VLA-4 Expression and Activation in B Cell Malignancies: Functional and Clinical Aspects

CD49d promotes disease progression in chronic lymphocytic leukemia: new insights from CD49d bimodal expression

(2020) Erika Tissino et al.   BLOOD

TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia

(2020) Eva Szenes et al.   LEUKEMIA

Inhibiting Bruton’s Tyrosine Kinase in CLL and Other B-Cell Malignancies

(2019) Fabienne Lucas et al.   Targeted Oncology

Neutrophils promote VLA-4–dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation

(2019) Chelsea R. Parker Harp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins

(2018) Julia M. Laufer et al.   FASEB JOURNAL

Integrins in T Cell Physiology

(2018) Alessandra Bertoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia

(2018) Erika Tissino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Safety, Pharmacokinetics, and Pharmacodynamics of ME-401, an Oral, Potent, and Selective Inhibitor of Phosphatidylinositol 3-Kinase P110δ, Following Single Ascending Dose Administration to Healthy Volunteers

(2018) Ofir Moreno et al.   CLINICAL THERAPEUTICS

CXCR4- and BCR-triggered integrin activation in B-cell chronic lymphocytic leukemia cells depends on JAK2-activated Bruton's tyrosine kinase

(2018) Alessio Montresor et al.   Oncotarget

Real-World Lab Data in Natalizumab Treated Multiple Sclerosis Patients Up to 6 Years Long-Term Follow Up

(2018) Maxi Kaufmann et al.   Frontiers in Neurology

NOTCH1 mutations are associated with high CD49d expression in chronic lymphocytic leukemia: link between the NOTCH1 and the NF-κB pathways

(2017) D Benedetti et al.   LEUKEMIA

The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling

(2017) Kerry Tedford et al.   Nature Communications

The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival

(2017) Vanessa Stache et al.   OncoImmunology

Integrin-based therapeutics: biological basis, clinical use and new drugs

(2016) Klaus Ley et al.   NATURE REVIEWS DRUG DISCOVERY

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics

(2016) Eloy F. Robles et al.   Nature Communications

­­­­Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

(2016) Dominique R. Perez et al.   Oncotarget

B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity

(2015) Klaus Lehmann-Horn et al.   ANNALS OF NEUROLOGY

Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells

(2015) Ye F. Tian et al.   BIOMATERIALS

Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients With Active Ulcerative Colitis

(2015) Naoki Yoshimura et al.   GASTROENTEROLOGY

Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenstrom macroglobulinemia

(2015) M. F. M. de Rooij et al.   HAEMATOLOGICA

In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by α4β1 cytoplasmic-binding proteins

(2015) M Martínez-Moreno et al.   LEUKEMIA

VLA-4 and CXCR4 overexpression in bone marrow of an aleukemic B-cell acute lymphoblastic leukemia presenting with osteolytic bone lesions

(2015) Elisabeth Hinterseer et al.   LEUKEMIA & LYMPHOMA

Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin

(2015) Tommy Hui et al.   MATRIX BIOLOGY

Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenstrom macroglobulinemia

(2015) M. F. M. de Rooij et al.   HAEMATOLOGICA

CD49d Is the Strongest Flow Cytometry–Based Predictor of Overall Survival in Chronic Lymphocytic Leukemia

(2014) Pietro Bulian et al.   JOURNAL OF CLINICAL ONCOLOGY

CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow

(2014) Thomas C. Beck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation

(2014) K. Heinig et al.   Cancer Discovery

CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism

(2013) A. Zucchetto et al.   BLOOD

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion

(2012) Alexandre Chigaev et al.   Frontiers in Immunology

High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse

(2011) S. Shalapour et al.   HAEMATOLOGICA

Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen

(2010) E. Manevich-Mendelson et al.   BLOOD

SWAP-70 controls formation of the splenic marginal zone through regulating T1B-cell differentiation

(2010) Michaël Chopin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chronic lymphocytic leukemia microenvironment: shifting the balance from apoptosis to proliferation

(2009) S. Deaglio et al.   HAEMATOLOGICA

Real-time Analysis of Conformation-sensitive Antibody Binding Provides New Insights into Integrin Conformational Regulation

(2009) Alexandre Chigaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking integrin conformation to function

(2009) J. A. Askari et al.   JOURNAL OF CELL SCIENCE

Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids

(2009) João P Pereira et al.   NATURE IMMUNOLOGY

Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab

(2008) H. Bonig et al.   BLOOD

CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potential

(2008) Tait D. Shanafelt et al.   BRITISH JOURNAL OF HAEMATOLOGY

Fibronectin promotes cell proliferation of human pre-B cell line via its interactions with VLA-4 and VLA-5

(2008) Akane Harima et al.   Hematology

Activation of the Small GTPase Rac2 via the B Cell Receptor Regulates B Cell Adhesion and Immunological-Synapse Formation

(2008) Eloisa Arana et al.   IMMUNITY

The Solution Structure of EMILIN1 Globular C1q Domain Reveals a Disordered Insertion Necessary for Interaction with the α4β1 Integrin

(2008) Giuliana Verdone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia

(2007) V. Gattei et al.   BLOOD