The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk

(2019) Ajaz A. Bhat et al.   Frontiers in Physiology

Wnt signaling in intestinal inflammation

(2019) Lavanya Moparthi et al.   DIFFERENTIATION

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

(2019) W. Vallen Graham et al.   NATURE MEDICINE

Naringin attenuates MLC phosphorylation and NF-κB activation to protect sepsis-induced intestinal injury via RhoA/ROCK pathway

(2018) Zhiling Li et al.   BIOMEDICINE & PHARMACOTHERAPY

OTA induces intestinal epithelial barrier dysfunction and tight junction disruption in IPEC-J2 cells through ROS/Ca 2+ -mediated MLCK activation

(2018) Hong Wang et al.   ENVIRONMENTAL POLLUTION

Systems level expression correlation of Ras GTPase regulators

(2018) E. Besray Unal et al.   Cell Communication and Signaling

Therapeutic potentials of the Rho kinase inhibitor Fasudil in experimental autoimmune encephalomyelitis and the related mechanisms

(2018) Yuqing Yan et al.   METABOLIC BRAIN DISEASE

The Claudins: From Tight Junctions to Biological Systems

(2018) Sachiko Tsukita et al.   TRENDS IN BIOCHEMICAL SCIENCES

Contributions of intestinal epithelial barriers to health and disease

(2017) Wangsun Choi et al.   EXPERIMENTAL CELL RESEARCH

Interplay between tight junctions & adherens junctions

(2017) Hannah K. Campbell et al.   EXPERIMENTAL CELL RESEARCH

Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function

(2017) Torey R. Arnold et al.   EXPERIMENTAL CELL RESEARCH

Complementary Roles of Nod2 in Hematopoietic and Nonhematopoietic Cells in Preventing Gut Barrier Dysfunction Dependent on MLCK Activity

(2017) Ziad Al Nabhani et al.   INFLAMMATORY BOWEL DISEASES

Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-κB pathway

(2017) Yanting Zou et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease

(2017) Aaron Buckley et al.   Cold Spring Harbor Perspectives in Biology

Interactions of Intestinal Bacteria with Components of the Intestinal Mucus

(2017) Jean-Félix Sicard et al.   Frontiers in Cellular and Infection Microbiology

Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases

(2017) Yongjian Xiong et al.   Frontiers in Pharmacology

Beyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport

(2016) Jeremy R. Herrmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury

(2016) Younggeon Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression

(2016) Richard L Wu et al.   LABORATORY INVESTIGATION

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Polycomb Repressive Complex 2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or Neoplasia

(2016) Mikko Oittinen et al.   STEM CELLS

Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability

(2016) Lijun Du et al.   Gastroenterology Research and Practice

Prevalence of Inflammatory Bowel Disease Among Adults Aged ≥18 Years — United States, 2015

(2016) James M. Dahlhamer et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

E-cadherin can limit the transforming properties of activating  -catenin mutations

(2015) D. J. Huels et al.   EMBO JOURNAL

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

(2015) Andrea Michielan et al.   MEDIATORS OF INFLAMMATION

The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease

(2015) Svenja Hartmann et al.   Frontiers in Pharmacology

E-cadherin's role in development, tissue homeostasis and disease: Insights from mouse models

(2014) Marlon R. Schneider et al.   BIOESSAYS

CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors

(2014) R. Sakamori et al.   CANCER RESEARCH

Non-muscle Mlck is required for  -catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1 -mediated barrier dysfunction in brain endothelial cells

(2014) R. S. Beard et al.   JOURNAL OF CELL SCIENCE

Alteration of Tight Junction Gene Expression in Celiac Disease

(2014) Amaia Jauregi-Miguel et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling

(2014) Masatoshi Takeichi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RhoGTPases, actomyosin signaling and regulation of the Epithelial Apical Junctional Complex

(2014) Miguel Quiros et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of molecular remodeling in differential regulation of tight junction permeability

(2014) Jerrold R. Turner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells

(2014) S.-i. Kitajiri et al.   Biology Open

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

The N and C Termini of ZO-1 Are Surrounded by Distinct Proteins and Functional Protein Networks

(2013) Christina M. Van Itallie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

National estimates of the burden of inflammatory bowel disease among racial and ethnic groups in the United States

(2013) Geoffrey C. Nguyen et al.   Journal of Crohns & Colitis

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

(2013) Mary M. Buschmann et al.   MOLECULAR BIOLOGY OF THE CELL

The Role for Dickkopf-Homolog-1 in the Pathogenesis of Crohn’s Disease-Associated Fistulae

