Article
Pharmacology & Pharmacy
Ke Xu, Yu Liu, Huiyan Luo, Tengfei Wang
Summary: This study highlights the importance of efferocytosis in the progression of hepatocellular carcinoma (HCC) and develops a predictive model based on efferocytosis-related genes (ERGs) for assessing patient risk and prognosis. The results also reveal the presence of distinct immune environments and prognostic stratification within HCC based on ERGs. These findings contribute to the development of personalized treatment strategies, including immunotherapy and chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Wen Zhang, Zhongjian Liu, Shilin Xia, Lei Yao, Lan Li, Ziying Gan, Hui Tang, Qiang Guo, Xinmin Yan, Zhiwei Sun
Summary: The elevated expression of GDI2 in HCC patients is associated with more aggressive tumor status, including severe primary tumor extent, advanced pathological stage, and mutated TP53 status. High GDI2 expression is strongly correlated with a poor survival rate. Enrichment and immune infiltration analyses suggest that GDI2-associated signaling involves lipid metabolism and ECM constructing pathways related to the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Ziyu Meng, Xue Geng, Xiaoyue Lin, Ziwei Wang, Danchun Chen, Hua Liang, Ying Zhu, Yutong Sui
Summary: Hepatocellular carcinoma (HCC) is difficult to diagnose early and has resistance to therapeutic drugs. SLC37A3 is significantly upregulated in HCC and associated with tumor stages. Knockdown of SLC37A3 inhibits HCC tumor formation and cell proliferation, promotes apoptosis, and affects glucose metabolism regulation. SLC37A3 may serve as a potential diagnostic and prognostic biomarker for HCC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Kai Zhang, Enwu Yuan
Summary: This study created a unique prognostic profile based on NK cell marker genes that can accurately predict the efficacy of immunotherapy for HCC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Xiaozhen Peng, Ruochan Chen, Shenglan Cai, Shanshan Lu, Yiya Zhang
Summary: SLC1A4 expression in HCC is associated with prognosis, serving as an independent prognostic marker and being related to cell cycle, metabolism, and cancer-related pathways. Silencing SLC1A4 can inhibit proliferation, migration, cell cycle, and promote apoptosis in HCC cells, also affecting immune infiltration and chemokine expression. Additionally, potential sensitivity drugs for HCC patients with high-expressed SLC1A4 have been identified.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Haomin Wu, Shiqi Liu, Di Wu, Haonan Zhou, Guoxin Sui, Gang Wu
Summary: This study suggests that CDCA8 is a novel molecular bioindicator of prognosis in hepatocellular carcinoma patients and it is an excellent candidate for therapeutic target against HCC.
Article
Medicine, General & Internal
Qingfei Chu, Xinyu Gu, Qiuxian Zheng, Jing Wang, Haihong Zhu
Summary: This study found that high PPAT expression in hepatocellular carcinoma is associated with shorter survival time, higher tumor grade, and high expression of PD-L1 and CTLA4. Thus, PPAT could serve as a new prognostic biomarker for hepatocellular carcinoma patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Oncology
Matthias Stechele, Henrike Link, Heidrun Hirner-Eppeneder, Marianna Alunni-Fabbroni, Moritz Wildgruber, Lukas Salvermoser, Stefanie Corradini, Regina Schinner, Najib Ben Khaled, Daniel Roessler, Eithan Galun, Shraga Nahum Goldberg, Jens Ricke, Philipp Maximilian Kazmierczak
Summary: This study investigates the potential of circulating miR-21 and miR-210 levels as prognostic biomarkers for HCC treatment. The results suggest that increased miR-21 levels are associated with poor response and shorter time to systemic progression.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Cailin Xue, Peng Gao, Xiaohan Cui, Xudong Zhang, Jin Lei, Renzhi Li, Chunfu Zhu, Xihu Qin
Summary: The research indicates that ASRGL1 is overexpressed in hepatocellular carcinoma (HCC) and its expression is significantly correlated with immune infiltration in HCC and prognosis. ASRGL1 may potentially serve as a biomarker for the early detection and treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Cong Deng, Chaozeng Si, Xu Ye, Qiang Zhou, Tiansheng Zeng, Zeyong Huang, Wenhui Huang, Pei Zhu, Qingfu Zhong, Zhihua Wu, Huoyan Zhu, Qing Lin, Wenjuan Zhang, Lin Fu, Yongjiang Zheng, Tingting Qian
Summary: The study demonstrated that FSCN1 was significantly down-regulated in MM and high expression of FSCN1 and FSCN2 were associated with longer overall survival (OS) in MM patients. FSCN1 and FSCN2 could serve as favorable prognostic factors for predicting clinical outcomes in MM, and their combination could effectively predict longer event-free survival (EFS) and OS.
