Article
Agriculture, Multidisciplinary
Tianyuan Song, Miao Lv, Minzhi Zhou, Mingtao Huang, Lin Zheng, Mouming Zhao
Summary: The study explored the effect of EVs produced from VSMCs on HUVECs, revealing differential gene expression associated with endothelial dysfunction. LSW can improve endothelial function by repairing miRNA expression in VSMCs, suggesting potential mechanisms for the actions of Ang II and LSW on vascular endothelial cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Hematology
Craig B. Harrison, Silvia Cellone Trevelin, Daniel A. Richards, Celio X. C. Santos, Greta Sawyer, Andrea Markovinovic, Xiaohong Zhang, Min Zhang, Alison C. Brewer, Xiaoke Yin, Manuel Mayr, Ajay M. Shah
Summary: Fibroblast-specific deficiency of Nox2 attenuated ANG II-induced vascular remodeling and hypertension in mice, suggesting a crucial role for fibroblast Nox2 in regulating paracrine signaling to vascular smooth muscle cells via factors such as GDF6.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Food Science & Technology
Tianyuan Song, Minzhi Zhou, Wen Li, Miao Lv, Lin Zheng, Mouming Zhao
Summary: A soybean-derived vasoactive peptide (SVP) was prepared and shown to reduce blood pressure and attenuate inflammation in the aorta of spontaneous hypertensive rats (SHRs) by regulating the miRNA-19b/CYLD/TRAF6 axis.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Peripheral Vascular Disease
Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Kyle Preston, Victor Rizzo, Tomoki Hashimoto, Thomas M. Coffman, Matthew A. Sparks, Satoru Eguchi
Summary: Smooth muscle AT(1A) receptors mediate Ang II-induced vascular remodeling in both hypertensive and non-hypertensive conditions, contributing to medial hypertrophy and perivascular fibrosis. These findings indicate an independent etiology of blood pressure elevation and hypertensive vascular remodeling in response to Ang II.
Review
Health Care Sciences & Services
Zhuangzhuang Jia, Shuai Wang, Haifeng Yan, Yawen Cao, Xuan Zhang, Lin Wang, Zeyu Zhang, Shanshan Lin, Xianliang Wang, Jingyuan Mao
Summary: Pulmonary vascular remodeling, involving changes in the intima, media and adventitia, is a critical structural alteration and pathological feature in pulmonary hypertension. It includes the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), as well as interactions with pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis, and other factors are influenced by different mechanisms that contribute to disease progression. This article reviews these pathological changes and discusses the underlying mechanisms in the remodeling process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jingsi Zhang, Yuanshu Hui, Fengyi Liu, Qian Yang, Yi Lu, Yeting Chang, Qinlong Liu, Yanchun Ding
Summary: This study found that neohesperidin, as an antioxidant, can effectively inhibit hypertension and vascular remodeling induced by angiotensin II. The results of this study are of great significance for addressing global health problems.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Irakli Kopaliani, Natalia Jarzebska, Silke Billoff, Anne Kolouschek, Jens Martens-Lobenhoffer, Stefan R. Bornstein, Stefanie M. Bode-Boeger, Vinitha N. Ragavan, Norbert Weiss, Arduino A. Mangoni, Andreas Deussen, Roman N. Rodionov
Summary: In this study, overexpression of dimethylarginine dimethylaminohydrolase 1 (DDAH1) was found to protect against angiotensin II-induced cardiovascular damage, progression of hypertension, and adverse vascular remodeling in vivo. This protective effect is associated with decreased levels of asymmetric dimethylarginine, preservation of endothelial function, inhibition of cardiovascular inflammation, and lower activity of matrix metalloproteinase-2. The findings suggest that upregulation of DDAH1 might be a promising therapeutic approach against angiotensin II-induced end organ damage.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhuqi Huang, Sirui Shen, Mengyang Wang, Weixin Li, Gaojun Wu, Weijian Huang, Wu Luo, Guang Liang
Summary: Understanding the molecular mechanisms of pathological vascular remodeling is important for treating cardiovascular diseases and complications. Recent studies have highlighted the role of deubiquitinases, specifically OTUD1, in angiotensin II-induced vascular remodeling. OTUD1 deletion attenuates the pathological changes associated with vascular remodeling, while OTUD1 overexpression aggravates these changes. Mechanistically, OTUD1 deubiquitinates and stabilizes SMAD3, promoting SMAD3/SMAD4 complex formation and nuclear translocation, ultimately leading to transcriptional regulation of genes involved in vascular EndMT and remodeling. SMAD3 inhibition reverses OTUD1-promoted vascular remodeling. These findings suggest that OTUD1 could be a potential therapeutic target for diseases related to vascular remodeling.
