Editorial Material
Oncology
Amanda R. Moore, Shiva Malek
Summary: The study found that sotorasib provides clinical benefit for KRAS p.G12C-mutated non-small-cell lung cancer (NSCLC) and provides mechanistic insights into acquired resistance to KRAS(G12C)-specific inhibition.
Article
Multidisciplinary Sciences
Pavlo Gilchuk, Isaac Thomsen, Sandra Yoder, Eric Brady, James D. Chappell, Laura J. Stevens, Mark R. Denison, Rachel E. Sutton, Rita E. Chen, Laura A. VanBlargan, Naveenchandra Suryadevara, Seth J. Zost, Jonathan Schmitz, Jill M. Pulley, Michael S. Diamond, Jillian P. Rhoads, Gordon R. Bernard, Wesley H. Self, Todd W. Rice, Allison P. Wheeler, James E. Crowe, Robert H. Carnahan
Summary: The COVID-19 pandemic has highlighted the urgent need for rapid evaluation of neutralizing antibody responses and the development of antibody-based treatments. The currently approved serological tests do not measure antibody-mediated viral neutralization, and there is a need for standardized quantitative neutralization assays. This study presents a high-throughput two-step profiling approach for identifying neutralizing convalescent plasma. Additionally, the researchers introduce a neutralizing antibody standard reagent to calibrate antibody neutralizing activity in convalescent plasma.
Review
Biochemical Research Methods
Qi Song, Xindi Sun, Ziyi Dai, Yibo Gao, Xiuqing Gong, Bingpu Zhou, Jinbo Wu, Weijia Wen
Summary: COVID-19 is an acute respiratory disease caused by SARS-CoV-2 with high transmissibility, severe cases can lead to death. Currently, RT-PCR is the primary diagnostic method, yet POCT offers advantages of ease of use and timely detection, reducing the testing burden on central hospitals and facilitating early detection and treatment.
Article
Business
Petra A. Nylund, Alexander Brem
Summary: Digital platforms are changing economies and societies, challenging democratic institutions, and requiring an understanding of their development. Our research focuses on the impact of dominant platforms on standardization in innovation ecosystems at various levels. We found that ecosystem-based standardization accelerates innovation and enhances synergies, but also creates power asymmetry with implications for regulations and institutions.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Article
Psychology, Multidisciplinary
Danielle M. Dick
Summary: Human genetics is rapidly advancing, allowing comprehensive scanning of the genome and identification of specific variants associated with various outcomes. Large research teams are analyzing data from hundreds of thousands to millions of individuals to uncover genes related to underlying processes. However, rapid progress also brings ethical, social, and legal challenges, requiring increased public understanding of the influence of genes on behavioral outcomes and greater diversity in the field of genetics.
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jinyoung Lee, Matthieu Schapira
Summary: The study compared the selectivity profiles of four chemical probes and their respective negative controls, finding that chemical modifications neutralizing the charge can result in up to 80% of known off-targets being inactive against the control. Careful selection of negative controls for chemical probes is emphasized, and it is best practice to verify that two unrelated chemical probes targeting the same protein elicit the same phenotype.
ACS CHEMICAL BIOLOGY
(2021)
Review
Immunology
Zongwei Liu, Ting Meng, Xiaofang Tang, Ran Tian, Weijiang Guan
Summary: The long-term pandemic of COVID-19 calls for accurate diagnostic assays. Aggregation-induced emission (AIE) luminogens show potential in enhancing detection sensitivity in both nucleic acid and immunological assays.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Multidisciplinary Sciences
Miriam Merad, Catherine A. Blish, Federica Sallusto, Akiko Iwasaki
Summary: Considerable research effort has been focused on deciphering the immune response to SARS-CoV-2 infections and understanding the pathophysiology of COVID-19, including Long Covid syndrome. The hope is that knowledge gained from this research will be applied to studies of inflammatory processes in critical and chronic illnesses in the future.
Article
Biochemistry & Molecular Biology
David S. Khoury, Steffen S. Docken, Kanta Subbarao, Stephen J. Kent, Miles P. Davenport, Deborah Cromer
Summary: Booster vaccination is necessary to combat waning immunity and variants of SARS-CoV-2. Data on neutralization titers from multiple sources suggest that using ancestral vaccines can enhance protection against symptomatic and severe disease caused by variant viruses. Variant-modified vaccines may provide additional benefits. This study provides evidence-based guidance for future COVID-19 vaccine regimens.
Letter
Medicine, General & Internal
Juan P. Jaworski, Jens D. Lundgren, H. Clifford Lane, James D. Neaton
Summary: The study on rhesus macaques showed that monoclonal antibodies can penetrate infected tissues, suggesting that there may be other factors contributing to the lack of benefit of bamlanivimab in patients with Covid-19.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Chemistry, Analytical
Olena Filchakova, Dina Dossym, Aisha Ilyas, Tamila Kuanysheva, Altynay Abdizhamil, Rostislav Bukasov
Summary: More than six billion tests for COVID-19 have been conducted worldwide. This article emphasizes the importance of testing for the SARS-CoV-2 virus and corresponding human antibodies, not only for medical diagnosis and treatment, but also for economic and social activities. The review discusses the parameters of these tests and compares different detection methods. While RT-PCR remains the gold standard, there is a need for alternative methods that are less expensive and more accessible.
Article
Multidisciplinary Sciences
Gayatri Amirthalingam, Jamie Lopez Bernal, Nick J. Andrews, Heather Whitaker, Charlotte Gower, Julia Stowe, Elise Tessier, Sathyavani Subbarao, Georgina Ireland, Frances Baawuah, Ezra Linley, Lenesha Warrener, Michelle O'Brien, Corinne Whillock, Paul Moss, Shamez N. Ladhani, Kevin E. Brown, Mary E. Ramsay
Summary: The UK extended the interval between COVID-19 vaccine doses to 12 weeks, leading to higher antibody levels and estimated greater vaccine effectiveness. This study highlights the importance of an extended vaccine schedule in enhancing protection against COVID-19.
NATURE COMMUNICATIONS
(2021)
Letter
Medicine, General & Internal
Arturo Casadevall, Michael J. Joyner, Liise-anne Pirofski
Summary: Research indicates that the antiviral activity of the monoclonal antibody LY-CoV555 was highest at the middle dose when treating patients with Covid-19. Additionally, there may be a correlation between dosage and efficacy, suggesting the possibility of dosage-dependent effects on the monoclonal antibody's efficacy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Paola de Candia, Francesco Prattichizzo, Silvia Garavelli, Rosalba La Grotta, Annunziata De Rosa, Agostina Pontarelli, Roberto Parrella, Antonio Ceriello, Giuseppe Matarese
Summary: The study results indicate that the use of convalescent plasma in early stages of COVID-19 can significantly reduce mortality, but its effectiveness is not significant in severe or critical conditions. Additionally, plasma with high antibody titers does not increase the benefit in reducing mortality.
Article
Virology
Se-Min Hwang, Yun Jung, Jiyeon Seo, Yoomi Jung, Shinae Park, Haesook Seo
Summary: This study evaluated a rapid detection kit for screening the vaccine response in homeless individuals. The results showed weak agreement between the rapid antibody test and confirmatory testing. However, it can be used as a screening tool for homeless individuals who received heterologous boost vaccination.