Article
Oncology
Hans-Christian Pommergaard, Allan Rasmussen, Jens Hillingso, Jan-Michael Kugler
Summary: In this study, the expression of ALDH family members in tumor and adjacent liver tissue of HCC patients was evaluated. The results showed that the expression of ALDH family members was correlated with overall survival and liver cirrhosis. Especially, ALDH1L1 may play a significant role. These findings suggest that ALDH family members may serve as prognostic biomarkers and potential targets for systemic treatment in HCC.
SURGICAL ONCOLOGY-OXFORD
(2022)
Article
Oncology
Guangtao Sun, Kejian Sun, Chao Shen
Summary: In this study, we found that eight optimal nuclear receptors (NRs) could serve as potential prognostic signatures for hepatocellular carcinoma (HCC) patients. The prognostic model based on these NRs and a nomogram incorporating multiple independent prognostic factors showed promise in predicting the long-term survival of HCC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Victoria Tserpeli, Dimitra Stergiopoulou, Dora Londra, Lydia Giannopoulou, Paul Buderath, Ioanna Balgkouranidou, Nikolaos Xenidis, Christina Grech, Eva Obermayr, Robert Zeillinger, Kitty Pavlakis, Theodoros Rampias, Stylianos Kakolyris, Sabine Kasimir-Bauer, Evi S. Lianidou
Summary: The study showed a significant correlation between DNA methylation of SLFN11 in plasma cfDNA and worse progression-free survival (PFS) in advanced stage HGSOC, indicating that this epigenetic alteration could be a predictor of resistance to platinum drugs in ovarian cancer. Further validation in larger patient cohorts is needed to explore the potential of SLFN11 promoter methylation as a prognostic biomarker and predictor of resistance to platinum-based chemotherapy in ovarian cancer.
Article
Dermatology
R. Varaljai, S. Elouali, S. S. Lueong, K. Wistuba-Hamprecht, T. Seremet, J. T. Siveke, J. C. Becker, A. Sucker, A. Paschen, P. A. Horn, B. Neyns, B. Weide, D. Schadendorf, A. Roesch
Summary: This study demonstrates that high cfDNA concentration can serve as a biomarker for melanoma regardless of tumor genotype, providing information on tumor burden, risk of progression, and risk of death.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Immunology
Ping Liu, Ziqing Zhu, Jiayao Ma, Le Wei, Ying Han, Edward Shen, Xiao Tan, Yihong Chen, Changjing Cai, Cao Guo, Yinghui Peng, Yan Gao, Yongting Liu, Qiaoqiao Huang, Le Gao, Yin Li, Zhaohui Jiang, Wantao Wu, Yihan Liu, Shan Zeng, Wei Li, Ziyang Feng, Hong Shen
Summary: Immunotherapy is a promising anti-cancer strategy in hepatocellular carcinoma (HCC), but there are limited biomarkers for patient selection. The role of methylcytosine (m(5)C) in predicting clinical responses to immunotherapy in HCC has not been fully understood. In this study, we identified a prognostic risk model and two diagnostic models based on m(5)C regulators, which showed promising results in predicting patient outcomes and distinguishing HCC tumors from normal liver tissues.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Xiaohui Guan, Jingyang Chen, Enze Zhu, Penggang Yin, Liu Yang, Xin Guan, Guangsheng Wang
Summary: By elaborately designing and providing a novel synthetic process, the composition and structure of C/N-NiCoMn-LDH/Ag (C/N-CNMA) can be delicately regulated, leading to improved conductivity and electrochemical activity of layered double hydroxides (LDHs), and thus superior charge storage capability and cycling stability at low temperatures.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Chenming Wang, Shiru Hong, Xin Guan, Yang Xiao, Ming Fu, Hua Meng, Yue Feng, Yuhan Zhou, Qiang Cao, Fangfang Yuan, Chenliang Liu, Guorong Zhong, Yingqian You, Tianhao Wu, Handong Yang, Xiaomin Zhang, Meian He, Tangchun Wu, Huan Guo
Summary: This study found that metal exposures are associated with aging, but the mechanisms are poorly understood. Advanced algorithms were used to establish biological age predictors, which were found to be associated with all-cause mortality. Additionally, the study observed mixture effects of multiple metals on biological aging.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Agronomy
Xin Guan, Giuseppe Mascaro
Summary: This study used the WEAP-MABIA model to simulate crop production in the main irrigation districts near Phoenix, Arizona, under different warming levels and water allocations. The results showed that crop production will decline in the coming decades, especially under higher warming scenarios, and will further decrease under water shortage measures, potentially reaching almost a 50% reduction by the end of the century.
