Article
Biochemistry & Molecular Biology
Yong Lin, Yushan Chen, Rongqiang Shen, Dingzhu Chen, Yimin Lin
Summary: The study found that microRNA-148a-3p regulates the function of esophageal carcinoma cells by targeting CEP55, suppressing malignant behaviors and affecting cell proliferation and migration.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Ophthalmology
Jinzhi Zhao, Xun Liu, Jiaqi Lin, Meixia Jiang, Fei Xu, Chuanli Zhang, Qin Tang, Limin Zhu, Lijie Dong, Tingting Lin
Summary: This study identified the differentially expressed miRNAs between high and low proliferation lacrimal gland adenoid cystic carcinoma (LACC) using miRNA microarray. Furthermore, the relationship between miR-29a-3p and AKT2 was validated. These findings have important implications for future targeted gene therapy in patients with high proliferation LACC.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Article
Biochemistry & Molecular Biology
Fei Xu, Meixia Jiang, Qin Tang, Jiaqi Lin, Xun Liu, Chuanli Zhang, Jinzhi Zhao, Yanjin He, Lijie Dong, Limin Zhu, Tingting Lin
Summary: This study investigated the role of miR-29a-3p in the pathogenesis of LACC-HGT. The results showed that miR-29a-3p was down-regulated in LACC-HGT, and it inhibited the proliferation, migration, and epithelial-mesenchymal transition of LACC cells by targeting Quaking expression. This study provides insights into the pathogenesis of LACC-HGT and potential targeted diagnostic methods.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Pathology
Chen-xing Hou, Li Wang, Man Cai, Ying Meng, Yu-ting Tang, Qing-hai Zhu, Wei Han, Nan-nan Sun, Ben Ma, Yong Hu, Jin-hai Ye
Summary: Sphk1 is overexpressed in salivary adenoid cystic carcinoma (SACC), promoting tumorigenesis by activating the PI3K/Akt pathway. This finding provides novel intervention targets for SACC treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Liujia He, Shiming Chen, Yufan Ying, Haiyun Xie, Jiangfeng Li, Xueyou Ma, Weiyu Wang, Haixiang Shen, Xiao Wang, Xiangyi Zheng, Liping Xie
Summary: The study revealed that miR-501-3p is downregulated in renal cell carcinoma (RCC) and its overexpression inhibits cancer cell proliferation by targeting the WTAP gene. This regulation affects RCC progression through the miR-501-3p/WTAP/CDK2 axis.
Article
Biochemistry & Molecular Biology
Ming Li, Yannan Liu, Xinglin Jiang, Yuanxin Hang, Haiying Wang, Hang Liu, Zhuo Chen, Yubo Xiao
Summary: miR-144-3p inhibits CEP55 expression in non-small cell lung cancer cells, leading to suppression of cell proliferation and migration, and promotion of apoptosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Cell Biology
Yan Sun, Li Liu, Wanying Xing, Hai Sun
Summary: Sevoflurane inhibits proliferation, invasion, and migration while enhancing apoptosis of HCCLM3 and Huh7 cells by regulating miR-148a-3p. Up-regulation of miR-148a-3p or down-regulation of ROCK1 also inhibits cell progression in a similar manner.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Yong Li, Dai Song, Ting An, Jie Liu, Qian Yang, Shaokui Nan
Summary: miR-1226-3p was found to promote the proliferation of osteosarcoma cells, and it targeted TRAF3 in SaOS-2 cells.
Article
Biochemistry & Molecular Biology
Yentl Y. van der Zee, Lars M. T. Eijssen, Philipp Mews, Aarthi Ramakrishnan, Kelvin Alvarez, Casey K. Lardner, Hannah M. Cates, Deena M. Walker, Angelica Torres-Berrio, Caleb J. Browne, Ashley Cunningham, Flurin Cathomas, Hope Kronman, Eric M. Parise, Laurence de Nijs, Li Shen, James W. Murrough, Bart P. F. Rutten, Eric J. Nestler, Orna Issler
Summary: This study explored the potential use of miRNAs as biomarkers for MDD and its treatment. The findings showed that there were significant differences in blood miRNA signatures between stress-resilient and stress-susceptible mice after an incubation period. Additionally, ketamine treatment was more effective than imipramine at re-establishing baseline miRNA expression levels in mice that responded behaviorally to the drug. The study also identified miR-144-3p as a candidate biomarker for depression diagnosis and predicting ketamine treatment response.
MOLECULAR PSYCHIATRY
(2022)
Review
Oncology
Yunshan Li, Feihan Gu, Yaodong He, Junwei Xiang, Xu Huang, Yuanyin Wang, Ran Chen
Summary: Adenoid cystic carcinoma (ACC) is a rare tumor that usually occurs in the salivary glands, accounting for 1% of all head and neck cancers. Studies have found an association between miRNAs and ACC, and miRNAs are becoming reliable biomarkers for disease detection.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Pathology
Jose A. Plaza, Liubov Kastnerova, Alejandro A. Gru, Brittany Dulmage, Martin J. Sangueza, Dmitry V. Kazakov
Summary: Spiradenomas are benign cutaneous neoplasms with sweat gland differentiation, but they can also present with adenoid cystic carcinoma-like changes. The diagnosis of these tumors can be challenging and requires thorough histopathologic inspection to support the diagnosis.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Jing Han, Nannan Han, Zhimin Xu, Chunye Zhang, Jiannan Liu, Min Ruan
Summary: This study identified the profile of circRNA expression in SACC, with 5 up-regulated and 26 down-regulated circRNAs. The establishment of circRNA-miRNA system revealed an interaction between circRNA ABCA13 and cancer-related miRNA (miR-138-5p), suggesting circRNA ABCA13 may promote SACC through inhibition of miR-138-5p, providing a potential therapeutic target in SACC treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Jing-ru Yang, Xiao-ling Ling, Quan-lin Guan
Summary: The study revealed that Rap-related protein Rap-2a (RAP2A) is upregulated in hepatocellular carcinoma (HCC) tissues and cells, and plays a role in promoting tumor cell proliferation and apoptosis resistance, potentially through activating the mTOR signaling pathway.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Clinical Neurology
Chen Zhang, Hong He, Peter Ngan
SLEEP AND BREATHING
(2013)
Article
Cell Biology
Mingyuan Du, Yunlong Wang, Zhijian Liu, Leilei Wang, Zhengguo Cao, Chen Zhang, Yunru Hao, Hong He
Article
Multidisciplinary Sciences
Chen Zhang, Robin Bruggink, Frank Baan, Ewald Bronkhorst, Thomas Maal, Hong He, Edwin M. Ongkosuwito