Akkermansia muciniphila Aspartic Protease Amuc_1434* Inhibits Human Colorectal Cancer LS174T Cell Viability via TRAIL-Mediated Apoptosis Pathway

Elucidation of Akkermansia muciniphila Probiotic Traits Driven by Mucin Depletion

(2019) Jongoh Shin et al.   Frontiers in Microbiology

Akkermansia muciniphila is a promising probiotic

(2019) Ting Zhang et al.   Microbial Biotechnology

Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells

(2019) Anna Willms et al.   PLoS One

A Purified Aspartic Protease from Akkermansia Muciniphila Plays an Important Role in Degrading Muc2

(2019) Xin Meng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amygdalin, from Apricot Kernels, Induces Apoptosis and Causes Cell Cycle Arrest in Cancer Cells: An Updated Review

(2018) Mohammad Saleem et al.   Anti-Cancer Agents in Medicinal Chemistry

Mucin Expression in Colorectal Cancer (CRC)

(2018) Yaron Niv et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Fight them or feed them: how the intestinal mucus layer manages the gut microbiota

(2018) Bjoern O Schroeder   Gastroenterology Report

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53

(2017) Chunping Yao et al.   MEDICAL SCIENCE MONITOR

Development and progression of colorectal neoplasia

(2017) Upender Manne et al.   Cancer Biomarkers

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis

(2016) Kai Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling

(2016) Mingzuo Jiang et al.   Oncotarget

Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer

(2015) Justus Reunanen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biochemical characterisation of the neuraminidase pool of the human gut symbiont Akkermansia muciniphila

(2015) Kun Huang et al.   CARBOHYDRATE RESEARCH

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

(2015) Manish Kumar et al.   CYTOTECHNOLOGY

p53mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation

(2015) Xiao-Lan Li   WORLD JOURNAL OF GASTROENTEROLOGY

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator

(2014) Stephen Jun Fei Chong et al.   MITOCHONDRION

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

C-Reactive Protein Downregulates TRAIL Expression in Human Peripheral Monocytes via an Egr-1-Dependent Pathway

(2013) P. Secchiero et al.   CLINICAL CANCER RESEARCH

Novel drug discovery opportunities for colorectal cancer

(2013) Joshua C Curtin   Expert Opinion on Drug Discovery

Regulation of the Src-PP2A Interaction in Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis

(2013) Jing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Targets of TRAIL-Sensitizing Agents in Colorectal Cancer

(2012) Carmine Stolfi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative stress and heart failure

(2011) Hiroyuki Tsutsui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Cisplatin Restores TRAIL Apoptotic Pathway in Glioblastoma-Derived Stem Cells through Up-regulation of DR5 and Down-regulation of c-FLIP

(2011) Lijuan Ding et al.   CANCER INVESTIGATION

Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells

(2011) Jing Zhao et al.   CANCER LETTERS

The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes

(2011) Mark W. J. van Passel et al.   PLoS One

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

(2010) Chin Wen Png et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Trypsin-like protease-active extracellular protein extracts from Porphyromonas gingivalis ATCC 33277 induce apoptosis in bovine aortic endothelial cells

(2010) N. Tian et al.   JOURNAL OF PERIODONTAL RESEARCH

Genetic determinants at the interface of cancer and neurodegenerative disease

(2010) L G T Morris et al.   ONCOGENE

Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism

(2009) Panagiota G Stathopoulou et al.   BMC MICROBIOLOGY

TRAIL as a target in anti-cancer therapy

(2009) Gen Sheng Wu   CANCER LETTERS

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Combined treatment with lexatumumab and irradiation leads to strongly increased long term tumour control under normoxic and hypoxic conditions

(2009) Patrizia Marini et al.   Radiation Oncology