Article
Chemistry, Applied
Meng-Fan Li, Hua-Ling Cui, Wen-Yong Lou
Summary: This study introduces the use of Millettia speciosa Champ cellulose (MSCC) and carboxymethylcellulose (MSCCMC) in the fabrication of 3D-network hydrogels as a delivery system for probiotics. The structural features, swelling behavior, and pH-responsiveness of the MSCC-MSCCMC hydrogels were characterized, along with their encapsulation and controlled-release behavior for Lactobacillus paracasei BY2 (L. paracasei BY2). The results showed that the MSCC-MSCCMC hydrogels had porous and network structures, and their properties were influenced by the concentration of MSCCMC.
CARBOHYDRATE POLYMERS
(2023)
Article
Food Science & Technology
Yuanfei Ge, Jinyong Wu, Min Pang, Weiwei Zhu, Lijie Sun, Lixia Yuan, Xiangqin Wang, Xiangsong Chen, Jianming Yao
Summary: C-NeuAc/OHEC hydrogels were prepared as delivery vehicles for co-encapsulation of Pediococcus pentosaceus RQ-1 and isomaltose-oligosaccharide (IMO). The hydrogels exhibited good thermal stability and encapsulation efficiency at a ratio of C-NeuAc:OHEC = 5:4. Co-encapsulation with IMO significantly improved the survival rate of Pediococcus pentosaceus RQ-1, and storage with 1.0% IMO at 4 degrees C was found to be optimal.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hussein Abou-Yousef, Sawsan Dacrory, Mohamed Hasanin, Essam Saber, Samir Kamel
Summary: The present study successfully prepared a cellulose-based biodegradable hydrogel, and investigated its potential control of drug release as well as interactions with chitosan and streptomycin. The findings showed that chitosan/DAC hydrogels had minimal cytotoxicity towards normal skin fibroblast, and the DAC ratio played a key role in the release process. Further studies revealed potential interactions between chitosan, DAC, and streptomycin with specific binding energies and bond lengths.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Polymer Science
Anshan Huang, Yehong Chen, Chaojun Wu
Summary: This study successfully designed a natural nanocellulose self-healing hydrogel that can quickly self-heal and protect the wound from external damage.
Article
Chemistry, Physical
Mukul Kumar, Kavya Khushi, Anshika Bhardwaj, Debojit Kumar Deb, Nandini Singh, Daniyal Elahi, Simran Sharma, Gaurav Bajpai, Anirudh Srivastava
Summary: This study examines the influence of amphiphilic dyes and medicines in aqueous media. It finds a synergistic relationship between the dyes and medicines, leading to increased binding constant and encapsulation efficiency. Molecular docking analysis shows that electrostatic interactions play a crucial role in the binding of the drugs. Furthermore, the study demonstrates controlled release of the drugs and reduced cytotoxicity when combined with the dyes.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Applied
Guozhu Chang, Qifeng Dang, Chengsheng Liu, Xiaoyu Wang, Hao Song, Hong Gao, Hantian Sun, Bonian Zhang, Dongsu Cha
Summary: A new dual drug delivery system CMCSH was designed to promote diabetic wound healing effectively. This system improved drug availability, promoted cell proliferation, and reduced inflammation.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Mostafa Yusefi, Hui-Yin Chan, Sin-Yeang Teow, Pooneh Kia, Michiele Lee-Kiun Soon, Nor Azwadi Bin Che Sidik, Kamyar Shameli
Summary: The study synthesized layer-by-layer bionanocomposites from chitosan and rice straw cellulose encapsulated 5-Fluorouracil (CS-CF/5FU BNCs) with high biocompatibility and efficient drug release properties. The bionanocomposites showed promise in potential colorectal cancer treatment, demonstrating eco-friendly and innovative characteristics in nanodrug delivery.
