Review
Pharmacology & Pharmacy
Marie McCarthy, Patricia Murphy, Russell Rosenberg, Colin Orford
Summary: Sleep is seldom taken into account in drug development studies, despite it being crucial to human health and predictive of disease risk and progression. It is proposed that sleep should be conceptualized as a vital sign and measured as an integral component in drug development.
DRUG DISCOVERY TODAY
(2022)
Article
Medicine, General & Internal
Yi-Xin Wang, Jennifer J. Stuart, Janet W. Rich-Edwards, Stacey A. Missmer, Kathryn M. Rexrode, Leslie Farland, Kenneth J. Mukamal, Scott M. Nelson, Caren G. Solomon, Abigail Fraser, Jorge E. Chavarro
Summary: In this cohort study, both irregular and long menstrual cycles were associated with increased rates of CVD, which persisted even after accounting for subsequently established CVD risk factors.
Article
Psychology, Multidisciplinary
Vanesa Sainz, Beatriz Martin-Moya
Summary: Bullying is a concerning issue that is on the rise. Several bullying prevention programs, including TEI, KiVa, and Mediation Teams, have been implemented in schools to create a positive environment. Through qualitative interviews with experts and school staff, a comparative analysis shows that these prevention programs raise awareness, improve the school environment, and decrease instances of bullying. Overall, participating schools are highly satisfied with the results, highlighting the importance of implementing mandatory bullying prevention programs in all schools.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Pal Kraft, Brage Kraft
Summary: This study examines the mediating effect of social comparison processes on the relationship between income and subjective wellbeing (SWB). The findings suggest that while there is a positive correlation between income and SWB, income does not have a direct effect on SWB. Instead, subjective socioeconomic status and comparing oneself with individuals from a similar socioeconomic background play significant roles in predicting SWB, with social comparison being the most influential factor. Furthermore, the study highlights the mediating role of cognitive and affective factors between social comparison processes and SWB.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Engineering, Chemical
Alessandra Hausmann, Britta Buck, Laura Shaw, Tom Simons, Frank Kleine Jager, Daryl Williams
Summary: The importance of humidity in affecting powder flow and caking is well established. This study introduces a new method of directly introducing humidity into a powder rheometer to determine the powder flow response to humidity in-situ. The study confirms substantial humidity-induced changes in the flowability of non-conducting powders due to electrostatics, as well as changes in powder flow energy and agglomeration/caking for powders susceptible to humidity. This research anticipates the use of humidity-controlled powder rheometers for more sophisticated investigations of powder flow behavior.
Review
Veterinary Sciences
Lluis Ferre-Dolcet, Maria Montserrat Rivera del Alamo
Summary: The female reproductive tract undergoes structural changes during different reproductive stages, and the expression and location of aquaporins (AQPs) are regulated by ovarian steroid hormones. AQPs play important roles in water and solute transportation, follicular development, lubrication and preparation of the endometrium for embryo implantation and fetal development. In the placenta, AQPs ensure fluid support and fetal homeostasis during pregnancy.
VETERINARY SCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
Joseph R. Buckman, Tiemen Woutersen, Matthew J. Hashim
Summary: The adoption of health IT has a positive impact on communication between care providers and patients, resulting in improved patient outcomes. The communication between nurses and patients, as well as physicians and patients, mediates the relationship between health IT implementation and patient outcomes, extending the positive effects of technology implementation.
DECISION SUPPORT SYSTEMS
(2022)
Article
Public, Environmental & Occupational Health
Jeyong Jung, Byung-Jik Kim, Min-Jik Kim
Summary: This study investigates the relationship between job insecurity and employee's turnover intention, focusing on the mediation effect of meaningfulness of work and the moderating effect of coaching leadership. The results, based on data collected from 372 employees in South Korean organizations, show that meaningfulness of work acts as a mediator in the job insecurity-turnover intention link, and coaching leadership buffers the negative impact of job insecurity on meaningfulness of work. These findings highlight the importance of considering meaningfulness of work and coaching leadership as underlying processes and contingent factors in understanding the job insecurity-turnover intention relationship.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Environmental Sciences
Debarshi Sarkar, Parul Midha, Shashanka Sekhar Shanti, Shio Kumar Singh
Summary: Polybrominated diphenyl ethers (PBDEs), including decabromodiphenyl ether (BDE-209), are widely used as flame retardants in manufactured products, but the increasing levels of BDE-209 in biological samples has raised concerns about its reproductive toxicity, particularly in males. BDE-209 is structurally similar to thyroid hormone (TH) and can disrupt TH function. Exposure to BDE-209 can lead to male reproductive toxicity through various pathways, including impairment of steroidogenesis and oxidative stress. However, further research is needed to fully understand the adverse effects and mechanisms of BDE-209 on male reproductive health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Health Care Sciences & Services
Gianluca Santoro, Vladan Starcevic, Andrea Scalone, Josephin Cavallo, Alessandro Musetti, Adriano Schimmenti
Summary: This study aimed to examine the relationships between somatic symptoms, health anxiety, and cyberchondria. The results showed that the severity of somatic symptoms predicted increased levels of cyberchondria, and health anxiety partially mediated this association.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Clinical Neurology
Rosemarie Kobau, Lidia M. V. R. Moura
Summary: Compared to US adults without epilepsy, adults with epilepsy are more likely to face barriers in accessing prescription medication and specialty care due to financial and transportation difficulties. These challenges are influenced by social determinants of health (SDOH) which encompass various social, economic, institutional, and environmental factors. While there is substantial research on individual-level social needs in people with epilepsy, there is limited research on the associations between community-level SDOH and epilepsy outcomes.
