Article
Endocrinology & Metabolism
Cem Demirel, Pinar Ozcan, Firat Tulek, Hikmet Tunc Timur, Oezge Pasin
Summary: This study aims to evaluate whether subcutaneous progesterone supplementation can improve pregnancy rates in natural cycle frozen embryo transfers (FETs) when serum progesterone levels are below 10ng/mL. The results show that subcutaneous progesterone supplementation can effectively rescue luteal support and yield similar pregnancy rates compared to the normal progesterone group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
B. Lawrenz, H. M. Fatemi
Summary: This opinion article raises critical points about the sole focus on systemic progesterone levels in hormone replacement therapy frozen embryo transfer cycles and questions whether serum progesterone measurements truly represent the identification of an adequate luteal phase.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Elizabeth L. Wolfe, Denis Vaughan, Wendy Craig, Brianna Amaral, Alan Penzias, Denny Sakkas, Thomas L. Toth
Summary: This study compared the live birth rates in modified natural and programmed single blastocyst frozen embryo transfer cycles. The results showed no difference in live birth rates between programmed cycles using intramuscular progesterone or a combination of vaginal progesterone and intramuscular progesterone compared with modified natural cycles. However, the live birth rate decreased in programmed cycles that used exclusively vaginal progesterone. This study demonstrates that modified natural cycles and optimized programmed cycles have equivalent live birth rates.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
B. Lawrenz, B. Ata, E. Kalafat, L. Melado, I ElKhatib, R. Del Gallego, H. Fatemi
Summary: Serum progesterone (P4) levels on the embryo transfer (ET) day are not predictive of ongoing pregnancy (OP) following a single euploid blastocyst transfer in a natural cycle (NC) when luteal phase support (LPS) is routinely given.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Pedro Melo, Yealin Chung, Oonagh Pickering, Malcolm J. Price, Simon Fishel, Mohammed Khairy, Charles Kingsland, Philip Lowe, Georgios Petsas, Madhurima Rajkhowa, Victoria Sephton, Amanda Tozer, Simon Wood, Elena Labarta, Mark Wilcox, Adam Devall, Ioannis Gallos, Arri Coomarasamy
Summary: The study found that there is an association between luteal serum progesterone levels and FET outcomes. It suggests that there may be a minimum clinically important luteal serum concentration of progesterone required for optimal endocrine milieu during embryo implantation and early pregnancy after FET treatment. Further clinical trials are needed to assess the impact of administering higher-dose luteal phase support on outcomes in women with low serum progesterone levels at the time of FET.
FERTILITY AND STERILITY
(2021)
Review
Obstetrics & Gynecology
Yanbiao Jiang, Liyan Wang, Haofei Shen, Bin Wang, Jingyuan Wu, Kaiyan Hu, Yiqing Wang, Bin Ma, Xuehong Zhang
Summary: The study investigated the effect of progesterone supplementation on the reproductive outcomes of patients undergoing NC-FET cycles. The results showed that progesterone supplementation was associated with increased live birth rate and clinical pregnancy rate, especially in traditional NC-FET cycles.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Manuel Alvarez, Sofia Gaggiotti-Marre, Francisca Martinez, Lluc Coll, Sandra Garcia, Inaki Gonzalez-Foruria, Ignacio Rodriguez, Monica Parriego, Nikolaos P. Polyzos, Buenaventura Coroleu
Summary: This study investigated whether individualized luteal phase support based on serum progesterone levels the day before embryo transfer can improve pregnancy outcomes for patients with low progesterone. The results showed that adding daily subcutaneous progesterone injections for patients with low progesterone levels prior to embryo transfer can lead to similar reproductive outcomes as those with adequate progesterone levels.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Qianqian Zhu, Jialyu Huang, Yue Lin, Liyao Jiang, Xuefeng Huang, Jing Zhu
Summary: This study investigated the relationship between serum progesterone levels on the day of embryo transfer and the likelihood of live birth in artificial cycles using a combination of oral dydrogesterone and vaginal progesterone for luteal phase support. The results showed that there was no significant difference in the odds of live birth between the low and high progesterone groups after adjustment.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
K. Wanggren, M. Dahlgren Granbom, S. I. Iliadis, J. Gudmundsson, A. Stavreus-Evers
Summary: The supplementation with vaginal tablets of progesterone after frozen-thawed embryo transfer in natural cycles significantly improves the number of live births.
HUMAN REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Yossi Mizrachi, Eran Horowitz, Hadas Ganer Herman, Jacob Farhi, Arieh Raziel, Ariel Weissman
Summary: This study systematically reviewed and meta-analyzed whether luteal phase support (LPS) following natural cycle frozen embryo transfer (NC-FET) improves reproductive outcomes. The results indicated that progesterone LPS was associated with higher clinical pregnancy and live birth rates, while hCG administration for LPS did not show significant improvement. Further large randomized controlled trials are needed to validate these findings.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Multidisciplinary Sciences
Abdelhamid Benmachiche, Sebti Benbouhedja, Abdelali Zoghmar, Peter Samir Hesjaer Al Humaidan
Summary: The multivariate analysis suggests that midluteal progesterone level seems to impact live birth rates more than preovulatory progesterone level in women undergoing IVF treatment followed by fresh embryo transfer.
