期刊
BIOTECHNOLOGY LETTERS
卷 38, 期 1, 页码 191-201出版社
SPRINGER
DOI: 10.1007/s10529-015-1965-3
关键词
Carbon dot; Doxorubicin; Drug delivery; Nanosurface energy transfer; Visible release
资金
- National Nature Science Foundation of China [91227126]
- National Key Scientific Instrument and Equipment Development Project of China [2013YQ17046307]
- Nature Science Foundation of Liaoning Province, China [2013020177]
To prepare fluorescent carbon dots for loading cationic anticancer drug through donor-quenched nanosurface energy transfer in visible sensing of drug release. Highly fluorescent carbon dots (CDs) were prepared by a facile hydrothermal approach from citric acid and o-phenylenediamine. The obtained CDs showed a high quantum yield of 46 % and exhibited good cytocompatibility even at 1 mg/ml. The cationic anticancer drug doxorubicin (DOX) can be loaded onto the negatively charged CDs through electrostatic interactions. Additionally, the fluorescent CDs feature reversible donor-quenched mode nanosurface energy transfer. When loading the energy receptor DOX, the donor CDs' fluorescence was switched off, while it turned on again after DOX release from the surface through endocytic uptake. Most DOX molecules were released from the CDs after 6 h incubation and entered cell nuclear region after 8 h, suggesting the drug delivery system may have potential for visible sensing in drug release.
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