Review
Urology & Nephrology
Ruifeng Wang, Yiping Wang, David C. H. Harris, Qi Cao
Summary: Innate immune cells, including a newly discovered group of innate lymphoid cells (ILCs), play critical roles in kidney diseases by providing immunomodulatory cytokines and guiding immune responses. Understanding the function of ILCs in normal and diseased kidneys emphasizes the emerging importance of ILC-regulated immunity for future research and therapeutic interventions.
KIDNEY INTERNATIONAL
(2021)
Review
Immunology
Bernd Heinrich, Firouzeh Korangy
Summary: Innate lymphoid cells (ILCs) are a heterogeneous population of the innate immune system that play a crucial role in maintaining immune homeostasis. They exhibit high plasticity, allowing them to quickly respond to changes in their microenvironment. ILCs can transdifferentiate into different subsets in the tumor microenvironment, influencing the immune response and tumor therapy. This review summarizes the functional and plastic heterogeneity of ILCs in homeostasis and disease, with a focus on tumor-driven plasticity and the impact of ILC-induced inflammation on the tumor microenvironment and anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhiyu Ma, Jinsong Wang, Lei Hu, Songlin Wang
Summary: Periodontitis is an irreversible inflammatory response that occurs in periodontal tissues. Innate lymphoid cells (ILCs) have been found to play a crucial role in regulating immune responses in periodontitis. This review focuses on the intricate crosstalk between ILCs and the microenvironment in periodontal tissue homeostasis for the purpose of regulating or improving immune responses in periodontitis prevention and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Marek Wagner, Shigeo Koyasu
Summary: Innate lymphoid cells (ILCs), enriched in barrier tissues like skin, play a role in immune pathways despite lacking antigen receptors found on T and B cells. They are crucial in controlling melanoma and potentially benefiting patients with skin malignancies through their therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Kong, Han-Dong Li, Dan Wang, Xiaolin Gao, Chunsheng Yang, Minshu Li, Ting Chang, Qiang Liu
Summary: The study found a correlation between the reduction of ILC2 and disease severity in neuromyelitis optica spectrum disorder (NMOSD), and expanding ILC2 could alleviate the pathological conditions.
Review
Immunology
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujcic, Udo R. Markert
Summary: Members of the innate immune system, specifically innate lymphoid cells (ILCs), play important roles in the uterine environment, supporting pregnancy and placental development. These cells demonstrate immune memory, allowing them to remember previously encountered antigens and mount enhanced responses. By studying ILCs, we can gain insights into the immunological mechanisms underlying female fertility/infertility, placental development, and distinct outcomes in second pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jongho Ham, MinYeong Lim, Dongmo Kim, Hye Young Kim
Summary: Innate lymphoid cells (ILCs) are recently discovered innate immune cells that play a role in the defense against external insults in mucosal tissues. They exhibit characteristics similar to adaptive immune cells and can potentially have memory-like properties. Studies suggest that ILCs may play a significant role in the pathogenesis of asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Laura Matha, Itziar Martinez-Gonzalez, Catherine A. Steer, Fumio Takei
Summary: ILC2s are a type of cells that play critical roles in defending against parasites and allergens, producing large amounts of inflammatory factors upon activation. Studies have revealed novel properties of post-activation ILC2s, such as the generation of immunological memory and activation-induced migration.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Umit M. Sahiner, Janice A. Layhadi, Korneliusz Golebski, Zsolt Istvan Komlosi, Yaqi Peng, Bulent Sekerel, Stephen R. Durham, Helen Brough, Hideaki Morita, Mubeccel Akdis, Paul Turner, Kari Nadeau, Hergen Spits, Cezmi Akdis, Mohamed H. Shamji
Summary: Food allergy is a prevalent disease driven by uncontrolled type 2 immune response, commonly developing through skin sensitization with later allergy symptoms in the gastrointestinal tract. Recent studies suggest a possible role for innate lymphoid cells (ILCs) in driving food allergy.
Article
Medicine, General & Internal
Agata Poniewierska-Baran, Beata Tokarz-Deptula, Wieslaw Deptula
Summary: Innate lymphoid cells (ILCs) are an important group of immune cells that play a crucial role in regulating homeostasis and protecting humans from infections and diseases. Current research is focused on understanding the biology of ILCs and their functions in the human body, particularly in disease states such as cancer, metabolic disorders, and inflammation.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
Mingming Liu, Danni Wang, Lin Xu, Yan Pan, Huachen Huang, Minshu Li, Qiang Liu
Summary: Group 2 innate lymphoid cells (ILC2) have a suppressive effect on neuroinflammation and injury following intracerebral hemorrhage (ICH). Depletion of ILC2 exacerbates neurodeficits and brain edema after ICH, accompanied by increased microglia activity and leukocyte infiltration. Conversely, expansion of ILC2 reduces ICH injury, microglia activity, and leukocyte infiltration.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Obstetrics & Gynecology
Yiran Zhao, Yajie Zhu, Xi Chen, Hui Lin, Ningxin Qin, Zhiyang Zhou, Han Liu, Yanhui Hao, Chengliang Zhou, Xinmei Liu, Li Jin, Jianzhong Sheng, Hefeng Huang
Summary: The investigation of innate lymphoid cells (ILCs) has revealed their significance in successful pregnancy. This study showed that the proportion and distribution of circulating ILC subsets in peripheral blood changed dynamically during pregnancy. Late-pregnant women displayed a significantly higher proportion of circulating ILCs, mainly ILC2s, while ILC3s were decreased. Plasma progesterone and estradiol levels increased as pregnancy proceeded and were consistent with the expression of their receptors in ILC2s.
REPRODUCTIVE SCIENCES
(2022)
Review
Immunology
Kathrin Warner, Maryam Ghaedi, Douglas C. C. Chung, Nicolas Jacquelot, Pamela S. Ohashi
Summary: Innate lymphoid cells (ILCs), the innate counterparts of T cells, play a crucial role in immune responses and have a profound impact on diseases like cancer. ILCs can influence early tumor development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tiraput Poonpanichakul, Wilawan Chan-In, Anunya Opasawatchai, Fabien Loison, Oranart Matangkasombut, Varodom Charoensawan, Ponpan Matangkasombut
Summary: Helper innate lymphoid cells (hILCs) are activated during the febrile phase of Dengue virus (DENV) infection, displaying unique transcriptomic changes and cytokine production that correlate with disease severity. Targeting hILCs during the early innate response to DENV may help shape subsequent immune responses and potentially lessen disease severity.
FRONTIERS IN IMMUNOLOGY
(2021)