(2013) Sandra Michaela Frei et al.   PLoS One

Selective ROCK2 inhibition in focal cerebral ischemia

(2013) Jeong Hyun Lee et al.   Annals of Clinical and Translational Neurology

Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury

(2012) Anita Zahs et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Myosin light chain kinase: pulling the strings of epithelial tight junction function

(2012) Kevin E. Cunningham et al.   Annals of the New York Academy of Sciences

Rho family GTPases

(2012) Alan Hall   BIOCHEMICAL SOCIETY TRANSACTIONS

Intestinal Epithelial Barrier Dysfunction in Disease and Possible Therapeutical Interventions

(2012) R.-M. Catalioto et al.   CURRENT MEDICINAL CHEMISTRY

E-cadherin is required for intestinal morphogenesis in the mouse

(2012) Benjamin J. Bondow et al.   DEVELOPMENTAL BIOLOGY

Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition

(2012) Masami Wada et al.   GASTROENTEROLOGY

Regulation of ROCK Activity in Cancer

(2012) Marie Morgan-Fisher et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Effect of the myosin light chain kinase inhibitor ML-7 on the proteome of hearts subjected to ischemia–reperfusion injury

(2012) Han-bin Lin et al.   Journal of Proteomics

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myosin Light Chain Kinase Mediates Intestinal Barrier Disruption following Burn Injury

(2012) Chuanli Chen et al.   PLoS One

Cooperative Anti-Invasive Effect of Cdc42/Rac1 Activation and ROCK Inhibition in SW620 Colorectal Cancer Cells with Elevated Blebbing Activity

(2012) Marion de Toledo et al.   PLoS One

Comparative tight junction protein expressions in colonic Crohn’s disease, ulcerative colitis, and tuberculosis: a new perspective

(2012) Prasenjit Das et al.   VIRCHOWS ARCHIV

The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1

(2012) Annica Vlad-Fiegen et al.   FEBS Open Bio

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

Claudins: Control of Barrier Function and Regulation in Response to Oxidant Stress

(2011) Christian E. Overgaard et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of p115RhoGEF in lipopolysaccharide-induced mouse brain microvascular endothelial barrier dysfunction

(2011) Deng Xiaolu et al.   BRAIN RESEARCH

RhoA and NF-κB are involved in lipopolysaccharide-induced brain microvascular cell line hyperpermeability

(2011) F. He et al.   NEUROSCIENCE

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

(2011) Jiří Paleček et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

MicroRNA-449a Overexpression, Reduced NOTCH1 Signals and Scarce Goblet Cells Characterize the Small Intestine of Celiac Patients

(2011) Marina Capuano et al.   PLoS One

Control of polarized cell morphology and motility by adherens junctions

(2011) Sandrine Etienne-Manneville   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation

(2010) L. Libusova et al.   DEVELOPMENT

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

(2010) Atsushi Tamura et al.   GASTROENTEROLOGY

Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease

(2010) Dorottya Nagy Szakál et al.   VIRCHOWS ARCHIV

Roles of ZO-1 and ZO-2 in Establishment of the Belt-like Adherens and Tight Junctions with Paracellular Permselective Barrier Function

(2009) Sachiko Tsukita et al.   Annals of the New York Academy of Sciences

Celiac Disease: From Pathogenesis to Novel Therapies

(2009) Detlef Schuppan et al.   GASTROENTEROLOGY

Involvement of the Interaction of Afadin with ZO-1 in the Formation of Tight Junctions in Madin-Darby Canine Kidney Cells

(2009) Takako Ooshio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth

(2009) Michael R. Dohn et al.   JOURNAL OF CELL BIOLOGY

Molecular components of the adherens junction

(2008) Carien M. Niessen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

(2008) Liping Su et al.   GASTROENTEROLOGY

A p120 Catenin Isoform Switch Affects Rho Activity, Induces Tumor Cell Invasion, and Predicts Metastatic Disease

(2008) Masahiro Yanagisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKC and MLCK-Dependent, Cytokine-Induced Rat Coronary Endothelial Dysfunction

(2008) John H. Tinsley et al.   JOURNAL OF SURGICAL RESEARCH

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

(2008) Andrea Taddei et al.   NATURE CELL BIOLOGY

New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity

(2008) C. L. Tinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk of tight junction components with signaling pathways

(2007) Lorenza González-Mariscal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Stimulus-induced reorganization of tight junction structure: The role of membrane traffic

(2007) Dan Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES