Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice

Amyloid-β Immunotherapy for Alzheimer's Disease - Is It Now A Long Shot…?

(2019) Francesco Panza et al.   ANNALS OF NEUROLOGY

Review of Current Strategies for Delivering Alzheimer’s Disease Drugs across the Blood-Brain Barrier

(2019) Ka Wong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent Expansions on Cellular Models to Uncover the Scientific Barriers Towards Drug Development for Alzheimer’s Disease

(2019) Sunil Kumar Dubey et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Recent expansions of novel strategies towards the drug targeting into the brain

(2019) Amit Alexander et al.   International Journal of Nanomedicine

Studies on the Neuroprotection of Osthole on Glutamate-Induced Apoptotic Cells and an Alzheimer’s Disease Mouse Model via Modulation Oxidative Stress

(2019) Qiubo Chu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma

(2019) Sushant Lakkadwala et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery

(2019) Yunxin Xiao et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress

(2019) Fei Li et al.   LIFE SCIENCES

Transferrin Modified Dioscin Loaded PEGylated Liposomes: Characterization and In Vitro Antitumor Effect

(2019) Yuanyuan Wang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease

(2018) Fangfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region

(2018) Mukta Agrawal et al.   Expert Opinion on Drug Delivery

Modulation of the intrinsic neuronal excitability by multifunctional liposomes tailored for the treatment of Alzheimer's disease

(2018) Anna Binda et al.   International Journal of Nanomedicine

Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability

(2018) Wei Xiao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

(2018) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Development and characterization of morin hydrate-loaded micellar nanocarriers for the effective management of Alzheimer’s disease

(2018) Manpreet Singh et al.   JOURNAL OF MICROENCAPSULATION

The ability of liposomes, tailored for blood–brain barrier targeting, to reach the brain is dramatically affected by the disease state

(2018) Roberta Dal Magro et al.   Nanomedicine

Boosted Memory and Improved Brain Bioavailability of Rivastigmine: Targeting Effort to the Brain Using Covalently Tethered Lower Generation PAMAM Dendrimers with Lactoferrin

(2018) Avinash Gothwal et al.   MOLECULAR PHARMACEUTICS

Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways

(2018) Ke-Wei Chang et al.   NEUROCHEMISTRY INTERNATIONAL

Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease

(2018) Jing Sun et al.   BIOMATERIALS

Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines

(2018) Adel A. Gomaa et al.   BIOMEDICINE & PHARMACOTHERAPY

Liposome delivery systems for the treatment of Alzheimer’s disease

(2018) Callum Ross et al.   International Journal of Nanomedicine

Pseudoginsenoside-F11 alleviates cognitive deficits and Alzheimer’s disease-type pathologies in SAMP8 mice

(2018) Zhen Zhang et al.   PHARMACOLOGICAL RESEARCH

Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer's disease

(2018) Qian Guo et al.   Acta Pharmaceutica Sinica B

Multifunctional LUV liposomes decorated for BBB and amyloid targeting - B. In vivo brain targeting potential in wild-type and APP/PS1 mice

(2017) Konstantina Papadia et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Multifunctional liposomes delay phenotype progression and prevent memory impairment in a presymptomatic stage mouse model of Alzheimer disease

(2017) Simona Mancini et al.   JOURNAL OF CONTROLLED RELEASE

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

(2017) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Lychee Seed Saponins Improve Cognitive Function and Prevent Neuronal Injury via Inhibiting Neuronal Apoptosis in a Rat Model of Alzheimer’s Disease

(2017) Xiuling Wang et al.   Nutrients

Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice

(2017) Shao-Heng Li et al.   Frontiers in Neuroscience

Tat-haFGF 14–154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway

(2017) Tian Meng et al.   Molecular Therapy-Nucleic Acids

Penetratin Peptide-Functionalized Gold Nanostars: Enhanced BBB Permeability and NIR Photothermal Treatment of Alzheimer’s Disease Using Ultralow Irradiance

(2016) Tiantian Yin et al.   ACS Applied Materials & Interfaces

Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability

(2016) Songhua Xiao et al.   BIOMATERIALS

Transferrin liposomes of docetaxel for brain-targeted cancer applications: formulation and brain theranostics

(2016) Sonali et al.   DRUG DELIVERY

Subchronic exposure of benzo(a)pyrene interferes with the expression of Bcl-2, Ki-67, C-myc and p53, Bax, Caspase-3 in sub-regions of cerebral cortex and hippocampus

(2016) Jianlong He et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Transferrin-modified liposome promotes α-mangostin to penetrate the blood–brain barrier

(2016) Zhi-Lan Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Osthole Protects Bone Marrow-Derived Neural Stem Cells from Oxidative Damage through PI3K/Akt-1 Pathway

(2016) Yu-hui Yan et al.   NEUROCHEMICAL RESEARCH

Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer’s disease

(2016) Yanan Jiao et al.   NEUROPHARMACOLOGY

Development and optimization of transferrin-conjugated nanostructured lipid carriers for brain delivery of paclitaxel using Box–Behnken design

(2016) Jaber Emami et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models

(2015) Yvonne Bouter et al.   ACTA NEUROPATHOLOGICA

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury

(2015) Yang Xia et al.   Journal of Neuroinflammation

Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer—An in Vitro Model for Blood-Brain Barrier Permeability

(2015) Yan-Fang Yang et al.   MOLECULES

Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice

(2015) Chi-Wen Yeh et al.   NEUROBIOLOGY OF AGING

Liposomes, modified with PTDHIV-1 peptide, containing epirubicin and celecoxib, to target vasculogenic mimicry channels in invasive breast cancer

(2014) Rui-Jun Ju et al.   BIOMATERIALS

Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma

(2014) Xiu-Ying Li et al.   BIOMATERIALS

Multifunctional liposomes for nasal delivery of the anti-Alzheimer drug tacrine hydrochloride

(2014) Giuseppe Corace et al.   JOURNAL OF LIPOSOME RESEARCH

Neuroprotection Against Degeneration of SK-N-MC Cells Using Neuron Growth Factor-Encapsulated Liposomes with Surface Cereport and Transferrin

(2014) Yung-Chih Kuo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glioma targeting and blood–brain barrier penetration by dual-targeting doxorubincin liposomes

(2013) Jian-Qing Gao et al.   BIOMATERIALS

Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide

(2011) Francesca Re et al.   JOURNAL OF BIOTECHNOLOGY