Review
Infectious Diseases
Antonio Pizuorno, Nora A. Fierro, Edgar D. Copado-Villagrana, Maria E. Herrera-Solis, Gholamreza Oskrochi, Hassan Brim, Hassan Ashktorab
Summary: The study revealed differences in symptoms, comorbidities, and mortality rates of COVID-19 across different regions in Mexico, with high mortality likely related to high frequencies of comorbidities. Discrepancies in mortality rates and comorbidities frequencies across regions emphasize the need for improved strategies to achieve better outcomes in the population.
BMC INFECTIOUS DISEASES
(2021)
Article
Virology
Cesar Fernandez-de-las-Penas, Juan Torres-Macho, Carlos Guijarro, Jose D. Martin-Guerrero, Oscar J. Pellicer-Valero, Gustavo Plaza-Manzano
Summary: This multicenter cohort study visualized the fluctuating evolution and trajectory of gastrointestinal symptoms in previously hospitalized COVID-19 survivors. The study found that the prevalence of overall gastrointestinal symptoms and diarrhea decreased over time and recovered within the first two to three years after infection.
Review
Gastroenterology & Hepatology
Carmelina Calitri, Ilaria Fumi, Maria Giovanna Ignaccolo, Elena Banino, Stefania Benetti, Maria Maddalena Lupica, Francesca Fantone, Mariella Pace, Franco Garofalo
Summary: COVID-19 affects the gastrointestinal system in children, leading to symptoms such as vomiting, abdominal pain, and diarrhea. The virus can be detected in stool samples and gastrointestinal symptoms may precede severe manifestations, requiring supportive treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Infectious Diseases
Rifat Tasnim Juthi, Saiful Arefeen Sazed, Monira Sarmin, Rashidul Haque, Mohammad Shafiul Alam
Summary: SARS-CoV-2, the cause of COVID-19, has rapidly spread worldwide and caused significant mortality. Gastrointestinal symptoms, including diarrhea, are common in COVID-19 patients along with respiratory symptoms. The overexpression of angiotensin converting enzyme 2 (ACE2) in enterocytes, along with other factors such as gut dysbiosis and inflammatory response, contribute to the occurrence of diarrhea. SARS-CoV-2 can also damage liver cells. Currently, there is no effective treatment available.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Evan Xu, Yan Xie, Ziyad Al-Aly
Summary: In this study, the authors estimated the risks and one-year burdens of gastrointestinal disorders following SARS-CoV-2 infection. The results showed that people with COVID-19 had an increased risk of gastrointestinal disorders, which were correlated with the severity of the disease. These findings highlight the importance of post-covid care in addressing gastrointestinal health and diseases.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Monika Laszkowska, Judith Kim, Adam S. Faye, Andrew M. Joelson, Myles Ingram, Han Truong, Elisabeth R. Silver, Benjamin May, William G. Greendyke, Jason Zucker, Benjamin Lebwohl, Chin Hur, Daniel E. Freedberg
Summary: Enteric pathogens other than C.difficile do not seem to be a significant contributor to diarrhea in COVID-19 positive patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Hadar Meringer, Saurabh Mehandru
Summary: The definition, frequency, and pathophysiology of gastrointestinal involvement in post-acute COVID-19 syndrome are not fully understood. This article discusses emerging evidence that supports immunological signatures and highlights the unique nature of the gastrointestinal tract in this syndrome.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Tsvetelina Velikova, Violeta Snegarova, Alexander Kukov, Hristiana Batselova, Antoaneta Mihova, Radislav Nakov
Summary: This review analyzes the role of the gut mucosal immune system in response to SARS-CoV-2 infection and highlights the importance of immune responses in the treatment and prevention of COVID-19, suggesting that vaccines stimulating mucosal immunity may be more advantageous in combating the virus.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jilei Zhang, Shari Garrett, Jun Sun
Summary: The novel coronavirus SARS-CoV-2 can cause gastrointestinal symptoms in addition to respiratory symptoms, indicating a close association between gastrointestinal symptoms and COVID-19 disease. The virus may also impact the gut microbiota, and further research is ongoing regarding oral-fecal transmission and antiviral treatments.
Article
Gastroenterology & Hepatology
Yael R. Nobel, Steven H. Su, Michaela R. Anderson, Lyndon Luk, Jennifer L. Small-Saunders, Gissette Reyes-Soffer, Dympna Gallagher, Daniel E. Freedberg
Summary: Patients with gastrointestinal symptoms of SARS-CoV-2 have a milder clinical course, while body composition risk factors are associated with worse outcomes among patients without gastrointestinal symptoms. Additionally, future studies should explore the mechanisms for the altered disease course in patients with COVID-19 who present with gastrointestinal symptoms.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Immunology
Hao Zhang, Bo Shao, Qin Dang, Zhuang Chen, Quanbo Zhou, Hong Luo, Weitang Yuan, Zhenqiang Sun
Summary: COVID-19 is a new infectious disease primarily spread through the respiratory tract, potentially causing lung and gastrointestinal infections. The virus utilizes ACE2 as a cellular receptor for infection, potentially leading to direct infection of intestinal epithelial cells and impacting inflammatory responses and immune balance. The high expression of ACE2 in the intestines may contribute to the manifestation of gastrointestinal symptoms in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Ghazal Zoghi, Seyed Hamid Moosavy, Sadegh Yavarian, Mehdi HasaniAzad, Farid Khorrami, Masoud Sharegi Brojeni, Masoumeh Kheirandish
Summary: This study evaluated the gastrointestinal symptoms of 507 COVID-19 patients and found that 47.9% of patients had at least one GI symptom, with nausea and/or vomiting being the most common. Patients with GI symptoms were generally older and had lower rates of leukopenia and lymphopenia compared to those without GI symptoms.
BMC INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Oscar Peralta, Abraham Ortinez-Alvarez, Ricardo Torres-Jardon, Manuel Suarez-Lastra, Telma Castro, Luis Gerardo Ruiz-Suarez
Summary: During the COVID-19 pandemic lockdown, emissions of primary criteria pollutants in the Mexico City Metropolitan Area were significantly reduced, leading to a shift in the ozone formation zone from a VOC sensitive region to a NOx sensitive region. The study found the impacts of contingent short-term emissions control actions on ozone formation and proposed guidelines to enhance emission control policies in the post-COVID-19 era.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Gastroenterology & Hepatology
Emine Bukum, Ayse Oguz Ayarci, Kadir Guler
Summary: This study aimed to investigate the general characteristics of COVID-19 patients in our country with gastrointestinal symptoms and the effects of these symptoms on prognosis. The study found that patients with gastrointestinal symptoms were older and had higher rates of intensive care unit admission, intubation, and mortality. The white blood cell count and C-reactive protein values were significantly higher in patients without gastrointestinal symptoms.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Daniel Revollo-Fernandez, L. Rodriguez-Tapia, C. Medina-Rivas, J. A. Morales-Novelo
Summary: This study quantifies the impact of social and economic determinants on the probability of dying from COVID-19 in Mexico using an econometric model. The results indicate that variables related to vulnerable groups, such as poverty, lack of services, gender, age, pre-existing medical conditions, and access to water, can significantly increase the number of deaths. Therefore, it is recommended to develop more policies targeting vulnerable groups to reduce inequality gaps.