Article
Chemistry, Multidisciplinary
Qiushuo Sun, Lu Yu, Zhuocheng Zhang, Cheng Qian, Hongzhe Fang, Jintao Wang, Peipei Wu, Xiaojing Zhu, Jian Zhang, Liangjun Zhong, Rui He
Summary: This study presents a new degradable bone scaffold loaded with nano-HA and beta-TCP, with highly connected macropores achieved through freeze drying combined with stir foaming. In vitro tests demonstrate the biodegradation potential and appreciable swelling ratio of the scaffolds. The results of MC3T3-E1 cell culture suggest that the osteoinductivity and osteoconduction of the scaffolds increase with higher HCP content.
FRONTIERS IN CHEMISTRY
(2022)
Article
Engineering, Biomedical
Yogendra Pratap Singh, ShivDutt Purohit, Mukesh Kumar Gupta, Rakesh Bhaskar, Sung Soo Han, Sudip Dasgupta
Summary: Chitosan-gelatin-monetite (CGM)-based electrospun scaffolds have been developed that mimic the microstructure and composition of natural bone. The incorporation of 7% monetite into the scaffold enhances its mechanical properties and osteogenic potential, making it a potential candidate for bone tissue regeneration.
BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yunsheng Dong, Hui Xiao, Jie Wang, Tingting Yang, Naiqi Kang, Jiaxing Huang, Wei Cui, Yufei Liu, Qiang Yang, Shufang Wang
Summary: Constructing scaffolds with osteogenic activity through tissue engineering is an effective strategy for bone regeneration. This study used gelatin, silk fibroin, and Si3N4 to prepare silicon-functionalized bio-macromolecules composite scaffolds using 3DP technology. The scaffold showed good cyto-compatibility and promoted osteogenic differentiation of MSCs in vitro, and facilitated bone regeneration in vivo. The composite scaffold system has great potential for application in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Zhiming Zhang, Zijie Rong, Guofeng Wu, Yihan Wang, Zhiwen Tan, Juan Zheng, Yanglei Jin, Zhihao Liang, Chun Liu, Jiasong Guo, Lixin Zhu
Summary: The study introduced a controlled-oxygen-generating composite scaffold to enhance seed cell survival and improve bone defect reconstruction.
APPLIED MATERIALS TODAY
(2021)
Article
Biochemistry & Molecular Biology
Sakchi Bhushan, Sandhya Singh, Tushar Kanti Maiti, Ankita Das, Ananya Barui, Leena R. Chaudhari, Meghnad G. Joshi, Dharm Dutt
Summary: Cell-free and cell-loaded constructs are used to repair critical-sized bone defects, with interest in enhancing three-dimensional scaffolds with free radical scavenging materials. In this study, CG-CNPs nanocomposite scaffolds with improved physico-chemical, mechanical, and biological properties were fabricated using freeze-drying. These scaffolds showed cyto-friendly behavior, antimicrobial activity, and demonstrated the best characteristics in terms of porosity, weight loss, compressive modulus, and Ca/P ratio. Therefore, the CG-CNP2 scaffolds are highly biocompatible and suitable for bone defect repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Ceramics
Buesra Bulut, Seyma Duman
Summary: This report evaluated the mechanical behavior, bioactivity, and cytotoxicity of novel chitosan/akermanite-TiO2 (CS/AK/Ti) composite scaffolds fabricated using the 3D-printing method. It was found that the mechanical properties were significantly affected by the amount of TiO2, and the scaffolds possessed bone-like apatite forming ability with good cell behaviors. The outcomes suggested that the 3D-printed scaffolds have potential applications in bone tissue engineering.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Sneh Gautam, Shiv Dutt Purohit, Hemant Singh, Amit Kumar Dinda, Pravin D. Potdar, Chhavi Sharma, Chia -Fu Chou, Narayan Chandra Mishra
Summary: Bone tissue engineering has received attention for the treatment of bone injury. A tri-polymer scaffold (PCL-gelatin-chitosan) was fabricated through electrospinning and treated with nanohydroxyapatite. The modified scaffold showed a uniform distribution of nanohydroxyapatite particles on the surface of fibers.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Orthopedics
Sara Tabatabaee, Nafiseh Baheiraei, Mojdeh Salehnia
Summary: A scaffold composed of PHEMA, gelatin, and GO was fabricated and evaluated for its potential in bone tissue engineering. The scaffold exhibited a porous interconnected structure, good mechanical strength and electrical conductivity. It also demonstrated the ability to induce osteogenesis in stem cells. These findings suggest that the PHEMA-Gel-GO scaffold holds promise for bone tissue regeneration.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Nazanin Baneshi, Bahareh Kamyab Moghadas, Adedotun Adetunla, Mohd Yusmiaidil Putera Mohd Yusof, Mohammad Dehghani, Amirsalar Khandan, Saeed Saber-Samandari, Davood Toghraie
Summary: This study developed a scaffold with ideal properties using freeze-drying technology to treat fractures and injuries, validated its bioactivity, and biocompatibility. Through bioactivity testing, cell behavioral, and antibacterial experiments, it was found that the titanium sample scaffold gradually degrades while supporting cell growth, preserving the mechanical properties of the implants.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Engineering, Biomedical
Yogendra Pratap Singh, Sudip Dasgupta, Rakesh Bhaskar, Ashish Kumar Agrawal
Summary: This study focused on fabricating a gelatin-based composite scaffold with monetite nanoparticles to enhance its chemical, mechanical, and osteogenic properties. The scaffolds showed an interconnected porous microstructure with improved mechanical strength and stability, along with >80% porosity and a distribution of 3D interconnected pore sizes. Increasing the monetite content up to 20 wt% resulted in higher compressive strength and bioactivity, making them efficient candidates for repairing and regenerating bone tissues in musculoskeletal defect sites.
