Article
Materials Science, Multidisciplinary
Zhitong Chen, Guojun Chen, Richard Obenchain, Rui Zhang, Fan Bai, Tianxu Fang, Hanwen Wang, Yingjie Lu, Richard E. Wirz, Zhen Gu
Summary: This article introduces the delivery methods of cold atmospheric plasma (CAP) in biomedical applications, such as sterilization, wound healing, and cancer therapy. It also presents the future research needs in this field, providing insights for researchers from various disciplines.
Editorial Material
Dermatology
[Anonymous]
Summary: Cold plasma therapy is a promising innovative approach for the treatment of chronic wounds. This case report demonstrates that through repeated application of cold plasma, a chronic wound completely healed within 8 weeks, with no adverse effects. This provides a basis for further research to confirm the effectiveness of active wound dressings with cold plasma in the treatment of chronic wounds.
ADVANCES IN SKIN & WOUND CARE
(2022)
Review
Biochemistry & Molecular Biology
Sunil Kumar Dubey, Shraddha Parab, Amit Alexander, Mukta Agrawal, Vaishnav Pavan Kumar Achalla, Udit Narayan Pal, Murali Monohar Pandey, Prashant Kesharwani
Summary: Cold atmospheric plasma therapy is a novel, simple, non-invasive treatment approach mainly used in wound healing. It is distinct from blood plasma and is generated as the fourth state of matter through irradiation or electric field. This review emphasizes the application of cold plasma in wound healing, discussing wound types, healing process, and mechanisms of cold atmospheric plasma therapy.
PROCESS BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
S. E. Aragona, G. Mereghetti, G. Ciprandi
Summary: Wound healing is a complex process that has been constantly evolving in our understanding. The field of Regenerative Medicine, focusing on the use of stem cells and biomaterials, has recently gained great attention. The healing process encompasses inflammatory reaction, cell proliferation, and extracellular matrix remodelling. However, wound repair often results in incomplete regeneration and hyperproduction of collagen, leading to new tissue with 80% similarity to the original tissue. Regenerative Medicine research has focused on in vitro and in vivo cellular models to study tissue repair and regeneration. This new perspective aims to shift the focus from inflammation to regeneration.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Health Care Sciences & Services
Tatiana Bolgeo, Antonio Maconi, Menada Gardalini, Denise Gatti, Roberta Di Matteo, Marco Lapidari, Yaroslava Longhitano, Gabriele Savioli, Andrea Piccioni, Christian Zanza
Summary: Critically ill patients are prone to skin wounds, which have negative impacts on their quality of life, medication plans, and hospital stays. Cold atmospheric plasma (CAP) has been suggested as a potential solution to reduce wound contamination and promote healing. This review examines how CAP works, its mechanisms, and its applications in critical care settings, with a focus on its success in treating bedsores and potential implications for healthcare.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Fei Tan, Yang Wang, Shiqun Zhang, Runying Shui, Jianghan Chen
Summary: This comprehensive review summarizes the recent advances in cold atmospheric plasma-based skin therapy, including the optimization of intact skin and the treatment of various skin diseases. The review also analyzes the safety aspect of plasma treatment and proposes ways to mitigate potential risks.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ruotao Li, Kai Liu, Xu Huang, Di Li, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Skin wound repair is a complex process involving multiple cellular and molecular interactions. Bioactive materials can promote wound healing by modulating the wound microenvironment and cell behaviors.
Review
Cell Biology
Diana Pereira, Ines Sequeira
Summary: Epithelial tissues have a natural ability for renewal and regeneration, crucial for providing the ultimate barrier against the external environment. The oral mucosa is known for its outstanding healing potential with minimal scarring, contributing to reducing fibrotic tissue formation. The combination of cell therapy and bioengineering to leverage the scarless properties of the oral mucosa for skin and esophageal wound healing is a promising avenue for achieving scarless wound healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Xuran Li, Xiaoqing Rui, Danni Li, Yanhong Wang, Fei Tan
Summary: This article provides a comprehensive review of the oncological potential of cold atmospheric plasma (CAP) in the treatment of head and neck cancer (HNC). It discusses the anti-tumor effect of CAP in various types of HNC, including upper aerodigestive tract cancers, head and neck glandular cancers, and skin cancers. CAP is a versatile treatment option that can be used for different types of tumors and can work in synergy with existing clinical therapies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yasmeen Shamiya, Shruthi Polla Ravi, Ali Coyle, Subrata Chakrabarti, Arghya Paul
Summary: This article reviews emerging therapeutic nanoparticles for treating diabetic wounds and discusses their discrete delivery mechanisms and sites of action. The current challenges of these nanoengineered materials for successful clinical translation are critically assessed, along with their potential for growth in the clinical marketplace.
