Article
Chemistry, Multidisciplinary
Mungyo Jung, Hyeongseop Kim, Jung Won Hwang, Yejoo Choi, Mikyung Kang, Cheesue Kim, Jihye Hong, Na Kyung Lee, Sangjun Moon, Jong Wook Chang, Suk-joo Choi, Soo-young Oh, Byung-Soo Kim, Duk L. Na, Hyemin Jang
Summary: Alzheimer's disease (AD) is a complex neurodegenerative disease with limited treatment options. Mesenchymal stem cell (MSC) therapy, with its ability to target multiple pathological mechanisms, has recently emerged as a potential novel treatment. However, the low brain retention efficiency of MSCs and the limited therapeutic abilities of autologous MSCs pose challenges to their effectiveness. In this study, we developed iron oxide nanoparticle (IONP)-incorporated human Wharton's jelly-derived MSCs (MSC-IONPs) to enhance their therapeutic potential. With the use of magnetic guidance, MSC-IONPs showed higher brain retention efficiency, leading to improved therapeutic efficacy in murine models of AD. Furthermore, allogeneic MSCs derived from human Wharton's jelly may offer superior therapeutic abilities compared to autologous MSCs in aged AD patients. This study provides a promising strategy for the development of MSC therapies for AD.
Article
Biochemistry & Molecular Biology
Karolina H. Markiewicz, Katarzyna Niemirowicz-Laskowska, Dawid Szymczuk, Kacper Makarewicz, Iwona Misztalewska-Turkowicz, Przemyslaw Wielgat, Anna M. Majcher-Fitas, Sylwia Milewska, Halina Car, Agnieszka Z. Wilczewska
Summary: One promising strategy for improving cancer treatment is combination therapy, such as the use of nanoformulations containing doxorubicin and iron oxide particles covered with polymeric shells for anti-cancer activity. The study showed that the developed systems effectively inhibited human breast cancer cell growth even at low doses, while demonstrating high compatibility and lack of toxicity against various cell lines. Synergistic effects were observed with the polymer-iron oxide hybrids, suggesting potential for reducing drug toxicity and enhancing therapeutic efficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiaoying Ma, Jingyun Chen, Jiajun Liu, Baixue Xu, Xinyu Liang, Xiaotong Yang, Yun Feng, Xin Liang, Jianwen Liu
Summary: In cancer treatment, mesenchymal stem cells (MSCs) exhibit tropism towards colon cancer stem cells (CCSCs), particularly CD133(+)/CD44(+) cells. When recruited by CCSCs, BMSCs transform into cancer-associated fibroblasts and secrete more IL-8, resulting in increased stemness of CCSCs. Targeting the IL-8/CXCR2 pathway in BMSCs could potentially improve therapy targeting CCSCs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ai Li, Tianyuan Zhang, Ting Huang, Ruyi Lin, Jiafu Mu, Yuanqin Su, Hao Sun, Xinchi Jiang, Honghui Wu, Donghang Xu, Hongcui Cao, Xiaoyi Sun, Daishun Ling, Jianqing Gao
Summary: In this study, gene transfection using magnetosome-like ferrimagnetic iron oxide nanochains (MFIONs) achieved high expression of HSV-tk in MSCs and promoted gap junction intercellular communication (GJIC) between MSCs and tumor cells, leading to significantly inhibited growth of glioma through an improved bystander effect. The results suggest that iron oxide nanoparticles have the potential to enhance suicide gene expression levels in MSCs and improve the sensitivity of glioma cells to HSV-tk/GCV suicide gene therapy.
Article
Biochemistry & Molecular Biology
Ana S. Serras, Sergio P. Camoes, Bernardo Antunes, Vera M. Costa, Flavio Dionisio, Volkan Yazar, Rui Vitorino, Fernando Remiao, Matilde Castro, Nuno G. Oliveira, Joana P. Miranda
Summary: The study found that the MSC secretome under 3D conditions (CM3D) can alleviate Dox-induced cytotoxicity in non-tumor cells without compromising the chemotherapy effect on malignant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Donghang Xu, Yuanqin Su, Qianhao Xu, Ting Huang, Zhilan Chen, Tianyuan Zhang
Summary: In this study, a magnetic gene complex was prepared for gene delivery to BM-MSCs. The use of UIONPs promoted gene delivery to BM-MSCs through magnetic force. Lowering the N/P ratio of free PEI reduced cytotoxicity to BM-MSCs without affecting transgene expression levels. Magnetic gene delivery enhances gene expression and reduces the required amount of PEI, providing a potential strategy for efficient and safe gene delivery to stem cells.