BIOMEDICAL MATERIALS
(2021)
Article
Polymer Science
Maria V. Reyes-Peces, Rafael Fernandez-Montesinos, Maria del Mar Mesa-Diaz, Jose Ignacio Vilches-Perez, Jose Luis Cardenas-Leal, Nicolas de la Rosa-fox, Mercedes Salido, Manuel Pinero
Summary: We synthesized mesoporous silica-gelatin hybrid aerogels with different gelatin contents for tissue-engineering applications. Increasing gelatin content led to a decrease in textural parameters and significant changes in the structure, thermal properties and mechanical behavior of the aerogels. The samples exhibited hydrophilic behavior, fast swelling, and positive effects on osteoblast differentiation. The biomaterials described are versatile, easily sterilized, and suitable for various bone tissue-engineering applications.
Review
Polymer Science
Mohammad Javad Javid-Naderi, Javad Behravan, Negar Karimi-Hajishohreh, Shirin Toosi
Summary: Damage or loss of bone tissue is a major issue affecting human well-being, and tissue engineering is used to recover and regenerate bone fractures and damage. Polymer biomaterials are the most commonly required materials for synthetic bone scaffolds due to their suitable mechanical properties and degradation rates. Synthetic polymers offer advantages in bone replacement because they can be designed and changed easily, and their biocompatibility has been widely accepted in tissue engineering. This article updates on materials and application usage of scaffolds in bone tissue engineering for hard tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Jie Xu, Huan Fang, Ya Su, Yue Kang, Deli Xu, Yuen Yee Cheng, Yi Nie, Hong Wang, Tianqing Liu, Kedong Song
Summary: Finding a bioink suitable for 3D bioprinting that can mimic the microenvironment of native skin and prevent bacterial infection remains a major challenge in skin tissue engineering. In this study, a tissue-specific extracellular matrix-based bioink was prepared, and a novel scaffold was obtained using an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The hybrid scaffold exhibited excellent properties including antibacterial activity, hemostatic effect, and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Biomaterials
Sneh Gautam, Chhavi Sharma, Shiv Dutt Purohit, Hemant Singh, Amit Kumar Dinda, Pravin D. Potdar, Chia-Fu Chou, Narayan Chandra Mishra
Summary: The electrospun Gelatin-PCL-nHAp nanocomposite scaffold showed promising results for bone tissue engineering applications, with good viability and proliferation of human osteoblasts. Analysis also indicated efficient cellular attachment and characteristic polygonal morphology of osteoblasts on the scaffold surface, demonstrating its potential for BTE.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Milena S. Malherbi, Luciano C. Dias, Mariana S. Z. Lima, Larissa G. Ribeiro, Valdirlei F. Freitas, Taiana G. M. Bonadio, Ludmilla M. Silva, Gilvan B. Souza, Eduardo A. Volnistem, Jaciele M. Rosso, Daniel M. Silva, Luiz F. Cotica, Wilson R. Weinand, Ivair A. Santos
Summary: This study synthesized hydroxyapatite/beta-tricalcium phosphate/polyvinylidene fluoride biocomposites and used electrical stimuli to improve and accelerate bone regeneration in vitro. The results showed that the growth rate of hydroxyapatite in the biocomposite significantly increased under specific electric field conditions.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Materials Science, Composites
Reza Barbaz-Isfahani, Saeed Saber-Samandari, Manouchehr Salehi
Summary: This study investigates the effect of enhancing multicore microcapsules with various nanoparticles on the healing efficiency of microcapsule-based self-healing polymers. The results show that increasing the volume fraction of microcapsules can enhance the healing efficiency, while increasing the strength of microcapsules can decrease the healing efficiency.
