Article
Neurosciences
Aleksi J. Sihvonen, Paula Virtala, Anja Thiede, Marja Laasonen, Teija Kujala
Summary: This study utilized a hodological approach to investigate the relationships between structural white matter connectivity and reading skills and phonological processing. The findings revealed specific brain regions associated with reading skills and phonological processing, as well as structural connectivity anomalies in dyslexics.
Article
Neurosciences
Qiuting Wen, Shannon L. Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R. Farlow, Frederick W. Unverzagt, Sujuan Gao, Liana G. Apostolova, Andrew J. Saykin, Yu-Chien Wu
Summary: The study explored the spatial pattern of tau-white matter (WM) associations across the whole brain and found a distinct spatial pattern resembling the typical propagation of tau pathology in Alzheimer's disease (AD). The association between tau and WM degeneration highlights the important role of WM alterations in the AD pathological cascade.
Article
Neurosciences
Steven L. Meisler, John D. E. Gabrieli
Summary: Reading involves a widely distributed brain network and white matter tracts play an important role in transmitting information between constituent network nodes. A study with a large dataset of 686 children found that while white matter FA increased with age, there were no significant correlations between overall reading abilities and tract FAs. However, higher FA in specific tracts was associated with better nonword reading skills in older children.
Article
Clinical Neurology
Heather M. Clark, Nirubol Tosakulwong, Stephen D. Weigand, Farwa Ali, Hugo Botha, Nha Trang Thu Pham, Christopher G. Schwarz, Robert Reid, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, J. Eric Ahlskog, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study found that impairments in swallowing function were associated with specific brain regions' reduced gray matter volumes and abnormal white matter integrity. The impairments in the oral and pharyngeal phases of swallowing corresponded to different regions of neuroanatomical impairment.
MOVEMENT DISORDERS
(2021)
Article
Geriatrics & Gerontology
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
Summary: This study aimed to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. The results showed that disrupted white matter integrity is associated with visuomotor processing speed, semantic memory, and executive function, while cortical surface area is related to cognitive scores. These findings contribute to a better understanding of the pathological process underlying cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Bingxin Zhao, Tengfei Li, Yue Yang, Xifeng Wang, Tianyou Luo, Yue Shan, Ziliang Zhu, Di Xiong, Mads E. Hauberg, Jaroslav Bendl, John F. Fullard, Panagiotis Roussos, Yun Li, Jason L. Stein, Hongtu Zhu
Summary: The study identified common genetic variants influencing white matter microstructure and detected multiple associated loci, some of which were related to brain diseases. Additionally, genetic correlations were observed between white matter microstructure and a wide range of complex traits and diseases.
Article
Immunology
Aoife O'Donovan, Amber Bahorik, Stephen Sidney, Lenore J. Launer, Kristine Yaffe
Summary: The study found that increasing or high inflammation trajectories from early to mid adulthood are associated with worse brain health, as indexed by lower white matter volume and/or worse white matter integrity.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Behavioral Sciences
Vincent DeLuca, Toms Voits
Summary: Bilingualism has been found to delay age-related neurocognitive decline and influence white matter integrity. However, previous research has mainly focused on older adults and young adults, neglecting the middle-aged population. This study used DTI to examine the effects of bilingualism and degree of bilingual engagement on white matter integrity. The results showed that bilingualism, particularly higher engagement, can slow down the decline in white matter integrity associated with aging.
Article
Clinical Neurology
Ali Baran Tanrikulu, Ikbal Inanli, Serdar Arslan, Ali Metehan Caliskan, Ismet Esra Cicek, Ibrahim Eren
Summary: This study aimed to investigate the white matter (WM) integrity within different stages of bipolar disorder (BD) and its potential as a biomarker for clinical staging. The results suggest that WM integrity in the corpus callosum genu and right sagittal stratum may serve as biomarkers for clinical staging of BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Jose M. Guerrero-Gonzalez, Benjamin Yeske, Gregory R. Kirk, Michael J. Bell, Peter A. Ferrazzano, Andrew L. Alexander
Summary: Imaging-based quantitative measures from diffusion-weighted MRI can extract microscopic information from human brain tissues. Group-level comparisons are useful for investigating abnormal brain conditions, but individualized analyses are necessary when abnormalities do not spatially coincide across subjects. A framework for single-subject multidimensional analysis based on the Mahalanobis distance is presented in this study. Using this framework, statistically significant deviations from normative data were detected in severe TBI patients, indicating the heterogeneity of TBI. The method also demonstrated good specificity in the control group.
