Article
Materials Science, Ceramics
Samuel Brito Ferreira Santos, Pascally Maria Aparecida Guerra de Araujo, Isabela Alves dos Santos, Ana Cristina Figueiredo de Melo Costa, Alvaro Silva Lima, Libia de Sousa Conrado
Summary: This study proposes a novel approach for the development of magnetic nanoparticles for drug delivery systems, by conducting drug release tests and pharmacokinetic modeling. Results show that the incorporation of hydroxyapatite enhances the drug carrying capacity, as indicated by drug release tests on FeFe2O4 and CoFe2O4 based nanocarriers.
CERAMICS INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Feng-Huei Lin, Yu-Chen Hsu, Kuo-Chi Chang, Yan-Jye Shyong
Summary: The objective of this study was to develop HAp particles for targeted delivery of honokiol to tumor sites after glioma surgical management. Honokiol is released from the HAp-honokiol particles inside cancer cells through endocytosis and acid lysosomal dissolution. HAp-honokiol treatment showed sustained drug release without compromising drug efficacy, leading to a significant reduction in tumor size in a mouse glioma model. These findings suggest that HAp-honokiol particles have potential as an effective drug delivery system for glioma treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Gurdyal Singh, Ravinder Pal Singh
Summary: This study presents the co-substitution of strontium and sulphate into hydroxyapatite structure through microwave synthesis to obtain nanopowders with potential for antibacterial and drug delivery applications, showcasing their multifunctional therapeutic potential.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jonas Kost, Jorg Huwyler, Maxim Puchkov
Summary: This study introduces an inorganic calcium phosphate microparticle with a hollow internal structure, known as template inverted particle (TIP), as a biocompatible and multifunctional microcapsule. A unique particle geometry is achieved by enclosing a hollow cavity with a specially engineered porous shell. The study focuses on utilizing TIP as an excipient for the design of solid dosage forms. The results demonstrate the potential of multifunctional TIP microcapsules as pharmaceutical drug delivery devices.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Polymer Science
Jovana Milutinov, Veljko Krstonosic, Dejan Cirin, Nebojsa Pavlovic
Summary: Novel delivery systems such as emulgels play an important role in incorporating and protecting active substances for cosmetics, drugs, and food ingredients. The selection of main constituents determines the stability and efficacy of emulgels, which are dual-controlled release systems. Emulsifiers and gelling agents are crucial in ensuring emulsion stability and improving sensory properties.
Review
Integrative & Complementary Medicine
Xiaoqing Zhong, Zhenning Di, Yuanxin Xu, Qifan Liang, Kuanhan Feng, Yuting Zhang, Liuqing Di, Ruoning Wang
Summary: Mineral drugs are an important part of traditional Chinese medicine, but their safety and scientific nature are controversial due to heavy metals and strong toxicity. The development of nanomedicine offers promising prospects for mineral drug delivery, although research on mineral drug delivery systems is currently limited.
Article
Pharmacology & Pharmacy
Carmen Moya-Lopez, Alberto Juan, Murillo Donizeti, Jesus Valcarcel, Jose A. Vazquez, Eduardo Solano, David Chapron, Patrice Bourson, Ivan Bravo, Carlos Alonso-Moreno, Pilar Clemente-Casares, Carlos Gracia-Fernandez, Alessandro Longo, Georges Salloum-Abou-Jaoude, Alberto Ocana, Manuel M. Pineiro, Carolina Hermida-Merino, Daniel Hermida-Merino
Summary: A series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles with different nanostructures were designed for personalized treatment approaches. The systems were customized for drug release, ease of storage and local administration, biocompatibility, and cell growth capability at the biomolecular level. The study successfully formulated nanoparticles with different antitumoral compounds and characterized the bionanocomposites using various techniques. The drug release profiles were analyzed and correlated to the nanostructure of the drug delivery system.
Article
Materials Science, Ceramics
Dagmara Slota, Wioletta Florkiewicz, Karina Pietak, Klaudia Pluta, Julia Sadlik, Krzysztof Miernik, Agnieszka Sobczak-Kupiec
Summary: In this study, ceramics-polymer materials based on hydroxyapatite, polyvinylpyrrolidone and betaine were developed as biomaterials. The prepared materials showed strong sorption capacity and bioactivity, with the ability to generate new apatite layers in biological fluid. These findings indicate the potential of the materials as carriers of active substance and in bone tissue regeneration.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Dagmara Slota, Karina Pietak, Wioletta Florkiewicz, Josef Jampilek, Agnieszka Tomala, Mateusz M. M. Urbaniak, Agata Tomaszewska, Karolina Rudnicka, Agnieszka Sobczak-Kupiec
Summary: Bioactive calcium phosphate ceramics (CaPs) are important components of bone structure. This study compared different ceramic powders and analyzed their physicochemical properties. The results confirmed the purity of the materials and the validity of the synthesis methods. Additionally, the specific surface area of the ceramics was found to affect drug release efficiency.
