Article
Biology
Jack Gisby, Candice L. Clarke, Nicholas Medjeral-Thomas, Talat H. Malik, Artemis Papadaki, Paige M. Mortimer, Norzawani B. Buang, Shanice Lewis, Marie Pereira, Frederic Toulza, Ester Fagnano, Marie-Anne Mawhin, Emma E. Dutton, Lunnathaya Tapeng, Arianne C. Richard, Paul D. W. Kirk, Jacques Behmoaras, Eleanor Sandhu, Stephen P. McAdoo, Maria F. Prendecki, Matthew C. Pickering, Marina Botto, Michelle Willicombe, David C. Thomas, James Edward Peters
Summary: Analysis of blood samples from ESKD patients with COVID-19 revealed protein markers associated with clinical severity, including epithelial damage, immune activation, and cell-cell interactions, providing potential drug targets.
Article
Biology
Noha M. Elemam, Haifa Hannawi, Kashif Bin Naeem, Suad Hannawi
Summary: This study investigated the impact of liver injury on clinical and laboratory assessments in COVID-19 patients, revealing that patients with liver injury are at higher risk for serious outcomes, including higher mortality rates.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Yuxia Ma, Bowen Cheng, Jiahui Shen, Hang Wang, Fengliu Feng, Yifan Zhang, Haoran Jiao
Summary: In Shanghai, the study found that temperature, temperature humidity index, and wind effect index were negatively associated with daily confirmed COVID-19 cases, while air quality index, PM2.5, PM10, NO2, and SO2 were significantly associated with an increase in cases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Suyu Gao, Qingqing Yang, Xuanxuan Wang, Wen Hu, Yun Lu, Kun Yang, Qiaoli Jiang, Wenjing Li, Haibo Song, Feng Sun, Hong Cheng
Summary: This study investigated the association between drug treatments and drug-induced liver injury (DILI) in hospitalized patients with COVID-19. The results showed that patients who received antibiotics, antifungal agents, and corticosteroids had a higher risk of DILI. Additionally, parenteral nutrition and enteral nutrition were identified as risk factors for liver injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Yiru Chen, Xiuneng Li, Yu Dai, Jingjing Zhang
Summary: There is an association between abnormal thyroid-related hormones in COVID-19 patients and the severity of the disease and mortality.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anjali Rao, Sagar Ranka, Colby Ayers, Nicholas Hendren, Anna Rosenblatt, Heather M. Alger, Christine Rutan, Wally Omar, Rohan Khera, Kamal Gupta, Purav Mody, Christopher DeFilippi, Sandeep R. Das, S. Susan Hedayati, James A. de Lemos
Summary: In patients hospitalized with COVID-19, acute kidney injury (AKI) is significantly associated with all-cause mortality and major adverse cardiac events, while chronic kidney disease (CKD) and end-stage kidney disease are not linked to these outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Patricia P. Bloom, Eric A. Meyerowitz, Zoe Reinus, Michael Daidone, Jenna Gustafson, Arthur Y. Kim, Esperance Schaefer, Raymond T. Chung
Summary: In COVID-19 patients, abnormalities in liver biochemistries, particularly AST and ALT, are common on admission and throughout the course of illness. Aminotransferases are frequently elevated, while alkaline phosphatase and total bilirubin elevations are rare. AST-dominant aminotransferase elevation seems to correlate with disease severity and reflects true hepatic injury.
