Article
Biochemistry & Molecular Biology
Chow-Seng Kong, Alexandra Almansa Ordonez, Sarah Turner, Tina Tremaine, Joanne Muter, Emma S. Lucas, Emma Salisbury, Rita Vassena, Gustavo Tiscornia, Ali A. Fouladi-Nashta, Geraldine Hartshorne, Jan J. Brosens, Paul J. Brighton
Summary: The study found that uterine natural killer cells play a crucial role in embryo biosensing and implantation process, highlighting their importance in selectively eliminating senescent decidual cells.
Review
Biochemistry & Molecular Biology
Manizha Shekibi, Sophea Heng, Guiying Nie
Summary: The development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Recent studies have focused on the role of microRNAs (miRNAs) in the regulation of endometrial receptivity. This review provides an up-to-date knowledge of the miRNAs identified in humans and mice that may play a functional role in the establishment of receptivity. The findings suggest that miRNAs could be potential biomarkers and therapeutic targets for improving endometrial receptivity in human fertility treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yanshe Xie, Guangbin Liu, Xupeng Zang, Qun Hu, Chen Zhou, Yaokun Li, Dewu Liu, Linjun Hong
Summary: The study revealed that uterine fluids' EVs contain various small RNAs that may be vital in the formation of a receptive endometrium and embryo implantation.
Article
Immunology
Yue Li, Si-Ting Chen, Yu-Ying He, Bo Li, Chen Yang, Zhen-Shan Yang, Zeng-Ming Yang
Summary: In this study, the involvement of secreted HMGB1 in early mouse pregnancy was investigated. It was found that HMGB1 can be detected in the uterine lumen fluid and its secretion is influenced by the presence of blastocysts. The presence of trypsin in blastocysts and its ability to stimulate HB-EGF production was also demonstrated. Furthermore, the role of PAR2-HMGB1-ADAM17-HB-EGF signaling pathway in decidualization was identified.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Maria Diniz-da-Costa, Chow-Seng Kong, Katherine J. Fishwick, Thomas Rawlings, Paul J. Brighton, Amelia Hawkes, Joshua Odendaal, Siobhan Quenby, Sascha Ott, Emma S. Lucas, Pavle Vrljicak, Jan J. Brosens
Summary: The study identifies a highly proliferative population of mesenchymal cells (hPMC) in midluteal human endometrium, potentially serving as novel decidual precursors; hPMC differ from endometrial stromal cells in the expression of genes for prolactin and other decidual transcription factors, and show signs of differentiation into a decidual subpopulation discovered in early pregnancy; recurrent pregnancy loss is associated with depletion of hPMC.
Review
Biology
Dylan Siriwardena, Thorsten E. E. Boroviak
Summary: Successful embryo development requires implantation of the conceptus into the uterus. Non-human primates provide important insights into trophoblast development, uterine receptivity and embryo invasion, which are difficult to study in humans. This review examines the conservation and divergence of embryo implantation processes among primates and compares them to rodent models, discussing trophectoderm compartmentalization, endometrial remodeling, and embryo adhesion and invasion. The authors propose that studying invasion depth between primate species could lead to new insights and treatment strategies for placental disorders in humans.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Review
Cell Biology
Jan J. Brosens, Phillip R. Bennett, Vikki M. Abrahams, Rosanna Ramhorst, Arri Coomarasamy, Siobhan Quenby, Emma S. Lucas, Rajiv C. McCoy
Summary: Compared to other mammals, human pregnancy is unique in its involvement of chromosomally diverse embryos and the cyclical breakdown and regeneration of the uterine mucosa. Understanding the mechanisms behind miscarriage can provide insights into the maternal selection of embryos during early gestation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Aikaterini Berdiaki, Sophia Zafeiropoulou, Fanourios Makrygiannakis, Panagiotis Drakopoulos, Timur Gurgan, Antonios Makrigiannakis
Summary: Ageing has an impact on the function and gene expression of endometrial stromal cells, which is important for understanding the causes of infertility.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Immunology
Nupur Mukherjee, Richa Sharma, Deepak Modi
Summary: Recurrent implantation failure (RIF) can be caused by uterine factors, male factors, or embryo factors. It is associated with disrupted endometrial receptivity, altered gene expression, immunologic disturbances, and epigenetic alterations. RIF is a heterogeneous condition with varied immune responses, and personalized therapies based on the patient's immune status are being tested.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Editorial Material
Biology
J. Julie Kim
Summary: A new laboratory model helps to study the role of senescent cells in fostering a uterine environment that can support an embryo.
Article
Cell Biology
Jing Long, Weike Li, Mengyue Chen, Yubin Ding, Xuemei Chen, Chao Tong, Na Li, Xueqing Liu, Junlin He, Chuan Peng, Yanqing Geng, Taihang Liu, Xinyi Mu, Fangfang Li, Yingxiong Wang, Rufei Gao
Summary: Uterine deficiency of Dnmt3b impairs decidualization and consequent embryo implantation defects. Pgk1 may play a significant role in the decidualization process.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Cell Biology
Vineet K. Maurya, Francesco J. DeMayo, John P. Lydon
Summary: The synchrony between progesterone-driven endometrial receptivity and the arrival of a euploid blastocyst is crucial for successful embryo implantation and establishment of pregnancy. Aberrant progesterone molecular responses can lead to infertility, early embryo miscarriage, gestational complications, and endometrial pathologies. Further identification and functional analysis of key molecular mediators and modifiers of the endometrial response to progesterone may provide insight into early endometrial changes and lead to more effective diagnostics and therapies for female infertility and gynecological morbidities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shengchen Gu, Xupeng Zang, Lei Jiang, Ting Gu, Fanming Meng, Sixiu Huang, Gengyuan Cai, Zicong Li, Zhenfang Wu, Linjun Hong
Summary: In this study, we investigated the miRNA expression profile in healthy and arresting embryo implantation site of porcine endometrium on day 28 of gestation using small RNA sequencing. We identified differentially expressed miRNAs and predicted their target genes. Furthermore, we confirmed the binding of miR-205 to tubulointerstitial nephritis antigen-like 1 (TINAGL1) using fluorescence in situ hybridization and a dual-luciferase report gene assay. Our findings suggest that miR-205 inhibits angiogenesis in the maternal endometrium, leading to the formation of arresting embryos during implantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Obstetrics & Gynecology
Jianghong Cheng, Zizhuo Sha, Junyang Li, Bixuan Li, Xianyang Luo, Zhiming Zhang, Yi Zhou, Shuai Chen, Yang Wang
Summary: Embryo implantation and decidualization are vital for successful pregnancy, and defects in these processes can lead to adverse pregnancy outcomes. Around 75% of failed pregnancies are caused by implantation failure or defects. This article reviews recent advances in understanding the molecular mechanisms of estrogen and progesterone regulation in establishing uterine receptivity, blastocyst implantation, and decidualization, with the aim of developing strategies to prevent or treat implantation defects and improve pregnancy rates.
REPRODUCTIVE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Kaiyu Chen, Junyong Liang, Ti Qin, Yunchao Zhang, Xi Chen, Zhengguang Wang
Summary: Extracellular vesicles (EVs) are membrane-coating nanoparticles derived from cells. They play an important role in early pregnancy, especially during embryo implantation, by transporting proteins and nucleic acids, stimulating the immune system, and regulating gene expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)