Article
Pharmacology & Pharmacy
Oscar Ivan Martinez-Munoz, Claudia Elizabeth Mora-Huertas
Summary: Nanoprecipitation is a practical method for preparing nanoscale carriers with low cost, easy setup, and minimal environmental impact. Chinese universities are leaders in this field, focusing on cancer treatments followed by neurodegenerative and diabetes diseases. New proposals for targeted and stimuli response particles, as well as advancements in polymers and prodrugs, have been made.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jon Andrade del Olmo, Leyre Perez-Alvarez, Virginia Saez Martinez, Sandra Benito Cid, Leire Ruiz-Rubio, Raul Perez Gonzalez, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: In the biomedical community, there has been a focus on developing antibacterial coatings to prevent implant-associated infections. Traditional mono-functional antibacterial strategies have not been sufficient for long-term success. Researchers have recently turned their attention to novel bifunctional or multifunctional antibacterial coatings that combine multiple antibacterial mechanisms. In this study, chitosan-based hydrogel coatings with genipin and polyethylene glycol crosslinking agents were created on a Ti6Al4V surface. These hydrogel coatings demonstrated excellent biocompatibility, as well as the ability to promote cell proliferation and differentiation. Additionally, they showed outstanding bacteria-repelling and contact killing ability. The controlled release of drugs could further enhance their multifunctional antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Fengjiao Zhang, Sufeng Zhang, Rui Lin, Shuyuan Cui, Xiaokai Jing, Sergiu Coseri
Summary: This study successfully synthesized an injectable and self-healing pH-responsive hydrogel that can be used as a carrier for drug delivery systems. The hydrogel exhibited notable mechanical properties, good self-healing ability, pH responsiveness, and excellent antibacterial properties. It also showed a high drug loading capacity and sustained drug release behavior, as well as good cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Dapeng Zhang, Elena N. Atochina-Vasserman, Devendra S. Maurya, Ning Huang, Qi Xiao, Nathan Ona, Matthew Liu, Hamna Shahnawaz, Houping Ni, Kyunghee Kim, Margaret M. Billingsley, Darrin J. Pochan, Michael J. Mitchell, Drew Weissman, Virgil Percec
Summary: Efficient delivery of nucleic acids is crucial for genetic nanomedicine. While viral vectors are highly efficient, they can also cause severe immune responses, toxicity, and mutations. Nonviral lipid nanoparticles containing specific components show promise for mRNA delivery, but challenges such as stability at low temperatures need to be addressed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Engineering, Environmental
Fenzan Wu, Yan Zu, Wanqing Weng, Yanhong Yang, Jie Hu, Yuqin Mao, Changmin Shao, Jian Xiao
Summary: An intelligent drug delivery system, stretched inverse opal film (SIOF), is proposed in this study for spinal cord injury (SCI) repair. The SIOF with interconnected nanopores can host drugs and regulate their release. The Drugs-Gel@SIOF showed excellent performance in inhibiting inflammation and promoting axon growth, leading to the recovery of motor function in a spinal cord trauma rat model.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Physical
Shirin Mollazadeh, Amirhossein Sahebkar, Mohsen Shahlaei, Sajad Moradi
Summary: The therapeutic efficacy of drugs, particularly hydrophobic anticancer agents, can be significantly enhanced through advanced nanoplatforms. Modification of nanoparticles with polymers and chemical functional groups has gained increasing interest for improving pharmacokinetic properties, reducing toxicity, and enhancing targeted drug delivery. Molecular dynamic simulation is a valuable computational method for understanding the behavior and structural changes of nanoparticles, although theoretical limitations exist. Simulation of nano drug delivery systems has proven effective in interpreting experimental findings and predicting material selection for experimental conditions.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Materials Science, Ceramics
Aleksandra Laskus-Zakrzewska, Anna Zgadzaj, Joanna Kolmas
Summary: Dicalcium phosphate dihydrate (DCPD) enriched with different amounts of Zn2+ ions was synthesized in aqueous solution via standard precipitation method. Characterization tests confirmed the successful introduction of zinc ions into the DCPD crystal, making it a promising material for mineralized tissue engineering.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Szurkowska, Paulina Kazimierczak, Joanna Kolmas
Summary: This study aimed to fabricate hydroxyapatite-based composite beads as local carriers for raloxifene. With modifications of magnesium and silicon ions, as well as the addition of organic matrices such as chondroitin sulphate and keratin, the beads demonstrated improved resistance to crushing and sustained drug release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Barbara Kolodziejska, Natalia Stepien, Joanna Kolmas
Summary: This study summarizes the role of strontium in the treatment of osteoporosis, highlighting its multidirectional effects on bone tissue and its similarities to calcium. It discusses the unique mechanism of action of strontium ranelate and the increasing interest in using strontium ions in ceramics as bone replacement materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Bialik, Marzena Kuras, Marcin Sobczak, Ewa Oledzka
Summary: Rectal drug delivery offers a viable option for both local and systemic medication. Recent developments in thermosensitive liquid suppositories have shown promise, despite current limitations. Further research and development are necessary to fully uncover the potential of rectal drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Aleksandra Laskus-Zakrzewska, Paulina Kazimierczak, Joanna Kolmas
Summary: Porous 3D granules based on zinc and selenium-containing calcium phosphates were fabricated using a droplet-extrusion technique for delivering simvastatin to bones, showing potential clinical applications.