DRUG DISCOVERY TODAY
(2022)
Review
Cell Biology
Ning Zeng, Hongbo Chen, Yiping Wu, Zeming Liu
Summary: Wound healing in the human body is a complex physiological regulation mechanism, with adipose stem cells playing an important role in regenerative medicine. Adipose stem cells are easy to obtain, high-yielding, rich in components and cytokines, and highly practical.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Marek Konop, Mateusz Rybka, Adrian Drapala
Summary: Researchers are exploring the use of keratin biomaterials as wound dressings to aid in skin regeneration, due to their tissue biocompatibility, biodegradability, mechanical durability, and natural abundance properties.
Article
Engineering, Biomedical
Abigail L. Lauterbach, Anna J. Slezak, Ruyi Wang, Shijie Cao, Michal M. Raczy, Elyse A. Watkins, Carlos J. Medina Jimenez, Jeffrey A. Hubbell
Summary: Butyrate, an important bacterial metabolite, has a complex role in regulating immunity and maintaining epithelial barriers. However, its clinical translation is hindered by poor bioavailability, strong odor, and high dosage requirements. A novel polymeric delivery platform has been developed for controlled release of butyrate, which also has potential for other therapeutically relevant metabolites. This platform shows efficacy in the treatment of non-healing diabetic wounds by modulating immune cell activation and altering the soluble signals in the wound microenvironment, addressing a significant clinical need.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Kotaro Tanaka, Ryohei Ogino, Sho Yamakawa, Shota Suda, Kenji Hayashida
Summary: Skin wounds usually heal on their own, but this is only true for healthy individuals. Mesenchymal stem cells (MSCs) have been found to play a significant role in wound healing and regeneration, with their ability to self-renew and differentiate, as well as their anti-inflammatory and immunomodulatory properties. This review aims to explain the functions and effects of MSCs in wound healing.
Article
Agriculture, Dairy & Animal Science
Chen-Yi Su, Michael W. Hughes, Tzu-Yu Liu, Cheng-Ming Chuong, Hao-Ven Wang, Wei-Cheng Yang
Summary: Cutaneous wound healing in cetaceans, such as Fraser's dolphins, differs from terrestrial mammals in terms of histological features and stages of wound healing. Understanding the mechanism of wound healing in cetaceans could provide insights for veterinary and human regenerative medicine. Further research is needed to delve deeper into the unique mechanisms of dolphin wound healing.
Article
Pathology
Dusan Brany, Dana Dvorska, Marian Grendar, Marcela Nachajova, Peter Szepe, Zora Lasabova, Pavol Zubor, Jozef Visnovsky, Erika Halasova
PATHOLOGY RESEARCH AND PRACTICE
(2019)
Article
Biochemistry & Molecular Biology
Dana Dvorska, Dusan Brany, Balint Nagy, Marian Grendar, Robert Poka, Beata Soltesz, Marianna Jagelkova, Katarina Zelinova, Zora Lasabova, Pavol Zubor, Zuzana Dankova
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Dana Dvorska, Henrieta Skovierova, Dusan Brany, Erika Halasova, Zuzana Dankova
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Oncology
Pavol Zubor, Zuzana Dankova, Zuzana Kolkova, Veronika Holubekova, Dusan Brany, Sandra Mersakova, Marek Samec, Alena Liskova, Lenka Koklesova, Peter Kubatka, Jan Bujnak, Karol Kajo, Milos Mlyncek, Frank A. Giordano, Olga Golubnitschaja
Article
Cell & Tissue Engineering
Jan Strnadel, Romana Zahumenska, Vladimir Nosal, Marek Smolar, Juraj Marcinek, Michal Kalman, Stefan Juhas, Jana Juhasova, Hana Studenovska, Hugo Dumortier, Tomas Chromec, Henrieta Skovierova, Barbora Mitruskova, Ivan Kapralik, Sandra Mersakova, Dusan Brany, Erika Halasova
STEM CELL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Dana Dvorska, Dusan Brany, Marcela Nachajova, Erika Halasova, Zuzana Dankova
Summary: Breast cancer is a heterogeneous and common gynaecological cancer, with various factors affecting its development. Research interest has shifted to the role of non-coding RNAs in tumour development and their potential as therapeutic targets, as their abnormal expression is closely linked to breast cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Zuzana Dankova, Elena Novakova, Maria Skerenova, Veronika Holubekova, Vincent Lucansky, Dana Dvorska, Dusan Brany, Zuzana Kolkova, Jan Strnadel, Sandra Mersakova, Katarina Janikova, Marek Samec, Michal Pokusa, Martin Petras, Miroslava Sarlinova, Ivana Kasubova, Dusan Loderer, Vladimira Sadlonova, Jana Kompanikova, Nina Kotlebova, Adriana Kompanikova, Martina Hrnciarova, Andrea Stanclova, Martina Antosova, Anton Dzian, Vladimir Nosal, Ivan Kocan, Dalibor Murgas, Dusan Krkoska, Andrea Calkovska, Erika Halasova