Article
Cardiac & Cardiovascular Systems
Zhiyuan Ma, Gayathri Viswanathan, Mason Sellig, Chanpreet Jassal, Issac Choi, Aditi Garikipati, Xinyu Xiong, Nour Nazo, Sudarshan Rajagopal
Summary: Pulmonary arterial hypertension (PAH) is a disease characterized by abnormal pulmonary vascular remodeling, with current therapies primarily benefiting through promoting pulmonary vascular reverse remodeling and vasodilation.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Yuan Li, Madhu B. Anand-Srivastava
Summary: Heterotrimeric G-proteins regulate various cellular functions through the activation of signaling mechanisms such as adenylyl cyclase/cAMP and phospholipase C (PLC)/phosphatidyl inositol (PI) turnover. Abnormal expression of Gi alpha proteins and associated abnormalities in adenylyl cyclase/cAMP levels contribute to pathological conditions including hypertension. Enhanced expression of Gi alpha proteins in vascular smooth muscle cells (VSMC) from hypertensive rats is associated with VSMC proliferation and hypertrophy, and is influenced by vasoactive peptides, oxidative stress, and signaling pathways such as MAP kinase/PI3 kinase.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stephanie Cicalese, Keiichi Torimoto, Keisuke Okuno, Katherine J. Elliott, Victor Rizzo, Tomoki Hashimoto, Satoru Eguchi
Summary: This study demonstrates that a chemical chaperone called 3HNA can prevent vascular remodeling and hypertension by preserving protein homeostasis. In a mouse model, treatment with 3HNA prevented AngII-induced hypertension and reduced vascular medial thickening and perivascular fibrosis. Additionally, 3HNA attenuated an increase in protein synthesis in AngII-stimulated vascular smooth muscle cells.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Engineering, Biomedical
Chen Wang, Changyang Xing, Zhelong Li, Yunnan Liu, Qiaoying Li, Yixiao Wang, Jiao Hu, Lijun Yuan, Guodong Yang
Summary: Arterial stiffness due to vessel remodeling is closely linked to raised blood pressure. This study explored the role of extracellular vesicle (EV) mediated intercellular communication in blood vessel remodeling under hypertension. The study revealed that the secretion of EV by arterial endothelial cells increased under hypertension, and the miRNA profile in EV changed significantly. miR-320d/423-5p showed the most significant increase, and delivery of mimics or inhibitors of miR-320d/423-5p via EV replicated or alleviated the phenotype of hypertension, respectively.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Tianyuan Song, Minzhi Zhou, Wen Li, Lin Zheng, Jianping Wu, Mouming Zhao
Summary: This study found that tripeptide LSW can exert a protective effect against endothelial dysfunction induced by oxidized low-density lipoprotein (oxLDL) by packaging miRNA-145 from vascular smooth muscle cells (VSMCs) in extracellular vesicles (EVs) and targeting programmed cell death protein 4 (PDCD4) expression in vascular endothelial cells (VECs). This reveals a novel function of LSW as a regulator of functional EVs from vascular cells in oxLDL-induced atherosclerosis.
Article
Agriculture, Multidisciplinary
Shuguang Wang, Guowan Su, Xun Zhang, Guohui Song, Lixia Zhang, Lin Zheng, Mouming Zhao
Summary: The study found that walnut protein hydrolysates (WPH) could improve memory deficits in mice by regulating the cholinergic system and oxidative stress, without obvious anti-inflammatory effects. By using peptidomics and in silico docking prediction, potential neuroprotective peptides were identified, such as FY and SGFDAE, which showed promising AchE and Keap1 inhibitory effects and neuroprotective capacity in scopolamine-induced zebrafish models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Tianyuan Song, Miao Lv, Minzhi Zhou, Mingtao Huang, Lin Zheng, Mouming Zhao
Summary: The study explored the effect of EVs produced from VSMCs on HUVECs, revealing differential gene expression associated with endothelial dysfunction. LSW can improve endothelial function by repairing miRNA expression in VSMCs, suggesting potential mechanisms for the actions of Ang II and LSW on vascular endothelial cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Rong Xu, Lin Zheng, Guowan Su, Mouming Zhao, Qing Yang, Jinmei Wang
Summary: This study investigated the protective effects of guar gum, xanthan gum, and carrageenan on the gastric digestion of pepsin-soluble undenatured type II collagen under pH 2.0. Anionic polysaccharides such as xanthan gum and carrageenan were found to improve the gastric digestive stability of SC II. Through electrostatic interaction, a small amount of carrageenan could effectively protect SC II from degradation during gastric digestion, while xanthan gum required a higher dosage for a similar protective effect.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Chuqiao Xiao, Fidel Toldra, Feibai Zhou, Leticia Mora, Lixin Luo, Lin Zheng, Donghui Luo, Mouming Zhao
Summary: This study investigates the mechanism of how KPC stabilizes ADH, revealing the conformational changes and binding interactions between KPC and ADH. The vital role of Cys residue in the bio-activity of KPC is also validated. The favorable ADMET profile suggests the potential applicability of KPC as a drug or functional food ingredient.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Qi Zhang, Lin Zheng, Guowan Su, Donghui Luo, Mingtao Huang, Yunzi Feng, Mouming Zhao
Summary: This study aimed to explore the beneficial effects and underlying mechanisms of peptide Trp-Cys-Pro-Phe-Ser-Arg-Ser-Phe (WCPFSRSF) against excitotoxicity. The results demonstrated that WCPFSRSF could repair cell membrane damage induced by glutamate and promote cell survival. Transcriptome analysis revealed that WCPFSRSF regulated cAMP-related signaling and synapse-related function. WCPFSRSF could be used as a regulator for synaptic plasticity and neurotrophic-related pathway.