Article
Chemistry, Physical
Natalia Byra, Sylwester Krukowski, Jaroslaw Sadlo, Waclaw Kolodziejski
Summary: Hydroxyapatite is a major component in mammalian hard tissues and has various applications such as bone and dental implantology and drug delivery systems. Studying the surface properties of hydroxyapatite can provide insights into bone mineralization and degradation processes.
Article
Biochemistry & Molecular Biology
Kamil Pajor, Anna Michalicha, Anna Belcarz, Lukasz Pajchel, Anna Zgadzaj, Filip Wojas, Joanna Kolmas
Summary: The aim of this study was to investigate the physicochemical properties and biological activity of different types of porous granules containing silver or gallium ions. The results showed that the granules were porous and exhibited slow release of the substituted ions, with high antibacterial activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Analytical
Monika Budnicka, Monika Sobiech, Joanna Kolmas, Piotr Lulinski
Summary: This review highlights the importance of detection and determination of s-block metal ions using ion-imprinted polymers. It discusses the application of these materials in environmental, food, and biomedical fields, and identifies the frontiers in the design of s-block metal ion-imprinted polymers. The review concludes with a summary and future perspectives for further development in this field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Maria Bialik, Joanna Proc, Anna Zgadzaj, Karolina Mulas, Marzena Kuras, Marcin Sobczak, Ewa Oledzka
Summary: This study developed thermosensitive liquid suppositories carrying the antihypertensive drug metoprolol tartrate. It was the first to use biodegradable nanoparticles to produce liquid metoprolol suppositories and optimized their rheological and mechanical properties for rectal administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Barbara Kolodziejska, Lukasz Pajchel, Anna Zgadzaj, Joanna Kolmas
Summary: The aim of this study was to obtain and characterize composite biomaterials containing carbonated hydroxyapatite and natural polymer-collagen protein. The obtained materials showed favorable physicochemical properties and could be used as targeted delivery matrices for wound healing after tooth extractions.
Review
Biochemistry & Molecular Biology
Magda Molenda, Joanna Kolmas
Summary: Zinc is essential for human health, particularly for the normal development and homeostasis of bone tissue. It plays a role in the synthesis, mineralization, and turnover of bone, promoting osteoblast differentiation and inhibiting osteoclast formation. Zinc also regulates the RANKL/RANK/OPG pathway, facilitating bone remodeling. However, the mechanisms of zinc's activity on bone tissue are still not fully understood and documented.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Kamil Pajor, Lukasz Pajchel, Anna Zgadzaj, Paulina Kowalska, Anna Kowalczuk, Joanna Kolmas
Summary: Various calcium phosphates enriched in silver or gallium ions were synthesized and analyzed via FT-IR, PXRD, and AAS. These calcium phosphate powders, along with sodium alginate and chondroitin, were used to produce composite granules loaded with ciprofloxacin. The release of silver, gallium ions, and ciprofloxacin was examined, and the granules exhibited low cytotoxicity, high antibacterial activity, and different release profiles depending on the type of calcium phosphate.
Article
Pharmacology & Pharmacy
Maria Bialik, Piotr Kurkowski, Katarzyna Strzelecka, Marzena Kuras, Marcin Sobczak, Karolina Mulas, Anna Zgadzaj, Monika E. Czerwinska, Marianna Gniadek, Ewa Oledzka
Summary: The fundamental objective of this work was to develop double-layered nanosystems based on biodegradable polymers for combination therapy of arterial hypertension. The nanosystems were designed and characterised with furosemide and atenolol as model antihypertensive drugs. The release kinetics and cytotoxicity of the nanosystems were evaluated, showing good release performance and non-toxicity in cell experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sylwester Krukowski, Konrad Sztelmach
Summary: The study aimed to examine the effect of collagen amino acids on the physicochemical properties of hydroxyapatite. The results showed that amino acids influenced the relative content of labile phosphate groups in the hydrated surface layer, leading to differences in some physicochemical properties of hydroxyapatite.
Article
Materials Science, Biomaterials
Paulina Kazimierczak, Joanna Golus, Joanna Kolmas, Michal Wojcik, Dorota Kolodynska, Agata Przekora
Summary: Development of bone scaffolds with antibacterial activity and non-toxicity to human cells remains challenging. In this study, three variants of Zn-doped hydroxyapatite (HA) nanopowder were synthesized to produce macroporous chitosan/agarose/nanoHA biomaterials with high antibacterial activity. The scaffold with low zinc content showed gradual release of Zn2+ ions, preventing toxic concentration and providing prolonged antibacterial activity. The developed biomaterial was non-toxic to human cells and showed antibacterial activity against various bacteria.
BIOMATERIALS ADVANCES
(2022)