JOURNAL OF REINFORCED PLASTICS AND COMPOSITES
(2023)
Article
Materials Science, Multidisciplinary
M. Mohammadzadeh Rad, S. Saber-Samandari, D. Olegovich Bokov, Wanich Suksatan, Mh Malekipour Esfahani, M. Y. P. M. Yusof, A. S. El-Shafay
Summary: In this study, nanocrystalline-Hydroxyapatite (n-HA) was combined with Polymethyl Methacrylate (PMMA) bone cement-Elastin (ELN) to produce a bone cement for orthopedic applications. The adaptability, weight loss, and pH change of the bone cement were evaluated using simulated body fluid (SBF) and phosphate-buffered saline (PBS). The morphology and microchemical analysis of the bone cement materials were examined using Field Emission Scanning Electron Microscopy (FE-SEM) and Energy-dispersive X-ray Spectroscopy (EDX). The mechanical properties, such as elastic modulus and impact strength, were measured using tensile test and Charpy impact test. The study found that the bone cement had low water absorption and porosity, and exhibited proper mechanical performance. This research is significant for the development of bone application materials.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Huixing Liang, S. Niazi Angili, M. Morovvati, Xiang Li, S. Saber-Samandari, M. Y. P. M. Yusof, A. Khandan, D. Toghraie
Summary: The use of space holder method in the fabrication of composite scaffolds with calcium silicate bioceramic (Wollastonite) and titanium particles (TiO2-TiNP) has resulted in improved mechanical properties and potential biomedical applications.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Ali Khalvandi, Mohammad Mohammadi Aghdam, Saeed Saber-Samandari
Summary: In this research, a novel nanocomposite bone scaffold made of Gelatin, Polypyrrole, Akermanite, and Magnetite was fabricated using the freeze-drying method. The scaffold exhibited good bioactivity and non-isotropic behavior according to microscopic and mechanical testing. This study provides a new approach for the design and fabrication of bone scaffolds.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART N-JOURNAL OF NANOMATERIALS NANOENGINEERING AND NANOSYSTEMS
(2022)
Article
Materials Science, Textiles
Reza Barbaz-Isfahani, Hooman Dadras, Alireza Taherzadeh-Fard, Mohammad Amin Zarezadeh-Mehrizi, Saeed Saber-Samandari, Manouchehr Salehi, Gholamhossein Liaghat
Summary: This study investigates the synergistic effects of adding different loadings of nanoparticles (MWCNT, CuO, TiO2, and clay) into glass fiber reinforced polymer (GFRP) composites on their mechanical properties. The results show that adding MWCNT and CuO nanoparticles significantly improves the tensile properties of GFRP composites. The hybrid addition of MWCNT, TiO2, and CuO nanoparticles demonstrates the highest enhancement of bending properties. Quasi-static tests indicate that GFRP composites with 0.5 wt.% MWCNT exhibit significantly higher peak load.
FIBERS AND POLYMERS
(2022)
Article
Electrochemistry
P. Bagheri, S. Saber-Samandari, A. Sadeghi, S. Akhtarian, A. Doostmohammadi
Summary: In this research, hydroxyapatite powder particles were coated on a Ti-6Al-4V alloy substrate using the plasma spraying method. The study aimed to take advantage of titanium's mechanical properties and hydroxyapatite's biological properties to create bone implants. Preheating the substrate was found to improve adhesion and reduce residual stress, however, it also resulted in the formation of an amorphous phase in the coating, leading to weaker mechanical properties.
TRANSACTIONS OF THE INSTITUTE OF METAL FINISHING
(2023)
Article
Engineering, Biomedical
Fatemeh Karami, Saeed Saber-Samandari
Summary: In this study, a multifunctional wound dressing based on carboxymethyl chitosan/sodium alginate hydrogel containing a nanostructured lipid carrier (NLC) was prepared. The dressing showed appropriate properties for absorbing exudates and maintaining wound moisture. It displayed excellent antibacterial activity and high biocompatibility, and had the ability to release the loaded drug slowly over a prolonged period of time. The results suggest that this novel nanocomposite could be a promising candidate as a wound dressing for treating various chronic wounds in skin tissues.
BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Azin Rashidy Ahmady, Kavoos Razmjooee, Vida Nazar, Saeed Saber-Samandari
Summary: This study compared alginate microparticles and nanoparticles as thymol delivery systems. The results showed that thymol-loaded alginate nanoparticles released thymol in a more sustainable and controllable manner, and both carriers exhibited good cell viability and antibacterial properties.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Physical
Azin Rashidy Ahmady, Atefeh Solouk, Saeed Saber-Samandari, Somaye Akbari, Hadi Ghanbari, Bogumil E. Brycki
Summary: Nano-in-nano delivery technique is explored to address the limitations of most nanostructures used for drug delivery. This study investigated the release behavior of a novel nanoparticles-in-nanofibers delivery system composed of capsaicin-loaded alginate nanoparticles embedded in polycaprolactone-chitosan nanofiber mats. The results showed that embedding capsaicin-loaded alginate nanoparticles in polycaprolactone-chitosan nanofibers prolonged capsaicin release and effectively inhibited the proliferation of MCF-7 human breast cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Composites
Sina Shayanfar, Majid Nikkhah, Saeed Saber-Samandari, Manouchehr Salehi
Summary: This study aimed to investigate the behavior and failure resistance of composite materials, as well as the effect of nanoparticles on their flexural properties. Different weight percentages of nano-clay and nano-silica were added to a hybrid composite to analyze their effect. The addition of nanoparticles up to 1 wt.% improved flexural strength and modulus, and the samples containing nanoparticles were more resistant to damage growth.
JOURNAL OF COMPOSITE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Saeed Saber-Samandari, Davood Toghraie
Summary: A new nanocomposite scaffold was successfully synthesized in this study, which exhibited high porosity and the ability to induce bone-like apatite formation by incorporating carbon nanotubes and montmorillonite nanoparticles in a gelatin network. After soaking in simulated body fluid for 14 days, the scaffold surface successfully deposited Ca2+, CO32-, and PO43- ions. In addition, the introduction of nanoparticles significantly improved the mechanical properties of the scaffold and reduced the enzymatic degradation rate. The scaffold showed good biocompatibility and high photothermal efficiency, making it suitable for tissue engineering applications.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Reza Barbaz-Isfahani, Hooman Dadras, Saeed Saber-Samandari, Alireza Taherzadeh-Fard, Gholamhossein Liaghat
Summary: This study investigates the effects of incorporating various types of nanoparticles, both singularly and in hybrid form, on the low-velocity impact (LVI) response of glass fiber reinforced polymer (GFRP) composites. The experimental results reveal that specimens with a single loading of MWCNT or nano-clay have a lower maximum contact force compared to pure specimens with fully rebounding behavior. Furthermore, incorporating more MWCNTs results in stiffer behavior and more brittleness.
Article
Materials Science, Composites
Maysam Alinia, Saeed Saber-Samandari, Seyyed Ali Sadough Vanini
Summary: The purpose of this study is to investigate the effects of adding nano-clay and nano-silica particles on the vibrational characteristics of composite cylindrical panels in corrosive environments. The study finds that adding nanoparticles can significantly improve the mechanical properties and natural frequencies of the composites, with nano-clay being more effective.
JOURNAL OF REINFORCED PLASTICS AND COMPOSITES
(2023)
Article
Materials Science, Multidisciplinary
Guoqi Guo, As'ad Alizadeh, Saeed Saber-Samandari, Maboud Hekmatifar, Jun Li, Mohammed Al-Bahrani, Navid Nasajpour-Esfahani, Mahmoud Shamsborhan, Davood Toghraie
Summary: Bullets are used as projectiles in firearms for various purposes. They also have industrial applications such as precision drilling, cutting, and shaping of hard materials. Different industries, such as automotive and aerospace, use fibers and fabrics with high toughness and tensile strength to resist impact and projectiles. In a recent study, the impact of external force on the strength of Kevlar nanofibers reinforced with silicon dioxide nanoparticles and ethylene glycol was investigated. The findings suggest that optimizing the external force is crucial for an effective collision process.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Materials Science, Multidisciplinary
Farshad Rahmani, Reza Barbaz-Isfahani, Saeed Saber-Samandari, Manouchehr Salehi
Summary: The aim of this study is to investigate the critical buckling force of a sandwich structure with the addition of nanoparticles to composite faces in an acidic environment. The addition of 3 wt% nanoclay shows better performance in improving the durability of the structure against changes in the length and mass of the composite specimens. The immersion in 5% sulfuric acid for 30 days significantly reduces the critical buckling force of composite sandwiches.
MATERIALS TODAY COMMUNICATIONS
(2023)