Article
Medicine, Research & Experimental
Weiqian Hu, Weijun Wang, Xin Jiang, Zeyu Wang, Rong Lin
Summary: This study investigates the potential role and mechanisms of bone marrow-derived MSCs in colitis-associated colon cancer. Early administration of MSCs inhibits the occurrence of CAC by decreasing inflammatory cytokines and inducing Treg infiltration via TGF-beta. Late administration promotes the progression of CAC by inducing a shift in Th1/Th2 immune balance to Th2 through IL-4 secretion. The immune balance influenced by MSCs can be reversed by IL-12.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Rolla Al-Shalabi, Rana Abu-Huwaij, Rania Hamed, Manal M. Abbas
Summary: This study demonstrated the successful synthesis of greenly synthesized iron oxide nanoparticles (IONPs) from Spinacia oleracea leaf extract, coated with polyethylene glycol (PEG) and conjugated with doxorubicin (DOX). The combination of PEGylation and DOX conjugation significantly improved the cytotoxic activity of IONPs on triple-negative breast cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Chemical
Ncobile Bagezile Mdlovu, Kuen-Song Lin, Meng-Tzu Weng, Ndumiso Vukile Mdlovu
Summary: The study aimed to synthesize nanocarriers for doxorubicin delivery in liver cancer treatment, overcoming the limitations of chemotherapy. The results demonstrated high biocompatibility and significant reduction in cancer cell viability upon drug conjugation, with additional decrease observed when exposed to an external magnetic field.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Elisa Parcero Hernandes, Raquel Dosciatti Bini, Karina Midori Endo, Verci Alves de Oliveira Junior, Igor Vivian de Almeida, Gustavo Sanguino Dias, Ivair Aparecido dos Santos, Paula Nunes de Oliveira, Veronica Elisa Pimenta Vicentini, Luiz Fernando Cotica
Summary: This study investigates the biocompatibility of magnetic nanoparticles as a drug carrier system, showing that NP-Fe3O4/SiO2 and NP-Fe3O4 have high cell viability against breast adenocarcinoma cells (MCF-7) and can potentially be used for treating breast cancer.
Article
Medicine, Research & Experimental
Ramazan Rezaei, Kaveh Baghaei, Davar Amani, Andrea Piccin, Seyed Mahmoud Hashemi, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
Summary: This study demonstrated that tumor-derived exosomes can efficiently deliver miR-375 mimic to reverse the EMT process, inhibiting invasion and migration of cancer cells. TEXomiR also alleviated cell phenotype changes and reduced the expression of CD44 and CD133 in the EMT process.
Review
Cell Biology
Kosha J. Mehta
Summary: Mesenchymal stem cells (MSCs) play a valuable role in cell-based therapy for various pathological conditions, but iron-loading can hinder their functionality and impact both allogeneic and autologous MSC therapy. Understanding MSC biology from an iron perspective is clinically significant, highlighting the importance of iron regulation for MSC physiology in health and disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marco Franchi, Konstantinos-Athanasios Karamanos, Concettina Cappadone, Natalia Calonghi, Nicola Greco, Leonardo Franchi, Maurizio Onisto, Valentina Masola
Summary: The study aimed to understand the behavior of colon cancer cells during the initial steps of extracellular matrix invasion. The results showed that different types and concentrations of matrix substrates can affect the expression of genes and phenotypes in colon cancer cells, while drug-resistant cells exhibited weaker invasion ability.
Article
Chemistry, Physical
Yu-Jin Kim, Jaeyoung Lee, Gwang-Bum Im, Jihun Song, Jiwoo Song, Jiyong Chung, Taekyung Yu, Suk Ho Bhang
Summary: In this study, a dual therapeutic metal ion-releasing nanoparticle was developed to enhance osteogenic differentiation of stem cells and induce angiogenesis. Zinc and iron were synthesized together into a nanoparticle with a pH-sensitive degradation property to promote osteogenic gene expression and angiogenic factor secretion for human mesenchymal stem cells.
Article
Cell Biology
Jun Yan, Te Liu, Yang Li, Jun Zhang, Bo Shi, Fuqiang Zhang, Xuejia Hou, Xiaowen Zhang, Wanxing Cui, Jing Li, Hua Yao, Xiuying Li, Yufei Gao, Jinlan Jiang
Summary: This study presents a magnetic targeting technique for the transplantation of a large number of cells into the affected brain area, which can be used as a potential therapy for cerebral infarction.