Summary: The global impact of the COVID-19 pandemic on the economy and healthcare is profound, with varying test results between different kits highlighting the advantages of antigen testing in detecting individuals with higher viral loads.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Dusan Brany, Dana Dvorska, Jan Strnadel, Tatiana Matakova, Erika Halasova, Henrieta Skovierova
Summary: Cold atmospheric plasma shows great potential in modern medicine. It has been used in clinical treatment of skin diseases, chronic wounds, and has effects on tumour cells. Current research focuses on its applications in internal structures and its synergistic effects with pharmaceuticals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Jan Strnadel, Hugo M. Dumortier, Dominika Hajduchova, Romana Zahumenska, Vladimir Nosal, Marek Smolar, Juraj Marcinek, Michal Kalman, Sandra Mersakova, Dusan Brany, Stefan Juhas, Jana Juhasova, Hana Studenovska, Barbora Mitruskova, Stanislava Suroviakova, Slavomira Novakova, Henrieta Skovierova, Egon Kurca, Renata Pecova, Lukas Plank, Erika Halasova
Summary: In this study, a new iPS cell line was generated for modeling the sporadic form of ALS. The cell line was derived from skin fibroblasts obtained through reprogramming and characterized through various analyses, demonstrating its normal karyotype and ability to differentiate into cells from three germ layers.
STEM CELL RESEARCH
(2022)
Article
Clinical Neurology
Michaela Krivosova, Jana Adamcakova, Erik Kaadt, Birgitte Hviid Mumm, Dana Dvorska, Dusan Brany, Zuzana Dankova, Matus Dohal, Marek Samec, Nikola Ferencova, Ingrid Tonhajzerova, Igor Ondrejka, Igor Hrtanek, Peter Hutka, Miloslav Oppa, Juraj Mokry, Betina Elfving
Summary: This study investigated the plasma levels of vascular endothelial growth factor (VEGF) in children and adolescents with major depressive disorder (MDD) and examined the impact of antidepressant treatment on VEGF levels. The results showed that the levels of VEGF were significantly increased in depressed individuals and were decreased after a short course of antidepressant treatment. Additionally, certain microRNAs were found to be associated with the regulation of VEGF. This study supports the use of VEGF as a biomarker for MDD in children and adolescents and highlights the importance of understanding the underlying regulatory mechanisms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Virology
Tatiana Burjanivova, Eva Lukacova, Vincent Lucansky, Marek Samec, Petar Podlesniy, Zuzana Kolkova, Lenka Reizigova, Marian Grendar, Eva Turyova, Veronika Holubekova, Bibiana Malicherova, Vladimir Nosal, Ivana Kasubova, Robert Dusenka, Denisa Osinova, Jana Hosalova Matisova, Dana Dvorska, Dusan Brany, Zuzana Dankova, Elena Novakova, Andrea Calkovska, Erika Halasova
Summary: Monitoring SARS-CoV-2 in air traffic is crucial to prevent the virus from spreading globally. We developed sensitive detection methods, ddPCR and RT-qPCR, for early and accurate detection of SARS-CoV-2. Analysis of patient samples showed higher positivity with ddPCR compared to RT-qPCR. We also identified a positive sample using ddPCR from saliva samples of passengers and airport staff. Our findings demonstrate the advantages of saliva collection and the suitability of ddPCR for virus detection.
Article
Oncology
Romana Zahumenska, Michal Kalman, Juraj Marcinek, Sandra Mersakova, Martin Kertys, Miroslav Pindura, Blazej Palkoci, Roman Kycina, Martin Vojtko, Tomas Chromec, Hugo Maurice Dumortier, Henrieta Skovierova, Slavomira Novakova, Barbora Mitruskova, Ivan Kapralik, Dusan Loderer, Marian Grendar, Dusan Brany, Juraj Mokry, Michael Bouvet, Mark A. Valasek, Jan Janik, Lukas Plank, Ludovit Laca, Erika Halasova, Jan Strnadel
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis. Surgery is only possible for a limited number of patients, while chemotherapy and radiotherapy can only extend survival. New in vitro and in vivo models are urgently needed to study this type of cancer.
Article
Obstetrics & Gynecology
Z. Dankova, M. Grendar, D. Dvorska, D. Brany, I Stastny, M. Bobrovska, T. Balharek, P. Zubor
CESKA GYNEKOLOGIE-CZECH GYNAECOLOGY
(2020)
Article
Obstetrics & Gynecology
D. Dvorska, D. Brany, Z. Dankova, E. Halasova, J. visnovsky
CESKA GYNEKOLOGIE-CZECH GYNAECOLOGY
(2018)