Review
Cardiac & Cardiovascular Systems
Yonghao Lan, Wei Liu, Yujie Zhou
Summary: COVID-19, caused by SARS-CoV-2, has led to a global pandemic with significant morbidity and mortality. While primarily affecting the respiratory system, there is also evidence of myocardial injury in severe cases, particularly with right ventricular damage being associated with higher mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Ze-yang Ding, Gan-xun Li, Lin Chen, Chang Shu, Jia Song, Wei Wang, Yu-wei Wang, Qian Chen, Guan-nan Jin, Tong-tong Liu, Jun-nan Liang, Peng Zhu, Wei Zhu, Yong Li, Bin-hao Zhang, Huan Feng, Wan-guang Zhang, Zhen-yu Yin, Wen-kui Yu, Yang Yang, Hua-qiu Zhang, Zhou-ping Tang, Hui Wang, Jun-bo Hu, Ji-hong Liu, Ping Yin, Xiao-ping Chen, Bixiang Zhang
Summary: Liver test abnormalities were common in COVID-19 patients, with elevated levels of AST and D-Bil being independent predictors of COVID-19-related mortality. HBV infection did not increase the risk of poor COVID-19 outcomes.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Victor Arevalos, Luis Ortega-Paz, Juan Jose Rodriguez-Arias, Margarita Calvo, Leticia Castrillo, Anthony Salazar, Merce Roque, Ana Paula Dantas, Manel Sabate, Salvatore Brugaletta
Summary: The exact mechanisms of myocardial injury in COVID-19 are still unknown. This study found that myocardial injury in COVID-19 patients is associated with inflammation and coagulopathy, leading to a worse in-hospital prognosis. Treatment with anticoagulant agents may help improve in-hospital outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jean-Francois Dufour, Thomas Marjot, Chiara Becchetti, Herbert Tilg
Summary: Knowledge on the effects of SARS-CoV-2 infection and COVID-19 in liver diseases has rapidly increased during the pandemic. Patients with chronic liver disease, especially decompensated cirrhosis, are at a higher risk for severe COVID-19 and death. Liver transplantation was impacted due to concerns about donation and infection in recipients, but did not contribute to worse outcomes. Limited data suggests that specific therapy for COVID-19 in liver transplant recipients may be promising. The immune response induced by COVID-19 vaccines seems to be impaired in patients with chronic liver disease and liver transplant recipients, suggesting a need for revised vaccination schedules in this population.
Article
Medicine, General & Internal
Dafan Chen, Min Ning, Yun Feng, Jun Liu
Summary: In the early stage of the COVID-19 pandemic, gastrointestinal symptoms and liver injury are common throughout the course of the disease and are associated with severe disease and longer duration.
FRONTIERS IN MEDICINE
(2022)
Article
Virology
Toshiki Kuno, Matsuo So, Yoshihisa Miyamoto, Masao Iwagami, Mai Takahashi, Natalia N. Egorova
Summary: The study aimed to explore the association between hospitalizations of patients who tested positive for COVID-19 antibodies and reduced in-hospital mortality. Patients with positive COVID-19 antibody tests showed lower in-hospital mortality compared to those with negative test results after adjustments for patient characteristics and treatments. In conclusion, positive COVID-19 antibody test results were linked to a decreased risk of in-hospital mortality for COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Michael U. Anyanwu
Summary: This study found a lower COVID-19 mortality rate in countries with higher malaria prevalence, and a significant positive correlation between median age, life expectancy, and mortality rate for those aged 65 and older with COVID-19 mortality.
BMC INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Suresh Nath Neupane, Erin Ruel
Summary: This study investigates the impact of racial residential segregation on COVID-19 mortality. The results show that as racial residential segregation increases, mortality rates also increase. Controlling for segregation, Blacks and Asians have a higher risk of mortality, while Hispanics and other racial groups have a lower risk of mortality.
JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Meijuan Tu, Wanrong Yi, Ai-Xi Yu, Jun Lin, Ai-Ming Yu
Article
Oncology
Jie Cheng, Yao-Jia Lao, Qian Wang, Kai Huang, Juan-Li Mou, Jia-Hui Feng, Fan Hu, Meng-Lu Lin, Jun Lin
Summary: In young-onset CRC patients, preoperative CEA positive was found to be a significant predictor of distant metastasis (DM). A novel nomogram containing clinical and pathological features was established to predict DM in advanced CRC patients younger than 50 years old, showing high accuracy and stability. This tool can serve as an early alert for clinicians to DM and help in developing better clinical treatment regimens.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Yang Liu, Wenxin Wang, Xuewei Huang, Xingyuan Zhang, Lijin Lin, Juan-Juan Qin, Fang Lei, Jingjing Cai, Bo Cheng
Summary: This study analyzed the burden of stroke specifically attributable to high fasting plasma glucose (HFPG) in various countries and regions globally. The results demonstrate a close relationship between HFPG and stroke burden, which is influenced by age and gender. Therefore, targeted prevention and control strategies for HFPG are of paramount importance in reducing the burden of stroke.
