The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China

(2020) Sheng-Qun Deng et al.   Journal of Clinical Medicine

The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease

(2020) Li Chen et al.   CARDIOVASCULAR RESEARCH

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion

(2020) Xinling Wang et al.   Cellular & Molecular Immunology

Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19

(2020) Peng Zhang et al.   CIRCULATION RESEARCH

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Prominent changes in blood coagulation of patients with SARS-CoV-2 infection

(2020) Huan Han et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

(2020) Bo Li et al.   Clinical Research in Cardiology

Coronaviruses and the cardiovascular system: acute and long-term implications

(2020) Tian-Yuan Xiong et al.   EUROPEAN HEART JOURNAL

Acute pulmonary embolism and COVID-19 pneumonia: a random association?

(2020) Gian Battista Danzi et al.   EUROPEAN HEART JOURNAL

Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19)

(2020) Giuseppe Lippi et al.   European Journal of Internal Medicine

Joint HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19

(2020) Biykem Bozkurt et al.   JOURNAL OF CARDIAC FAILURE

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up

(2020) Behnood Bikdeli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients

(2020) Jean‐François Llitjos et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

(2020) Giuseppe Mancia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

(2020) Harmony R. Reynolds et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19

(2020) Mandeep R. Mehra et al.   NEW ENGLAND JOURNAL OF MEDICINE

ST-Segment Elevation in Patients with Covid-19 — A Case Series

(2020) Sripal Bangalore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure

(2020) Luca Spiezia et al.   THROMBOSIS AND HAEMOSTASIS

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

(2020) Tao Chen et al.   BMJ-British Medical Journal

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19)

(2020) Neil Mehta et al.   JAMA Cardiology

Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)

(2020) Riccardo M. Inciardi et al.   JAMA Cardiology

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Tao Guo et al.   JAMA Cardiology

Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China

(2020) Juyi Li et al.   JAMA Cardiology

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China

(2020) Shaobo Shi et al.   JAMA Cardiology

Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)

(2020) Samuel James Brake et al.   Journal of Clinical Medicine

Severe COVID-19 infection associated with endothelial activation

(2020) Robert Escher et al.   THROMBOSIS RESEARCH

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

2018 ESC/ESH Guidelines for the management of arterial hypertension

(2018) Bryan Williams et al.   JOURNAL OF HYPERTENSION

The Role of Natural Antibodies to CC Chemokine Receptor 5 in HIV Infection

(2017) Assunta Venuti et al.   Frontiers in Immunology

Role of angiotensin-converting enzyme (ACE) and ACE2 in a rat model of smoke inhalation induced acute respiratory distress syndrome

(2015) Zhao Yilin et al.   BURNS

Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats

(2015) Jan Klimas et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Vascular Angiotensin-Converting Enzyme 2

(2010) Daniel Batlle et al.   CIRCULATION RESEARCH

Angiotensin-converting enzyme 2 is a key modulator of the renin–angiotensin system in cardiovascular and renal disease

(2010) Chris Tikellis et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway

(2008) Vijay Koka et al.   AMERICAN JOURNAL OF PATHOLOGY

Cardiac Overexpression of Angiotensin Converting Enzyme 2 Protects the Heart From Ischemia-Induced Pathophysiology

(2008) Shant Der Sarkissian et al.   HYPERTENSION