Review
Obstetrics & Gynecology
Yossi Mizrachi, Ariel Weissman, Genia Rozen, Peter A. W. Rogers, Catharyn Stern, Alex Polyakov
Summary: Moderate quality evidence suggests that progesterone luteal phase support is beneficial in natural and modified frozen embryo transfer cycles. Further research is needed to determine the optimal timing and method of administration.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Genetics & Heredity
Ronit Beck-Fruchter, Simon Nothman, Shira Baram, Yoel Geslevich, Amir Weiss
Summary: This study found a significant association between serum progesterone and estradiol levels and live birth rates in AC-FET. Lower levels of progesterone and estradiol were associated with lower live birth rates. The findings suggest that monitoring and potentially adjusting these hormone levels may improve outcomes in artificial cycle frozen embryo transfer.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Multidisciplinary Sciences
Wen-Jing Jiang, Zhen-Gao Sun, Jing-Yan Song
Summary: Premature initiation of progesterone luteal phase support (LPS) 24 hours after hCG trigger did not affect live birth rate in modified natural cycle frozen-thawed embryo transfer. This study provides valuable insights for clinical decisions and patient choices.
Article
Endocrinology & Metabolism
Hongyuan Gao, Jing Ye, Hongjuan Ye, Qingqing Hong, Lihua Sun, Qiuju Chen
Summary: This study found that low serum progesterone levels on the day of frozen embryo transfer in artificial endometrium preparation cycles are associated with increased pregnancy risks, and strengthened luteal phase support may help improve pregnancy outcomes for women in artificial cycles.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Alessandro Conforti, Frank Tuettelmann, Carlo Alviggi, Hermann M. Behre, Robert Fischer, Liang Hu, Nikolaos P. Polyzos, Dana Chuderland, Gottumukkala Achyuta Rama Raju, Thomas D'Hooghe, Manuela Simoni, Sesh K. Sunkara, Salvatore Longobardi
Summary: A Delphi consensus was conducted to evaluate the influence of single nucleotide polymorphisms (SNPs) in genes encoding gonadotropin and gonadotropin receptors on clinical ovarian stimulation outcomes following assisted reproductive technology (ART) treatment. The results showed that some gene variants are associated with ovarian stimulation outcomes, but further research is needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Lluc Coll, Monica Parriego, Beatriz Carrasco, Ignacio Rodriguez, Montserrat Boada, Buenaventura Coroleu, Nikolaos P. Polyzos, Francesca Vidal, Anna Veiga
Summary: The prevalence of embryo mosaicism in preimplantation genetic testing for aneuploidy (PGT-A) cycles is not significantly associated with the trophectoderm biopsy technique or the time to tubing. As long as standardized high quality procedures are followed, the specific approach to trophectoderm biopsy does not increase the generation of artefactual mosaicism. The study suggests that minimizing blastocyst manipulation should be the goal during biopsy procedures.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Review
Obstetrics & Gynecology
Ana Raquel Neves, Pedro Montoya-Botero, Noemie Sachs-Guedj, Nikolaos P. Polyzos
Summary: The literature regarding the association between the number of oocytes retrieved and the cumulative live birth rate (CLBR) is conflicting. Some studies suggest a continuous increase in CLBR with more oocytes retrieved, while others find a plateau. The association between oocyte number and CLBR varies according to patients' age.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Panagiotis Drakopoulos, Yakoub Khalaf, Sandro C. Esteves, Nikolaos P. Polyzos, Sesh K. Sunkara, Daniel Shapiro, Botros Rizk, Hong Ye, Michael Costello, Yulia Koloda, Bruno Salle, Monica Lispi, Thomas D'Hooghe, Antonio La Marca
Summary: A high ovarian response refers to a greater number of follicles and/or oocytes compared to a normal response. It can be diagnosed before oocyte pick-up when there are >18-20 follicles ≥11-12 mm, or after oocyte pick-up when >18-20 oocytes have been retrieved. Women with a high response are at high risk of ovarian hyperstimulation syndrome (OHSS). Appropriate management strategies, such as individualized gonadotropin dosing, monitoring, and choice of protocols, can greatly reduce the risk of high response.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Chemistry, Applied
Wesclen Vilar Nogueira, Francisco Javier Moyano, Marcelo Borges Tesser, Jaqueline Garda-Buffon
Summary: This study evaluated the potential of peroxidase from soybean meal to mitigate aflatoxin B-1 in fish feed. The results showed that a mitigation efficiency of 90% could be achieved when the enzyme activity was 0.035U/g, temperature was 32 degrees C, time was 6 hours, and humidity was 70%. This suggests that the application of peroxidase in the feed industry could be a promising tool for reducing the risk of aflatoxin contamination in fish farming.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Endocrinology & Metabolism
A. Racca, M. Alvarez, S. Garcia Martinez, I. Rodriguez, I. Gonzalez-Foruria, N. P. Polyzos, B. Coroleu
Summary: The main objective of this study is to determine the optimal trade-off progesterone (P4) values on the day of embryo transfer (ET), identify low P4-human chorionic gonadotropin (hCG), and establish whether P4 supplementation started on the hCG day can increase the success rate of the frozen embryo transfer (FET) cycle.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Raquel Quiros-Pozo, Francisco Javier Moyano, Khalida Bainour, Sara Ramirez-Bolanos, Anais Ventura-Castellano, Javier Roo, Lidia Robaina
Summary: The diversification of mullet species in marine aquaculture is essential for sustainable development. This study characterized the digestive biochemistry of two mullet species and evaluated the effects of different feeding frequencies. The results demonstrated the importance of feeding three times per day and highlighted the interspecific differences in digestive response and body composition.
