期刊
CEREBRAL CORTEX
卷 28, 期 1, 页码 267-280出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhw376
关键词
corticofugal; iontophoresis; LGN; receptive field; V1
资金
- National Natural Science Foundation of China [31571078]
- Biotechnology and Biological Sciences Research Council [G022305/1]
- Medical Research Council [G0701535]
- BBSRC [BB/G022305/1] Funding Source: UKRI
- MRC [G0701535] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G022305/1] Funding Source: researchfish
- Medical Research Council [G0701535] Funding Source: researchfish
The projections between the thalamus and primary visual cortex (V1) are a key reciprocal neural circuit, relaying retinal signals to cortical layers 4 & 6 while being simultaneously regulated by massive layer 6 corticothalamic feedback. Effectively dissecting the influence of this corticothalamic feedback circuit in higher mammals remains a challenge for vision research. By pharmacologically increasing the focal gain of visually driven layer 6 responses of cat V1 in a controlled fashion, we examined the effects of such focal cortical changes on the response amplitudes and spatial structure of the receptive fields (RFs) of individual dorsal lateral geniculate nucleus (dLGN) cells. We found that enhancing visually driven cortical feedback could facilitate or suppress the overall responses of dLGN cells, and such an effect was linked to the orientation preference of the cortical neuron. Related to these selective retinotopic gain changes, enhanced feedback induced the RFs of dLGN cells to expand, contract or shift their spatial focus. Our results provide further evidence for a functional mechanism through which the cortex can selectively gate visual information flow from the thalamus back to the visual cortex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据