Article
Cardiac & Cardiovascular Systems
Wenzhu Li, Chase W. Kessinger, Makoto Orii, Hang Lee, Lang Wang, Ido Weinberg, Michael R. Jaff, Guy L. Reed, Peter Libby, Ahmed Tawakol, Peter K. Henke, Farouc A. Jaffer
Summary: The study found that RBF can reduce thrombus burden parameters and vein wall fibrosis and inflammation in mice on day 4 but not later. In the clinical study, PCDT demonstrated maximal benefits in improving quality of life and symptom scores for patients with symptom-onset-to-randomization timeframes of 4 to 8 days.
Article
Hematology
Axel Rosell, Gargi Gautam, Fredrika Wannberg, Henry Ng, Hanna Gry, Emma Vingback, Staffan Lundstrom, Nigel Mackman, Hakan Wallen, Eli Westerlund, Charlotte Thalin
Summary: This study found that H3Cit-DNA is an independent predictor for occult cancer in patients with VTE and is elevated in cancer-associated VTE. This suggests that H3Cit-DNA may be a useful diagnostic marker for cancer in patients with VTE and that elevated NET formation is a hallmark of cancer-associated VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Fisheries
Neila Alvarez de Haro, Andre P. Van, Calum T. Robb, Adriano G. Rossi, Andrew P. Desbois
Summary: This study investigated the release of extracellular traps (ETs) by immune cells of Atlantic salmon, revealing significant stimulation of ET release by calcium ionophore and the fish pathogenic bacterium A. salmonicida. Microscopic observations showed bacteria associated with ETs, with reduced bacterial colonies recovered after co-incubation with neutrophils induced to release ETs. Interestingly, spontaneous ET release was inversely associated with fish mass, indicating a potential role in innate immunity and host-pathogen interaction in protecting against infectious diseases in cultured stocks.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Rainer Kaiser, Raphael Escaig, Johanna Erber, Leo Nicolai
Summary: Neutrophils and platelets, two abundant cell types in peripheral blood, play important roles in immune responses and clot formation in cardiovascular diseases. This review describes their physical interactions, the impact of release of granule contents on each other, and their contribution to thromboinflammation in COVID-19. Targeting neutrophil-platelet interactions may provide a novel treatment strategy in cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Jingrui Sui, Ruinan Lu, Konstantine Halkidis, Nicole K. Kocher, Wenjing Cao, Marisa B. Marques, X. Long Zheng
Summary: The study demonstrates that plasma levels of S100A8/A9, histone/DNA complexes, and cfDNA are significantly increased in acute iTTP patients, and are associated with disease severity and mortality.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Huijie Wang, Mary Cushman, Frits R. Rosendaal, Astrid van Hylckama Vlieg
Summary: This study found that a remote history of venous thrombosis (VT) is associated with an increased risk of VT in older individuals, providing valuable information for clinicians to advise patients on VT prevention.
Article
Hematology
Nirav Dhanesha, Manish Jain, Prakash Doddapattar, Anetta Undas, Anil K. Chauhan
Summary: The study found that cellular Fn-EDA levels were significantly elevated in VTE patients’ plasma and positively correlated with body mass index. HF diet increased DVT susceptibility in WT mice, while Fn-EDA-deficient mice exhibited reduced thrombus weight and incidence of DVT.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Bruna de Moraes Mazetto, Bidossessi Wilfried Hounkpe, Sabrina da Silva Saraiva, Gislaine Vieira-Damiani, Ana Paula Rosa dos Santos, Bruna Cardoso Jacinto, Camila de Oliveira Vaz, Gabriela Tripiquia Vechiatto Mesquita, Joyce Maria Annichino-Bizzacchi, Erich Vinicius De Paula, Fernanda Andrade Orsi
Summary: This study demonstrates the association between thrombotic antiphospholipid syndrome (APS) and increased neutrophil extracellular trap (NET) formation, particularly in patients with triple antiphospholipid positivity and recurrent thrombosis.
THROMBOSIS RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Yilu Zhou, Weimin Tao, Fuyi Shen, Weijia Du, Zhendong Xu, Zhiqiang Liu
Summary: Neutrophil extracellular traps (NETs) play a crucial role in the formation of arterial, venous, and cancer-related thrombosis by promoting coagulation and disrupting vascular microenvironmental homeostasis. These findings provide new targets for the prevention and treatment of thrombosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Immunology
Mengting Yao, Jiacheng Ma, Dongwen Wu, Chucun Fang, Zilong Wang, Tianting Guo, Jianwen Mo
Summary: Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that presents as swelling and pain in the lower limbs. The most serious complication of DVT is pulmonary embolism (PE) with high mortality. Understanding the underlying mechanisms of DVT is crucial for early diagnosis and treatment as patients usually show clinical symptoms after thrombus formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Anetta Undas
Summary: Fibrinolysis is crucial for maintaining or restoring the patency of veins and pulmonary arteries obstructed by thrombi. Impaired fibrinolysis is implicated in venous thromboembolism (VTE) through complex mechanisms, with markers like clot lysis time predicting recurrent deep-vein thrombosis and pulmonary embolism. This overview summarizes the link between fibrinolysis and VTE, along with its long-term consequences.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Hematology
Tobias Frischmuth, Kristian Hindberg, Pal Aukrust, Thor Ueland, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: This study aimed to investigate the association between plasma PAI-1 levels and the risk of future incident VTE, as well as to explore the potential mediation of PAI-1 on the VTE risk in obesity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Biochemistry & Molecular Biology
Eleonora Galli, Elena Maggio, Fulvio Pomero
Summary: Septic patients are at a high risk of thrombotic complications due to coagulation disorders. The interconnected and reciprocal influence of immune and coagulation systems, known as immunothrombosis, plays a critical role in host defense and thrombogenesis. Dysregulation of this network during sepsis can lead to pathological thrombosis.
Article
Immunology
Veronica Ines Landoni, Jose R. Pittaluga, Agostina Carestia, Luis Alejandro Castillo, Marcelo de Campos Nebel, Daiana Martire-Greco, Federico Birnberg-Weiss, Mirta Schattner, Pablo Schierloh, Gabriela C. Fernandez
Summary: Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in the pediatric population. Stx and LPS induce NETs formation, leading to endothelial damage in HUS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Hematology
Qin Bai, Yao Lu, Yanhua Chen, Han Zhang, Weiwei Zhang, Huang Wu, Aiqing Wen
Summary: The study demonstrates that METTL3-mediated N-6-methyladenosine modification has a crucial role in fibrinolysis and may be a potential target for the treatment of thrombotic disorders.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)