Article
Obstetrics & Gynecology
Inaki Gonzalez-Foruria, Sandra Garcia, Manuel Alvarez, Annalisa Racca, Maria Hernandez, Nikolaos P. Polyzos, Buenaventura Coroleu
Summary: This study evaluated the reproductive outcomes of patients with high-serum progesterone levels before frozen embryo transfer (FET) under hormonal replacement therapy. The results showed no significant differences in clinical pregnancy, miscarriage, and live birth rates between the use of vaginal progesterone alone or in combination with subcutaneous progesterone for FET in different types of embryo transfers. The live birth rates were comparable between patients with high-serum progesterone levels and the rest of the patients.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Chloe Maignien, Rami El Hachem, Mathilde Bourdon, Louis Marcellin, Celine Chalas, Catherine Patrat, Inaki Gonzalez-Foruria, Charles Chapron, Pietro Santulli
Summary: This study aimed to investigate the reproductive outcomes and prognostic factors of live birth rates in patients with endometriosis referred to oocyte donation after multiple IVF failures. The study found that oocyte donation is a viable option for addressing infertility and recurrent IVF failures in patients with endometriosis.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Medicine, General & Internal
Valeria Donno, Sandra Garcia-Martinez, Nikolaos P. Polyzos
Summary: This retrospective observational study analyzed 5190 ovarian stimulation cycles and found no association between patients' BMI or weight and the efficiency of different types of triggers to induce final oocyte maturation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
K. Lundin, J. G. ESHRE Addons Working Grp, J. G. Bentzen, G. Bozdag, T. Ebner, J. Harper, N. Le Clef, A. Moffett, S. Norcross, N. P. Polyzos, S. Rautakallio-Hokkanen, I Sfontouris, K. Sermon, N. Vermeulen, A. Pinborg
Summary: This study focused on the safety and efficacy of add-ons used in ART treatment. The study formulated 42 recommendations covering various aspects such as diagnosis, laboratory tests, and clinical management. However, most of the recommendations were based on low-quality evidence.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Mina Popovic, Lorena Borot, Aline R. Lorenzon, Ana Luiza Rossi de Castro Lopes, Denny Sakkas, Belen Lledo, Ruth Morales, Jose Antonio Ortiz, Nikolaos P. Polyzos, Monica Parriego, Felicitas Azpiroz, Micaela Galain, Aida Pujol, Bjorn Menten, Lien Dhaenens, Frauke Vanden Meerschaut, Dominic Stoop, Maria Rodriguez, Enrique Perez de la Blanca, Amelia Rodriguez, Rita Vassena
Summary: The diagnosis of mosaicism affects the ploidy rates across different providers offering preimplantation genetic testing for aneuploidies (PGT-A), with providers reporting low rates of mosaicism having significantly higher euploidy rates.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Noemie Sachs-Guedj, Buenaventura Coroleu, Maria Angela Pascual, Ignacio Rodriguez, Nikolaos Polyzos
Summary: The presence of adenomyosis has a significant negative impact on the clinical outcomes of patients undergoing frozen embryo transfer (FET), leading to higher miscarriage rates, lower clinical pregnancy rates, and lower live birth rates. The use of GnRH agonist pre-treatment does not appear to improve clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Wesclen Vilar Nogueira, Maria Jesus Aznar-Garcia, Francisca P. Martinez-Antequera, Antonia M. Barros de Las Heras, Marcelo Borges Tesser, Jaqueline Garda-Buffon, Francisco Javier Moyano
Summary: Peroxidase is effective in mitigating mycotoxins in fish feeds. However, its use may have unwanted side effects on the nutritional quality of fatty acids and polyphenols present in the feed, affecting their bioavailability and the overall quality of the final product.
Article
Agriculture, Dairy & Animal Science
Francisco Javier Toledo-Solis, Amin Mokhles Abadi Farahani, Sara Yague, Inmaculada Mateos-Aparicio, Valentin Perez, Ana Maria Larran, Francisco Javier Moyano, Ignacio Fernandez
Summary: Red vetchling meal has the potential to replace soybean meal in fish diets, with the ability to replace up to 66% of soybean meal without any negative effects on fish growth or physiology.