Article
Computer Science, Artificial Intelligence
Yi Wang, Yuan Zhang, Chi Ma, Rui Wang, Zhe Guo, Yu Shen, Miaomiao Wang, Hongying Meng
Summary: Punctate White Matter Damage (PWMD) is a common neonatal brain disease that affects neurological function. The difficulty in diagnosis leads to missed treatment opportunities. This study proposes a new method using T1 MRI and DTI to analyze PWMD, which effectively predicts and analyzes the impact of lesions on fiber tracts through super-resolution and image registration.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2023)
Article
Neurosciences
M. D. Wheelock, A. M. Goodman, N. G. Harnett, K. H. Wood, S. Mrug, D. A. Granger, D. C. Knight
Summary: The study investigated sex differences in stress reactivity and the GFA of white matter tracts connecting the prefrontal cortex and limbic system. Results showed significant differences between men and women in cortisol reactivity and GFA, with men demonstrating higher cortisol reactivity and GFA within the cingulum compared to women.
Article
Cell Biology
Zdenek Wurst, Barbora Bircak Kuchtova, Jan Kremen, Anastasiya Lahutsina, Ibrahim Ibrahim, Jaroslav Tintera, Ales Bartos, Marek Brabec, Tanya Rai, Petr Zach, Vladimir Musil, Nicoletta Olympiou, Jana Mrzilkova
Summary: The volume reduction of gray matter structures is accompanied by an asymmetric increase in white matter fibers in Alzheimer's disease patients. This study used diffusion tensor imaging to investigate white matter structure changes in the motor basal ganglia in Alzheimer's disease patients. Measurements were taken in ten patients and ten healthy controls, revealing a decrease in the number of tracts and general fractional anisotropy in the right caudate nucleus of Alzheimer's disease patients. An increase in the left and right putamen was observed. Furthermore, a decrease in structural volume was observed in the left and right putamen.
Article
Neurosciences
Maya Yablonski, Benjamin Menashe, Michal Ben-Shachar
Summary: The study demonstrates significant correlations between the bilateral ventral tracts and morphological processing, extending beyond reading to oral production. Additionally, significant correlations were found in the dorsal tract associated with oral fluency and speech production.
Article
Neurosciences
Sarah J. Short, Dae Kun Jang, Rachel J. Steiner, Rebecca L. Stephens, Jessica B. Girault, Martin Styner, John H. Gilmore
Summary: DTI is a non-invasive neuroimaging method that is widely used in the investigation of white matter fiber pathways. Early DTI studies have shown significant microstructural and maturational changes in the brain during the first two years of life. Appropriate image processing for infant MR imaging requires age-specific reference atlases. This article provides an overview of the procedures used to generate two atlas resources for neonates and 1- to 2-year-old populations.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Nic. J. A. van der Wee, Amy C. Bilderbeck, Maria Cabello, Jose L. Ayuso-Mateos, Ilja M. J. Saris, Erik J. Giltay, Brenda W. J. H. Penninx, Celso Arango, Anke Post, Stefano Porcelli
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Review
Behavioral Sciences
Stefano Porcelli, Nic Van der Wee, Steven van der Werff, Moji Aghajani, Jeffrey C. Glennon, Sabrina van Heukelum, Floriana Mogavero, Antonio Lobo, Francisco Javier Olivera, Elena Lobo, Mar Posadas, Juergen Dukart, Rouba Kozak, Estibaliz Arce, Arfan Ikram, Jacob Vorstman, Amy Bilderbeck, Ilja Saris, Martien J. Kas, Alessandro Serretti
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Article
Multidisciplinary Sciences
Ilja M. J. Saris, Brenda W. J. H. Penninx, Richard Dinga, Marie-Jose van Tol, Dick J. Veltman, Nic J. A. van der Wee, Moji Aghajani
SCIENTIFIC REPORTS
(2020)
Article
Psychiatry
I. M. J. Saris, M. Aghajani, S. J. A. van der Werff, N. J. A. van der Wee, B. W. J. H. Penninx
ACTA PSYCHIATRICA SCANDINAVICA
(2017)