Article
Food Science & Technology
Shuguang Wang, Lin Zheng, Tiantian Zhao, Qi Zhang, Guowan Su, Mouming Zhao
Summary: The study found that active peptides in defatted walnut meal hydrolysate have neuroprotective effects on glutamate-induced apoptosis in PC12 cells, possibly through activating antioxidant defense mechanisms and regulating apoptosis-related proteins.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Chemistry, Applied
Chunyan Yu, Lin Zheng, Yongjian Cai, Qiangzhong Zhao, Mouming Zhao
Summary: This study aimed to explore the desirable characteristics of casein hydrolysates with enhanced emulsion forming and antioxidative abilities. They found that casein hydrolysates prepared by trypsin at a lower degree of hydrolysis exhibited higher zeta potential absolute values, smaller particle size, and improved antioxidant properties compared to other enzymes. Peptidomics analysis indicated that the trypsin hydrolysates contained more peptides with cationic amphiphilic properties, which contributed to their better emulsion formation and inhibition of lipid oxidation ability.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Tianyuan Song, Minzhi Zhou, Wen Li, Miao Lv, Lin Zheng, Mouming Zhao
Summary: A soybean-derived vasoactive peptide (SVP) was prepared and shown to reduce blood pressure and attenuate inflammation in the aorta of spontaneous hypertensive rats (SHRs) by regulating the miRNA-19b/CYLD/TRAF6 axis.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agriculture, Multidisciplinary
Shuguang Wang, Guowan Su, Jiangping Fan, Zhichao Xiao, Lin Zheng, Mouming Zhao, Jianping Wu
Summary: The neuroprotective effect of Arg-containing peptides from walnut storage protein sequences in scopolamine-induced zebrafish was investigated in this study. The results showed that these peptides displayed potent neuroprotection through regulation of neurotransmitter levels and antioxidant enzyme activity. Furthermore, Arg-containing peptides released efficiently from walnut protein following hydrolysis and their neuroprotective capacity was confirmed. The combination of in silico hydrolysis and controlled enzymatic release was suggested as an effective approach to obtain these neuroprotective peptides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tianyuan Song, Minzhi Zhou, Wen Li, Lin Zheng, Jianping Wu, Mouming Zhao
Summary: This study found that tripeptide LSW can exert a protective effect against endothelial dysfunction induced by oxidized low-density lipoprotein (oxLDL) by packaging miRNA-145 from vascular smooth muscle cells (VSMCs) in extracellular vesicles (EVs) and targeting programmed cell death protein 4 (PDCD4) expression in vascular endothelial cells (VECs). This reveals a novel function of LSW as a regulator of functional EVs from vascular cells in oxLDL-induced atherosclerosis.
Article
Chemistry, Applied
Qiongyao Xu, Lin Zheng, Mingtao Huang, Mouming Zhao
Summary: Collagen contains abundant DPP-IV inhibitory peptide motifs, and Gly-Pro-type peptides with 4 to 9 residues exhibit potent DPP-IV inhibition. Different proteases have discrepancy in releasing these peptides.
Article
Food Science & Technology
Qi Zhang, Lin Zheng, Donghui Luo, Mingtao Huang, Yunzi Feng, Mouming Zhao
Summary: Our study revealed that WCPFSRSF can improve memory impairment induced by sleep deprivation and exert its effect by inhibiting glial cell activation and neuroinflammation.
Article
Agriculture, Multidisciplinary
Wen Li, Miao Lv, Tiantian Zhang, Minzhi Zhou, Lin Zheng, Tianyuan Song, Mouming Zhao
Summary: This study demonstrated the cardioprotective function of peptides from bovine myocardium extract. The analysis of active ingredients showed that the hydrolyzed extract contained more peptides with hydrophobic amino acids. The results suggested that the enzymatic hydrolysis extract was more effective in reducing myocardial injury compared to the water extract.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Tingting Wang, Lin Zheng, Shuguang Wang, Mouming Zhao, Xiaoling Liu
Summary: The present study investigated the anti-diabetic activity and potential mechanisms of sea cucumber gonad hydrolysates (SCGH) in a rat model of type II diabetes induced by streptozotocin (STZ) combined with high-fat diet (HFD). Results showed that SCGH significantly reduced water intake, fasting blood glucose level, and glycated hemoglobin level. Moreover, the oral glucose tolerance, insulin resistance, and plasma lipid level in diabetic rats were also alleviated. Furthermore, histological analysis showed that SCGH effectively protected the tissue structure of the liver. Mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway and promoted lipid metabolism via activating the AMPK signaling pathway.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