JOURNAL OF DIABETES
(2022)
Article
Public, Environmental & Occupational Health
Ming Zhuo, Ze Chen, Mao-Lin Zhong, Ye-Mao Liu, Fang Lei, Juan-Juan Qin, Tao Sun, Chengzhang Yang, Ming-Ming Chen, Xiao-Hui Song, Li-Feng Wang, Yi Li, Xiao-Jing Zhang, Lihua Zhu, Jingjing Cai, Jun-Ming Ye, Gang Zhou, Yong Zeng
Summary: This study assessed the burden of non-communicable chronic diseases attributable to a diet low in fibre globally from 1990 to 2019. The findings showed an increasing trend in the disability-adjusted life-years rates caused by a low-fibre diet in certain regions, and a rise in the burden of diabetes in some areas.
PUBLIC HEALTH NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang, Shilong Zhong
Summary: In this study, several plasma metabolic signatures associated with the risk of death and major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) were identified and validated using widely-targeted metabolomics. The study also revealed that these metabolic signatures appear to increase the risks of death or MACE by promoting adverse left ventricular dysfunction. These findings contribute to improving risk stratification and provide support for potential therapeutic targets in CAD.
CELL AND BIOSCIENCE
(2022)
Article
Endocrinology & Metabolism
Fang Lei, Juan-Juan Qin, Xiaohui Song, Ye-Mao Liu, Ming-Ming Chen, Tao Sun, Xuewei Huang, Ke-Qiong Deng, Xiuran Zuo, Dongai Yao, Li-Juan Xu, Huiming Lu, Gang Wang, Feng Liu, Lidong Chen, Jie Luo, Jiahong Xia, Lin Wang, QiongYu Yang, Peng Zhang, Yan-Xiao Ji, Xiao-Jing Zhang, Zhi-Gang She, Qiang Zeng, Hongliang Li, Jingjing Cai
Summary: This study found a high prevalence of MAFLD in China, with a strong association between MAFLD and other metabolic diseases. MAFLD was also significantly associated with a higher risk of atrial fibrillation (AF).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ming Zhuo, Ze Chen, Mao-Lin Zhong, Fang Lei, Juan-Juan Qin, Shuhua Liu, Ye-Mao Liu, Tao Sun, Xiao-Jing Zhang, Lihua Zhu, Jingjing Cai, Jun-Ming Ye, Erping Yang
Summary: In this study, the association between insulin resistance (IR) and bone mass was evaluated in a Chinese population. The results showed a significant correlation between IR and low bone mass as well as osteoporosis. These findings suggest the importance of bone mass monitoring and early prevention strategies in individuals with IR to prevent the occurrence of low bone mass and osteoporosis.