Article
Public, Environmental & Occupational Health
Sam Hugh-Jones, Anna Wilding, Luke Munford, Matt Sutton
Summary: Previous studies have shown that smoking, exercise, and social interaction play a mediating role in the relationship between physical and mental health. This study explores the effects of different mediators on the relationship between past and future physical and mental health across different age and gender groups. The results indicate that in-person social interaction is the most significant mediator in the relationship between mental health and future physical health.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Medicine, General & Internal
Shiue-Shan Weng, Yen-Tsung Huang, Yi-Ting Huang, Yi-Ping Li, Li-Yin Chien
Summary: The use of assisted reproductive technology (ART) is associated with an increased risk of childhood cancers, independent of preterm birth and low birth weight.
Review
Plant Sciences
Zeguang Liu, Peter Farkas, Kai Wang, Morgan-Oceane Kohli, Teresa B. Fitzpatrick
Summary: B vitamins are essential micronutrients for human and plant health. Each B vitamin is a family of compounds with physiological relevance. The homeostasis of vitamers is crucial for overall health and metabolism. Research should focus on understanding the significance of vitamer homeostasis and exploring its potential for supporting human health.
Article
Multidisciplinary Sciences
Thomas V. Johnson, David J. Calkins, Brad Fortune, Jeffrey L. Goldberg, Anna La Torre, Deepak A. Lamba, Jason S. Meyer, Thomas A. Reh, Valerie A. Wallace, Donald J. Zack, Petr Baranov
Summary: Neuronal repopulation, achieved through transplantation or transdifferentiation, has the potential to restore function in neurodegenerative diseases or acute injuries. The evaluation of engrafted neurons is crucial and recent studies have identified mechanisms for cell reporter transfer and misexpression in host cells, leading to potential misidentification of cell origin. This article discusses the common reasons for artifactual labeling of host neurons with donor cell reporters, using the retina as an example, and suggests strategies to prevent erroneous conclusions based on misidentification of cell origin.
Article
Obstetrics & Gynecology
Harrison T. Reeder, Sebastien Haneuse, Anna M. Modest, Michele R. Hacker, Leanna S. Sudhof, Stefania I. Papatheodorou
Summary: This study used the semicompeting risks framework to jointly model the risk and timing of preeclampsia and delivery, providing clinically relevant predictions of outcome trajectories in different risk categories. The results showed nuanced relationships between various risk factors and the timings of preeclampsia diagnosis and delivery, offering meaningful information for clinical decision-making.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Sarah Martinez, Enxhi Rrapi, Michele R. Hacker, Mytien Nguyen, Donna B. Jeffe, Aimee Capellan, Sara McKinney
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Michael Leung, Sebastian T. Rowland, Brent A. Coull, Anna M. Modest, Michele R. Hacker, Joel Schwartz, Marianthi-Anna Kioumourtzoglou, Marc G. Weisskopf, Ander Wilson
Summary: Distributed lag models (DLMs) are used to estimate lagged associations and identify critical exposure windows. A simulation study on prenatal NO2 exposure and birth weight revealed that bias amplification and variance inflation can occur in certain combinations of DLM estimation approaches and time-trend adjustment methods with low-spatial-resolution exposures and extended lags. The spatial resolution of exposure data and the parameterizations of the time trend adjustment and lag constraints should be jointly considered in DLM analyses.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Heather H. Burris, Kristin D. Gerson, Alexa Woodward, Allyson M. Redhunt, Rachel Ledyard, Kasey Brennan, Andrea A. Baccarelli, Jonathan L. Hecht, Ai-Ris Y. Collier, Michele R. Hacker
Summary: Preterm birth remains a major public health issue, and the pathogenesis of spontaneous preterm birth is not fully understood. This study aims to identify a subset of microRNAs that can predict spontaneous preterm birth through analyzing the association between cervical microRNA expression and preterm birth.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Environmental Sciences
Marissa Chan, Emma V. Preston, Victoria Fruh, Marlee R. Quinn, Michele R. Hacker, Blair J. Wylie, Karen O'Brien, Paige L. Williams, Russ Hauser, Tamarra James-Todd, Shruthi Mahalingaiah
Summary: Prenatal exposure to personal care products may be associated with adverse birth outcomes such as preterm birth and low birth weight. Hair product use, nail polish use, and certain personal care products were found to have associations with birth weight and birth length. These findings can inform future interventions and clinical recommendations to reduce exposures linked to adverse pregnancy outcomes.
ENVIRONMENTAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Werner M. Neuhausser, Yuval Fouks, Si Won Lee, Annliz Macharia, Insoo Hyun, Eli Y. Adashi, Alan S. Penzias, Michele R. Hacker, Denny Sakkas, Denis Vaughan
Summary: The acceptance of heritable genome editing (HGE) and whole genome sequencing for preimplantation genetic testing (PGT-WGS) of human embryos has increased after the onset of COVID-19. More participants reported a positive attitude towards HGE for therapeutic and enhancement indications in 2021 compared to 2018, while support for PGT-WGS remained similar.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Ai-ris Y. Collier, Anna M. Modest, Ricardo A. Aguayo, Esther A. Bondzie, Shivani Patel, Michele R. Hacker, Dan H. Barouch
Summary: This study aimed to investigate the differences in T cell phenotype and function in uterine intervillous blood (IVB) between normal pregnancy and preeclampsia, and to explore the immunologic basis of preeclampsia. The results showed that preeclampsia was associated with a greater pro-inflammatory cytokine ratio in uterine IVB T cell subsets, indicating an inflammation-related mechanism of preeclampsia. Therefore, IVB sampling is a useful tool for studying human uterine T cell biology and may provide insights for immunotherapeutic strategies for preeclampsia.
REPRODUCTIVE SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Allyson M. Redhunt, Rachel Ledyard, Ai-ris Y. Collier, Michele R. Hacker, Heather H. Burris
Summary: This study investigates the impact of psychosocial stressors on inequities in preterm birth rates and the role of resilience. The findings suggest that high resilience is insufficient to overcome racial inequities in preterm birth rates between Black and White individuals, as the inequity remains significant even among individuals with the highest resilience levels.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Oncology
Kaitlin Nicholson, Annliz Macharia, Rachel Furuya, Chelsea Manning, Michele R. Hacker, Devon A. Harris, Katharine Esselen, Joseph Dottino
Summary: This study found an association between BMI and age at diagnosis of endometrial intraepithelial neoplasia (EIN), with increasing BMI being associated with an earlier age at diagnosis in premenopausal patients.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Environmental Sciences
Veronica A. Wang, Michael Leung, Anna M. Modest, Carolina L. Zilli Vieira, Michele R. Hacker, Joel Schwartz, Brent A. Coull, Petros Koutrakis, Stefania Papatheodorou
Summary: Solar and geomagnetic activity were found to be associated with fetal growth. The study showed positive associations between prenatal exposures and larger head parameters measured before 24 weeks' gestation, negative associations with smaller fetal parameters measured after 24 weeks' gestation, and no association with birth weight.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Meeting Abstract
Oncology
Cheryl L. Brunelle, Amanda W. Jung, Louisa H. Smith, Kayla Daniell, Maria S. Asdourian, Loryn K. Bucci, Brooke Juhel, Elizabeth K. Hausman, George E. Naoum, Alphonse G. Taghian
Meeting Abstract
Oncology
Brooke Juhel, Cheryl L. Brunelle, Madison C. Bernstein, Louisa H. Smith, Amanda W. Jung, Elizabeth K. Hausman, Loryn K. Bucci, George E. Naoum, Alphonse G. Taghian
Meeting Abstract
Oncology
Amanda W. Jung, Brooke Juhel, Louisa H. Smith, Cheryl L. Brunelle, Elizabeth K. Hausman, Loryn K. Bucci, George E. Naoum, Alphonse G. Taghian
Article
Medicine, Research & Experimental
Brooke C. Juhel, Cheryl L. Brunelle, Madison C. Bernstein, Louisa H. Smith, Amanda W. Jung, Hazim S. Ababneh, Elizabeth K. Hausman, Loryn K. Bucci, Tess Bernstein, George E. Naoum, Alphonse G. Taghian
Summary: Lymph node swelling is a common side effect of mRNA COVID-19 vaccines, and it can be distressing for women treated for breast cancer. A study involving 621 patients who received the vaccine found that the most frequent side effects were injection site soreness, fatigue, muscle soreness, headache, and chills, with a median duration of less than 48 hours. These findings will help educate patients about the expected side effects of future vaccine doses, particularly lymph node swelling which may affect mammograms.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Bridgette W. Wamakima, Sara McKinney, Laura Bookman, Annika Gompers, Michele R. Hacker, Huma Farid
Summary: This study investigated the risk of clear cell adenocarcinoma in women aged 50 and above who were exposed to diethylstilbestrol (DES) in utero. The results showed a low incidence of DES-related cancers in women aged 50 and above, suggesting a need to reconsider the screening guidelines for these patients.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2023)