AGRICULTURAL AND FOREST METEOROLOGY
(2023)
Article
Engineering, Electrical & Electronic
Zhenpo Wang, Xiaolin Ding, Lei Zhang
Summary: A full X-by-wire chassis coordinated control scheme is proposed in this paper by utilizing Direct Yaw-moment Control, Active Front Steering, Anti-Slip Regulation, and Active Roll Control. A vehicle state prediction module is established to generate reference vehicle states and a decentralized event-triggered discrete sliding mode control scheme is developed to track these references by coordinating the subsystems. The hardware-in-the-loop tests show that the proposed scheme can improve vehicle stability, handling performance, comfort, and rollover prevention.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Ecology
Lin Chao, Yanyan Liu, Weidong Zhang, Qingkui Wang, Xin Guan, Qingpeng Yang, Longchi Chen, Jianbing Zhang, Baoqing Hu, Zhanfeng Liu, Silong Wang, Gregoire T. Freschet
Summary: The magnitude of the rhizosphere priming effect (RPE) is influenced by root morphology, architecture, and physiology, with mean diameter of first-order roots and root exudate-derived respiration positively correlated with the RPE.
Article
Materials Science, Multidisciplinary
Jing Pan, Lijun Su, Liyong Du, Xin Guan, Guanghua Zhang, Sanam SaeidNahaei
Summary: This study presents an effective postprocessing method for recrystallizing the perovskite emissive layer. The method involves annealing and plasma treatment, which are time-saving and do not require vacuum tools. Applying this process reduces the grain size of the MAPbBr3 and increases the carrier recombination rate and photoluminescence quantum yields of the perovskite emitters. These results indeed improve the luminance, external quantum efficiency, and lifetime of the devices.
Article
Computer Science, Information Systems
Xueqing Yang, Xin Guan, Ning Wang, Yongnan Liu, Huayang Wu, Yan Zhang
Summary: Smart grid integrates distributed energy resources and massive information to facilitate energy flow in industries. Accommodating renewable energy is crucial for achieving energy efficiency, but optimal policies are difficult to obtain due to intermittency. To capture renewable energy statuses for decision-making, heterogeneous information is collected by end devices in smart grid, posing challenges for existing algorithms. This article proposes a cloud-edge-end computing scheme to efficiently repair missing values and obtain optimal policies in two separate layers using deep learning and deep reinforcement learning algorithms. Simulations on a real power grid dataset demonstrate the effectiveness of the proposed fault-tolerant renewable energy accommodation algorithm.
IEEE TRANSACTIONS ON CLOUD COMPUTING
(2023)
Article
Nutrition & Dietetics
Yuchao Feng, Xia Fan, Dengcheng Suo, Shu Zhang, Yantao Ma, Haoyu Wang, Xin Guan, Hongzhi Yang, Changyuan Wang
Summary: Heat stress caused by high temperatures has adverse effects on the safety and health of humans and animals. This study characterized the components of mung bean that regulate heat stress and found that polyphenols in mung bean have antioxidant and heat stress-regulating effects. Specific polyphenols like vitexin, orientin, and caffeic acid were identified as the main regulators of heat stress, with orientin having the best effect.