Article
Cardiac & Cardiovascular Systems
Tao Sun, Zhanpeng Wang, Fang Lei, Lijin Lin, Xingyuan Zhang, Xiaohui Song, Yan-Xiao Ji, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Jingjing Cai, Peng Jia, Hongliang Li
Summary: This study found that long-term exposure to PM2.5 and PM10 is positively associated with atrial fibrillation (AF) prevalence in China. The association is stronger in females, people under 65 years old, and those with hypertension and diabetes. Furthermore, the study identified PM2.5 sulfate as having the highest contribution to the overall mixture effects among all PM2.5 chemical constituents.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Jie Cheng, Kai Huang, Juan-Li Mou, Yao-Jia Lao, Jia-Hui Feng, Fan Hu, Meng-Lu Lin, Tangnuer Maimaitiaishan, Jian Shang, Jun Lin
Summary: This study aimed to investigate the clinical role of admission chloride in cirrhotic patients with esophagogastric varices. The results showed that hypocholemia and increasing Child-Pugh score were independent predictors of 1-year mortality.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Biochemical Research Methods
Yuanyuan Cao, Tao Sun, Zhanpeng Wang, Fang Lei, Lijin Lin, Xingyuan Zhang, Xiaohui Song, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Jingjing Cai, Shujuan Yang, Peng Jia, Jian Li, Hongliang Li
Summary: A study conducted in China revealed the association between PM2.5 exposure and pulmonary nodules, with NO3(-) particles identified as the highest risk factor.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yingying Hu, Fan Zhou, Fang Lei, Lijin Lin, Xuewei Huang, Tao Sun, Weifang Liu, Xingyuan Zhang, Jingjing Cai, Zhi-Gang She, Hongliang Li
Summary: A retrospective cross-sectional study involving 177,540 individuals in the Chinese population shows a nonlinear relationship between thyroid function parameters and metabolic dysfunction-associated fatty liver disease (MAFLD). Higher levels of free triiodothyronine (FT3) are associated with an increased risk of MAFLD when FT3 is less than 5.58pmol/L but a decreased risk when FT3 is greater than or equal to 5.58pmol/L. Additionally, higher levels of free tetra-iodothyronine (FT4) are associated with a decreased risk of MAFLD, while thyroid stimulating hormone (TSH) concentration is positively associated with MAFLD risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Fang Lei, Xiao-Ming Wang, Changquan Wang, Xuewei Huang, Ye-Mao Liu, Juan-Juan Qin, Peng Zhang, Yan-Xiao Ji, Zhi-Gang She, Jingjing Cai, Huo-ping Li, Xiao-Jing Zhang, Hongliang Li
Summary: This study investigated the correlation between metabolic dysfunction-associated fatty liver disease (MAFLD) and subclinical carotid atherosclerosis (SCA) in a nationwide population in China. The results showed a significant association between MAFLD and SCA, particularly in individuals with high hepatic steatosis index and young adults.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yu Xu, Bo Liu, Lijin Lin, Fang Lei, Tao Sun, Xingyuan Zhang, Xiaohui Song, Xuewei Huang, Qiang Zeng, Jingjing Cai, Zhifang Wang, Hongliang Li
Summary: This study found a strong correlation between serum ApoB and CKD, suggesting that high levels of serum ApoB may increase the risk of CKD. Monitoring and reducing serum ApoB levels could be an alternative approach for the prevention and treatment of CKD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tao Sun, Mao Ye, Fang Lei, Juan-Juan Qin, Ye-Mao Liu, Ze Chen, Ming-Ming Chen, Chengzhang Yang, Peng Zhang, Yan-Xiao Ji, Xiao-Jing Zhang, Zhi-Gang She, Jingjing Cai, Zhao-Xia Jin, Hongliang Li
Summary: This study analyzed the recent trends in the prevalence of atrial fibrillation (AF) in China and its age-related disparities in the healthy check-up population. The overall prevalence of AF remained stable at 0.4%-0.45% from 2012 to 2017, but showed an undesirable upward trend in the 35-44 age group. In addition to traditional risk factors, such as age ≥65 and coronary heart disease, elevated uric acid and impaired renal function were tightly correlated with AF in the population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Lijin Lin, Huxiang Huang, Fang Lei, Tao Sun, Ze Chen, Kun Qin, Manyao Li, Yingying Hu, Xuewei Huang, Xingyuan Zhang, Peng Zhang, Xiao-Jing Zhang, Zhi-Gang She, Jingjing Cai, Shujuan Yang, Peng Jia, Hongliang Li
Summary: This study explored the relationship between long-term exposure to PM2.5 and its constituents, and vascular damage in individuals with metabolic abnormalities. The results revealed a significant association between PM2.5 and its constituents with elevated brachial-ankle pulse wave velocity and decreased ankle-brachial index, indicating vascular damage.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)