Muraro, Anna Nowak-Wegrzyn, Roni Nugraha, Markus Ollert, Kati Palosuo, Elide Anna Pastorello, Sarita Ulhas Patil, Thomas Platts-Mills, Anna Pomes, Pascal Poncet, Ekaterina Potapova, Lars K. Poulsen, Christian Radauer, Suzana Radulovic, Monika Raulf, Pierre Rouge, Joaquin Sastre, Sakura Sato, Enrico Scala, Johannes M. Schmid, Peter Schmid-Grendelmeier, Denise Schrama, Helene Senechal, Claudia Traidl-Hoffmann, Marcela Valverde-Monge, Marianne van Hage, Ronald van Ree, Kitty Verhoeckx, Stefan Vieths, Magnus Wickman, Josefina Zakzuk, Paolo M. Matricardi, Karin Hoffmann-Sommergruber
Summary: Since the discovery of IgE as a mediator of allergic diseases, our knowledge about its immunological mechanisms has greatly increased. Innovations in bioscience and technology have facilitated the production of well-defined molecules for component-resolved diagnosis, allowing personalized management of allergic diseases. The Molecular Allergology User's Guide 2.0 provides updated information on allergen molecules, their clinical relevance, and diagnostic algorithms, serving as a valuable resource for clinicians and scientists.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Allergy
Nikolaos G. Papadopoulos, Cezmi Akdis, Mubeccel Akdis, Athanasios Damialis, Giuseppina Esposito, Ioana Fergadiotou, Christian Goroncy, Pierre Guitton, Maia Gotua, Kleanthis Erotokritou, Tuomas Jartti, Clare Murray, Athanasios Nenes, Sotirios Nikoletseas, Susetta Finotto, Spyros N. Pandis, Valeria Ramiconi, Angela Simpson, Aki Soudunsaari, Anna Starbrost, Maria Staiano, Antonio Varriale, Paraskevi Xepapadaki, Torsten Zuberbier, Isabella Annesi-Maesano
Summary: While the number and types of indoor air pollutants is increasing, little is known about the impact of their synergistic interactions on human health. Different populations have varying susceptibility to pollutants, and low socioeconomic backgrounds further contribute to susceptibility. The SynAir-G project aims to understand and quantify the interactions between different pollutants in order to improve targeting and standards, specifically in the school setting. It will develop a comprehensive monitoring system, advance environmentally friendly interventions, and disseminate knowledge to stakeholders.
Article
Biology
Velky Ahumada, Josefina Zakzuk, Lorenz Aglas, Sandra Coronado, Peter Briza, Ronald Regino, Fatima Ferreira, Luis Caraballo
Summary: Immunity to Ascaris lumbricoides affects the pathogenesis of allergic diseases. Antibody responses to two A. lumbricoides molecules, Asc l 5 and Al-CPI, have different patterns of immune response to the parasite.
Article
Anesthesiology
A. R. Heller, C. Bartenschlager, J. O. Brunner, G. Marckmann
Summary: With the implementation of the new German Triage Act, there has been a prolonged discussion which has left physicians, social associations, lawyers, and ethicists dissatisfied. The act prevents allocation decisions that prioritize new patients with better chances of success over those whose treatment has already begun, leading to a first come first served allocation and higher mortality rates. Despite evidence that age and frailty strongly determine short-term survival, the act prohibits their use as prioritization criteria. The only option left is the consistent termination of treatment desired by the patient, regardless of resource scarcity.
Article
Anesthesiology
Sara Garber, Jens O. Brunner, Axel R. Heller, Georg Marckmann, Christina C. Bartenschlager
Summary: The increase in patients during the COVID-19 pandemic poses challenges to the healthcare system, especially in the intensive care unit. Through infection control measures and logistical efforts, Germany successfully treated all patients needing intensive care without triage, even in regions with high patient pressure and low capacities. A study found that implementing a triage policy based on survival probabilities can reduce mortality in the intensive care unit for all patient groups.
Article
Computer Science, Interdisciplinary Applications
Sebastian Kraul, Markus Seizinger, Jens O. Brunner
Summary: This article presents a model that predicts the optimal dual variables for the cutting stock problem. The model analyzes the impact of different attributes on the optimal dual variables within problem instances. Two learning algorithms are developed to predict the best algorithm configuration based on the predicted optimal dual variables, eliminating the need for numerical tests. Computational studies show the effectiveness of both algorithms, with the choice depending on the variability in item quantities between instances.
INFORMS JOURNAL ON COMPUTING
(2023)