FRONTIERS IN NUTRITION
(2023)
Article
Construction & Building Technology
Lingbo Yu, Shuai Bai, Xinchun Guan
Summary: This paper aims to achieve multi-scale crack control of concrete by using graphene oxide (GO) and macroscopic steel fiber in combination, and to reveal the multi-scale collaborative reinforcement mechanism of GO and steel fiber. The results showed that GO reinforced UHPC had the best fracture property, and steel fiber and GO showed good synergistic crack control effect. GO directly acted on controlling the cracking of concrete matrix at the nanoscale, thus improving the fracture energy of UHPC matrix. A prediction model for fracture energy of straight steel fiber UHPC was established, which showed that the initial fiber-matrix bond strength and slip hardening coefficient had a powerful influence on the UHPC fracture energy.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Zhimu Bu, Gongyan Fang, Haixia Yu, Dewei Kong, Yanbing Huo, Xinyu Ma, Hui Chong, Xin Guan, Daxin Liu, Kexin Fan, Min Yan, Wujun Ma, Jiansheng Chen
Summary: Improving wheat quality by adjusting its storage protein genes is crucial due to rising living standards. Gene pyramiding of high molecular weight subunits, NGli-D2 and Sec-1(s) successfully enhanced dough elasticity and improved overall protein composition. The sedimentation values and mixograph parameters were significantly increased, and celiac disease epitopes were reduced, offering potential for better wheat processing quality and reduced risk of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Mechanical
Xin-long Liu, Xin Guan, Ti-Ming Zhang, Yuan Zhong, Wu-lue Zhang, Song Zhang, Qian Xiao, Yi-ting Zheng, Ming-sheng Gao, Dao-yun Chen, Wen-bing Yang
Summary: To improve the material matching performance of carbon skateboard/contact rails, three different contact pairs (powder metallurgy carbon skateboard/stainless steel, copper-impregnated carbon skateboard/stainless steel and copper-impregnated carbon skateboard/tin bronze) were studied for their current-carrying friction performance. Results showed that the copper-base powder metallurgy/stainless steel contacts maintained low and stable contact resistance and friction coefficient under different currents, while the copper-impregnated/stainless steel and copper-impregnated/tin bronze contact pairs were more sensitive to increased currents. Wear mechanisms of the three contact pairs were mainly abrasive wear, oxidative wear, and adhesive wear, according to tribological analysis.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Engineering, Civil
Jingcai Zhang, Yong Ding, Xinchun Guan
Summary: The aim of this study is to investigate the dynamic response of planar frame sub-structure isolated by friction pendulum bearings subjected to a middle column removal scenario. The study presents and evaluates the dynamic structural behaviors, load transfer mechanisms, progressive collapse resistance, and dynamic increase factor (DIF) results of FPBs-isolated planar frame. The results show that the compressive arching action (CAA) and catenary action (CA) cannot be fully developed for buildings isolated by FPBs due to the significant reduction in the lateral stiffness of the isolated layer caused by FPBs. The DIF of buildings isolated by FPBs initially decreases and then barely changes with an increase in the stabilized vertical displacement of the failed column. The presented fitted formula for DIF of planar frame isolated by FPBs describes the obtained results well. The friction coefficient and equivalent radius of FPBs show very limited influence on the dynamic response of planar frame isolated by FPBs under progressive collapse, but reinforcing the peripheral constraints of the failed column can enhance the progressive collapse resistance of isolated planar frame.
Article
Engineering, Electrical & Electronic
Haibin Wang, Xin Guan, Xiao Yi, Shuangming Li
Summary: This paper proposes a new information processing method called fuzzy Belief-Rule-Base (BRB), which addresses the deficiency of traditional intention recognition methods in handling uncertain information. The method combines the advantages of fuzzy sets and Dempster-Shafer (DS) theory. Experimental verification shows that the fuzzy belief-rule-base achieves high accuracy, effectiveness, and reliability under the condition of small samples.
JOURNAL OF ELECTRONICS & INFORMATION TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Zhonghua Chen, Xin Guan, Ningxuan Wen, Lujun Pan, Zeng Fan
Summary: Flexible and self-supporting PEDOT:PSS thick films with evident thermoelectric (TE) property anisotropy were developed through a wet-winding approach. Highly oriented and ordered PEDOT:PSS chain packing facilitated intra-chain charge transport and resulted in anisotropic films with a power factor 2.4 times higher than isotropic counterparts. The fiber-wound films also exhibited high mechanical strength and excellent stability, allowing the assembly of a TE generator with a good match between optimal property direction and temperature difference direction.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dongyu Liu, Bin Yu, Xin Guan, Bin Song, Huikai Pan, Renbing Wang, Xi Feng, Lixia Pan, Huidan Huang, Zhe Wang, Hongxi Wu, Zhixia Qiu, Zhiyu Li, Jinlei Bian
Summary: This study introduces a novel dimerized STING agonist, diBSP01, which shows promising binding and activation properties for STING in vitro with the benzo[b]selenophene scaffold. Additionally, the study presents the development of the first photoactivatable STING agonist, caged-diBSP01, which demonstrates no biological potency without light stimulation but regains its STING agonistic activity after 400 nm irradiation. The optically controlled in vivo anticancer activity of caged-diBSP01 is also validated in a zebrafish xenograft model.