Article
Gastroenterology & Hepatology
Colleen R. Kelly, Eugene F. Yen, Ari M. Grinspan, Stacy A. Kahn, Ashish Atreja, James D. Lewis, Thomas A. Moore, David T. Rubin, Alison M. Kim, Sonya Serra, Yanina Nersesova, Lydia Fredell, Dea Hunsicker, Daniel McDonald, Rob Knight, Jessica R. Allegretti, Joel Pekow, Imad Absah, Ronald Hsu, Jennifer Vincent, Sahil Khanna, Lyn Tangen, Carl Crawford, Mark C. Mattar, Lea Ann Chen, Monika Fischer, Razvan Arsenescu, Paul Feuerstadt, Jonathan Goldstein, David Kerman, Adam C. Ehrlich, Gary D. Wu, Loren Laine
Summary: This study demonstrated the high effectiveness and good safety profile of FMT for CDI. Assessment of new conditions at long-term follow-up will be important for determining the full safety profile of FMT as this registry grows.
Article
Cell Biology
Taylor M. Halsey, Anusha S. Thomas, Tomo Hayase, Weijie Ma, Hamzah Abu-Sbeih, Baohua Sun, Edwin Roger Parra, Zhi-Dong Jiang, Herbert L. DuPont, Christopher Sanchez, Rawan El-Himri, Alexandria Brown, Ivonne Flores, Lauren McDaniel, Miriam Ortega Turrubiates, Matthew Hensel, Dung Pham, Stephanie S. Watowich, Eiko Hayase, Chia-Chi Chang, Robert R. Jenq, Yinghong Wang
Summary: Immune checkpoint inhibitors (ICIs) are effective in treating advanced malignancies but can also lead to immune-related adverse events like immune-mediated colitis (IMC). Fecal microbiota transplantation (FMT) may be a beneficial treatment for IMC due to its ability to manipulate microbial composition. In this study, 12 patients with refractory IMC underwent FMT, resulting in symptom improvement in 83% of patients and requiring repeat FMT in 25% of patients.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Morten Nilsen, Asima Lokmic, Inga Leena Angell, Karin C. Lodrup Carlsen, Kai-Hakon Carlsen, Guttorm Haugen, Gunilla Hedlin, Christine Monceyron Jonassen, Benjamin J. Marsland, Bjorn Nordlund, Eva Maria Rehbinder, Carina Madelen Saunders, Havard O. Skjerven, Lars Snipen, Anne Cathrine Staff, Cilla Soderhall, Riyas Vettukattil, Knut Rudi
Summary: This study investigated the sharing of bacteria between mothers and children, as well as the nutrient utilization potential for the gut microbiota from a large cohort. Results showed a relationship between mother-child sharing of Bacteroides, vaginal delivery, and host-derived mucins. Additionally, an increase in metagenome size corresponded to an increase in diversity in nutrient utilization, with dietary polysaccharides playing a key role.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Santiago Garcia, Payam Dehghani, Cindy Grines, Laura Davidson, Keshav R. Nayak, Jacqueline Saw, Ron Waksman, John Blair, Bagai Akshay, Ross Garberich, Christian Schmidt, Hung Q. Ly, Scott Sharkey, Nestor Mercado, Carlos E. Alfonso, Naoki Misumida, Deepak Acharya, Mina Madan, Abdul Moiz Hafiz, Nosheen Javed, Jay Shavadia, Jay Stone, M. Chadi Alraies, Wah Htun, William Downey, Brian A. Bergmark, Jospeh Ebinger, Tareq Alyousef, Houman Khalili, Chao-Wei Hwang, Joshua Purow, Alexander Llanos, Brent McGrath, Mark Tannenbaum, Jon Resar, Rodrigo Bagur, Pedro Cox-Alomar, Ada C. Stefanescu Schmidt, Lindsey A. Cilia, Farouc A. Jaffer, Michael Gharacholou, Michael Salinger, Brian Case, Ameer Kabour, Xuming Dai, Osama Elkhateeb, Taisei Kobayashi, Hahn-Ho Kim, Mazen Roumia, Frank Aguirre, Jeffrey Rade, Aun-Yeong Chong, Hurst M. Hall, Shy Amlani, Alireza Bagherli, Rajan A. G. Patel, David A. Wood, Frederick G. Welt, Jay Giri, Ehtisham Mahmud, Timothy D. Henry
Summary: The NACMI registry study describes the characteristics and outcomes of COVID-19 patients with STEMI, indicating that COVID+ patients have unique situations in treatment and prognosis.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chongming Wu, Tianda Chen, Wenyi Xu, Tingting Zhang, Yuwei Pei, Yanan Yang, Fang Zhang, Hao Guo, Qingshi Wang, Li Wang, Bowen Zhao
Summary: The development of preservation methods is essential for microbiome research, and the self-made preservation buffer (PB buffer) demonstrated in this study showed promising results in stabilizing microbial consortia in human fecal and saliva samples under various environmental conditions. This method, which does not require freezing facilities, could be a valuable choice for stabilizing samples in the absence of liquid nitrogen.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Haiming Fang, Tingting Yao, Wanli Li, Na Pan, Hang Xu, Qian Zhao, Yuan Su, Kangwei Xiong, Jiajia Wang
Summary: This study evaluated the efficacy and safety of fecal microbiota transplantation (FMT) for adult chronic insomnia. The results showed that FMT significantly improved the insomnia, anxiety, depression, and quality of life in patients with chronic insomnia. The study also found that the increase in certain bacteria was positively correlated with the efficacy of FMT.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Food Science & Technology
Fengli Zhang, Wenqi Huang, Lina Zhao
Summary: This preliminary study investigates the modulatory effects of a formulation containing Ganoderma lucidum, Grifola frondosa, and American ginseng on gut microbiota and fecal metabolism. The findings suggest that the immune enhancement observed with JGGA may be attributed to the targeted modulation of gut microbiota and fecal metabolism, thus promoting increased immunity in the body.
