期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 579, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.119161
关键词
Oligofucoidan; Chitosan; Self-assembled; Nanoparticles; Radioprotection
资金
- Ministry of Science and Technology of the Republic of China (Taiwan) [MOST 105-2221-E-011-151-MY3, 105-2221-E-011-133-MY3]
- National Taiwan University of Science and Technology [TMU-NTUST-104-10, TMU-NTUST-105-07, TMU-NTUST-106-06]
- National Taiwan University [TMU-NTUST-104-10, TMU-NTUST-105-07, TMU-NTUST-106-06]
- Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital [10908, 10909]
- Hi-Q Marine Biotech International Ltd., New Taipei City, Taiwan
- Taipei Medical University [TMU-NTUST-104-10, TMU-NTUST-105-07, TMU-NTUST-106-06]
Fucoidan, a sulphated polysaccharide, plays a vital role in reducing cellular oxidative damage by exerting potential antioxidant activity. However, because of the negative surface charges of oligofucoidan, it shows poor oral intestinal absorption. To overcome this drawback, the oligofucoidan polysaccharides self-assembled with opposite charge based polysaccharides (chitosan) to form the chitosan-fucoidan polysaccharides (C-1-F3P) nanoparticles (NPs) of 190-230 nm in size. The oligofucoidan and C-1-F3P NPs were studied for their radioprotective property using mice exposed to 5 Gy radiation. The C-1-F3P NPs prevents radiation induced lipid peroxidation and restores intestinal enzymatic and non-enzymatic antioxidants (p < 0.05) status. In addition, hematoxylin-eosin staining revealed the radioprotective effect of oligofucoidan and C-1-F3P NPs by mitigating the loss of crypt and villi in the small intestine. Thus, the present study demonstrated that C-1-F3P NPs can be considered as a radioprotective agent that can be used for the prevention and treatment of Gy-radiation-induced intestine injury.
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