Article
Chemistry, Physical
Siddhartha Guchhait, Aparna Roy, Siddhartha Das, Meheboob Khan, Ananya Pradhan, Sujata Maiti Choudhury, Sumita Roy
Summary: Three synthesized short tripeptide-based amphiphiles showed good gelation abilities and were characterized using various instrumental techniques. They were found to be capable of encapsulating and releasing drugs, with potential applications in localized breast cancer therapy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Mariana Chelu, Jose Calderon Moreno, Irina Atkinson, Jeanina Pandele Cusu, Adriana Rusu, Veronica Bratan, Ludmila Aricov, Mihai Anastasescu, Ana-Maria Seciu-Grama, Adina Magdalena Musuc
Summary: A facile and green synthesis method was developed to obtain zinc oxide nanoparticles using three polysaccharide gums. The biosynthesized nanoparticles were then incorporated into a functionalized chitosan hydrogel matrix. The study showed that the use of polysaccharides as chelates allows for the synthesis of ZnO nanoparticles with controlled morphology. The hydrogels exhibited corrugated topographies and were cytocompatible in cell culture experiments. These novel green hydrogels show promising potential as delivery systems for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Xiangyu Lin, Lizhen Guo, Hiba Shaghaleh, Yousef Alhaj Hamoud, Xu Xu, He Liu
Summary: A novel MOF MIL-100(Fe)@CNFs hydrogel for slow-release fertilizers with temperature and pH response was prepared. Characterization of the hydrogels and evaluation using urea as a model fertilizer showed that MC10% hydrogels exhibited superior swelling capacity, water-retention, and slow-release performance. Additionally, wheat fertilized with MC hydrogels showed increased growth and photosynthetic rate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Wangfang Deng, Yanjun Tang, Jiangchun Mao, Yiming Zhou, Tianying Chen, Xianmei Zhu
Summary: This study reinforced sodium alginate/chitosan hydrogels using cellulose nanofibril (CNF) as a crosslinker, improving mechanical properties and demonstrating excellent sustained release performance. The addition of CNF effectively strengthened the network structure of the hydrogels, but also reduced their swelling performance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Paper & Wood
Elaheh Dalir Abdolahinia, Mahdieh Alipour, Marziyeh Aghazadeh, Mehdi Hassanpour, Marjan Ghorbani, Zahra Aghazadeh
Summary: The complex anatomy of teeth hinders regenerative treatments. This study developed an injectable hydrogel containing MTA and evaluated its physicochemical properties. The hydrogel promoted proliferation and differentiation of human dental pulp stem cells, suggesting its potential as a scaffold for regenerative endodontic procedures.
Article
Polymer Science
Praewa Promdontree, Pakpoom Kheolamai, Artjima Ounkaew, Ravin Narain, Sarute Ummartyotin
Summary: Cellulose nanocrystals were successfully extracted from hemp and used to form a composite hydrogel with polyvinyl alcohol. The composite material showed improved thermal stability and swelling behavior compared to pristine polyvinyl alcohol. The cellulose nanocrystals extracted from hemp were identified as a promising candidate for medical scaffold materials.
Article
Pharmacology & Pharmacy
Rasmita Dash, Madhulika Yadav, Jyotirmaya Biswal, Anshuman Chandra, Vijay Kumar Goel, Tripti Sharma, Shakti Ketan Prusty, Sujata Mohapatra
Summary: Conjugate drugs are being widely studied for their potential in improving the properties of drugs. A new conjugate derivative (AT-CU) of atorvastatin and curcumin was synthesized and evaluated in terms of its physical and therapeutic properties. Chitosan-modified PLGA nanoparticles were prepared and showed improved drug encapsulation efficiency and reduced burst release. In vivo studies further confirmed the effectiveness of the ideal formulation in treating atherosclerosis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Environmental
Rangrong Yoksan, Narumol Noivoil
Summary: This study demonstrates that encapsulation of vitexin in chitosan nanoparticles can improve its solubility and dispersion stability, as well as extend its half-life. The loading capacity and encapsulation efficiency of vitexin in chitosan nanoparticles are related to the initial concentration, and the nanoparticles show antioxidant and lipid oxidation retardation activities. Additionally, the loaded vitexin in chitosan nanoparticles are stable in acidic and neutral pH media, which can withstand the harsh gastrointestinal environment, and the bioaccessibility of vitexin is enhanced after encapsulation.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)