Article
Gastroenterology & Hepatology
Yao-Wen Cheng, Dana Alhaffar, Srishti Saha, Sahil Khanna, Matthew Bohm, Emmalee Phelps, Marwan Ghabril, Eric Orman, Sagi Sashidhar, Nicholas Rogers, Huiping Xu, Alexander Khoruts, Byron Vaughn, Dina Kao, Karen Wong, Giovanni Cammarota, Gianluca Ianiro, Tanvi Dhere, Colleen S. Kraft, Nirja Mehta, Michael H. Woodworth, Jessica R. Allegretti, Lotem Nativ, Jenna Marcus, Najwa El-Nachef, Monika Fischer
Summary: The study found that FMT was safe and effective in treating CDI in patients with cirrhosis, with a success rate of 85.7%. Risk factors for FMT failure in these patients included the use of non-CDI antibiotics, severe Child-Pugh scores, and probiotic use. The rate of FMT-related adverse events was 33.3%, but severe adverse events were rare and not associated with infection or death.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Infectious Diseases
Junpeng Wang, Xin Li, Xiaoqiang Wu, Zhiwei Wang, Xuan Wu, Shanmei Wang, Gaopeng Jing, Tianzhong Yan
Summary: This study demonstrated the therapeutic effect of FMT on infections caused by CRKP for a renal transplant patient. By analyzing microbial characteristics and diversity, the study showed that the microbial composition of the patient post FMT resembled the donor composition, indicating potential therapeutic effects.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Yapeng Yang, Jinhui He, Yuqing Wang, Lifeng Liang, Zeyue Zhang, Xiang Tan, Shiyu Tao, Zhifeng Wu, Miaomiao Dong, Jixia Zheng, Hang Zhang, Shuaifei Feng, Wei Cheng, Qiyi Chen, Hong Wei
Summary: Whole intestinal microbiota transplantation (WIMT) is more effective than fecal microbiota transplantation (FMT) in the treatment of inflammatory bowel disease (IBD). WIMT can replicate the community structure more accurately and reduce the inflammatory response of the host, alleviating the symptoms of IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Shiqi Xu, Jonathan A. Lane, Juchun Chen, Yuxing Zheng, Hongwei Wang, Xiong Fu, Qiang Huang, Sushil Dhital, Feitong Liu, Bin Zhang
Summary: The results of this study show that the short-term in vitro fermentation outcomes depend more on the initial gut microbiota composition than on the molecular specificity of HMOs. These findings have implications for the design of personalized infant nutritional solutions and future therapies.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Catherine M. Cappetto
Summary: This case study investigates the successful treatment of CDI with early and repeated FMT during an acute, refractory episode of the disease, when pharmacologic antimicrobial therapy had failed. It suggests a potential role for FMT in such cases and contributes to the understanding of optimal timing for antibiotic cessation surrounding FMT.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2021)
Review
Microbiology
Cansu Celik, Orhan Pinar, Nisa Sipahi
Summary: The demand for livestock-originated food is endless, and it is important to understand the hazard points in livestock breeding. Pathogens, including Aliarcobacter, pose a threat to farm-animal breeding and public health. Aliarcobacter is capable of colonizing livestock intestines and is transmitted through feces, contaminating slaughterhouses and milk products. Additionally, it can also be transmitted vertically and horizontally, including through offspring that abort in farm animals. The global circulation of farm-animal products is a significant route for the transmission of zoonotic agents. The prevalence of Aliarcobacter in fecal samples varies worldwide, and antibiotic resistance has become a major concern in animal breeding and the food industry. Treatment options for Aliarcobacter-infected farm animals are limited.
Article
Geriatrics & Gerontology
C. Nivet, V Duhalde, M. Beaurain, P. Delobel, I Quelven, L. Alric
Summary: FMT is effective and well-tolerated in very old frail patients, improving their quality of life and limiting functional loss.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Immunology
Sofia de la Villa, Sergio Herrero, Patricia Munoz, Carmen Rodriguez, Maricela Valerio, Elena Reigadas, Ana Alvarez-Uria, Luis Alcala, Mercedes Marin, Maria Olmedo, Martha Kestler, Esther Chamorro, Emilio Bouza
Summary: This study aimed to describe the frequency and effectiveness of Bezlotoxumab (BZX) and fecal microbiota transplantation (FMT) in real-world practice for treating Clostridioides difficile infection (CDI). The results showed that both BZX and FMT had similar effectiveness in preventing CDI recurrence despite their application to different populations.
OPEN FORUM INFECTIOUS DISEASES
(2023)